Details of the Target

General Information of Target

Target ID LDTP00855
Target Name AP-1 complex subunit gamma-1 (AP1G1)
Gene Name AP1G1
Gene ID 164
Synonyms
ADTG; CLAPG1; AP-1 complex subunit gamma-1; Adaptor protein complex AP-1 subunit gamma-1; Adaptor-related protein complex 1 subunit gamma-1; Clathrin assembly protein complex 1 gamma-1 large chain; Gamma1-adaptin; Golgi adaptor HA1/AP1 adaptin subunit gamma-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLG
YPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQG
LALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATK
NLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGI
SDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIK
SESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVS
IKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHID
TIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCI
GEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCT
VNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQ
TNGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPSSAGGELLDLL
GDINLTGAPAAAPAPASVPQISQPPFLLDGLSSQPLFNDIAAGIPSITAYSKNGLKIEFT
FERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSIVPAFNTGTITQ
VIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ
Target Bioclass
Transporter and channel
Family
Adaptor complexes large subunit family
Subcellular location
Golgi apparatus
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.
Uniprot ID
O43747
Ensemble ID
ENST00000299980.9
HGNC ID
HGNC:555

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE410 SNV: p.T720S DBIA    Probe Info 
NCIH23 SNV: p.S623C DBIA    Probe Info 
RL952 SNV: p.R24Q DBIA    Probe Info 
SKMEL30 SNV: p.V327M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.60  LDD0402  [1]
TH211
 Probe Info  		Y231(10.04)  LDD0257  [2]
STPyne
 Probe Info  		K214(3.04); K571(1.56); K797(9.12)  LDD0277  [3]
BTD
 Probe Info  		C539(18.30)  LDD1699  [4]
Probe 1
 Probe Info  		Y45(49.68); Y152(3.04); Y432(36.40); Y566(14.09)  LDD3495  [5]
DBIA
 Probe Info  		C539(80.19)  LDD0209  [6]
HHS-482
 Probe Info  		Y231(1.48)  LDD0285  [7]
HHS-475
 Probe Info  		Y231(0.97)  LDD0264  [8]
HHS-465
 Probe Info  		Y231(1.99)  LDD2237  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C160(0.00); C400(0.00); C392(0.00); C70(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C160(0.00); C400(0.00); C392(0.00); C539(0.00)  LDD0036  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C160(0.00); C400(0.00); C392(0.00); C539(0.00)  LDD0037  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
WYneO
 Probe Info  		C539(0.00); C400(0.00)  LDD0022  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
OSF
 Probe Info  		N.A.  LDD0029  [16]
PF-06672131
 Probe Info  		N.A.  LDD0017  [17]
SF
 Probe Info  		N.A.  LDD0028  [16]
1c-yne
 Probe Info  		N.A.  LDD0228  [18]
Acrolein
 Probe Info  		C400(0.00); C392(0.00); C353(0.00); C31(0.00)  LDD0217  [19]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [19]
Methacrolein
 Probe Info  		C400(0.00); C160(0.00); C353(0.00); C539(0.00)  LDD0218  [19]
W1
 Probe Info  		N.A.  LDD0236  [20]
NAIA_5
 Probe Info  		C160(0.00); C400(0.00); C31(0.00); C353(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]
Alk-rapa
 Probe Info  		2.41  LDD0213  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C160(0.82)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C539(1.07); C353(0.97)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C160(1.11); C539(0.92); C353(1.49)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C160(1.35); C539(0.98); C353(1.79); C106(1.90)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C539(1.11)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C160(0.40); C353(0.64); C400(1.05); C47(0.69)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C160(0.90); C353(0.74)  LDD2131  [4]
 LDCM0025  4SU-RNA HEK-293T C31(2.03)  LDD0371  [25]
 LDCM0214  AC1 HEK-293T C539(0.91); C106(0.96); C353(0.93); C400(1.00)  LDD1507  [26]
 LDCM0215  AC10 HEK-293T C539(0.93); C106(0.98); C353(0.97); C400(1.05)  LDD1508  [26]
 LDCM0226  AC11 HEK-293T C539(0.90); C106(0.94); C353(0.96); C400(1.04)  LDD1509  [26]
 LDCM0237  AC12 HEK-293T C539(0.89); C106(0.97); C353(1.03); C400(1.05)  LDD1510  [26]
 LDCM0259  AC14 HEK-293T C539(0.97); C106(0.97); C353(0.96); C400(1.13)  LDD1512  [26]
 LDCM0270  AC15 HEK-293T C539(0.91); C106(0.96); C353(0.98); C400(1.05)  LDD1513  [26]
 LDCM0276  AC17 HEK-293T C539(0.99); C106(0.98); C353(0.90); C400(1.01)  LDD1515  [26]
 LDCM0277  AC18 HEK-293T C539(0.98); C106(1.06); C353(1.03); C400(1.03)  LDD1516  [26]
 LDCM0278  AC19 HEK-293T C539(1.00); C106(0.91); C353(0.92); C400(1.03)  LDD1517  [26]
 LDCM0279  AC2 HEK-293T C539(0.97); C106(1.06); C353(0.97); C400(1.04)  LDD1518  [26]
 LDCM0280  AC20 HEK-293T C539(0.96); C106(0.99); C353(1.03); C400(1.02)  LDD1519  [26]
 LDCM0281  AC21 HEK-293T C539(1.02); C106(1.00); C353(1.01); C400(1.08)  LDD1520  [26]
 LDCM0282  AC22 HEK-293T C539(1.01); C106(1.00); C353(0.83); C400(1.08)  LDD1521  [26]
 LDCM0283  AC23 HEK-293T C539(0.94); C106(0.96); C353(0.94); C400(1.05)  LDD1522  [26]
 LDCM0284  AC24 HEK-293T C539(0.97); C106(0.96); C353(1.02); C400(1.05)  LDD1523  [26]
 LDCM0285  AC25 HEK-293T C539(0.88); C106(0.96); C353(0.95); C400(1.00)  LDD1524  [26]
 LDCM0286  AC26 HEK-293T C539(0.98); C106(0.90); C353(0.97); C400(1.03)  LDD1525  [26]
 LDCM0287  AC27 HEK-293T C539(1.02); C106(0.93); C353(0.97); C400(1.05)  LDD1526  [26]
 LDCM0288  AC28 HEK-293T C539(0.93); C106(1.04); C353(1.02); C400(1.07)  LDD1527  [26]
 LDCM0289  AC29 HEK-293T C539(0.98); C106(0.96); C353(1.00); C400(1.10)  LDD1528  [26]
 LDCM0290  AC3 HEK-293T C539(0.92); C106(1.02); C353(0.96); C400(1.01)  LDD1529  [26]
 LDCM0291  AC30 HEK-293T C539(0.99); C106(1.02); C353(0.97); C400(0.99)  LDD1530  [26]
 LDCM0292  AC31 HEK-293T C539(0.97); C106(1.00); C353(1.04); C400(1.06)  LDD1531  [26]
 LDCM0293  AC32 HEK-293T C539(1.02); C106(0.95); C353(1.05); C400(1.11)  LDD1532  [26]
 LDCM0294  AC33 HEK-293T C539(0.89); C106(0.96); C353(0.93); C400(1.02)  LDD1533  [26]
 LDCM0295  AC34 HEK-293T C539(1.00); C106(0.93); C353(1.01); C400(1.01)  LDD1534  [26]
 LDCM0296  AC35 HEK-293T C539(0.95); C106(0.90); C353(0.96); C400(1.01)  LDD1535  [26]
 LDCM0297  AC36 HEK-293T C539(0.93); C106(0.97); C353(1.00); C400(1.05)  LDD1536  [26]
 LDCM0298  AC37 HEK-293T C539(0.93); C106(0.99); C353(0.96); C400(0.96)  LDD1537  [26]
 LDCM0299  AC38 HEK-293T C539(0.88); C106(0.96); C353(0.97); C400(0.96)  LDD1538  [26]
 LDCM0300  AC39 HEK-293T C539(0.85); C106(1.01); C353(0.92); C400(1.03)  LDD1539  [26]
 LDCM0301  AC4 HEK-293T C539(0.88); C106(1.04); C353(0.96); C400(1.04)  LDD1540  [26]
 LDCM0302  AC40 HEK-293T C539(1.00); C106(0.91); C353(0.95); C400(1.03)  LDD1541  [26]
 LDCM0303  AC41 HEK-293T C539(0.93); C106(0.98); C353(0.94); C400(1.04)  LDD1542  [26]
 LDCM0304  AC42 HEK-293T C539(0.92); C106(0.99); C353(0.98); C400(1.01)  LDD1543  [26]
 LDCM0305  AC43 HEK-293T C539(0.88); C106(0.91); C353(1.00); C400(0.98)  LDD1544  [26]
 LDCM0306  AC44 HEK-293T C539(0.91); C106(1.05); C353(1.01); C400(1.05)  LDD1545  [26]
 LDCM0307  AC45 HEK-293T C539(0.97); C106(0.98); C353(0.97); C400(1.04)  LDD1546  [26]
 LDCM0308  AC46 HEK-293T C539(0.88); C106(1.02); C353(0.97); C400(1.02)  LDD1547  [26]
 LDCM0309  AC47 HEK-293T C539(0.91); C106(0.98); C353(0.95); C400(1.10)  LDD1548  [26]
 LDCM0310  AC48 HEK-293T C539(1.06); C106(0.95); C353(0.96); C400(1.11)  LDD1549  [26]
 LDCM0311  AC49 HEK-293T C539(0.92); C106(0.97); C353(0.93); C400(0.96)  LDD1550  [26]
 LDCM0312  AC5 HEK-293T C539(0.99); C106(1.03); C353(0.90); C400(1.01)  LDD1551  [26]
 LDCM0313  AC50 HEK-293T C539(1.00); C106(1.02); C353(0.99); C400(1.03)  LDD1552  [26]
 LDCM0314  AC51 HEK-293T C539(0.92); C106(1.02); C353(0.94); C400(0.96)  LDD1553  [26]
 LDCM0315  AC52 HEK-293T C539(0.90); C106(1.05); C353(0.95); C400(1.01)  LDD1554  [26]
 LDCM0316  AC53 HEK-293T C539(0.97); C106(1.05); C353(0.97); C400(1.03)  LDD1555  [26]
 LDCM0317  AC54 HEK-293T C539(0.97); C106(0.99); C353(0.99); C400(1.00)  LDD1556  [26]
 LDCM0318  AC55 HEK-293T C539(0.92); C106(1.00); C353(0.92); C400(0.99)  LDD1557  [26]
 LDCM0319  AC56 HEK-293T C539(1.04); C106(0.96); C353(0.98); C400(1.02)  LDD1558  [26]
 LDCM0320  AC57 HEK-293T C539(0.96); C106(0.95); C353(0.92); C400(1.03)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C539(1.04); C106(1.07); C353(1.01); C400(1.03)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C539(1.05); C106(1.04); C353(0.93); C400(1.08)  LDD1561  [26]
 LDCM0323  AC6 HEK-293T C539(0.96); C106(1.02); C353(0.99); C400(1.05)  LDD1562  [26]
 LDCM0324  AC60 HEK-293T C539(0.89); C106(1.02); C353(0.99); C400(1.09)  LDD1563  [26]
 LDCM0325  AC61 HEK-293T C539(0.95); C106(1.03); C353(0.91); C400(1.06)  LDD1564  [26]
 LDCM0326  AC62 HEK-293T C539(0.97); C106(1.02); C353(0.98); C400(1.11)  LDD1565  [26]
 LDCM0327  AC63 HEK-293T C539(0.96); C106(1.00); C353(0.96); C400(1.08)  LDD1566  [26]
 LDCM0328  AC64 HEK-293T C539(1.01); C106(1.05); C353(0.97); C400(1.05)  LDD1567  [26]
 LDCM0334  AC7 HEK-293T C539(0.91); C106(0.97); C353(0.96); C400(1.09)  LDD1568  [26]
 LDCM0345  AC8 HEK-293T C539(1.03); C106(0.97); C353(1.01); C400(1.12)  LDD1569  [26]
 LDCM0545  Acetamide MDA-MB-231 C160(0.65); C539(0.75); C47(0.49)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C160(1.03)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C539(0.94); C106(0.95); C353(0.95); C400(1.09)  LDD1511  [26]
 LDCM0356  AKOS034007680 HEK-293T C539(0.91); C106(0.95); C353(0.94); C400(1.05)  LDD1570  [26]
 LDCM0275  AKOS034007705 HEK-293T C539(1.02); C106(0.95); C353(0.97); C400(1.01)  LDD1514  [26]
 LDCM0156  Aniline NCI-H1299 11.66  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C160(0.84); C539(0.62); C353(1.20); C47(0.80)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C400(0.00); C160(0.00); C353(0.00); C31(0.00)  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C400(1.35); C160(0.52); C70(0.28)  LDD2227  [21]
 LDCM0367  CL1 HEK-293T C539(0.88); C106(1.03); C353(1.00); C400(1.03)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C539(1.10); C106(1.01); C353(1.15); C400(1.21)  LDD1572  [26]
 LDCM0369  CL100 HEK-293T C539(0.88); C160(1.15); C106(0.99); C353(0.93)  LDD1573  [26]
 LDCM0370  CL101 HEK-293T C539(1.02); C106(1.00); C353(0.99); C400(0.97)  LDD1574  [26]
 LDCM0371  CL102 HEK-293T C539(0.92); C106(1.01); C353(0.97); C400(1.04)  LDD1575  [26]
 LDCM0372  CL103 HEK-293T C539(0.94); C106(1.01); C353(1.03); C400(1.03)  LDD1576  [26]
 LDCM0373  CL104 HEK-293T C539(0.93); C160(0.95); C106(1.00); C353(0.95)  LDD1577  [26]
 LDCM0374  CL105 HEK-293T C539(0.97); C106(1.05); C353(1.01); C400(0.92)  LDD1578  [26]
 LDCM0375  CL106 HEK-293T C539(0.92); C106(0.94); C353(0.99); C400(1.03)  LDD1579  [26]
 LDCM0376  CL107 HEK-293T C539(0.94); C106(1.00); C353(1.05); C400(1.05)  LDD1580  [26]
 LDCM0377  CL108 HEK-293T C539(0.94); C160(0.95); C106(0.98); C353(0.97)  LDD1581  [26]
 LDCM0378  CL109 HEK-293T C539(0.96); C106(1.03); C353(1.00); C400(1.04)  LDD1582  [26]
 LDCM0379  CL11 HEK-293T C539(1.27); C106(1.06); C353(1.06); C400(1.12)  LDD1583  [26]
 LDCM0380  CL110 HEK-293T C539(0.93); C106(0.99); C353(1.02); C400(1.09)  LDD1584  [26]
 LDCM0381  CL111 HEK-293T C539(0.99); C106(1.01); C353(1.02); C400(1.07)  LDD1585  [26]
 LDCM0382  CL112 HEK-293T C539(1.01); C160(1.22); C106(0.99); C353(0.95)  LDD1586  [26]
 LDCM0383  CL113 HEK-293T C539(0.99); C106(0.98); C353(1.02); C400(0.99)  LDD1587  [26]
 LDCM0384  CL114 HEK-293T C539(0.91); C106(0.99); C353(1.04); C400(1.07)  LDD1588  [26]
 LDCM0385  CL115 HEK-293T C539(0.95); C106(1.11); C353(1.03); C400(0.98)  LDD1589  [26]
 LDCM0386  CL116 HEK-293T C539(1.03); C160(1.04); C106(0.97); C353(0.95)  LDD1590  [26]
 LDCM0387  CL117 HEK-293T C539(0.96); C106(1.04); C353(1.04); C400(0.95)  LDD1591  [26]
 LDCM0388  CL118 HEK-293T C539(0.93); C106(0.92); C353(0.92); C400(1.01)  LDD1592  [26]
 LDCM0389  CL119 HEK-293T C539(0.96); C106(1.02); C353(1.01); C400(1.08)  LDD1593  [26]
 LDCM0390  CL12 HEK-293T C539(1.52); C106(0.96); C353(1.08); C400(1.20)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C539(0.87); C160(0.89); C106(0.95); C353(0.92)  LDD1595  [26]
 LDCM0392  CL121 HEK-293T C539(0.96); C106(1.03); C353(1.03); C400(0.98)  LDD1596  [26]
 LDCM0393  CL122 HEK-293T C539(0.96); C106(0.99); C353(0.98); C400(1.04)  LDD1597  [26]
 LDCM0394  CL123 HEK-293T C539(0.91); C106(1.15); C353(1.20); C400(1.11)  LDD1598  [26]
 LDCM0395  CL124 HEK-293T C539(1.07); C160(0.98); C106(0.98); C353(0.94)  LDD1599  [26]
 LDCM0396  CL125 HEK-293T C539(1.05); C106(1.25); C353(0.97); C400(0.99)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C539(0.97); C106(1.08); C353(0.94); C400(1.09)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C539(1.01); C106(1.18); C353(1.01); C400(1.04)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C539(1.01); C160(0.98); C106(1.01); C353(0.91)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C539(0.94); C106(1.01); C353(0.93); C400(0.92)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C539(0.91); C106(0.93); C353(0.95); C400(1.08)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C539(0.81); C106(1.03); C353(1.04); C400(1.12)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C539(0.90); C160(1.09); C106(0.97); C353(0.93)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C539(0.79); C106(0.89); C353(0.97); C400(1.06)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C539(1.00); C106(0.95); C353(1.05); C400(1.12)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C539(1.12); C106(0.85); C353(0.99); C400(1.06)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C539(0.97); C106(0.94); C353(0.90); C400(1.06)  LDD1611  [26]
 LDCM0408  CL20 HEK-293T C539(1.11); C106(0.92); C353(1.07); C400(1.02)  LDD1612  [26]
 LDCM0409  CL21 HEK-293T C539(1.07); C106(0.96); C353(1.19); C400(1.16)  LDD1613  [26]
 LDCM0410  CL22 HEK-293T C539(1.25); C106(0.94); C353(1.03); C400(1.04)  LDD1614  [26]
 LDCM0411  CL23 HEK-293T C539(1.26); C106(0.92); C353(1.09); C400(1.11)  LDD1615  [26]
 LDCM0412  CL24 HEK-293T C539(1.52); C106(0.92); C353(1.08); C400(1.16)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C539(0.90); C106(1.24); C353(1.04); C400(1.04)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C539(0.88); C106(0.95); C353(1.00); C400(1.00)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C539(0.94); C106(1.01); C353(1.06); C400(1.11)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C539(1.00); C160(1.02); C106(0.96); C353(0.94)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C539(0.95); C106(0.95); C353(0.99); C400(1.02)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C539(0.92); C106(1.05); C353(1.04); C400(1.02)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C539(1.05); C106(0.95); C353(1.08); C400(1.08)  LDD1623  [26]
 LDCM0420  CL31 HEK-293T C539(1.10); C106(0.87); C353(1.05); C400(1.08)  LDD1624  [26]
 LDCM0421  CL32 HEK-293T C539(1.10); C106(0.97); C353(1.04); C400(1.03)  LDD1625  [26]
 LDCM0422  CL33 HEK-293T C539(1.13); C106(1.09); C353(1.24); C400(1.44)  LDD1626  [26]
 LDCM0423  CL34 HEK-293T C539(1.37); C106(0.93); C353(1.12); C400(1.05)  LDD1627  [26]
 LDCM0424  CL35 HEK-293T C539(1.46); C106(0.94); C353(1.14); C400(1.18)  LDD1628  [26]
 LDCM0425  CL36 HEK-293T C539(1.46); C106(1.02); C353(1.08); C400(1.24)  LDD1629  [26]
 LDCM0426  CL37 HEK-293T C539(0.90); C106(1.09); C353(0.99); C400(0.92)  LDD1630  [26]
 LDCM0428  CL39 HEK-293T C539(0.92); C106(1.25); C353(1.01); C400(1.06)  LDD1632  [26]
 LDCM0429  CL4 HEK-293T C539(0.95); C160(1.34); C106(1.01); C353(0.97)  LDD1633  [26]
 LDCM0430  CL40 HEK-293T C539(0.94); C160(1.14); C106(0.97); C353(0.93)  LDD1634  [26]
 LDCM0431  CL41 HEK-293T C539(0.89); C106(0.92); C353(0.95); C400(1.08)  LDD1635  [26]
 LDCM0432  CL42 HEK-293T C539(1.05); C106(0.89); C353(1.01); C400(1.05)  LDD1636  [26]
 LDCM0433  CL43 HEK-293T C539(1.03); C106(0.90); C353(1.09); C400(1.11)  LDD1637  [26]
 LDCM0434  CL44 HEK-293T C539(1.05); C106(0.97); C353(1.04); C400(1.09)  LDD1638  [26]
 LDCM0435  CL45 HEK-293T C539(1.22); C106(0.88); C353(1.13); C400(1.01)  LDD1639  [26]
 LDCM0436  CL46 HEK-293T C539(1.31); C106(0.93); C353(1.11); C400(1.18)  LDD1640  [26]
 LDCM0437  CL47 HEK-293T C539(1.44); C106(0.97); C353(1.09); C400(1.12)  LDD1641  [26]
 LDCM0438  CL48 HEK-293T C539(1.52); C106(0.93); C353(1.12); C400(1.19)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C539(0.98); C106(1.15); C353(1.03); C400(0.98)  LDD1643  [26]
 LDCM0440  CL5 HEK-293T C539(0.90); C106(0.97); C353(0.90); C400(1.00)  LDD1644  [26]
 LDCM0441  CL50 HEK-293T C539(0.90); C106(0.91); C353(0.97); C400(1.06)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C539(0.88); C160(1.12); C106(0.91); C353(0.92)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C539(0.84); C106(0.91); C353(1.01); C400(1.03)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C539(0.94); C106(0.91); C353(1.17); C400(1.36)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C539(1.05); C106(0.86); C353(1.04); C400(1.07)  LDD1649  [26]
 LDCM0447  CL56 HEK-293T C539(1.08); C106(1.01); C353(1.00); C400(1.13)  LDD1650  [26]
 LDCM0448  CL57 HEK-293T C539(1.11); C106(0.94); C353(1.11); C400(1.10)  LDD1651  [26]
 LDCM0449  CL58 HEK-293T C539(1.31); C106(0.97); C353(1.10); C400(1.05)  LDD1652  [26]
 LDCM0450  CL59 HEK-293T C539(1.25); C106(0.82); C353(1.02); C400(1.10)  LDD1653  [26]
 LDCM0451  CL6 HEK-293T C539(0.96); C106(0.91); C353(1.12); C400(1.18)  LDD1654  [26]
 LDCM0452  CL60 HEK-293T C539(1.49); C106(0.92); C353(1.10); C400(1.13)  LDD1655  [26]
 LDCM0453  CL61 HEK-293T C539(0.99); C106(1.16); C353(1.02); C400(1.03)  LDD1656  [26]
 LDCM0454  CL62 HEK-293T C539(0.94); C106(0.92); C353(0.94); C400(0.94)  LDD1657  [26]
 LDCM0455  CL63 HEK-293T C539(0.93); C106(1.06); C353(1.04); C400(0.99)  LDD1658  [26]
 LDCM0456  CL64 HEK-293T C539(0.86); C160(1.08); C106(0.94); C353(0.97)  LDD1659  [26]
 LDCM0457  CL65 HEK-293T C539(0.91); C106(0.85); C353(0.92); C400(1.02)  LDD1660  [26]
 LDCM0458  CL66 HEK-293T C539(1.00); C106(0.89); C353(0.99); C400(1.07)  LDD1661  [26]
 LDCM0459  CL67 HEK-293T C539(1.07); C106(0.88); C353(1.00); C400(1.04)  LDD1662  [26]
 LDCM0460  CL68 HEK-293T C539(1.04); C106(0.95); C353(1.05); C400(1.10)  LDD1663  [26]
 LDCM0461  CL69 HEK-293T C539(1.14); C106(0.95); C353(1.14); C400(1.18)  LDD1664  [26]
 LDCM0462  CL7 HEK-293T C539(1.08); C106(0.90); C353(1.02); C400(0.97)  LDD1665  [26]
 LDCM0463  CL70 HEK-293T C539(1.26); C106(0.85); C353(1.00); C400(1.07)  LDD1666  [26]
 LDCM0464  CL71 HEK-293T C539(1.19); C106(0.87); C353(1.07); C400(1.09)  LDD1667  [26]
 LDCM0465  CL72 HEK-293T C539(1.38); C106(0.89); C353(1.04); C400(1.15)  LDD1668  [26]
 LDCM0466  CL73 HEK-293T C539(0.91); C106(1.14); C353(1.02); C400(0.99)  LDD1669  [26]
 LDCM0467  CL74 HEK-293T C539(0.91); C106(1.04); C353(0.95); C400(1.00)  LDD1670  [26]
 LDCM0469  CL76 HEK-293T C539(0.94); C160(1.15); C106(0.96); C353(0.91)  LDD1672  [26]
 LDCM0470  CL77 HEK-293T C539(0.84); C106(0.94); C353(0.97); C400(1.05)  LDD1673  [26]
 LDCM0471  CL78 HEK-293T C539(1.01); C106(0.95); C353(1.01); C400(1.10)  LDD1674  [26]
 LDCM0472  CL79 HEK-293T C539(1.00); C106(0.91); C353(1.03); C400(1.05)  LDD1675  [26]
 LDCM0473  CL8 HEK-293T C539(0.89); C106(1.01); C353(1.63); C400(1.58)  LDD1676  [26]
 LDCM0474  CL80 HEK-293T C539(1.10); C106(0.93); C353(1.07); C400(1.06)  LDD1677  [26]
 LDCM0475  CL81 HEK-293T C539(1.10); C106(0.93); C353(1.08); C400(1.07)  LDD1678  [26]
 LDCM0476  CL82 HEK-293T C539(1.19); C106(0.93); C353(1.04); C400(1.02)  LDD1679  [26]
 LDCM0477  CL83 HEK-293T C539(1.08); C106(0.86); C353(1.11); C400(1.07)  LDD1680  [26]
 LDCM0478  CL84 HEK-293T C539(1.29); C106(0.90); C353(1.11); C400(1.17)  LDD1681  [26]
 LDCM0479  CL85 HEK-293T C539(0.97); C106(1.27); C353(0.98); C400(1.00)  LDD1682  [26]
 LDCM0480  CL86 HEK-293T C539(0.92); C106(1.19); C353(0.91); C400(1.05)  LDD1683  [26]
 LDCM0481  CL87 HEK-293T C539(0.88); C106(1.32); C353(0.99); C400(0.99)  LDD1684  [26]
 LDCM0482  CL88 HEK-293T C539(0.89); C160(1.03); C106(1.03); C353(0.92)  LDD1685  [26]
 LDCM0483  CL89 HEK-293T C539(0.93); C106(1.00); C353(0.96); C400(1.07)  LDD1686  [26]
 LDCM0484  CL9 HEK-293T C539(1.13); C106(1.01); C353(1.14); C400(1.09)  LDD1687  [26]
 LDCM0485  CL90 HEK-293T C539(0.87); C106(1.01); C353(1.09); C400(1.36)  LDD1688  [26]
 LDCM0486  CL91 HEK-293T C539(0.89); C106(1.00); C353(1.01); C400(0.96)  LDD1689  [26]
 LDCM0487  CL92 HEK-293T C539(0.96); C106(1.06); C353(1.09); C400(1.07)  LDD1690  [26]
 LDCM0488  CL93 HEK-293T C539(1.04); C106(1.01); C353(1.06); C400(1.19)  LDD1691  [26]
 LDCM0489  CL94 HEK-293T C539(1.12); C106(0.93); C353(1.01); C400(1.05)  LDD1692  [26]
 LDCM0490  CL95 HEK-293T C539(0.96); C106(0.86); C353(1.39); C400(1.23)  LDD1693  [26]
 LDCM0491  CL96 HEK-293T C539(1.28); C106(1.00); C353(1.10); C400(1.14)  LDD1694  [26]
 LDCM0492  CL97 HEK-293T C539(0.95); C106(1.09); C353(1.04); C400(0.97)  LDD1695  [26]
 LDCM0493  CL98 HEK-293T C539(0.95); C106(0.96); C353(0.94); C400(0.99)  LDD1696  [26]
 LDCM0494  CL99 HEK-293T C539(0.92); C106(1.22); C353(1.01); C400(0.97)  LDD1697  [26]
 LDCM0495  E2913 HEK-293T C539(0.88); C106(1.23); C353(1.03); C400(1.01)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C539(0.83)  LDD1702  [4]
 LDCM0625  F8 Ramos C539(0.85); C160(0.51); C31(0.68)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C539(0.57); C160(0.53); C31(1.05)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C539(0.04); C160(20.00); C31(0.47); C70(0.36)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C539(0.54); C160(0.72); C31(0.92)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C539(0.92); C160(0.80); C31(1.02)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C539(0.44); C160(0.70); C31(0.30); C70(0.79)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C539(0.49); C160(0.59); C31(0.54)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C539(1.45); C160(0.98); C31(0.92)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C539(0.77); C160(0.99); C31(1.30)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C539(1.23); C160(0.88); C31(0.85)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C539(0.56); C160(2.02); C31(0.88)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C539(1.50); C160(0.74); C31(1.25)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C539(0.80); C160(1.38); C31(1.02)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C539(0.61); C160(0.40); C31(1.35)  LDD2201  [27]
 LDCM0468  Fragment33 HEK-293T C539(0.90); C106(1.11); C353(0.98); C400(1.03)  LDD1671  [26]
 LDCM0596  Fragment38 Ramos C539(0.90); C160(1.06); C31(0.94)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C539(0.74); C160(1.14); C31(0.81)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C539(0.86); C106(0.95); C353(0.95); C400(0.97)  LDD1631  [26]
 LDCM0610  Fragment52 Ramos C539(0.88); C160(0.56); C31(1.34)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C539(0.69); C160(0.99); C31(1.11)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C539(0.70); C160(0.71); C31(0.41); C70(1.28)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C539(0.60); C160(0.62); C31(0.70)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y231(0.97)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y231(1.15)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y231(0.80)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y231(1.68)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y231(0.73)  LDD0268  [8]
 LDCM0107  IAA HeLa C400(0.00); H211(0.00); C160(0.00); C353(0.00)  LDD0221  [19]
 LDCM0123  JWB131 DM93 Y231(1.48)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y231(0.68)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y231(2.13)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y231(3.25)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y231(1.66)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y231(0.54)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y231(0.49)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y231(1.69)  LDD0292  [7]
 LDCM0022  KB02 HEK-293T C539(0.91); C106(1.04); C353(0.91); C400(0.95)  LDD1492  [26]
 LDCM0023  KB03 Jurkat C539(80.19)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C106(2.28)  LDD3310  [28]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C539(1.08)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C160(0.95); C539(0.60); C47(1.04)  LDD2121  [4]
 LDCM0109  NEM HeLa H211(0.00); H418(0.00); H340(0.00)  LDD0223  [19]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C160(0.91); C353(1.03); C47(1.01)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C160(0.58)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C539(0.99)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C160(1.26); C539(0.97); C353(3.13)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C539(1.25)  LDD2094  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C160(0.87)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C160(0.34); C539(1.07)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C160(1.34); C539(0.67); C400(1.04)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C539(0.95)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C400(0.90)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C160(0.92); C539(1.09); C400(0.91)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C539(1.13)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C160(0.71); C539(0.69); C353(0.74); C106(1.19)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C160(1.32); C539(0.76); C353(1.40)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C160(0.68); C353(0.47)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C160(0.06); C539(0.92); C353(1.23)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C160(0.06); C353(1.22)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C160(2.00); C539(2.53); C106(1.59)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C160(1.09); C539(0.89); C353(1.05); C400(1.03)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C160(0.08); C539(0.57); C353(0.80); C400(0.65)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C160(0.92); C539(1.06); C353(1.07); C400(1.02)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C160(1.20); C539(0.79); C353(1.30); C400(0.89)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C160(0.70)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C160(1.24); C539(0.87)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C353(0.61)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C539(0.72); C353(0.46)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C160(1.47); C539(0.84)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C160(1.61); C539(0.89); C353(1.38); C47(1.58)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C160(1.18); C539(0.84); C353(1.22); C400(1.04)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C160(4.02); C539(1.06)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C160(1.02); C539(0.52); C353(1.22); C400(0.97)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C400(0.89)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C160(0.35); C353(0.91)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C160(1.70); C539(2.69); C353(1.84)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C160(1.12); C539(0.75); C353(1.37); C400(1.05)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C160(1.09)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C160(0.62); C400(0.60)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C353(1.29)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C160(0.59); C539(0.59); C400(0.77)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C160(0.08)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C539(1.69)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C539(0.59); C31(0.07)  LDD2206  [29]
 LDCM0628  OTUB2-COV-1 HEK-293T C31(0.31)  LDD2207  [29]
 LDCM0131  RA190 MM1.R C400(2.10); C539(0.99)  LDD0304  [30]
 LDCM0090  Rapamycin JHH-7 2.41  LDD0213  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha- and gamma-adaptin-binding protein p34 (AAGAB) . Q6PD74
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit sigma-2 (AP1S2) Adaptor complexes small subunit family P56377
Ataxin-1 (ATXN1) ATXN1 family P54253
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Ubiquitin-like protein 7 (UBL7) . Q96S82

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
25 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.