Details of the Target

General Information of Target

Target ID LDTP18177
Target Name Solute carrier family 35 member E1 (SLC35E1)
Gene Name SLC35E1
Gene ID 79939
Synonyms
Solute carrier family 35 member E1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMI
KDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQF
PRQVLDSKAPKPEDIDEEDDDVPDLVENFDEASKNEAN
Target Bioclass
Transporter and channel
Family
TPT transporter family, SLC35E subfamily
Subcellular location
Membrane
Function Putative transporter.
Uniprot ID
Q96K37
Ensemble ID
ENST00000595753.6
HGNC ID
HGNC:20803

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH358 SNV: p.V350F .
ONS76 SNV: p.V30L .
SHP77 SNV: p.S162C .
SNGM SNV: p.V133M .
SW756 SNV: p.E26Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y337(6.17); Y394(5.70); Y111(20.00)  LDD0260  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K345(4.12); K367(8.85)  LDD0277  [3]
DBIA
 Probe Info  		C34(0.79)  LDD1509  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [7]
AOyne
 Probe Info  		14.20  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		3.75  LDD0213  [9]
OEA-DA
 Probe Info  		18.15  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C34(0.79)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C34(1.01)  LDD1510  [4]
 LDCM0270  AC15 HEK-293T C34(1.10)  LDD1513  [4]
 LDCM0278  AC19 HEK-293T C34(0.70)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C34(1.04)  LDD1519  [4]
 LDCM0283  AC23 HEK-293T C34(1.05)  LDD1522  [4]
 LDCM0287  AC27 HEK-293T C34(0.88)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C34(0.90)  LDD1527  [4]
 LDCM0290  AC3 HEK-293T C34(0.78)  LDD1529  [4]
 LDCM0292  AC31 HEK-293T C34(1.05)  LDD1531  [4]
 LDCM0296  AC35 HEK-293T C34(0.95)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C34(0.93)  LDD1536  [4]
 LDCM0300  AC39 HEK-293T C34(0.96)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C34(0.89)  LDD1540  [4]
 LDCM0305  AC43 HEK-293T C34(0.87)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C34(0.89)  LDD1545  [4]
 LDCM0309  AC47 HEK-293T C34(1.00)  LDD1548  [4]
 LDCM0314  AC51 HEK-293T C34(0.98)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C34(0.90)  LDD1554  [4]
 LDCM0318  AC55 HEK-293T C34(0.93)  LDD1557  [4]
 LDCM0322  AC59 HEK-293T C34(0.96)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C34(0.93)  LDD1563  [4]
 LDCM0327  AC63 HEK-293T C34(0.99)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C34(1.00)  LDD1568  [4]
 LDCM0371  CL102 HEK-293T C34(0.87)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C34(0.82)  LDD1579  [4]
 LDCM0379  CL11 HEK-293T C34(1.13)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C34(1.01)  LDD1584  [4]
 LDCM0384  CL114 HEK-293T C34(0.76)  LDD1588  [4]
 LDCM0388  CL118 HEK-293T C34(0.85)  LDD1592  [4]
 LDCM0393  CL122 HEK-293T C34(1.06)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C34(0.88)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C34(0.79)  LDD1605  [4]
 LDCM0406  CL19 HEK-293T C34(0.93)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C34(0.99)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C34(1.31)  LDD1612  [4]
 LDCM0411  CL23 HEK-293T C34(1.27)  LDD1615  [4]
 LDCM0414  CL26 HEK-293T C34(0.91)  LDD1618  [4]
 LDCM0420  CL31 HEK-293T C34(0.83)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C34(1.15)  LDD1625  [4]
 LDCM0424  CL35 HEK-293T C34(1.00)  LDD1628  [4]
 LDCM0433  CL43 HEK-293T C34(0.92)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C34(0.97)  LDD1638  [4]
 LDCM0437  CL47 HEK-293T C34(1.09)  LDD1641  [4]
 LDCM0441  CL50 HEK-293T C34(0.83)  LDD1645  [4]
 LDCM0446  CL55 HEK-293T C34(1.23)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C34(0.89)  LDD1650  [4]
 LDCM0450  CL59 HEK-293T C34(1.10)  LDD1653  [4]
 LDCM0454  CL62 HEK-293T C34(0.75)  LDD1657  [4]
 LDCM0459  CL67 HEK-293T C34(1.17)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C34(1.26)  LDD1663  [4]
 LDCM0462  CL7 HEK-293T C34(1.11)  LDD1665  [4]
 LDCM0464  CL71 HEK-293T C34(1.11)  LDD1667  [4]
 LDCM0467  CL74 HEK-293T C34(0.91)  LDD1670  [4]
 LDCM0472  CL79 HEK-293T C34(0.81)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C34(1.58)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C34(1.09)  LDD1677  [4]
 LDCM0477  CL83 HEK-293T C34(1.08)  LDD1680  [4]
 LDCM0480  CL86 HEK-293T C34(1.11)  LDD1683  [4]
 LDCM0486  CL91 HEK-293T C34(1.14)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C34(1.09)  LDD1690  [4]
 LDCM0490  CL95 HEK-293T C34(1.54)  LDD1693  [4]
 LDCM0493  CL98 HEK-293T C34(0.98)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C34(0.82)  LDD1631  [4]
 LDCM0090  Rapamycin JHH-7 3.75  LDD0213  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ferritin heavy polypeptide-like 17 (FTHL17) Ferritin family Q9BXU8
55 kDa erythrocyte membrane protein (MPP1) MAGUK family Q00013

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570