Details of the Target

General Information of Target

Target ID LDTP00212
Target Name AP-3 complex subunit beta-1 (AP3B1)
Gene Name AP3B1
Gene ID 8546
Synonyms
ADTB3A; AP-3 complex subunit beta-1; Adaptor protein complex AP-3 subunit beta-1; Adaptor-related protein complex 3 subunit beta-1; Beta-3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKL
DAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTF
QRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSL
DPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWG
QVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLL
IRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATM
SIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQF
AAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEII
KHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLG
AKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLA
QKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEW
TPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDS
SSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSS
DSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVALPTPALSP
SLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMV
SIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTA
SFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPS
VIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIG
SVLLRELKPVLSQG
Target Bioclass
Other
Family
Adaptor complexes large subunit family
Subcellular location
Cytoplasmic vesicle, clathrin-coated vesicle membrane
Function
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Uniprot ID
O00203
Ensemble ID
ENST00000255194.11
HGNC ID
HGNC:566

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HS936T Insertion: p.A422SfsTer19
SNV: p.E635K		 DBIA    Probe Info 
IGR1 SNV: p.D56N DBIA    Probe Info 
IM95 Deletion: p.K923NfsTer4 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.K923NfsTer4
Insertion: p.I597NfsTer12		 DBIA    Probe Info 
JURKAT Deletion: p.K923NfsTer4 .
LNCaP clone FGC Insertion: p.L924TfsTer11 DBIA    Probe Info 
LS180 Deletion: p.K923NfsTer4 DBIA    Probe Info 
MCC13 Substitution: p.S451F DBIA    Probe Info 
MDAMB453 SNV: p.S31L DBIA    Probe Info 
MFE319 SNV: p.R347G DBIA    Probe Info 
MKN1 SNV: p.K59E DBIA    Probe Info 
RKO Deletion: p.I597YfsTer3 DBIA    Probe Info 
SKMEL2 Deletion: p.K923NfsTer4 DBIA    Probe Info 
SW1116 SNV: p.D820H DBIA    Probe Info 
TE10 SNV: p.T868A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.12  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K125(3.19); K168(4.88); K305(1.22); K414(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y544(41.98); Y564(17.06); Y568(12.22)  LDD3495  [4]
BTD
 Probe Info  		C893(1.38)  LDD2089  [5]
AHL-Pu-1
 Probe Info  		C507(20.00)  LDD0170  [6]
IPM
 Probe Info  		C893(1.91)  LDD1701  [5]
DBIA
 Probe Info  		C893(1.04)  LDD0078  [7]
ATP probe
 Probe Info  		K72(0.00); K74(0.00); K337(0.00); K596(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C507(0.00); C893(0.00)  LDD0037  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
AOyne
 Probe Info  		6.70  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
HHS-475
 Probe Info  		Y564(1.67)  LDD2238  [14]
HHS-482
 Probe Info  		Y564(1.31)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C201
 Probe Info  		25.28  LDD1877  [15]
FFF probe3
 Probe Info  		5.87  LDD0465  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [17]
Alk-rapa
 Probe Info  		3.12  LDD0213  [18]
OEA-DA
 Probe Info  		4.80  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C507(20.00)  LDD0170  [6]
 LDCM0214  AC1 HCT 116 C215(0.85); C507(1.12); C893(1.07)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C215(0.70); C507(0.77); C893(1.10); C970(0.99)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C215(0.49); C507(0.55); C893(0.97)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C215(0.67); C507(0.57); C893(0.82)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C215(0.49); C507(0.51); C893(0.88)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C215(0.56); C507(0.50); C893(0.97)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C215(0.52); C507(0.50); C893(0.92)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C215(0.60); C507(0.46); C893(0.90)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C215(0.66); C507(0.48); C893(1.03)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C215(0.61); C507(0.54); C893(0.91)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C215(0.72); C507(0.69); C893(0.91)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C215(0.67); C507(0.75); C893(0.83)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C215(0.74); C507(0.79); C893(1.12); C970(0.94)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C215(0.60); C507(0.69); C893(0.85)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C215(0.70); C507(0.53); C893(0.84)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C215(0.49); C507(0.49); C893(0.88)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C215(0.97); C507(0.87); C893(1.02)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C215(0.98); C507(0.71); C893(0.98)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C215(0.71); C507(0.65); C893(1.06)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C215(0.86); C507(0.67); C893(0.99)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C215(0.95); C507(0.72); C893(1.02)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C215(0.79); C507(0.77); C893(0.96)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C215(0.87); C507(0.74); C893(0.95)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C215(0.75); C507(0.79); C893(1.10); C970(1.14)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C215(0.80); C507(0.85); C893(0.97)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C215(1.08); C507(0.81); C893(1.06)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C215(0.95); C507(0.79); C893(0.98)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C215(0.99); C507(0.84); C893(1.20)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C215(0.99); C507(0.89); C893(1.22)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C215(0.96); C507(0.73); C893(0.97)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C215(0.87); C507(0.72); C893(0.97)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C215(0.95); C507(0.69); C893(1.10)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C215(1.09); C507(1.10); C893(1.29); C970(1.07)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C215(0.88); C507(1.08); C893(1.26); C970(1.03)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C215(0.84); C507(0.92); C893(1.26); C970(0.96)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C215(0.98); C507(1.02); C893(1.00); C970(1.36)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C215(0.95); C507(1.16); C893(1.23); C970(1.00)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C215(0.87); C507(1.08); C893(1.12); C970(0.87)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C215(0.88); C507(0.93); C893(1.21); C970(0.97)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C215(0.85); C507(1.03); C893(1.30); C970(0.88)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C215(0.83); C507(1.12); C893(1.27); C970(0.89)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C215(0.85); C507(1.23); C893(1.23); C970(0.81)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C215(0.79); C507(1.05); C893(1.39); C970(0.88)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C215(1.01); C507(1.10); C893(1.19); C970(0.92)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C215(0.74); C507(0.79); C893(0.90); C970(0.82)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C215(1.03); C507(1.10); C893(1.37); C970(0.95)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C215(1.04); C507(1.31); C893(1.25); C970(0.86)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C215(1.00); C507(1.42); C893(1.18); C970(1.00)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C215(0.88); C507(0.87); C893(0.98); C970(0.84)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C507(0.50); C215(0.66); C893(1.06); C970(1.24)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C507(0.58); C215(0.75); C970(0.95); C893(1.04)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C507(0.59); C215(0.78); C970(0.90); C893(1.12)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C507(0.58); C215(0.71); C893(1.01); C970(1.03)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C507(0.68); C215(0.69); C970(1.22); C893(1.39)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C507(0.55); C215(0.68); C970(1.01); C893(1.26)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C507(0.71); C215(0.81); C970(0.97); C893(1.06)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C507(0.68); C215(0.75); C970(0.96); C893(1.04)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C215(0.56); C507(0.64); C970(0.90); C893(0.98)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C215(0.58); C507(0.66); C893(1.13); C970(1.14)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C507(0.62); C215(0.77); C970(1.16); C893(1.48)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C215(0.66); C507(0.60); C893(1.00); C970(1.01)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C215(0.57); C507(0.57); C893(1.10); C970(1.02)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C215(0.81); C507(0.71); C893(0.99); C970(1.11)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C215(0.73); C507(0.91); C893(0.97); C970(1.13)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C507(0.80); C215(0.84); C893(1.20)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C507(0.74); C215(0.85); C893(1.16)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C507(0.73); C215(0.82); C893(1.10)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C215(0.89); C507(1.02); C893(1.03)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C507(0.83); C215(0.92); C893(1.27)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C507(0.68); C215(0.75); C893(1.18)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C507(0.89); C215(1.08); C893(1.20)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C507(0.79); C215(0.83); C893(1.50)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C507(0.87); C215(1.05); C893(1.24)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C215(0.70); C507(0.81); C893(0.98)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C215(0.66); C507(0.75); C893(1.13)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C507(0.67); C215(0.80); C893(0.94)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C507(0.71); C215(0.73); C893(1.13)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C507(0.75); C215(0.75); C893(1.17)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C215(0.94); C893(1.03); C507(1.13)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C507(0.68); C215(0.78); C893(1.12)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C507(0.70); C215(0.78); C893(1.09)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C507(0.66); C215(0.75); C893(1.04)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C507(0.65); C215(0.71); C893(0.93)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C507(0.67); C215(0.75); C893(0.90)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C893(0.97); C215(0.98); C507(1.04)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C893(0.99); C507(1.09); C215(1.09)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C893(0.96); C507(1.04); C215(1.08)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C893(0.88); C507(1.03); C215(1.10)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C893(0.96); C507(0.99); C215(1.04)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C215(0.83); C507(0.97); C893(1.04)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C893(0.90); C507(1.09); C215(1.19)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C215(0.95); C893(1.02); C507(1.06)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C893(0.95); C507(1.06); C215(1.08)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C893(0.93); C215(1.09); C507(1.10)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C893(0.91); C215(1.06); C507(1.09)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C893(0.93); C507(1.03); C215(1.04)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C215(1.01); C893(1.09); C507(1.10)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C507(1.08); C215(1.14); C893(1.14)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C893(1.20); C215(1.21); C507(1.27)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C893(1.09); C507(1.13); C215(1.19)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C215(0.93); C507(1.03); C893(1.12)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C507(1.07); C215(1.12); C893(1.16)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C215(1.15); C893(1.27); C507(1.29)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C215(1.03); C507(1.04); C893(1.22)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C507(1.03); C215(1.06); C893(1.13)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C507(1.05); C215(1.06); C893(1.12)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C893(1.10); C507(1.12); C215(1.24)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C893(1.11); C215(1.34); C507(1.46)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C215(0.72); C507(0.91); C893(1.15)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C215(0.69); C507(0.81); C893(1.14)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C215(0.73); C507(0.89); C893(1.14)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C507(0.71); C215(0.80); C970(0.84); C893(1.12)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C215(0.69); C507(0.89); C893(1.03)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C215(0.74); C507(0.88); C893(1.07)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C215(0.75); C507(0.88); C893(1.14)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C215(0.77); C507(0.93); C893(1.13)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C215(0.73); C507(0.97); C893(1.15)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C215(0.93); C507(0.94); C893(1.27)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C215(0.89); C507(0.89); C893(1.18)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C215(0.84); C507(0.96); C893(1.25)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C507(1.00); C893(1.05); C215(1.07)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C507(0.90); C215(1.04); C893(1.13)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C215(0.85); C507(0.86); C970(0.89); C893(1.11)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C507(0.90); C215(0.97); C893(1.15)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C215(1.03); C893(1.06); C507(1.12)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C507(0.99); C893(1.11); C215(1.31)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C507(1.09); C893(1.34); C215(1.38)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C507(1.18); C893(1.30); C215(1.46)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C215(1.16); C507(1.26); C893(1.40)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C507(0.92); C893(1.17); C215(1.19)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C507(0.92); C215(1.15); C893(1.16)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C507(0.99); C893(1.03); C215(1.43)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C507(1.03); C893(1.09); C215(1.37)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C215(0.76); C507(0.79); C970(0.89); C893(1.17)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C507(0.99); C893(1.12); C215(1.27)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C215(0.70); C893(1.04); C507(1.05)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C215(1.32); C507(1.32); C893(1.46)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C507(0.76); C215(0.99); C893(1.24)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C215(0.68); C507(0.73); C893(1.22)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C215(0.66); C507(0.67); C893(1.17)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C507(0.77); C215(0.87); C893(1.10)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C507(0.83); C215(0.99); C893(1.05)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C507(0.66); C215(0.78); C893(1.03)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C507(0.64); C215(0.75); C893(1.07)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C507(0.91); C215(1.03); C893(1.05)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C507(0.68); C215(0.87); C893(1.24)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C507(0.70); C215(0.78); C893(1.28)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C215(0.67); C507(0.70); C893(1.12)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C215(0.65); C507(0.65); C893(1.04)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C215(0.73); C507(0.78); C893(0.96)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C507(0.67); C215(0.77); C893(1.06)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C507(0.66); C215(0.69); C893(1.17)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C215(0.43); C507(0.58); C893(1.06)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C507(0.57); C215(0.69); C893(0.98)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C215(0.87); C507(0.93); C893(1.00); C970(1.01)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C507(0.75); C215(0.87); C970(0.90); C893(1.04)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C507(0.73); C215(0.81); C970(1.08); C893(1.16)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C893(1.04)  LDD0078  [7]
 LDCM0367  CL1 HCT 116 C893(0.89); C215(0.95); C507(1.15)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C215(0.69); C507(0.97); C893(1.14)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C215(0.81); C507(1.00); C893(1.14)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C507(0.70); C215(0.75); C893(0.98); C970(1.58)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C215(0.81); C893(0.96); C507(1.01); C970(1.61)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C507(0.81); C215(0.93); C893(0.97); C970(3.18)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C507(0.84); C215(0.85); C893(1.03); C970(2.28)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C507(0.69); C215(0.92); C893(1.24)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C507(0.69); C215(0.96); C893(1.42)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C507(0.69); C215(0.92); C893(1.26)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C507(0.74); C215(0.88); C893(1.20)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C507(0.67); C215(0.87); C893(1.18)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C215(0.79); C507(1.10); C893(1.16)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C507(0.62); C215(0.71); C893(1.31)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C507(0.71); C215(0.81); C893(1.29)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C507(0.87); C215(0.95); C893(1.08)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C215(0.68); C507(0.69); C893(1.06)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C215(0.71); C507(0.72); C893(1.15)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C507(0.72); C215(0.77); C893(0.86)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C507(0.78); C215(0.83); C893(0.92)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C893(1.01); C507(1.22); C215(1.30)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C893(1.00); C507(1.03); C215(1.08)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C893(0.97); C215(0.99); C507(0.99)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C215(0.60); C893(1.09); C507(1.15)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C893(1.05); C215(1.06); C507(1.10)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C215(0.63); C507(0.84); C893(1.03)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C893(1.06); C215(1.11); C507(1.17)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C507(1.00); C215(1.08); C893(1.08)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C893(1.05); C507(1.06); C215(1.10)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C215(0.79); C507(0.99); C893(1.12)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C215(0.69); C507(0.93); C893(0.97)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C215(0.75); C507(0.89); C893(1.07)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C215(0.72); C507(0.85); C893(1.05)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C215(0.66); C893(1.00); C507(1.09)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C893(0.89); C215(0.95); C507(0.99)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C215(0.81); C893(0.98); C507(0.99)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C215(0.81); C507(0.88); C893(0.91)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C507(0.82); C893(0.88); C215(0.92)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C215(0.74); C507(0.77); C893(0.80)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C507(0.74); C215(0.78); C893(0.84)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C893(0.95); C507(1.18); C215(1.23)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C507(0.70); C893(0.86); C215(0.90)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C507(0.72); C215(0.76); C893(0.94)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C507(0.95); C215(1.02); C893(1.17)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C507(0.70); C215(0.85); C893(0.95)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C507(0.75); C215(0.83); C893(1.07)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C215(0.87); C507(0.75); C893(0.98)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C215(0.78); C507(0.68); C893(0.94)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C215(0.95); C507(0.70); C893(0.90)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C215(0.91); C507(0.73); C893(0.89)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C215(0.83); C507(0.74); C893(0.98)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C215(1.16); C507(1.08); C893(0.95)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C215(0.93); C507(0.76); C893(0.88)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C215(0.79); C507(0.77); C893(1.00)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C215(0.76); C507(0.78); C893(1.10)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C215(0.77); C507(0.71); C893(1.02)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C215(0.83); C507(0.81); C893(0.95)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C215(0.81); C507(0.73); C893(1.02)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C215(0.84); C507(0.76); C893(0.95)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C215(0.87); C507(0.75); C893(1.03)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C215(0.77); C507(0.72); C893(1.06)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C215(0.73); C507(1.00); C893(0.78)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C215(0.88); C507(0.85); C893(1.09)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C215(0.90); C507(0.77); C893(0.90)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C215(0.92); C507(0.92); C893(1.11)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C215(0.81); C507(0.94); C893(1.02)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C215(0.79); C507(0.77); C893(1.01)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C215(0.79); C507(0.86); C893(1.04)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C215(1.26); C507(1.19); C893(1.13)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C215(1.17); C507(1.15); C893(1.16)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C215(1.37); C507(1.05); C893(1.10)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C215(1.20); C507(0.91); C893(1.14)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C215(0.86); C507(1.06); C893(0.95)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C215(1.10); C507(0.98); C893(1.02)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C215(1.29); C507(1.09); C893(1.14)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C215(1.17); C507(0.98); C893(1.14)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C215(1.18); C507(0.96); C893(0.99)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C215(1.21); C507(1.06); C893(1.10)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C215(1.09); C507(0.96); C893(1.15)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C215(1.07); C507(0.99); C893(1.16)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C215(1.03); C507(1.00); C893(0.99)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C215(1.04); C507(1.09); C893(1.11)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C215(1.16); C507(1.05); C893(1.04)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C215(1.37); C507(1.08); C893(0.99)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C215(1.11); C507(1.01); C893(1.09)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C215(0.67); C507(0.87); C893(1.16); C970(1.32)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C215(0.81); C507(0.97); C893(1.16); C970(2.35)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C215(0.87); C507(0.85); C893(1.15); C970(2.53)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C215(0.68); C507(0.71); C893(1.04); C970(3.38)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C215(0.95); C507(0.94); C893(1.11); C970(1.15)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C215(0.92); C507(0.84); C893(1.22); C970(2.99)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C215(0.67); C507(0.89); C893(1.05); C970(1.02)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C215(0.83); C507(0.95); C893(0.99); C970(3.14)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C215(1.39); C507(0.92); C893(1.03); C970(3.97)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C215(0.63); C507(0.97); C893(1.29)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C215(0.64); C507(0.79); C893(1.22); C970(0.98)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C215(1.05); C507(0.83); C893(1.30); C970(2.44)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C215(0.83); C507(0.92); C893(1.02); C970(0.81)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C215(0.80); C507(0.96); C893(1.11); C970(3.10)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C215(0.74); C507(0.88); C893(1.01); C970(2.42)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C215(1.17); C507(0.85); C893(0.94)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C215(0.95); C507(0.84); C893(1.01)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C215(0.90); C507(0.80); C893(1.01)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C215(0.91); C507(0.75); C893(1.02)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C215(0.60); C507(0.97); C893(1.11)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C215(1.13); C507(1.14); C893(0.94)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C215(1.06); C507(0.84); C893(1.11)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C215(1.17); C507(0.85); C893(1.14)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C215(1.08); C507(0.89); C893(1.17)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C215(1.20); C507(0.92); C893(1.28)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C215(1.12); C507(0.88); C893(1.06)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C215(1.03); C507(0.99); C893(1.08)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C215(1.04); C507(0.86); C893(1.03)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C215(1.19); C507(0.80); C893(1.05)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C215(1.38); C507(1.18); C893(1.21)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C215(0.95); C507(0.92); C893(1.02)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C215(1.38); C507(1.14); C893(1.07)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C215(0.90); C507(0.96); C893(1.07)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C215(0.92); C507(1.09); C893(1.05)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C215(0.93); C507(1.12); C893(1.07)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C215(0.75); C507(0.84); C893(0.96)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C215(0.80); C507(0.88); C893(1.03)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C215(0.75); C507(0.87); C893(1.00)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C215(0.80); C507(0.90); C893(1.04)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C215(0.85); C507(1.03); C893(1.12)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C215(0.79); C507(0.92); C893(1.05)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C893(1.13); C507(0.89); C215(1.12); C230(0.98)  LDD1698  [20]
 LDCM0468  Fragment33 HCT 116 C215(0.90); C507(0.74); C893(1.03); C970(2.80)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C215(0.84); C507(0.85); C893(1.21)  LDD0744  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C507(2.97); C893(1.65)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C507(3.33); C893(1.54)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C507(2.80); C893(1.21)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [11]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C893(1.38)  LDD2089  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C893(0.69)  LDD2114  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C893(0.91)  LDD2140  [5]
 LDCM0090  Rapamycin JHH-7 3.12  LDD0213  [18]
 LDCM0021  THZ1 HCT 116 C893(1.04)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Kinesin-like protein KIF3A (KIF3A) Kinesin family Q9Y496
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Alpha-synuclein (SNCA) Synuclein family P37840
Ankyrin-3 (ANK3) . Q12955
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402