Details of the Target

General Information of Target

Target ID LDTP11824
Target Name Sodium-coupled neutral amino acid symporter 1 (SLC38A1)
Gene Name SLC38A1
Gene ID 81539
Synonyms
ATA1; NAT2; SAT1; SNAT1; Sodium-coupled neutral amino acid symporter 1; Amino acid transporter A1; N-system amino acid transporter 2; Solute carrier family 38 member 1; System A amino acid transporter 1; System N amino acid transporter 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCIFHRNIKGFMVQTGDPTGTG
RGGNSIWGKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGK
VIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Amino acid/polyamine transporter 2 family
Subcellular location
Cell membrane
Function
Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis. May also contributes to amino acid transport in placental trophoblasts. Also regulates synaptic plasticity.
TTD ID
T30844
Uniprot ID
Q9H2H9
DrugMap ID
TT1YE9Z
Ensemble ID
ENST00000398637.10
HGNC ID
HGNC:13447

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.72  LDD0402  [1]
CHEMBL5175495
 Probe Info  		6.83  LDD0196  [2]
STPyne
 Probe Info  		K60(2.37)  LDD0277  [3]
BTD
 Probe Info  		C131(1.22)  LDD2099  [4]
DBIA
 Probe Info  		C131(2.21)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
IPM
 Probe Info  		N.A.  LDD0005  [7]
NHS
 Probe Info  		N.A.  LDD0010  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]
AOyne
 Probe Info  		12.30  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C419
 Probe Info  		8.94  LDD2074  [11]
C420
 Probe Info  		11.16  LDD2075  [11]
STS-1
 Probe Info  		N.A.  LDD0136  [12]
STS-2
 Probe Info  		N.A.  LDD0138  [12]
Alk-rapa
 Probe Info  		5.30  LDD0213  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C131(1.31)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C131(0.89)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C131(1.14)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C131(0.87)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C131(1.07)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C131(0.78)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C131(1.00)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C131(0.92)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C131(0.88)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C131(0.96)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C131(1.10)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C131(0.94)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C131(0.99)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C131(0.91)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C131(0.91)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C131(0.79)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C131(1.01)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C131(0.75)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C131(0.91)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C131(0.90)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C131(0.98)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C131(0.87)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C131(0.84)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C131(0.95)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C131(0.84)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C131(0.89)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C131(0.86)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C131(1.12)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C131(0.92)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C131(0.80)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C131(0.91)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C131(0.83)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C131(1.02)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C131(0.94)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C131(0.84)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C131(0.85)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C131(0.91)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C131(0.92)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C131(0.84)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C131(0.95)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C131(0.97)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C131(0.88)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C131(0.93)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C131(0.79)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C131(0.99)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C131(0.95)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C131(0.79)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C131(0.87)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C131(0.90)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C131(0.83)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C131(0.90)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C131(1.03)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C131(0.90)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C131(0.97)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C131(1.00)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C131(1.01)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C131(0.84)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C131(0.87)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C131(0.92)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C131(0.98)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C131(0.98)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C131(0.89)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C131(1.01)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C131(1.14)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C131(1.00)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C131(1.06)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C131(1.12)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C131(1.06)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C131(0.88)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C131(0.97)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C131(1.00)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C131(1.00)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C131(1.02)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C131(1.19)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C131(1.07)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C131(0.88)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C131(1.06)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C131(0.83)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C131(1.13)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C131(0.81)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C131(0.95)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C131(0.86)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C131(0.85)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C131(0.86)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C131(0.96)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C131(0.96)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C131(1.05)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C131(1.01)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C131(1.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C131(0.98)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C131(0.93)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C131(1.14)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C131(0.95)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C131(1.08)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C131(0.92)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C131(0.97)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C131(0.96)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C131(1.33)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C131(1.50)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C131(1.17)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C131(1.17)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C131(1.06)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C131(1.04)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C131(1.12)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C131(1.05)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C131(1.18)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C131(0.95)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C131(0.97)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C131(1.11)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C131(1.10)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C131(1.01)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C131(0.92)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C131(1.14)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C131(0.97)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C131(1.00)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C131(1.19)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C131(1.11)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C131(0.78)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C131(0.98)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C131(0.91)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C131(1.02)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C131(1.07)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C131(1.07)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C131(1.51)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C131(1.69)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C131(0.90)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C131(0.89)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C131(1.09)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C131(1.27)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C131(1.56)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C131(0.97)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C131(1.02)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C131(1.56)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C131(1.04)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C131(1.22)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C131(1.55)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C131(0.98)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C131(0.92)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C131(0.84)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C131(0.87)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C131(0.84)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C131(0.98)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C131(0.87)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C131(0.93)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C131(0.98)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C131(0.91)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C131(1.04)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C131(1.00)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C131(1.08)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C131(0.82)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C131(1.14)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C131(0.88)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C131(0.85)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C131(0.99)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C131(1.17)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C131(0.96)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C131(0.93)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.37  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C131(1.05)  LDD2171  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C131(0.88)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C131(1.08)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C131(1.00)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C131(0.92)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C131(1.01)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C131(1.04)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C131(1.00)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C131(0.96)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C131(0.96)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C131(0.99)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C131(1.04)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C131(0.87)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C131(1.01)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C131(0.87)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C131(0.99)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C131(0.96)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C131(0.81)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C131(0.85)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C131(0.85)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C131(0.89)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C131(1.00)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C131(1.03)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C131(0.95)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C131(0.97)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C131(1.05)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C131(0.84)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C131(0.93)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C131(1.05)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C131(1.02)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C131(0.94)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C131(0.98)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C131(0.95)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C131(1.10)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C131(0.90)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C131(1.13)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C131(0.95)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C131(0.95)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C131(0.94)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C131(0.98)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C131(0.84)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C131(0.89)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C131(0.85)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C131(0.82)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C131(1.04)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C131(0.82)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C131(0.93)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C131(0.93)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C131(0.91)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C131(0.73)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C131(0.77)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C131(0.85)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C131(0.91)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C131(0.97)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C131(0.96)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C131(0.80)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C131(0.79)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C131(0.80)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C131(0.89)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C131(0.79)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C131(0.86)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C131(0.76)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C131(0.72)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C131(0.81)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C131(0.80)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C131(0.81)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C131(0.87)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C131(0.77)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C131(0.94)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C131(0.81)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C131(0.70)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C131(0.73)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C131(1.09)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C131(0.98)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C131(1.20)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C131(0.80)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C131(0.92)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C131(0.76)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C131(1.18)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C131(1.61)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C131(0.75)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C131(0.80)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C131(1.13)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C131(1.37)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C131(1.15)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C131(1.36)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C131(1.14)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C131(1.13)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C131(1.02)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C131(1.10)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C131(1.07)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C131(1.02)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C131(1.06)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C131(1.12)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C131(0.95)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C131(1.28)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C131(1.13)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C131(1.00)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C131(1.01)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C131(1.12)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C131(1.00)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C131(0.92)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C131(0.86)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C131(0.93)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C131(0.88)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C131(0.97)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C131(0.99)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C131(1.03)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C131(0.97)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C131(0.92)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C131(0.93)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C131(0.86)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C131(1.05)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C131(0.98)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C131(0.95)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C131(1.06)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C131(0.85)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C131(0.99)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C131(0.97)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C131(0.99)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C131(1.09)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C131(0.93)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C131(1.02)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C131(1.19)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C131(1.02)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C131(0.91)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C131(0.93)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C131(0.94)  LDD1698  [14]
 LDCM0625  F8 Ramos C288(1.99)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C288(0.20)  LDD2190  [15]
 LDCM0586  Fragment28 Ramos C288(1.68)  LDD2198  [15]
 LDCM0468  Fragment33 HCT 116 C131(1.16)  LDD0785  [5]
 LDCM0566  Fragment4 Ramos C288(1.03)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C131(0.93)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C131(2.21)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C131(2.54)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C131(1.15)  LDD0082  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C131(1.22)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C131(0.85)  LDD2101  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C131(1.00)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C131(1.23)  LDD2107  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C131(0.98)  LDD2127  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C131(1.03)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C131(0.61)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C131(1.16)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C131(0.89)  LDD2137  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C131(0.84)  LDD2148  [4]
 LDCM0090  Rapamycin JHH-7 5.30  LDD0213  [13]
 LDCM0021  THZ1 HCT 116 C131(1.05)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein with metallophosphoesterase domain (TMPPE) LOC643853 family Q6ZT21
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Solute carrier family 13 member 4 (SLC13A4) SLC13A/DASS transporter family Q9UKG4
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Metabotropic glutamate receptor 2 (GRM2) G-protein coupled receptor 3 family Q14416
Immunoglobulin
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amphoterin-induced protein 1 (AMIGO1) AMIGO family Q86WK6
Programmed cell death 1 ligand 2 (PDCD1LG2) BTN/MOG family Q9BQ51
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
Protein reprimo (RPRM) Reprimo family Q9NS64
Secretoglobin family 1D member 1 (SCGB1D1) Secretoglobin family O95968
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Complement C1q-like protein 4 (C1QL4) . Q86Z23
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Small integral membrane protein 3 (SMIM3) . Q9BZL3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Asparagine Small molecular drug DB00174
L-glutamine Small molecular drug DB00130

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578