General Information of Target

Target ID LDTP03822
Target Name Activin receptor type-1B (ACVR1B)
Gene Name ACVR1B
Gene ID 91
Synonyms
ACVRLK4; ALK4; Activin receptor type-1B; EC 2.7.11.30; Activin receptor type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Subcellular location
Cell membrane
Function
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
TTD ID
T47594
Uniprot ID
P36896
DrugMap ID
TTPKHTZ
Ensemble ID
ENST00000257963.9
HGNC ID
HGNC:172
ChEMBL ID
CHEMBL5310

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 SNV: p.H157R .
HCT15 SNV: p.G6Ter; p.W279Ter; p.R296G; p.V446D .
ICC3 Insertion: .
SNV: .
.
MOLT4 SNV: p.P116S; p.E117D; p.R474Ter .
REH SNV: p.E88D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C448(0.99); C476(0.78); C417(1.00); C172(0.96)  LDD1492  [1]
WYneN
 Probe Info 
N.A.  LDD0021  [2]
AOyne
 Probe Info 
13.80  LDD0443  [3]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C070
 Probe Info 
14.12  LDD1766  [4]
C071
 Probe Info 
8.94  LDD1767  [4]
C072
 Probe Info 
8.57  LDD1768  [4]
C112
 Probe Info 
20.25  LDD1799  [4]
C161
 Probe Info 
10.85  LDD1841  [4]
C187
 Probe Info 
20.97  LDD1865  [4]
C310
 Probe Info 
33.36  LDD1977  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C476(1.13); C417(0.90); C349(0.90); C448(1.31)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C476(1.00); C417(1.10); C349(1.13); C448(1.28)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C417(1.34); C349(1.09); C448(1.21); C95(0.99)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C476(0.95); C417(1.19); C448(1.01); C172(1.15)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C476(0.98); C417(0.94); C349(1.10)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C417(1.24); C349(1.01); C448(1.05); C172(1.06)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C476(0.90); C417(1.08); C349(0.99); C448(1.13)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C476(1.03); C417(1.01); C349(0.92); C448(0.99)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C417(1.58); C349(0.99); C448(1.18); C95(1.13)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C476(1.00); C417(1.16); C349(1.24); C448(1.29)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C476(0.86); C417(1.19); C448(1.07); C172(1.37)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C417(1.35); C349(1.09); C448(1.05)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C476(1.08); C417(0.89); C349(0.89)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C417(1.00); C349(1.05); C448(1.02); C172(1.09)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C476(0.99); C417(0.94); C349(1.02); C400(0.93)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C476(0.93); C417(0.96); C349(1.01); C448(1.16)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C476(1.00); C417(0.92); C349(1.10); C448(1.08)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C417(1.07); C349(1.04); C448(1.21); C95(1.05)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C476(1.03); C417(0.99); C448(1.10); C172(1.18)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C417(1.28); C349(1.10); C448(1.12)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C417(0.87); C349(1.24); C448(1.28); C95(1.18)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C476(0.99); C417(0.92); C349(0.94)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C417(1.21); C349(0.89); C448(1.00); C172(1.05)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C476(0.94); C417(1.03); C349(0.95); C400(0.94)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C476(1.00); C417(1.61); C349(0.91); C448(1.24)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C476(0.99); C417(1.28); C349(1.07); C448(1.20)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C417(1.00); C349(1.17); C448(1.21); C95(1.14)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C476(0.93); C417(1.08); C448(1.18); C172(1.20)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C417(0.89); C349(1.11); C448(1.13)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C476(0.93); C417(1.22); C349(1.16)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C417(0.87); C349(1.15); C448(1.02); C172(1.33)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C476(1.03); C417(0.82); C448(1.15); C172(0.90)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C476(1.06); C417(1.19); C349(1.03); C400(1.23)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C476(1.09); C417(1.08); C349(1.12); C448(1.24)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C476(1.08); C417(1.05); C349(1.11); C448(1.36)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C417(0.88); C349(1.22); C448(1.24); C95(0.87)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C476(0.99); C417(0.92); C448(1.08); C172(1.43)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C417(1.08); C349(1.10); C448(1.06)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C476(0.99); C417(1.11); C349(0.89)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C417(0.92); C349(1.16); C448(1.02); C172(1.03)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C476(0.93); C417(0.89); C349(1.12); C400(1.00)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C476(0.97); C417(0.73); C349(1.03); C448(1.28)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C417(0.89); C349(1.07); C448(1.20)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C476(1.01); C417(1.07); C349(0.93); C448(1.19)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C417(1.26); C349(1.22); C448(1.31); C95(1.07)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C476(0.97); C417(1.21); C448(1.02); C172(1.29)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C417(1.42); C349(1.05); C448(1.07)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C476(0.99); C417(1.02); C349(1.05)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C417(0.99); C349(1.08); C448(1.02); C172(1.18)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C476(1.01); C417(1.52); C349(1.20); C400(0.87)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C476(1.05); C417(0.80); C349(1.04); C448(1.25)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C476(1.14); C417(1.02); C349(1.04); C448(1.12)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C417(1.16); C349(1.13); C448(1.20); C95(1.14)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C476(0.89); C417(1.04); C349(0.97)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C476(0.99); C417(1.59); C448(1.16); C172(1.10)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C417(1.15); C349(0.98); C448(1.13)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C476(0.95); C417(1.13); C349(0.88)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C417(1.00); C349(1.00); C448(1.00); C172(1.34)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C476(1.01); C417(0.89); C349(1.09); C400(1.00)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C417(0.91); C349(1.03); C448(1.07); C172(1.25)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C476(1.05); C417(1.00); C349(0.90); C400(1.03)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C417(1.08); C349(1.06); C448(1.10)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C476(0.98); C417(0.96); C349(1.12); C448(1.36)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C476(0.96); C417(1.02); C349(1.01); C400(1.09)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C476(1.06); C417(0.98); C349(0.96)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C476(1.01); C417(1.20); C349(0.98)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C476(1.06); C417(0.81); C349(1.06); C448(1.17)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C476(1.09); C417(1.16); C349(0.99)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C476(1.05); C349(1.13); C448(1.29); C172(1.12)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C417(0.99); C349(0.98); C448(1.17)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C476(1.05); C417(1.07); C349(1.03); C448(1.19)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C476(1.02); C417(0.97); C349(0.92)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C476(1.02); C349(1.16); C448(0.98); C172(1.14)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C417(1.20); C349(1.06); C448(1.19)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C476(0.95); C417(1.42); C349(1.03); C448(1.09)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C476(0.93); C417(0.93); C349(0.91)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C417(1.24); C349(1.11); C448(0.78); C172(1.59)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C476(1.02); C349(1.19); C448(1.18); C172(0.83)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C417(1.05); C349(1.28); C448(1.11)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C476(0.92); C417(0.91); C349(1.11); C448(1.13)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C476(1.03); C417(0.95); C349(0.76)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C476(0.99); C349(1.16); C448(1.40); C172(0.94)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C417(1.16); C349(1.00); C448(1.09)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C476(1.05); C417(1.34); C349(1.03); C448(1.10)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C476(0.94); C417(0.94); C349(1.06)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C476(0.88); C349(1.17); C448(1.15); C172(0.93)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C417(2.20); C349(1.16); C448(1.08)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C476(1.19); C417(1.19); C349(0.86); C400(0.92)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C476(0.99); C417(1.14); C349(1.04); C448(1.21)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C476(0.93); C417(0.94); C349(1.10)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C476(1.01); C349(1.06); C448(1.17); C172(1.13)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C417(1.28); C349(1.24); C448(1.15)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C476(1.07); C417(1.18); C349(1.28); C448(1.24)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C476(0.98); C417(1.11); C349(1.05)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C476(0.97); C349(1.07); C448(1.19); C172(0.95)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C417(1.19); C349(0.98); C448(1.15)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C476(1.01); C417(0.99); C349(1.08); C448(1.27)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C476(0.99); C417(0.95); C349(1.09)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C476(0.92); C349(1.05); C448(1.16); C172(1.34)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C417(1.08); C349(1.28); C448(1.23)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C476(0.99); C417(1.11); C349(1.00); C448(1.49)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C476(1.27); C417(1.29); C349(1.09); C448(1.35)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C476(0.99); C417(1.57); C349(1.15); C448(1.20)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C417(1.39); C349(1.14); C448(1.07); C95(1.13)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C476(0.97); C349(1.02); C448(1.22); C172(0.94)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C476(1.02); C417(1.52); C448(0.79); C172(1.59)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C417(1.45); C349(1.56); C448(0.91)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C476(1.06); C417(1.22); C349(0.91)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C417(1.12); C349(1.13); C448(0.68); C172(1.58)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C476(1.15); C417(1.16); C349(0.93); C400(0.98)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C476(1.16); C417(0.94); C349(0.84)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C476(0.89); C349(1.21); C448(1.06); C172(0.67)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C417(1.70); C349(0.94); C448(1.07)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C476(1.02); C417(1.02); C349(1.05); C448(1.08)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C476(0.95); C417(0.64); C349(0.93); C448(1.02)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C417(1.04); C349(1.11); C448(1.20)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C476(1.03); C417(1.09); C349(1.07); C448(1.03)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C417(1.34); C349(1.02); C448(1.03); C95(1.14)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C476(1.03); C417(2.24); C448(0.80); C172(1.16)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C417(1.61); C349(1.38); C448(0.96)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C476(1.04); C417(1.18); C349(1.08)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C417(1.05); C349(1.10); C448(0.78); C172(1.31)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C476(1.05); C417(0.95); C349(0.96); C400(1.13)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C476(1.08); C417(0.93); C349(0.99)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C417(1.09); C349(1.06); C448(1.13)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C476(1.19); C417(1.19); C349(1.16); C448(1.32)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C476(0.98); C417(1.12); C349(1.13); C448(1.10)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C476(0.94); C417(1.17); C349(1.08); C448(1.05)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C476(1.14); C417(0.99); C349(0.98); C448(0.94)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C417(1.09); C349(1.00); C448(0.96); C95(1.05)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C476(0.99); C417(1.24); C448(0.88); C172(1.45)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C417(1.38); C349(1.07); C448(0.92)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C476(0.96); C417(1.26); C349(0.99)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C417(1.24); C349(0.90); C448(0.77); C172(1.57)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C476(1.03); C417(1.81); C349(0.94); C400(1.00)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C476(1.14); C417(0.97); C349(1.01)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C476(1.27); C417(1.13); C349(1.04); C448(1.13)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C476(0.97); C349(1.01); C448(1.21); C172(0.75)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C476(1.09); C417(1.26); C349(1.10); C448(1.18)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C476(1.22); C417(0.98); C349(1.26); C448(1.41)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C476(1.19); C417(1.35); C349(1.49); C448(1.22)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C417(1.27); C349(0.97); C448(0.98); C95(1.10)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C476(0.93); C417(1.07); C448(0.85); C172(1.18)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C417(1.11); C349(1.47); C448(0.99)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C476(1.04); C417(1.50); C349(0.95)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C417(1.65); C349(1.10); C448(0.71); C172(1.23)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C476(1.27); C417(1.29); C349(1.12); C448(1.20)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C476(1.00); C417(1.34); C349(0.92); C400(0.94)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C476(1.00); C417(1.03); C349(0.91)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C476(0.91); C349(1.06); C448(1.24); C172(0.82)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C417(0.86); C349(1.07); C448(1.15)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C476(1.10); C417(1.04); C349(1.21); C448(1.22)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C476(0.98); C417(1.05); C349(0.98); C448(1.27)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C476(1.08); C417(1.27); C349(1.01); C448(1.20)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C417(1.18); C349(1.17); C448(1.00); C95(0.96)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C476(1.00); C417(0.87); C448(0.83); C172(1.26)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C417(1.23); C349(1.30); C448(0.89)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C417(1.05); C349(1.14); C448(1.00); C95(1.04)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C476(1.05); C417(1.14); C349(0.95)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C417(0.96); C349(1.13); C448(0.74); C172(1.25)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C476(1.06); C417(1.34); C349(0.89); C400(1.20)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C476(0.97); C417(0.76); C349(0.91)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C476(0.92); C349(1.07); C448(1.26); C172(0.51)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C476(1.02); C417(0.91); C349(1.00); C448(1.09)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C476(1.01); C417(0.94); C349(1.23); C448(1.24)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C476(1.05); C417(1.18); C349(1.01); C448(1.20)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C417(1.26); C349(1.05); C448(1.10); C95(1.02)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C476(1.85); C417(1.20); C448(1.06); C172(2.03)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C476(0.93); C417(1.11); C448(0.81); C172(1.30)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C417(1.38); C349(1.10); C448(0.88)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C476(1.10); C417(1.25); C349(0.98)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C417(1.07); C349(1.04); C448(0.88); C172(1.12)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C476(1.09); C417(1.17); C349(0.93); C400(0.91)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C476(1.14); C417(0.92); C349(1.18)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C476(1.18); C349(1.22); C448(1.34); C172(0.95)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C417(1.09); C349(1.10); C448(1.21)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C476(1.14); C417(0.86); C349(1.16); C448(1.20)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C476(1.12); C417(0.72); C349(1.03); C448(1.40)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C417(1.34); C349(1.12); C448(0.96)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C476(1.35); C417(1.13); C349(1.39); C448(1.57)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C417(1.05); C349(1.04); C448(1.13); C95(1.08)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C476(0.94); C417(1.74); C448(1.03); C172(1.33)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C417(1.90); C349(1.42); C448(0.97)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C476(1.00); C417(1.02); C349(0.82)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C417(1.49); C349(1.10); C448(0.99); C172(1.64)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C476(1.19); C417(0.96); C349(1.03); C400(1.02)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C476(0.97); C417(0.92); C349(0.92)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C476(1.00); C349(1.11); C448(1.11); C172(1.43)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C417(0.94); C349(1.07); C448(1.02)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C417(1.32); C349(1.16); C448(1.13)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C417(1.36); C349(1.06); C448(1.19)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C476(0.89); C349(0.99); C448(1.07); C172(0.81)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C448(0.99); C476(0.78); C417(1.00); C172(0.96)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C448(1.05); C476(1.01); C417(1.09); C172(0.90)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C448(1.03); C476(0.96); C417(1.10); C172(0.70)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) FKBP-type PPIase family P62942
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 7 (SMAD7) Dwarfin/SMAD family O15105

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171
Pmid23639540c13d Small molecular drug D0F2MP
Pmid23639540c13r Small molecular drug D05NEC
Patented
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bdbm108945 Small molecular drug D05YMG
Us10030004, Compound 11a Small molecular drug D0Z9FM
Us10030004, Compound 19 Small molecular drug D0E9VJ
Us10030004, Compound 33 Small molecular drug D0IA7H
Us9682983, 1 Small molecular drug D01RXV
Us9682983, 33 Small molecular drug D0F7CA

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587