Details of the Target

General Information of Target

Target ID LDTP04342
Target Name Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)
Gene Name GNAQ
Gene ID 2776
Synonyms
GAQ; Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding protein alpha-q
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
IIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEK
VSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVL
RVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQR
DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Target Type
Literature-reported
Target Bioclass
Other
Family
G-alpha family, G(q) subfamily
Subcellular location
Cell membrane
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Together with GNA11, required for heart development.
TTD ID
T12290
Uniprot ID
P50148
DrugMap ID
TTL1SRG
Ensemble ID
ENST00000286548.9
HGNC ID
HGNC:4390
ChEMBL ID
CHEMBL3286079

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		10.45  LDD0122  [1]
TH211
 Probe Info  		Y192(20.00); Y151(8.86); Y145(6.49)  LDD0260  [2]
DBIA
 Probe Info  		C330(2.26)  LDD3312  [3]
IPM
 Probe Info  		C330(4.28)  LDD1701  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C144(0.00); C330(0.00)  LDD0037  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [10]
Alk-rapa
 Probe Info  		2.58  LDD0213  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C144(1.02)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C144(1.14)  LDD1508  [12]
 LDCM0237  AC12 HEK-293T C144(1.10)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C144(0.99)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C144(0.96)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C144(0.95)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C144(1.09)  LDD1516  [12]
 LDCM0279  AC2 HEK-293T C144(1.23)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C144(1.07)  LDD1519  [12]
 LDCM0282  AC22 HEK-293T C144(0.84)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C144(0.87)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C144(1.27)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C144(0.98)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C144(1.02)  LDD1525  [12]
 LDCM0288  AC28 HEK-293T C144(0.97)  LDD1527  [12]
 LDCM0291  AC30 HEK-293T C144(1.12)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C144(0.93)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C144(1.11)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C144(1.04)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C144(1.13)  LDD1534  [12]
 LDCM0297  AC36 HEK-293T C144(1.03)  LDD1536  [12]
 LDCM0299  AC38 HEK-293T C144(0.84)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C144(0.97)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C144(1.03)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C144(1.00)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C144(1.01)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C144(1.02)  LDD1543  [12]
 LDCM0306  AC44 HEK-293T C144(1.04)  LDD1545  [12]
 LDCM0308  AC46 HEK-293T C144(0.87)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C144(1.19)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C144(1.05)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C144(0.99)  LDD1550  [12]
 LDCM0313  AC50 HEK-293T C144(1.14)  LDD1552  [12]
 LDCM0315  AC52 HEK-293T C144(1.01)  LDD1554  [12]
 LDCM0317  AC54 HEK-293T C144(1.11)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C144(1.20)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C144(1.02)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C144(0.94)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C144(1.05)  LDD1560  [12]
 LDCM0323  AC6 HEK-293T C144(0.75)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C144(1.01)  LDD1563  [12]
 LDCM0326  AC62 HEK-293T C144(1.18)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C144(0.70)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C144(1.21)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C144(0.86)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C144(1.04)  LDD1569  [12]
 LDCM0356  AKOS034007680 HEK-293T C144(1.06)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C144(1.11)  LDD1514  [12]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0368  CL10 HEK-293T C144(1.05)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C144(0.79)  LDD1573  [12]
 LDCM0372  CL103 HEK-293T C144(0.71)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C144(1.05)  LDD1577  [12]
 LDCM0376  CL107 HEK-293T C144(0.86)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C144(1.07)  LDD1581  [12]
 LDCM0379  CL11 HEK-293T C144(0.99)  LDD1583  [12]
 LDCM0381  CL111 HEK-293T C144(0.94)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C144(1.13)  LDD1586  [12]
 LDCM0385  CL115 HEK-293T C144(0.79)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C144(0.89)  LDD1590  [12]
 LDCM0389  CL119 HEK-293T C144(0.82)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C144(1.21)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C144(1.10)  LDD1595  [12]
 LDCM0394  CL123 HEK-293T C144(1.00)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C144(0.87)  LDD1599  [12]
 LDCM0398  CL127 HEK-293T C144(1.05)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C144(0.87)  LDD1603  [12]
 LDCM0402  CL15 HEK-293T C144(1.34)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C144(0.90)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C144(1.23)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C144(1.09)  LDD1609  [12]
 LDCM0408  CL20 HEK-293T C144(1.08)  LDD1612  [12]
 LDCM0410  CL22 HEK-293T C144(0.84)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C144(0.95)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C144(1.16)  LDD1616  [12]
 LDCM0415  CL27 HEK-293T C144(0.74)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C144(1.07)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C144(1.02)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C144(1.10)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C144(1.03)  LDD1623  [12]
 LDCM0421  CL32 HEK-293T C144(1.02)  LDD1625  [12]
 LDCM0423  CL34 HEK-293T C144(0.68)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C144(1.14)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C144(1.04)  LDD1629  [12]
 LDCM0428  CL39 HEK-293T C144(0.98)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C144(0.85)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C144(0.94)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C144(1.02)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C144(1.09)  LDD1636  [12]
 LDCM0434  CL44 HEK-293T C144(1.01)  LDD1638  [12]
 LDCM0436  CL46 HEK-293T C144(1.19)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C144(1.19)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C144(0.99)  LDD1642  [12]
 LDCM0440  CL5 HEK-293T C144(0.96)  LDD1644  [12]
 LDCM0443  CL52 HEK-293T C144(1.18)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C144(1.14)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C144(1.12)  LDD1648  [12]
 LDCM0447  CL56 HEK-293T C144(1.10)  LDD1650  [12]
 LDCM0449  CL58 HEK-293T C144(0.88)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C144(0.58)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C144(1.24)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C144(1.37)  LDD1655  [12]
 LDCM0455  CL63 HEK-293T C144(0.77)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C144(0.83)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C144(0.99)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C144(1.37)  LDD1661  [12]
 LDCM0460  CL68 HEK-293T C144(1.12)  LDD1663  [12]
 LDCM0463  CL70 HEK-293T C144(1.48)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C144(1.01)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C144(1.23)  LDD1668  [12]
 LDCM0469  CL76 HEK-293T C144(0.85)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C144(1.14)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C144(1.21)  LDD1674  [12]
 LDCM0473  CL8 HEK-293T C144(0.92)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C144(1.04)  LDD1677  [12]
 LDCM0476  CL82 HEK-293T C144(1.11)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C144(1.10)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C144(1.15)  LDD1681  [12]
 LDCM0481  CL87 HEK-293T C144(0.91)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C144(0.98)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C144(1.15)  LDD1686  [12]
 LDCM0485  CL90 HEK-293T C144(1.06)  LDD1688  [12]
 LDCM0487  CL92 HEK-293T C144(1.05)  LDD1690  [12]
 LDCM0489  CL94 HEK-293T C144(0.68)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C144(0.96)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C144(1.19)  LDD1694  [12]
 LDCM0494  CL99 HEK-293T C144(1.04)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C144(1.12)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C330(2.11)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C144(0.74)  LDD1671  [12]
 LDCM0022  KB02 HEK-293T C144(0.99)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C144(1.00)  LDD1497  [12]
 LDCM0024  KB05 HMCB C330(2.26)  LDD3312  [3]
 LDCM0109  NEM HeLa N.A.  LDD0227  [5]
 LDCM0090  Rapamycin JHH-7 2.58  LDD0213  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-arrestin-1 (ARRB1) Arrestin family P49407
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KiSS-1 receptor (KISS1R) G-protein coupled receptor 1 family Q969F8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
IQ motif and SEC7 domain-containing protein 1 (IQSEC1) BRAG family Q6DN90

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402