Details of the Target

General Information of Target

Target ID LDTP05000
Target Name Rho-related GTP-binding protein RhoB (RHOB)
Gene Name RHOB
Gene ID 388
Synonyms
ARH6; ARHB; Rho-related GTP-binding protein RhoB; Rho cDNA clone 6; h6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKD
LRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQ
KRYGSQNGCINCCKVL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rho family
Subcellular location
Late endosome membrane
Function
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
TTD ID
T58361
Uniprot ID
P62745
DrugMap ID
TT6LPFO
Ensemble ID
ENST00000272233.6
HGNC ID
HGNC:668
ChEMBL ID
CHEMBL1795102

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C16(0.86)  LDD2099  [1]
HHS-475
 Probe Info  		Y66(3.40)  LDD0264  [2]
DBIA
 Probe Info  		C20(1.21)  LDD0531  [3]
CY-1
 Probe Info  		Y154(0.00); Y156(0.00)  LDD0246  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C20(0.00); C83(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		C107(0.00); C159(0.00)  LDD0147  [6]
Acrolein
 Probe Info  		C20(0.00); C107(0.00); C159(0.00)  LDD0217  [7]
Crotonaldehyde
 Probe Info  		C159(0.00); C16(0.00)  LDD0219  [7]
Methacrolein
 Probe Info  		C20(0.00); C159(0.00); C16(0.00)  LDD0218  [7]
W1
 Probe Info  		C107(0.00); C16(0.00)  LDD0236  [8]
AOyne
 Probe Info  		14.30  LDD0443  [9]
NAIA_5
 Probe Info  		C107(0.00); C159(0.00); C16(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		3.84  LDD0213  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C20(1.21)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C16(0.98); C159(1.00); C107(1.03); C20(0.88)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C16(0.93); C159(1.00); C107(0.99); C20(0.81)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C16(1.02); C159(0.99); C107(0.98); C20(0.81)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C16(0.92); C159(0.94); C107(1.00); C20(0.79)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C16(0.88); C159(0.98); C107(1.04); C20(0.80)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C16(0.95); C159(0.93); C107(1.03); C20(0.83)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C16(1.00); C159(0.98); C107(1.03); C20(0.91)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C16(1.04); C159(1.04); C107(1.02); C20(0.72)  LDD1517  [12]
 LDCM0279  AC2 HCT 116 C20(1.01)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C16(1.05); C159(1.03); C107(0.99); C20(0.91)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C16(1.04); C159(0.99); C107(0.94); C20(0.84)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C16(0.90); C159(1.02); C107(0.94); C20(0.91)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C16(0.98); C159(0.98); C107(1.00); C20(0.90)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C16(1.06); C159(0.97); C107(0.97); C20(0.90)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C16(0.94); C159(0.98); C107(1.07); C20(0.94)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C16(1.02); C159(0.90); C107(1.02); C20(0.93)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C16(0.99); C159(0.98); C107(0.98); C20(0.84)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C16(1.03); C159(0.96); C107(1.02); C20(0.83)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C16(0.97); C159(0.93); C107(0.99); C20(0.88)  LDD1528  [12]
 LDCM0290  AC3 HCT 116 C20(0.95)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C16(0.94); C159(1.00); C107(0.94); C20(0.89)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C16(0.96); C159(1.08); C107(1.01); C20(0.89)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C16(1.09); C159(1.00); C107(0.96); C20(0.89)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C16(0.90); C159(1.04); C107(1.05); C20(0.86)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C16(0.96); C159(0.98); C107(0.99); C20(0.89)  LDD1534  [12]
 LDCM0296  AC35 HCT 116 C20(1.16)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C20(1.33)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C20(1.21)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C20(1.36)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C20(1.06)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C20(1.05)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C20(0.92)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C20(1.06)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C20(1.12)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C20(1.28)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C20(1.11)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C20(0.85)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C20(0.86)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C20(0.69)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C20(1.14)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C20(0.57)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C20(0.95)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C20(0.60)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C20(0.91)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C20(1.23)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C20(0.64)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C20(0.75)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C20(0.58)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C20(0.41)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C20(0.83)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C20(0.80)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C20(0.52)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C16(0.96); C159(0.99); C107(1.05); C20(0.85)  LDD1562  [12]
 LDCM0324  AC60 HCT 116 C20(0.97)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C20(1.55)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C20(0.54)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C20(0.86)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C20(0.52)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C20(0.93)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C20(1.12)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C20(0.28)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C20(0.90)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C20(0.87)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C16(0.92); C159(0.88); C107(1.02); C20(0.85)  LDD1568  [12]
 LDCM0335  AC70 HCT 116 C20(0.36)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C20(1.07)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C20(0.73)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C20(0.28)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C20(0.33)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C20(0.22)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C20(0.57)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C20(0.55)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C20(0.96)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C20(0.83)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C16(0.93); C159(0.96); C107(0.89); C20(0.83)  LDD1569  [12]
 LDCM0346  AC80 HCT 116 C20(0.64)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C20(0.80)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C20(0.16)  LDD0665  [3]
 LDCM0248  AKOS034007472 HEK-293T C16(0.91); C159(0.89); C107(0.93); C20(0.90)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C16(0.83); C159(1.06); C107(1.06); C20(0.79)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C16(0.93); C159(0.93); C107(0.92); C20(0.82)  LDD1514  [12]
 LDCM0108  Chloroacetamide HeLa C159(0.00); C16(0.00); C20(0.00)  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C159(0.29)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C20(0.71)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C20(0.82)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C20(0.93)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C16(0.93); C159(0.98); C107(1.01); C20(0.85)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C16(1.10); C159(1.12); C107(1.14); C20(0.80)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C16(0.91); C159(0.98); C107(0.95); C20(0.79)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C16(1.05); C159(0.94); C107(1.00); C20(0.88)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C16(1.02); C159(0.96); C107(0.98); C20(0.89)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C16(1.11); C159(1.02); C107(1.01); C20(0.87)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C16(0.99); C159(1.06); C107(0.96); C20(0.89)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C16(0.94); C159(0.95); C107(1.03); C20(0.97)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C16(1.07); C159(0.95); C107(1.02); C20(0.94)  LDD1582  [12]
 LDCM0379  CL11 HCT 116 C20(0.41)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C16(1.25); C159(1.07); C107(1.12); C20(0.76)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C16(1.17); C159(1.09); C107(1.08); C20(0.83)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C16(1.03); C159(0.93); C107(1.06); C20(0.91)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C16(0.91); C159(0.95); C107(0.93); C20(0.89)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C16(1.17); C159(1.04); C107(1.17); C20(0.85)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C16(0.93); C159(1.02); C107(1.02); C20(0.76)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C16(0.99); C159(0.97); C107(1.00); C20(0.84)  LDD1590  [12]
 LDCM0387  CL117 HCT 116 C20(0.60)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C20(1.14)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C20(0.99)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C20(0.35)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C20(1.11)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C20(1.05)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C20(1.18)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C20(0.73)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C20(0.64)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C20(1.00)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C20(0.96)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C20(1.24)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C20(0.60)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C20(0.76)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C20(0.85)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C20(0.59)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C20(1.15)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C20(1.25)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C20(1.75)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C20(1.35)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C20(0.98)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C20(0.80)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C20(0.65)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C20(0.24)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C20(0.87)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C20(0.56)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C20(0.61)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C20(1.03)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C20(1.00)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C20(0.94)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C20(0.94)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C20(0.95)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C20(1.42)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C20(1.16)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C20(1.76)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C20(1.49)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C20(0.63)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C20(0.66)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C20(0.83)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C20(0.51)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C20(0.66)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C20(0.80)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C20(0.89)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C20(0.89)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C20(0.34)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C20(0.52)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C20(1.04)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C20(0.70)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C16(1.30); C159(0.99); C107(0.92); C20(0.67)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C16(1.28); C159(1.11); C107(0.86); C20(0.68)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C16(1.39); C159(1.08); C107(1.12); C20(0.67)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C16(1.00); C159(1.02); C107(0.92); C20(0.90)  LDD1643  [12]
 LDCM0440  CL5 HCT 116 C20(0.87)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C16(0.97); C159(1.02); C107(1.02); C20(0.80)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C16(1.00); C159(0.93); C107(1.04); C20(0.76)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C16(0.92); C159(1.11); C107(1.09); C20(0.66)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C16(1.01); C159(0.98); C107(1.05); C20(0.72)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C16(0.94); C159(1.05); C107(1.11); C20(0.66)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C16(0.80); C159(1.05); C107(0.95); C20(0.60)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C16(1.22); C159(1.03); C107(1.18); C20(0.61)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C16(1.16); C159(0.97); C107(0.94); C20(0.64)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C16(1.32); C159(1.13); C107(0.91); C20(0.61)  LDD1653  [12]
 LDCM0451  CL6 HCT 116 C20(0.94)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C16(1.15); C159(1.09); C107(1.23); C20(0.64)  LDD1655  [12]
 LDCM0453  CL61 HCT 116 C20(1.03)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C20(0.93)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C20(0.89)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C20(0.69)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C20(1.03)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C20(0.54)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C20(0.70)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C20(0.97)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C20(0.98)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C20(0.51)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C20(1.11)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C20(0.82)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C20(0.89)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C20(0.86)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C20(0.76)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C20(1.04)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C20(0.98)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C20(0.94)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C20(0.59)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C20(0.33)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C20(1.28)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C20(0.81)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C20(0.34)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C20(0.46)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C20(0.27)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C20(0.88)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C20(1.15)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C20(0.82)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C20(0.42)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C20(0.23)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C20(0.66)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C20(0.81)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C20(0.89)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C20(0.89)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C20(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C20(0.91)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C20(0.98)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C20(0.88)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C20(0.97)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C20(0.97)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C20(0.88)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C16(0.88); C159(1.05); C107(1.07); C20(0.75)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C20(0.86)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C20(0.35)  LDD0744  [3]
 LDCM0116  HHS-0101 DM93 Y66(3.40)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y66(1.30)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y66(0.52)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y66(0.77)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y66(2.34)  LDD0268  [2]
 LDCM0107  IAA HeLa C16(0.00); C20(0.00)  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C16(0.88); C159(0.95); C107(1.00); C20(1.13)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C16(0.99); C159(1.12); C107(1.05); C20(1.02)  LDD1497  [12]
 LDCM0024  KB05 HMCB C159(1.52); C16(1.43); C20(1.33)  LDD3312  [13]
 LDCM0109  NEM HeLa N.A.  LDD0231  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C16(0.86)  LDD2099  [1]
 LDCM0090  Rapamycin JHH-7 3.84  LDD0213  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Botulinum Toxin Type A BiotechDrug DB00083

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840