Details of the Target

General Information of Target

Target ID LDTP12776
Target Name Sphingomyelin phosphodiesterase 4 (SMPD4)
Gene Name SMPD4
Gene ID 55627
Synonyms
KIAA1418; SKNY; Sphingomyelin phosphodiesterase 4; EC 3.1.4.12; Neutral sphingomyelinase 3; nSMase-3; nSMase3; Neutral sphingomyelinase III
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGTKPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSINSDT
PYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLA
WNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVKLSAGETETTLLVTKPLYE
LGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRV
ASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQH
TPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAW
SPITSLMWACGRHLYECTEEENDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNED
PQLKSLWYTLHFMKQYTEDMDQKSPGNKGSLVYAGIKSIVKSSLGMVESSRHNWSGLDKQ
SDIQNLNEERILALQLCGWIKKGTDVDVGPFLNSLVQEGEWERAAAVALFNLDIRRAIQI
LNEGASSEKGDLNLNVVAMALSGYTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSETG
SYDGVLYENKVAVRDRVAFACKFLSDTQLNRYIEKLTNEMKEAGNLEGILLTGLTKDGVD
LMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHR
SKLDPSSKPLAQVFVSCNFCGKSISYSCSAVPHQGRGFSQYGVSGSPTKSKVTSCPGCRK
PLPRCALCLINMGTPVSSCPGGTKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHML
SWFRDHAECPVSACTCKCMQLDTTGNLVPAETVQP
Target Type
Discontinued
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production.
TTD ID
T58716
Uniprot ID
Q9NXE4
DrugMap ID
TTZSJIV
Ensemble ID
ENST00000351288.10
HGNC ID
HGNC:32949

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.09  LDD0402  [1]
CHEMBL5175495
 Probe Info  		7.35  LDD0196  [2]
STPyne
 Probe Info  		K500(10.00); K604(8.31)  LDD0277  [3]
DBIA
 Probe Info  		C812(3.30)  LDD3311  [4]
BTD
 Probe Info  		C579(1.24)  LDD2093  [5]
AHL-Pu-1
 Probe Info  		C659(3.71)  LDD0168  [6]
CY4
 Probe Info  		C68(0.00); Q69(0.00)  LDD0247  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C68(0.00); C776(0.00); C698(0.00); C579(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C579(0.00); C776(0.00); C68(0.00); C698(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C579(0.00); C68(0.00); C164(0.00); C776(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		C164(0.00); C698(0.00)  LDD0026  [9]
NAIA_4
 Probe Info  		C464(0.00); C579(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C164(0.00); C776(0.00)  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
Compound 10
 Probe Info  		C164(0.00); C579(0.00)  LDD2216  [12]
IPM
 Probe Info  		C68(0.00); C221(0.00); C776(0.00); C579(0.00)  LDD0005  [11]
PPMS
 Probe Info  		N.A.  LDD0008  [11]
VSF
 Probe Info  		C776(0.00); C68(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C464(0.00); C579(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		C164(0.00); C579(0.00); C776(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		C579(0.00); C164(0.00); C766(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		C164(0.00); C776(0.00)  LDD0218  [14]
W1
 Probe Info  		C579(0.00); C164(0.00); C766(0.00); C776(0.00)  LDD0236  [15]
AOyne
 Probe Info  		13.60  LDD0443  [16]
NAIA_5
 Probe Info  		C776(0.00); C766(0.00); C579(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		16.75  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe2
 Probe Info  		11.74  LDD0463  [17]
FFF probe3
 Probe Info  		20.00  LDD0464  [17]
Alk-rapa
 Probe Info  		5.56  LDD0213  [18]
OEA-DA
 Probe Info  		6.24  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C164(0.77)  LDD2142  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C68(1.01); C579(1.13); C164(1.22)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C68(1.46)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C659(3.71)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C659(2.42)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C579(0.98); C68(0.98); C164(1.02); C221(1.04)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C579(0.99); C68(1.01); C164(0.93); C221(1.01)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C579(0.98); C68(0.98); C164(0.94); C221(1.09)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C579(1.02); C68(0.93); C164(0.97); C221(1.10)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C579(1.04); C68(0.99); C164(1.03); C221(1.03)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C579(0.93); C68(0.96); C164(0.92); C221(1.05)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C579(0.94); C68(0.97); C164(1.02); C221(0.99)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C579(0.95); C68(0.96); C164(0.90); C221(0.90)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C579(0.95); C68(0.99); C164(0.91); C221(0.98)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C579(0.92); C68(1.02); C164(0.96); C221(1.02)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C579(1.01); C68(1.00); C164(0.92); C221(1.03)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C579(0.96); C68(0.96); C164(1.02); C221(1.08)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C579(1.03); C68(0.95); C164(0.96); C221(0.92)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C579(1.04); C68(0.97); C164(1.03); C221(1.02)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C579(1.00); C68(0.97); C164(0.96); C221(1.06)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C579(0.99); C68(0.98); C164(0.92); C221(1.04)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C579(0.96); C68(0.98); C164(0.98); C221(0.99)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C579(0.95); C68(1.04); C164(0.96); C221(1.05)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C579(1.00); C68(0.91); C164(1.02); C221(1.00)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C579(1.01); C68(1.01); C164(0.92); C221(1.13)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C579(1.00); C68(0.99); C164(0.90); C221(1.06)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C579(0.97); C68(0.98); C164(1.09); C221(0.98)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C579(0.95); C68(0.94); C164(0.99); C221(1.04)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C579(0.90); C68(0.95); C164(0.94); C221(1.02)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C579(0.95); C68(1.01); C164(1.00); C221(0.99)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C579(0.96); C68(1.01); C164(1.03); C221(1.00)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C579(1.04); C68(1.04); C164(0.95); C221(1.06)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C579(0.94); C68(1.05); C164(0.99); C221(1.05)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C579(0.91); C68(0.96); C164(0.97); C221(1.11)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C579(1.01); C68(1.00); C164(0.98); C221(1.00)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C579(0.94); C68(0.99); C164(1.01); C221(1.06)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C579(0.97); C68(1.01); C164(0.97); C221(1.06)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C579(0.85); C68(0.98); C164(0.99); C221(1.03)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C579(0.95); C68(0.96); C164(1.12); C221(1.10)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C579(0.90); C68(0.97); C164(0.98); C221(0.93)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C579(0.97); C68(1.02); C164(0.93); C221(1.02)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C579(0.96); C68(0.94); C164(0.94); C221(1.10)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C579(0.97); C68(1.04); C164(0.90); C221(1.12)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C579(0.98); C68(0.89); C164(1.09); C221(0.96)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C579(0.95); C68(0.96); C164(0.99); C221(1.05)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C579(0.90); C68(0.94); C164(1.09); C221(1.05)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C579(0.95); C68(0.96); C164(1.14); C221(1.09)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C579(0.98); C68(1.03); C164(1.02); C221(1.12)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C579(0.92); C68(1.02); C164(1.01); C221(0.97)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C579(0.91); C68(1.03); C164(0.99); C221(1.01)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C579(0.91); C68(0.97); C164(0.87); C221(1.09)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C579(0.97); C68(0.99); C164(0.92); C221(1.12)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C579(0.99); C68(0.96); C164(1.15); C221(1.01)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C579(0.96); C68(1.01); C164(0.99); C221(1.08)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C579(0.94); C68(0.93); C164(1.01); C221(0.99)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C579(0.96); C68(1.00); C164(1.03); C221(1.03)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C579(0.95); C68(1.01); C164(1.02); C221(1.00)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C579(0.93); C68(1.00); C164(0.93); C221(1.02)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C579(1.02); C68(1.00); C164(1.14); C221(0.98)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C579(0.97); C68(1.00); C164(1.06); C221(1.09)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C579(0.94); C68(0.96); C164(0.89); C221(1.08)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C579(1.00); C68(0.90); C164(0.93); C221(1.00)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C579(0.91); C68(0.99); C164(1.01); C221(1.07)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C579(0.97); C68(0.90); C164(0.92); C221(1.00)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C579(0.99); C68(1.04); C164(1.01); C221(1.03)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C579(0.92); C68(1.06); C164(0.99); C221(0.99)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C579(1.00); C68(0.95); C164(0.97); C221(1.11)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C579(0.97); C68(1.01); C164(1.07); C221(1.05)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C579(0.88); C68(0.98); C164(1.00); C221(1.08)  LDD1514  [20]
 LDCM0108  Chloroacetamide HeLa C164(0.00); C698(0.00); C579(0.00); C766(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C698(20.00); C579(1.46); C776(0.90); C766(0.67)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C579(1.66); C68(1.13); C164(1.03); C221(1.12)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C579(1.62); C68(1.21); C164(1.07); C221(1.43)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C579(0.92); C68(0.94); C164(0.95); C221(1.17)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C579(1.02); C68(1.03); C164(0.99); C221(0.98)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C579(1.19); C68(1.01); C164(0.80); C221(1.21)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C579(0.98); C68(1.08); C164(0.91); C221(1.08)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C579(1.02); C68(0.95); C164(0.91); C221(1.10)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C579(1.16); C68(1.04); C164(0.98); C221(1.10)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C579(1.16); C68(1.00); C164(1.01); C221(1.10)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C579(0.96); C68(1.07); C164(0.88); C221(1.08)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C579(0.92); C68(0.96); C164(0.84); C221(1.09)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C579(1.32); C68(1.04); C164(0.97); C221(0.98)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C579(1.18); C68(1.42); C164(1.06); C221(1.39)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C579(1.38); C68(0.98); C164(0.87); C221(1.25)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C579(1.19); C68(1.00); C164(0.95); C221(1.14)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C579(1.00); C68(0.92); C164(1.00); C221(1.02)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C579(0.96); C68(1.12); C164(1.04); C221(0.94)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C579(1.22); C68(1.05); C164(0.85); C221(1.34)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C579(0.94); C68(1.11); C164(0.93); C221(1.06)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C579(0.92); C68(0.99); C164(0.94); C221(0.99)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C579(0.95); C68(1.06); C164(1.04); C221(1.05)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C579(0.87); C68(0.99); C164(0.95); C221(1.06)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C579(0.94); C68(1.02); C164(0.91); C221(1.09)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C579(1.17); C68(1.17); C164(1.09); C221(1.23)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C579(0.90); C68(0.98); C164(0.94); C221(1.08)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C579(1.03); C68(1.08); C164(0.97); C221(0.90)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C579(1.03); C68(1.03); C164(0.85); C221(1.14)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C579(1.23); C68(1.13); C164(0.98); C221(1.27)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C579(1.07); C68(1.00); C164(0.99); C221(1.23)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C579(0.85); C68(1.03); C164(0.94); C221(1.05)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C579(0.98); C68(1.03); C164(0.88); C221(1.05)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C579(0.94); C68(1.07); C164(0.87); C221(0.99)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C579(0.96); C68(0.95); C164(0.90); C221(1.05)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C579(1.25); C68(1.09); C164(0.96); C221(1.09)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C579(0.97); C68(1.09); C164(0.98); C221(1.12)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C579(1.52); C68(1.14); C164(1.04); C221(1.33)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C579(1.01); C68(1.04); C164(0.96); C221(1.20)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C579(1.35); C68(1.04); C164(1.12); C221(1.47)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C579(0.96); C68(1.08); C164(0.97); C221(0.98)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C579(1.09); C68(1.08); C164(0.98); C221(1.15)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C579(1.00); C68(1.10); C164(0.86); C221(1.13)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C579(1.00); C68(0.96); C164(1.01); C221(1.28)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C579(1.62); C68(0.99); C164(0.98); C221(1.58)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C579(1.15); C68(0.94); C164(1.07); C221(1.07)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C579(1.09); C68(1.43); C164(1.07); C221(1.25)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C579(1.09); C68(1.30); C164(1.06); C221(1.20)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C579(1.17); C68(1.09); C164(0.96); C221(1.06)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C579(0.94); C68(1.00); C164(0.84); C221(1.10)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C579(1.05); C68(1.03); C164(1.02); C221(1.07)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C579(0.99); C68(0.97); C164(1.02); C221(1.15)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C579(1.00); C68(1.03); C164(1.01); C221(1.07)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C579(1.07); C68(1.07); C164(0.92); C221(1.10)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C579(1.01); C68(1.00); C164(0.94); C221(1.03)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C579(1.08); C68(0.95); C164(0.83); C221(1.10)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C579(1.04); C68(0.92); C164(0.95); C221(1.18)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C579(1.63); C68(1.09); C164(1.19); C221(1.88)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C579(1.21); C68(0.98); C164(1.15); C221(1.29)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C579(1.12); C68(1.33); C164(0.97); C221(1.23)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C579(1.17); C68(1.20); C164(1.01); C221(1.33)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C579(1.01); C68(1.02); C164(0.99); C221(0.97)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C579(1.12); C68(1.03); C164(0.88); C221(1.18)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C579(1.11); C68(1.05); C164(1.05); C221(1.21)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C579(0.89); C68(0.95); C164(0.98); C221(1.01)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C579(1.51); C68(0.97); C164(0.98); C221(1.24)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C579(0.92); C68(1.01); C164(0.89); C221(1.01)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C579(0.93); C68(1.02); C164(0.93); C221(1.13)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C579(1.00); C68(0.92); C164(1.06); C221(1.19)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C579(1.26); C68(0.99); C164(0.97); C221(1.34)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C579(1.15); C68(0.84); C164(1.08); C221(1.11)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C579(1.06); C68(1.27); C164(1.09); C221(1.18)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C579(1.14); C68(1.08); C164(0.93); C221(1.26)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C579(1.08); C68(1.01); C164(0.97); C221(1.01)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C579(1.03); C68(0.98); C164(1.08); C221(1.09)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C579(1.11); C68(1.00); C164(0.84); C221(1.14)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C579(1.02); C68(1.02); C164(0.98); C221(1.20)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C579(1.52); C68(0.93); C164(1.14); C221(1.26)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C579(1.37); C68(1.18); C164(0.98); C221(1.45)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C579(1.00); C68(1.00); C164(0.90); C221(1.10)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C579(0.94); C68(0.84); C164(0.92); C221(1.19)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C579(1.33); C68(0.99); C164(0.95); C221(1.49)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C579(1.22); C68(0.81); C164(0.99); C221(1.16)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C579(1.06); C68(1.28); C164(0.97); C221(1.20)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C579(1.37); C68(1.06); C164(0.96); C221(1.36)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C579(1.08); C68(1.14); C164(1.00); C221(1.27)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C579(1.07); C68(1.06); C164(0.96); C221(1.11)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C579(0.92); C68(1.04); C164(0.92); C221(1.03)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C579(0.94); C68(1.04); C164(0.92); C221(1.00)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C579(1.51); C68(0.95); C164(0.91); C221(1.39)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C579(0.98); C68(0.94); C164(1.03); C221(1.06)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C579(0.93); C68(0.98); C164(0.94); C221(1.05)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C579(0.95); C68(0.97); C164(0.87); C221(1.02)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C579(1.06); C68(0.90); C164(0.92); C221(1.25)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C579(1.23); C68(0.96); C164(0.96); C221(1.39)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C579(1.01); C68(1.04); C164(0.97); C221(1.11)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C579(1.10); C68(0.84); C164(0.99); C221(1.07)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C579(1.03); C68(1.24); C164(0.96); C221(1.28)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C579(0.94); C68(1.14); C164(1.06); C221(1.25)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C579(1.09); C68(1.07); C164(0.95); C221(1.07)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C579(0.94); C68(1.03); C164(0.79); C221(1.13)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C579(1.00); C68(0.98); C164(0.92); C221(1.01)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C579(1.26); C68(1.07); C164(1.02); C221(1.38)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C579(0.98); C68(1.04); C164(0.95); C221(1.01)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C579(0.99); C68(1.01); C164(0.91); C221(1.09)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C579(1.84); C68(1.41); C164(1.20); C221(2.12)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C579(0.96); C68(0.91); C164(1.00); C221(1.08)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C579(0.99); C68(0.97); C164(0.95); C221(1.23)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C579(1.09); C68(0.91); C164(1.01); C221(1.14)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C579(1.12); C68(1.24); C164(1.03); C221(1.30)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C579(1.20); C68(1.10); C164(1.04); C221(1.35)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C579(1.09); C68(1.12); C164(0.90); C221(1.09)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C579(0.94); C68(1.11); C164(0.90); C221(1.09)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C579(0.96); C68(1.14); C164(0.82); C221(1.01)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C579(0.92); C68(1.02); C164(0.85); C221(1.08)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C579(0.92); C68(1.12); C164(1.02); C221(0.99)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C579(1.13); C68(0.92); C164(0.96); C221(1.36)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C579(1.65); C68(1.41); C164(1.01); C221(1.81)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C579(0.94); C68(1.05); C164(0.88); C221(1.04)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C579(1.09); C68(1.03); C164(1.05); C221(1.29)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C579(1.34); C68(1.03); C164(0.96); C221(1.44)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C579(1.13); C68(0.93); C164(1.04); C221(1.08)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C579(1.94); C68(1.35); C164(1.07); C221(1.50)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C579(1.18); C68(1.19); C164(0.96); C221(1.37)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C579(1.64); C68(1.07); C164(0.95); C221(1.08)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C579(1.09); C68(1.06); C164(0.95); C221(1.09)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C579(0.98); C68(1.03); C164(0.89); C221(1.08)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C579(0.94); C68(1.05); C164(0.89); C221(1.08)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C579(8.26); C766(2.43)  LDD1702  [5]
 LDCM0625  F8 Ramos C164(1.03); C776(1.44); C766(0.80); C579(0.90)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C164(1.34); C776(1.27); C766(0.67); C579(1.39)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C164(0.12); C776(8.91); C766(1.55); C579(1.59)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C164(1.86); C776(2.24); C766(1.26); C579(1.95)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C164(0.83); C776(0.79); C766(0.94); C579(0.72)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C164(2.36); C776(4.59); C766(0.77); C579(3.84)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C164(2.55); C776(5.39); C579(1.71); C68(3.73)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C164(0.87); C776(0.88); C766(0.90); C579(1.05)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C164(0.94); C776(0.56); C766(0.85); C579(0.32)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C164(0.78); C776(0.67); C766(0.93); C579(0.98)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C164(1.18); C776(0.91); C766(0.55); C579(0.66)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C164(0.86); C776(0.84); C766(0.87); C579(1.52)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C164(0.84); C776(1.01); C766(1.05); C579(0.59)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C164(1.22); C776(1.32); C766(1.06); C579(2.24)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C579(0.94); C68(1.07); C164(0.89); C221(1.11)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C164(1.00); C776(0.84); C766(0.87); C68(1.41)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C164(1.46); C776(1.83); C766(0.77); C579(1.90)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C579(0.98); C68(1.03); C164(0.84); C221(1.01)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C164(0.88); C776(0.88); C766(0.81); C68(1.34)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C164(0.98); C776(0.85); C766(0.99); C579(0.49)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C164(2.21); C776(1.96); C766(1.21); C68(2.00)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C164(2.19); C776(1.11); C766(0.80)  LDD2188  [21]
 LDCM0107  IAA HeLa C164(0.00); C776(0.00); C579(0.00); H789(0.00)  LDD0221  [14]
 LDCM0022  KB02 HEK-293T C68(1.05); C776(1.01); C164(1.00); C221(1.00)  LDD1492  [20]
 LDCM0023  KB03 Jurkat C698(4.72)  LDD0315  [22]
 LDCM0024  KB05 G361 C812(3.30)  LDD3311  [4]
 LDCM0109  NEM HeLa H537(0.00); H789(0.00)  LDD0223  [14]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C579(1.24)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C68(0.42)  LDD2096  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C68(1.00); C164(1.24)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C68(0.64); C579(1.46); C164(0.92)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C68(1.06)  LDD2111  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C164(0.96)  LDD2118  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C68(0.80); C579(1.15); C164(0.97)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C68(0.69)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C68(0.64); C579(1.10)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C68(1.03); C579(1.33); C164(1.02)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C68(1.04); C579(1.02)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C579(1.11)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C164(1.10)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C68(0.86); C579(0.99); C164(1.01)  LDD2137  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C579(1.90)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C579(0.96); C164(1.07)  LDD2146  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C579(1.60); C164(0.30)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C776(1.26); C164(0.89); C579(0.64); C766(0.29)  LDD2207  [23]
 LDCM0090  Rapamycin JHH-7 5.56  LDD0213  [18]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphatidyl Serine Small molecular drug DB00144
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nd1251 Small molecular drug D00ACC

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
19 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.