Details of the Target

General Information of Target

Target ID LDTP04512
Target Name Cationic amino acid transporter 2 (SLC7A2)
Gene Name SLC7A2
Gene ID 6542
Synonyms
ATRC2; CAT2; Cationic amino acid transporter 2; CAT-2; CAT2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL
SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPM
PRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLM
AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF
CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI
VLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS
YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Target Bioclass
Transporter and channel
Family
Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
Subcellular location
Cell membrane
Function
Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing. May play a role in classical or alternative activation of macrophages via its role in arginine transport.; [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2.; [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine).
Uniprot ID
P52569
Ensemble ID
ENST00000004531.14
HGNC ID
HGNC:11060

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Insertion: p.A169CfsTer24 .
EFO27 SNV: p.G437D .
ETK1 SNV: p.L410F .
KYSE410 SNV: p.G90E .
SNU1 SNV: p.D406G .
SSP25 SNV: p.L410F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		5.06  LDD0326  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
Probe 1
 Probe Info  		Y621(9,387.91)  LDD3495  [3]
DBIA
 Probe Info  		C416(2.82)  LDD3493  [4]
BTD
 Probe Info  		C31(1.07)  LDD2104  [5]
Acrolein
 Probe Info  		H640(0.00); H641(0.00)  LDD0222  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		N.A.  LDD0147  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C264
 Probe Info  		16.91  LDD1935  [10]
Alk-rapa
 Probe Info  		2.82  LDD0213  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C376(1.17)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C376(1.07)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C376(1.05)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C376(1.08)  LDD1510  [12]
 LDCM0276  AC17 HEK-293T C376(1.02)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C376(1.00)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C376(1.04)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C376(1.05)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C376(1.04)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C376(1.02)  LDD1520  [12]
 LDCM0284  AC24 HEK-293T C376(0.98)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C376(1.11)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C376(1.07)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C376(1.11)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C376(1.00)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C376(1.09)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C376(1.07)  LDD1529  [12]
 LDCM0293  AC32 HEK-293T C376(1.01)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C376(1.24)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C376(1.05)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C376(1.01)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C376(1.11)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C376(1.09)  LDD1537  [12]
 LDCM0301  AC4 HEK-293T C376(1.12)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C376(1.06)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C376(1.09)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C376(1.12)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C376(1.06)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C376(1.14)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C376(1.11)  LDD1546  [12]
 LDCM0310  AC48 HEK-293T C376(0.99)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C376(1.03)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C376(1.12)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C376(1.05)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C376(1.03)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C376(1.10)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C376(0.99)  LDD1555  [12]
 LDCM0319  AC56 HEK-293T C376(1.07)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C376(1.01)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C376(1.12)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C376(1.07)  LDD1561  [12]
 LDCM0324  AC60 HEK-293T C376(1.15)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C376(1.13)  LDD1564  [12]
 LDCM0328  AC64 HEK-293T C376(1.02)  LDD1567  [12]
 LDCM0345  AC8 HEK-293T C376(1.05)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C376(1.04)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C376(1.02)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C376(1.08)  LDD1514  [12]
 LDCM0108  Chloroacetamide HeLa H640(0.00); H641(0.00)  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C376(1.14)  LDD1571  [12]
 LDCM0369  CL100 HEK-293T C376(1.04)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C376(1.01)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C376(1.23)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C376(1.10)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C376(1.08)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C376(1.02)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C376(1.08)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C376(0.99)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C376(0.97)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C376(1.04)  LDD1582  [12]
 LDCM0380  CL110 HEK-293T C376(1.30)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C376(0.94)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C376(1.08)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C376(1.03)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C376(1.31)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C376(1.15)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C376(1.08)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C376(1.01)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C376(1.09)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C376(1.11)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C376(1.20)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C376(1.19)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C376(1.15)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C376(1.16)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C376(1.15)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C376(1.17)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C376(0.96)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C376(1.06)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C376(1.20)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C376(1.05)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C376(1.04)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C376(0.90)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C376(1.24)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C376(1.10)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C376(1.44)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C376(1.15)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C376(1.00)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C376(1.03)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C376(1.16)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C376(1.54)  LDD1613  [12]
 LDCM0412  CL24 HEK-293T C376(1.13)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C376(1.27)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C376(0.99)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C376(1.01)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C376(1.07)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C376(1.17)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C376(1.03)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C376(1.07)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C376(1.04)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C376(1.15)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C376(1.67)  LDD1626  [12]
 LDCM0425  CL36 HEK-293T C376(1.15)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C376(1.09)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C376(1.08)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C376(1.30)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C376(1.04)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C376(1.08)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C376(1.03)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C376(1.11)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C376(1.11)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C376(1.16)  LDD1639  [12]
 LDCM0438  CL48 HEK-293T C376(1.15)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C376(1.35)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C376(1.19)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C376(1.26)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C376(1.15)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C376(1.21)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C376(1.67)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C376(1.10)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C376(1.14)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C376(1.51)  LDD1651  [12]
 LDCM0451  CL6 HEK-293T C376(1.38)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C376(1.16)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C376(1.12)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C376(1.00)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C376(1.10)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C376(1.37)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C376(1.18)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C376(1.05)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C376(1.07)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C376(1.16)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C376(1.26)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C376(0.98)  LDD1665  [12]
 LDCM0465  CL72 HEK-293T C376(1.06)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C376(1.14)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C376(1.01)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C376(1.11)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C376(1.18)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C376(1.17)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C376(1.11)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C376(3.59)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C376(1.14)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C376(1.13)  LDD1678  [12]
 LDCM0478  CL84 HEK-293T C376(1.35)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C376(1.00)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C376(1.11)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C376(1.21)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C376(1.14)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C376(1.14)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C376(1.32)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C376(1.91)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C376(1.04)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C376(1.23)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C376(1.19)  LDD1691  [12]
 LDCM0491  CL96 HEK-293T C376(1.40)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C376(1.19)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C376(1.04)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C376(0.98)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C376(1.16)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C376(1.16)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C376(0.98)  LDD1631  [12]
 LDCM0022  KB02 AU565 C416(2.68)  LDD2265  [4]
 LDCM0023  KB03 MDA-MB-231 C376(4.69)  LDD1701  [5]
 LDCM0024  KB05 ZR-75-1 C416(2.82)  LDD3493  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C31(1.07)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C31(0.31)  LDD2105  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C376(0.12)  LDD2206  [13]
 LDCM0628  OTUB2-COV-1 HEK-293T C376(0.52)  LDD2207  [13]
 LDCM0090  Rapamycin JHH-7 2.82  LDD0213  [11]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lysine Small molecular drug DB00123
Ornithine Small molecular drug DB00129

References

1 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.