Details of the Target

General Information of Target

Target ID LDTP03227
Target Name Glycine cleavage system H protein, mitochondrial (GCSH)
Gene Name GCSH
Gene ID 2653
Synonyms
Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALRVVRSVRALLCTLRAVPSPAAPCPPRPWQLGVGAVRTLRTGPALLSVRKFTEKHEWV
TTENGIGTVGISNFAQEALGDVVYCSLPEVGTKLNKQDEFGALESVKAASELYSPLSGEV
TEINEALAENPGLVNKSCYEDGWLIKMTLSNPSELDELMSEEAYEKYIKSIEE
Target Bioclass
Other
Family
GcvH family
Subcellular location
Mitochondrion
Function
The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST).
Uniprot ID
P23434
Ensemble ID
ENST00000315467.9
HGNC ID
HGNC:4208

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		3.03  LDD0323  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
Probe 1
 Probe Info  		Y164(8.30)  LDD3495  [3]
DBIA
 Probe Info  		C138(1.46)  LDD3312  [4]
BTD
 Probe Info  		C138(1.26)  LDD2125  [5]
HHS-475
 Probe Info  		Y139(1.34)  LDD0264  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C85(0.00); C138(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
HHS-465
 Probe Info  		Y139(0.00); K93(0.00); Y84(0.00)  LDD2240  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		11.42  LDD0213  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C138(0.86); C85(0.78)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C138(1.05)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C138(0.99); C85(0.97)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C138(0.89); C85(1.14)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C138(0.89); C85(0.84)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C138(0.88)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C138(0.81); C85(1.21)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C138(0.91)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C138(0.76); C85(0.89)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C138(1.09)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C138(0.84); C85(1.00)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C138(0.96); C85(0.80)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C138(0.86); C85(0.95)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C138(0.91)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C138(1.01); C85(1.01)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C138(0.99); C85(1.44)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C138(1.00)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C138(0.94); C85(1.00)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C138(0.89); C85(1.03)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C138(0.96); C85(0.94)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C138(1.00); C85(1.02)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C138(0.86); C85(0.76)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C138(0.87)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C138(0.98); C85(0.96)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C138(0.82); C85(1.39)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C138(0.99)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C138(0.92); C85(0.99)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C138(0.85); C85(1.19)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C138(1.08); C85(1.13)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C138(0.90); C85(1.20)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C138(0.93)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C138(0.95); C85(1.05)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C138(0.97); C85(0.62)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C138(0.87); C85(0.90)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C138(0.91)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C138(0.92); C85(1.12)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C138(0.89); C85(1.03)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C138(0.97); C85(0.88)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C138(0.87); C85(0.98)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C138(0.87)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C138(0.98); C85(0.77)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C138(0.88); C85(0.83)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C138(1.05); C85(0.81)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C138(1.04)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C138(0.88); C85(1.00)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C138(0.88); C85(1.05)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C138(1.05); C85(0.98)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C138(0.89); C85(0.88)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C138(0.91)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C138(0.98); C85(0.78)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C138(0.77); C85(0.93)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C138(0.85)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C138(0.93); C85(1.08)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C138(0.88); C85(0.75)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C138(0.72); C85(0.89)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C138(0.88); C85(0.68)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C138(0.76); C85(0.90)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C138(0.76)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C138(0.89); C85(0.81)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C138(1.00)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C138(1.13); C85(0.78)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C138(0.97); C85(0.97)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C138(0.87); C85(1.08)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C138(0.99); C85(0.92)  LDD1514  [12]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C138(0.92); C85(0.95)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C138(0.76); C85(0.86)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C138(0.95); C85(0.86)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C138(0.89); C85(0.98)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C138(0.88); C85(1.15)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C138(0.98); C85(1.09)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C138(1.02); C85(1.01)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C138(0.88); C85(1.04)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C138(0.96); C85(0.91)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C138(0.99); C85(0.89)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C138(0.95); C85(1.02)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C138(0.89); C85(1.16)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C138(0.98)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C138(0.94); C85(1.22)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C138(0.88); C85(0.81)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C138(0.94); C85(0.87)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C138(0.92); C85(1.34)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C138(0.91); C85(1.13)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C138(0.94); C85(0.96)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C138(0.97); C85(1.22)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C138(0.93); C85(1.14)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C138(0.97); C85(1.20)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C138(0.96); C85(1.09)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C138(1.03); C85(0.66)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C138(0.97); C85(0.78)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C138(0.93); C85(1.17)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C138(1.05); C85(1.37)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C138(0.90); C85(0.79)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C138(0.94); C85(1.21)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C138(0.86); C85(0.95)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C138(0.91); C85(1.12)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C138(0.91); C85(0.87)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C138(0.85); C85(1.05)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C138(0.95); C85(0.86)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C138(0.98); C85(1.05)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C138(0.91); C85(0.95)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C138(0.91); C85(0.91)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C138(0.77); C85(1.15)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C138(0.96)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C138(1.22); C85(1.15)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C138(1.04); C85(1.27)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C138(0.98); C85(1.18)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C138(0.81); C85(0.52)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C138(0.93); C85(0.95)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C138(1.04)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C138(1.22); C85(0.48)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C138(0.90); C85(0.93)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C138(1.12); C85(0.93)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C138(0.98); C85(0.91)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C138(0.99); C85(1.10)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C138(0.94); C85(1.15)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C138(1.00); C85(1.18)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C138(1.00)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C138(1.00); C85(0.91)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C138(0.95); C85(1.00)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C138(0.86); C85(0.65)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C138(0.90); C85(0.69)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C138(0.92)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C138(1.05); C85(0.50)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C138(0.88); C85(0.95)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C138(1.01); C85(0.90)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C138(1.10); C85(1.19)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C138(0.99); C85(1.07)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C138(0.71); C85(0.98)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C138(1.02)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C138(1.09); C85(0.94)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C138(0.90); C85(1.14)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C138(0.93); C85(0.83)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C138(0.90); C85(0.83)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C138(0.90)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C138(1.05); C85(0.62)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C138(0.93); C85(0.98)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C138(1.04); C85(0.82)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C138(0.94); C85(1.31)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C138(1.01); C85(1.06)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C138(0.81); C85(0.68)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C138(0.98)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C138(1.03); C85(0.93)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C138(0.86); C85(0.75)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C138(0.85); C85(0.58)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C138(0.88); C85(0.74)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C138(0.89)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C138(0.92)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C138(1.13); C85(0.64)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C138(0.98); C85(0.92)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C138(1.01); C85(1.08)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C138(0.99); C85(0.96)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C138(0.94); C85(1.18)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C138(0.94); C85(1.61)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C138(0.92)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C138(1.03); C85(0.90)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C138(0.86); C85(0.84)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C138(0.98); C85(0.62)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C138(1.12); C85(0.97)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C138(0.90); C85(0.89)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C138(0.91)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C138(1.07); C85(0.76)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C138(0.90); C85(0.93)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C138(1.02); C85(0.97)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C138(0.99); C85(1.34)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C138(0.73); C85(1.06)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C138(0.95)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C138(1.08); C85(1.07)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C138(0.54); C85(0.80)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C138(1.04); C85(1.24)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C138(1.09); C85(0.87)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C138(0.96); C85(0.77)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C138(0.98)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C138(1.00); C85(0.66)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C138(0.92); C85(1.23)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C138(1.03); C85(1.34)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C138(0.91); C85(0.85)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C138(0.94); C85(1.19)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C138(0.82); C85(1.01)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C138(1.16); C85(0.64)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C138(0.69)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C138(1.10); C85(1.11)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C138(0.85); C85(1.14)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C138(0.92); C85(0.78)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C138(0.84); C85(0.88)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C138(0.73)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C138(0.90); C85(0.74)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C138(0.92); C85(0.86)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C138(1.02); C85(1.18)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C138(0.90); C85(1.01)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C138(0.94); C85(0.87)  LDD1698  [12]
 LDCM0625  F8 Ramos C138(0.65)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C138(0.60)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C138(0.43)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C138(0.57)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C138(0.96)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C138(1.28)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C138(0.57)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C138(0.92)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C138(1.40)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C138(1.42)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C138(0.87)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C138(1.32)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C138(1.58)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C138(0.53)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C138(0.93); C85(0.95)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C138(0.86)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C138(0.53)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C138(1.09); C85(1.28)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C138(1.16)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C138(1.49)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C138(0.53)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C138(0.48)  LDD2188  [13]
 LDCM0116  HHS-0101 DM93 Y139(1.34)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y139(1.22)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y139(0.98)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y139(1.27)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y139(1.49)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C138(0.95); C85(1.10)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C138(0.93); C85(1.02)  LDD1497  [12]
 LDCM0024  KB05 HMCB C138(1.46)  LDD3312  [4]
 LDCM0109  NEM HeLa N.A.  LDD0224  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C138(1.26)  LDD2125  [5]
 LDCM0131  RA190 MM1.R C138(1.04)  LDD0304  [14]
 LDCM0090  Rapamycin JHH-7 11.42  LDD0213  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Mediator of RNA polymerase II transcription subunit 11 (MED11) Mediator complex subunit 11 family Q9P086
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
N-myc-interactor (NMI) NMI family Q13287
Melanoma-associated antigen 11 (MAGEA11) . P43364
Melanoma-associated antigen 6 (MAGEA6) . P43360

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glycine Small molecular drug DB00145
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid . DB03187
Dihydrolipoic Acid . DB03760

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.