Details of the Target

General Information of Target

Target ID LDTP12697
Target Name Androgen-induced gene 1 protein (AIG1)
Gene Name AIG1
Gene ID 51390
Synonyms
Androgen-induced gene 1 protein; AIG-1; Fatty acid esters of hydroxy fatty acids hydrolase AIG1; FAHFA hydrolase AIG1; EC 3.1.-.-
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVPGVGLLTRLNLCARRRTRVQRPIVRLLSCPGTVAKDLRRDEQPSGSVETGFEDKIPK
RRFSEMQNERREQAQRTVLIHCPEKISENKFLKYLSQFGPINNHFFYESFGLYAVVEFCQ
KESIGSLQNGTHTPSTAMETAIPFRSRFFNLKLKNQTSERSRVRSSNQLPRSNKQLFELL
CYAESIDDQLNTLLKEFQLTEENTKLRYLTCSLIEDMAAAYFPDCIVRPFGSSVNTFGKL
GCDLDMFLDLDETRNLSAHKISGNFLMEFQVKNVPSERIATQKILSVLGECLDHFGPGCV
GVQKILNARCPLVRFSHQASGFQCDLTTNNRIALTSSELLYIYGALDSRVRALVFSVRCW
ARAHSLTSSIPGAWITNFSLTMMVIFFLQRRSPPILPTLDSLKTLADAEDKCVIEGNNCT
FVRDLSRIKPSQNTETLELLLKEFFEYFGNFAFDKNSINIRQGREQNKPDSSPLYIQNPF
ETSLNISKNVSQSQLQKFVDLARESAWILQQEDTDRPSISSNRPWGLVSLLLPSAPNRKS
FTKKKSNKFAIETVKNLLESLKGNRTENFTKTSGKRTISTQT
Target Bioclass
Enzyme
Family
AIG1 family
Subcellular location
Cell membrane
Function
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids.
Uniprot ID
Q9NVV5
Ensemble ID
ENST00000275235.8
HGNC ID
HGNC:21607

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		4.53  LDD0197  [1]
YN-4
 Probe Info  		100.00  LDD0445  [2]
BTD
 Probe Info  		C6(1.09)  LDD2141  [3]
Johansson_61
 Probe Info  		_(12.99)  LDD1487  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C6(1.09)  LDD0531  [6]
W1
 Probe Info  		C6(0.55)  LDD0239  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		6.53  LDD0213  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C6(1.09)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C18(1.57)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C6(0.90); C18(0.81)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C6(1.01); C18(0.92)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C6(1.09); C18(0.88)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C6(1.08); C18(0.63)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C6(0.90); C18(1.00)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C6(1.24); C18(2.34)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C6(0.97); C18(3.18)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C6(0.90); C18(0.80)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C6(1.10); C18(1.29)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C6(0.91); C18(1.13)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C18(1.05)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C6(1.04); C18(0.39)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C6(0.97); C18(0.29)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C6(0.97); C18(0.39)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C6(0.88)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C6(0.91)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C6(1.04)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C6(1.05)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C6(0.89)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C6(1.17)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C6(0.95)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C18(0.90)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C6(1.05)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C6(0.87)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C6(0.95)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C6(0.91)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C6(0.97)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C6(1.02)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C6(1.27)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C6(1.15)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C22(0.61); C6(0.90); C18(0.51)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C22(1.48); C6(0.92); C18(0.66)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C22(1.00); C6(0.81); C18(1.87)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C22(0.79); C6(1.21); C18(0.63)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C22(0.97); C6(0.86); C18(0.72)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C22(1.10); C6(0.99); C18(0.73)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C22(0.90); C6(1.04); C18(0.70)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C22(1.61); C6(1.02); C18(0.78)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C22(1.04); C6(1.04); C18(1.10)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C22(1.56); C6(1.12); C18(0.44)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C22(1.68); C6(1.03); C18(0.32)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C22(1.62); C6(0.97); C18(0.38)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C18(1.68)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C22(1.12); C6(1.15); C18(0.64)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C22(1.21); C6(1.02); C18(0.70)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C22(1.60); C6(1.14); C18(1.11)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C6(1.08)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C6(0.93)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C6(0.90)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C6(0.93)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C6(1.00)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C6(0.83)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C6(0.89)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C18(1.34)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C6(0.96)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C6(0.94)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C6(0.96)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C6(0.86)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C6(0.86)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C6(0.93)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C6(0.97)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C6(0.83)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C6(1.04)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C6(1.22)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C6(1.08)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C6(1.06)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C6(0.99)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C6(1.04)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C6(1.00)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C6(1.34)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C6(0.98)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C6(1.11)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C6(1.30)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C6(1.32)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C6(1.51)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C6(1.24)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C6(1.16)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C6(1.34)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C6(1.65)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C6(1.60)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C6(1.50)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C6(1.80)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C6(0.82)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C6(0.84)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C6(0.86)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C6(1.00)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C6(1.05)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C6(1.21)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C6(1.13)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C6(0.95)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C6(1.09)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C6(1.09)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C6(1.09)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C6(1.18)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C6(1.07)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C6(1.03)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C6(1.08)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C6(1.37)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C6(1.26)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C6(1.23)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C6(0.91)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C6(1.03)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C6(1.22)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C6(1.09)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C6(1.21)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C6(1.72)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C6(1.11); C18(1.09)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C6(1.01); C18(1.02)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C6(1.15); C18(1.31)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C18(0.90)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C6(1.66); C18(0.94)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C6(1.10); C18(0.98)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C6(1.24); C18(0.80)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C6(1.46); C18(1.21)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C6(1.30); C18(1.50)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C6(1.22); C18(1.13)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C6(1.09); C18(0.84)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C6(1.07); C18(1.06)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C22(0.95); C6(0.83); C18(1.05)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C22(1.00); C6(1.00); C18(1.30)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C18(1.39)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C22(0.88); C6(0.83); C18(1.90)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C22(1.04); C6(0.82); C18(1.24)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C22(1.05); C6(1.10); C18(1.24)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C22(0.95); C6(0.96); C18(1.48)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C22(0.75); C6(0.79); C18(1.92)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C22(1.18); C6(0.84); C18(1.20)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C22(0.80); C6(0.72); C18(1.10)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C22(0.85); C6(0.97); C18(1.68)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C22(1.00); C6(0.69); C18(1.24)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C22(0.84); C6(0.62); C18(2.37)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C18(1.40)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C22(0.99); C6(0.82); C18(1.43)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C22(0.85); C6(0.71); C18(1.35)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C22(1.36); C6(0.97); C18(1.53)  LDD0946  [6]
 LDCM0349  AC83 HCT 116 C6(2.51)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C6(1.80)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C6(1.26)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C6(1.72)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C6(1.04)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C6(1.33)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C6(1.38)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C6(0.98)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C6(1.95)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C6(1.85)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C6(1.16)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C6(1.21)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C6(1.30)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C6(1.07)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C6(1.97)  LDD0681  [6]
 LDCM0365  AC98 HEK-293T C6(0.89); C18(2.33)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C6(0.94); C18(0.71)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C18(1.49)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C18(1.40)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C18(1.35)  LDD0873  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HCT 116 C6(1.27)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C6(2.95)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C6(1.07)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C18(1.34)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C18(1.06)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C18(1.27)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C18(1.47)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C6(1.22)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C6(1.50)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C6(1.34)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C6(1.50)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C6(1.32)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C6(1.61)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C6(1.78)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C6(1.31)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C6(1.11)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C6(1.63)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C6(1.82)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C6(1.36)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C6(1.31)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C6(1.63)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C6(1.05)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C6(1.12)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C6(1.32)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C6(0.99)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C6(0.69)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C6(1.38)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C6(4.10)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C6(1.49)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C6(1.11); C18(0.93)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C6(1.45); C18(0.76)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C6(1.08); C18(1.21)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C6(1.23); C18(0.99)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C6(1.08)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C6(1.26)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C6(1.62)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C6(0.91); C18(1.11)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C6(1.28); C18(0.68)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C6(1.02); C18(0.89)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C6(0.96); C18(1.05)  LDD1004  [6]
 LDCM0407  CL2 HCT 116 C6(0.87)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C6(1.10); C18(0.82)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C6(1.25); C18(0.64)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C6(1.09); C18(0.78)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C6(0.99); C18(0.90)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C6(1.00); C18(2.07)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C6(1.00); C18(0.64)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C6(0.96); C18(0.96)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C6(1.18); C18(1.58)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C6(0.86); C18(1.12)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C6(0.82); C18(0.89)  LDD1015  [6]
 LDCM0418  CL3 HCT 116 C6(1.32)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C6(1.11); C18(0.49)  LDD1017  [6]
 LDCM0420  CL31 HCT 116 C6(1.24)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C6(1.66)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C6(11.32)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C6(3.99)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C6(1.51)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C6(2.72)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C6(2.31)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C6(1.92)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C6(1.30)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C6(1.48)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C6(2.22)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C6(2.70)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C6(2.34)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C6(2.45)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C6(2.98)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C6(1.42)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C6(1.11)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C6(1.17)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C6(1.21)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C6(0.98)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C6(1.30)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C6(1.67)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C6(1.32)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C6(1.40)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C6(3.24)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C6(0.97)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C6(1.10)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C6(1.51)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C6(1.11)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C6(1.22)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C6(1.32)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C6(1.29)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C22(1.15); C6(1.23); C18(0.47)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C22(1.18); C6(1.57); C18(0.66)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C22(1.84); C6(1.97); C18(0.65)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C22(2.25); C6(6.30); C18(0.85)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C22(1.50); C6(1.19); C18(0.90)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C22(0.98); C6(1.29); C18(0.55)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C22(1.39); C6(1.04); C18(0.70)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C22(1.29); C6(1.12); C18(0.69)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C22(1.04); C6(1.41); C18(0.87)  LDD1059  [6]
 LDCM0462  CL7 HCT 116 C6(1.21)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C22(1.71); C6(1.08); C18(0.81)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C22(1.89); C6(1.37); C18(1.16)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C22(1.01); C6(1.33); C18(0.92)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C22(1.41); C6(1.98); C18(0.74)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C22(3.19); C6(3.03); C18(0.41)  LDD1065  [6]
 LDCM0469  CL76 HCT 116 C6(1.07)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C6(1.12)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C6(1.02)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C6(1.33)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C6(5.24)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C6(1.04)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C6(1.19)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C6(1.60)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C6(1.93)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C6(2.18)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C6(1.20)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C6(1.09)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C6(1.32)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C6(1.41)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C6(2.00)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C6(1.23)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C6(3.75)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C6(1.23)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C6(0.97)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C6(1.20)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C6(0.88)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C6(1.04)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C6(0.97)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C6(1.06)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C6(1.27)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C6(1.40)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C6(1.01); C22(0.87)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C22(6.41); C6(1.74); C18(0.71)  LDD1066  [6]
 LDCM0427  Fragment51 HCT 116 C6(2.02)  LDD0744  [6]
 LDCM0615  Fragment63-R Jurkat _(12.99)  LDD1487  [4]
 LDCM0022  KB02 ICC10 C6(3.42)  LDD2379  [13]
 LDCM0023  KB03 ICC106 C6(12.16)  LDD2797  [13]
 LDCM0024  KB05 ICC10 C6(10.17)  LDD3213  [13]
 LDCM0109  NEM HeLa N.A.  LDD0227  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C6(1.09)  LDD2141  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C6(0.68)  LDD2207  [14]
 LDCM0090  Rapamycin JHH-7 6.53  LDD0213  [11]
 LDCM0112  W16 Hep-G2 C6(0.55)  LDD0239  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 3, mitochondrial (MRM3) RNA methyltransferase TrmH family Q9HC36
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) HIBADH-related family P31937
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) . Q96PM5
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 7 member 14 (SLC7A14) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8TBB6
Stomatin (STOM) Band 7/mec-2 family P27105
Claudin-7 (CLDN7) Claudin family O95471
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Lysosomal-associated transmembrane protein 5 (LAPTM5) LAPTM4/LAPTM5 transporter family Q13571
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Aquaporin-9 (AQP9) MIP/aquaporin (TC 1.A.8) family O43315
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Syntaxin-1A (STX1A) Syntaxin family Q16623
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane protein 106C (TMEM106C) TMEM106 family Q9BVX2
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) . Q9Y5Y7
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L2 (APOL2) Apolipoprotein L family Q9BQE5
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Apolipoprotein D (APOD) Lipocalin family P05090
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9
Bcl-2-interacting killer (BIK) . Q13323
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Thrombomodulin (THBD) . P07204
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.