Details of the Target

General Information of Target

Target ID LDTP01631
Target Name Mitochondrial pyruvate carrier 2 (MPC2)
Gene Name MPC2
Gene ID 25874
Synonyms
BRP44; Mitochondrial pyruvate carrier 2; Brain protein 44
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADM
ARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQE
LKAKAHK
Target Bioclass
Transporter and channel
Family
Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
Subcellular location
Mitochondrion inner membrane
Function Mediates the uptake of pyruvate into mitochondria.
Uniprot ID
O95563
Ensemble ID
ENST00000271373.9
HGNC ID
HGNC:24515
ChEMBL ID
CHEMBL4295686

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		7.17  LDD0196  [1]
TH211
 Probe Info  		Y32(7.31)  LDD0260  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
Jackson_14
 Probe Info  		3.23  LDD0123  [4]
YY4-yne
 Probe Info  		11.57  LDD0400  [5]
HPAP
 Probe Info  		3.25  LDD0063  [6]
EA-probe
 Probe Info  		C54(0.88)  LDD2210  [7]
DBIA
 Probe Info  		C54(0.98)  LDD1492  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
W1
 Probe Info  		N.A.  LDD0236  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.85  LDD1740  [14]
C071
 Probe Info  		11.55  LDD1767  [14]
C094
 Probe Info  		27.67  LDD1785  [14]
C231
 Probe Info  		11.55  LDD1904  [14]
C232
 Probe Info  		37.27  LDD1905  [14]
C235
 Probe Info  		21.41  LDD1908  [14]
C278
 Probe Info  		61.82  LDD1948  [14]
C285
 Probe Info  		26.91  LDD1955  [14]
C362
 Probe Info  		28.64  LDD2023  [14]
C400
 Probe Info  		5.86  LDD2059  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C54(0.97)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C54(1.00)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C54(1.02)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C54(0.98)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C54(1.04)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C54(1.00)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C54(0.97)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C54(0.94)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C54(0.96)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C54(0.96)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C54(1.01)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C54(1.00)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C54(1.01)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C54(0.96)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C54(1.00)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C54(1.00)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C54(0.94)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C54(0.97)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C54(0.96)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C54(0.98)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C54(1.01)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C54(0.95)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C54(0.98)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C54(1.02)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C54(0.97)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C54(1.05)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C54(0.99)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C54(1.00)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C54(1.04)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C54(1.03)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C54(1.02)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C54(0.98)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C54(1.03)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C54(1.04)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C54(0.92)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C54(0.97)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C54(1.01)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C54(0.97)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C54(1.02)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C54(1.03)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C54(1.00)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C54(1.01)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C54(1.02)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C54(1.02)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C54(1.00)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C54(1.01)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C54(0.97)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C54(1.08)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C54(1.01)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C54(0.99)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C54(1.02)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C54(1.01)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C54(1.01)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C54(1.06)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C54(1.00)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C54(0.99)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C54(1.00)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C54(1.03)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C54(1.00)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C54(1.00)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C54(1.00)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C54(0.96)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C54(1.05)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C54(1.02)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C54(1.26)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C54(1.48)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C54(1.05)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C54(1.05)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C54(1.06)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C54(0.96)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C54(1.01)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C54(1.11)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C54(0.86)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C54(0.95)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C54(1.04)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C54(1.13)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C54(0.77)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C54(0.92)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C54(0.97)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C54(0.96)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C54(1.14)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C54(0.89)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C54(1.04)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C54(0.98)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C54(1.07)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C54(0.99)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C54(1.04)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C54(1.12)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C54(1.00)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C54(1.12)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C54(0.99)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C54(0.99)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C54(1.07)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C54(1.06)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C54(0.96)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C54(0.96)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C54(1.00)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C54(1.07)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C54(0.94)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C54(1.09)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C54(1.03)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C54(0.92)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C54(1.06)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C54(1.02)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C54(1.01)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C54(1.11)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C54(1.13)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C54(1.15)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C54(0.75)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C54(1.11)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C54(1.37)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C54(0.96)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C54(1.13)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C54(1.05)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C54(0.96)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C54(1.08)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C54(0.98)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C54(0.99)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C54(1.01)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C54(1.18)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C54(1.26)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C54(0.67)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C54(1.03)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C54(1.08)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C54(1.04)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C54(1.14)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C54(1.03)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C54(0.99)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C54(0.96)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C54(1.02)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C54(1.01)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C54(0.95)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C54(0.98)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C54(0.72)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C54(1.07)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C54(1.11)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C54(0.98)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C54(1.02)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C54(1.04)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C54(1.02)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C54(1.17)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C54(1.08)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C54(1.04)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C54(1.07)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C54(1.15)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C54(0.79)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C54(1.17)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C54(1.01)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C54(1.02)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C54(0.98)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C54(1.13)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C54(1.04)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C54(0.93)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C54(0.98)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C54(1.02)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C54(1.00)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C54(1.07)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C54(1.18)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C54(1.03)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C54(0.83)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C54(1.00)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C54(1.03)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C54(0.94)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C54(1.02)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C54(0.96)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C54(1.06)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C54(0.99)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C54(1.25)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C54(1.00)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C54(0.99)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C54(1.00)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C54(0.96)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C54(1.10)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C54(1.10)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C54(0.97)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C54(1.00)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C54(1.01)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C54(0.91)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C54(1.10)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C54(1.27)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C54(1.05)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C54(0.97)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C54(1.06)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C54(1.02)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C54(1.09)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C54(1.05)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C54(1.08)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C54(0.95)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C54(1.00)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C54(1.07)  LDD1698  [8]
 LDCM0175  Ethacrynic acid HeLa C54(0.88)  LDD2210  [7]
 LDCM0625  F8 Ramos C54(0.51)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C54(1.37)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C54(0.05)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C54(1.96)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C54(1.09)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C54(4.43)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C54(3.01)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C54(1.15)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C54(1.13)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C54(1.08)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C54(1.05)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C54(0.89)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C54(0.98)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C54(1.19)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C54(1.03)  LDD1671  [8]
 LDCM0596  Fragment38 Ramos C54(0.83)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C54(1.16)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C54(0.98)  LDD1631  [8]
 LDCM0610  Fragment52 Ramos C54(0.67)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C54(0.52)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C54(1.02)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C54(4.23)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C54(0.98)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C54(0.91)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C54(0.86)  LDD1502  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C54(0.69)  LDD2206  [16]
 LDCM0628  OTUB2-COV-1 HEK-293T C54(0.73)  LDD2207  [16]
 LDCM0014  Panhematin K562 3.25  LDD0063  [6]
 LDCM0131  RA190 MM1.R C54(2.09)  LDD0304  [17]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 3.23  LDD0123  [4]
 LDCM0155  UK-5099 T cell 10.30  LDD0401  [5]
 LDCM0154  YY4 T cell 11.57  LDD0400  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MICOS complex subunit MIC10 (MICOS10) MICOS complex subunit Mic10 family Q5TGZ0
Mitochondrial pyruvate carrier 1 (MPC1) Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family Q9Y5U8
Mitochondrial pyruvate carrier 2 (MPC2) Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family O95563
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) Tim17/Tim22/Tim23 family O60830
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-I (APOC1) Apolipoprotein C1 family P02654
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Testis-expressed protein 44 (TEX44) . Q53QW1

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.