Details of the Target

General Information of Target

Target ID LDTP04619
Target Name 5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1)
Gene Name PRKAG1
Gene ID 5571
Synonyms
5'-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK subunit gamma-1; AMPKg
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKA
FFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREV
YLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFI
TEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDI
YSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL
VVVDENDVVKGIVSLSDILQALVLTGGEKKP
Target Bioclass
Enzyme
Family
5'-AMP-activated protein kinase gamma subunit family
Function
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Uniprot ID
P54619
Ensemble ID
ENST00000316299.9
HGNC ID
HGNC:9385
ChEMBL ID
CHEMBL2393

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HDMYZ SNV: p.E115G DBIA    Probe Info 
MELJUSO SNV: p.P22L DBIA    Probe Info 
WM2664 Insertion: p.P43SfsTer10 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.91  LDD0402  [1]
STPyne
 Probe Info  		K170(9.09)  LDD0277  [2]
DBIA
 Probe Info  		C6(4.01)  LDD3310  [3]
HPAP
 Probe Info  		3.70  LDD0062  [4]
HHS-465
 Probe Info  		Y255(9.25)  LDD2237  [5]
ATP probe
 Probe Info  		K170(0.00); K243(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C38(0.00); C279(0.00); C131(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C38(0.00); C279(0.00); C131(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C279(0.00); C131(0.00); C38(0.00)  LDD0037  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		C38(0.00); C279(0.00)  LDD2156  [9]
AOyne
 Probe Info  		13.50  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		16.98  LDD0471  [12]
STS-2
 Probe Info  		N.A.  LDD0138  [13]
Alk-rapa
 Probe Info  		2.63  LDD0213  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C38(0.76); C279(0.97); C131(0.84)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C38(1.02); C279(1.10); C131(1.09)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C38(1.02); C279(1.20); C131(0.94)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C38(1.02); C279(1.06)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C38(1.09); C279(1.01)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C38(0.92); C279(1.05)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C38(0.78); C279(0.85); C131(0.90)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C38(0.99); C279(0.98); C131(1.04)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C38(0.96); C279(1.00); C131(0.92)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C38(0.89); C279(1.01); C131(1.02)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C38(1.03); C279(1.07)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C38(1.06); C279(1.05)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C38(1.11); C279(0.91)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C38(0.89); C279(1.06)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C38(0.94); C279(1.04)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C38(0.97); C279(0.96); C131(0.85)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C38(1.05); C279(1.20); C131(1.02)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C38(1.06); C279(1.00); C131(1.02)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C38(1.03); C279(0.98)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C38(1.27); C279(0.99)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C38(1.05); C279(0.98); C131(0.95)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C38(1.06); C279(0.92)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C38(0.98); C279(1.07)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C38(1.01); C279(1.04)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C38(0.95); C279(0.99); C131(0.79)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C38(1.01); C279(1.13); C131(1.05)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C38(1.08); C279(1.04); C131(1.03)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C38(1.02); C279(1.19)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C38(0.99); C279(1.14)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C38(1.05); C279(0.97)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C38(1.11); C279(1.08)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C38(1.02); C279(1.09)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C38(0.96); C279(0.97)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C38(0.86); C279(0.95); C131(1.00)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C38(1.03); C279(1.10); C131(0.99)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C38(0.99); C279(0.98); C131(1.03)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C38(1.06); C279(1.17)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C38(1.19); C279(1.10)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C38(1.13); C279(0.98)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C38(0.93); C279(1.04)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C38(1.11); C279(1.18)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C38(0.92); C279(0.95); C131(0.95)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C38(0.99); C279(1.00)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C38(0.98); C279(1.08); C131(1.04)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C38(0.93); C279(1.02); C131(0.99)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C38(1.03); C279(1.01)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C38(0.92); C279(1.05)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C38(1.18); C279(1.03)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C38(0.93); C279(0.98)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C38(1.04); C279(1.16)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C38(0.71); C279(1.01); C131(0.87)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C38(0.98); C279(1.14); C131(1.03)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C38(1.04); C279(1.05); C131(1.12)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C38(1.10); C279(1.03)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C38(1.02); C279(1.12)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C38(0.90); C279(1.04)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C38(1.13); C279(1.03)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C38(0.91); C279(1.13)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C38(1.04); C279(1.05)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C38(0.93); C279(1.01)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C38(1.01); C279(1.01)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C38(1.03); C279(1.09)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C38(0.82); C279(0.95); C131(0.90)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C38(1.04); C279(1.12)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 14.70  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C38(0.95); C279(1.08)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C38(1.21); C279(1.32)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C279(0.99); C131(0.92)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C38(1.03); C279(1.04)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C38(1.03); C131(0.70)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C38(0.98); C279(1.12)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C279(0.91); C131(0.96)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C38(1.00); C279(0.96)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C38(1.11); C131(0.76)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C38(1.03); C279(1.05)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C279(1.05); C131(0.97)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C38(0.95); C279(0.87)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C38(1.14); C279(1.08)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C38(0.96); C131(0.85)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C38(1.08); C279(1.09)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C279(1.11); C131(0.90)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C38(0.99); C279(1.11)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C38(1.03); C131(0.75)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C38(1.18); C279(1.14)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C279(1.08); C131(0.98)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C38(1.13); C279(1.00)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C38(1.06); C131(0.87)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C38(0.99); C279(1.08)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C38(1.12); C279(1.35)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C279(1.01); C131(0.93)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C38(1.06); C279(0.93)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C38(1.07); C131(0.96)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C38(1.25); C279(1.25)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C279(0.94); C131(0.97)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C38(1.04); C279(1.01)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C38(0.96); C131(0.80)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C38(1.00); C279(1.09)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C279(1.06); C131(1.04)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C38(0.93); C279(1.04)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C38(1.03); C131(1.02)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C38(1.23); C279(1.12)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C279(1.06); C131(1.09)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C38(0.84); C279(0.97); C131(1.07)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C38(1.03); C279(1.32); C131(1.37)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C38(1.07); C279(0.90); C131(1.39)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C38(0.99); C131(1.03)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C38(1.21); C279(1.23)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C38(1.00); C279(1.27)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C38(1.18); C279(1.23)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C38(0.94); C279(1.14)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C38(1.09); C279(1.52)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C38(1.14); C279(0.93)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C38(0.96); C131(0.93)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C38(1.16); C279(1.23)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C279(0.99); C131(0.84)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C38(0.82); C279(0.94); C131(1.00)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C38(1.10); C279(1.10)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C38(1.02); C279(1.09); C131(1.23)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C38(1.09); C279(0.91); C131(1.34)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C38(1.16); C279(1.26)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C38(1.18); C279(1.24)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C38(1.22); C279(1.15)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C38(1.03); C279(0.97)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C38(1.08); C279(1.46)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C38(0.90); C279(1.01)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C38(1.09); C279(1.05)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C279(0.97); C131(1.01)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C279(0.93); C131(1.00)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C38(0.85); C279(0.80); C131(1.08)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C38(0.99); C279(0.98); C131(1.20)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C38(1.09); C279(1.04); C131(1.38)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C38(1.08); C279(1.05)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C38(0.99); C279(1.08)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C38(1.27); C279(1.37)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C38(1.05); C279(1.08)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C38(1.06); C279(1.50)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C38(0.95); C279(1.15)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C38(0.82); C279(0.85); C131(1.03)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C38(0.87); C131(0.83)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C279(1.08); C131(1.09)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C38(0.87); C279(0.97); C131(0.87)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C38(1.13); C279(1.15); C131(1.08)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C38(1.10); C279(0.95); C131(1.08)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C38(1.22); C279(1.30)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C38(1.04); C279(1.23)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C38(1.30); C279(1.34)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C38(1.26); C279(1.04)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C38(1.01); C279(1.14); C131(1.07)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C38(1.11); C279(1.54)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C38(1.04); C279(1.05)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C38(1.01); C131(0.68)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C38(0.96); C279(1.34)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C279(1.01); C131(0.89)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C38(0.88); C279(1.00); C131(0.95)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C38(1.04); C279(1.02); C131(1.18)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C38(1.17); C279(1.05); C131(1.33)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C38(1.17); C279(1.35)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C38(1.18); C279(1.14)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C38(0.95); C279(0.95); C131(1.11)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C38(1.14); C279(1.35)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C38(1.01); C279(1.12)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C38(1.21); C279(1.44)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C38(1.03); C279(1.01)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C38(1.02); C131(0.80)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C279(1.01); C131(0.94)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C38(1.07); C279(0.96); C131(1.05)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C38(1.08); C279(1.26); C131(1.11)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C38(1.13); C279(0.95); C131(1.31)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C38(1.05); C279(2.64)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C38(1.14); C279(1.01)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C38(1.25); C279(1.12)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C38(1.30); C279(1.12)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C38(1.08); C279(1.20)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C38(1.05); C279(1.42)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C38(1.02); C279(1.03)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C38(1.03); C131(0.94)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C38(1.34); C279(0.98)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C279(0.94); C131(1.01)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C38(0.96); C279(0.93); C131(0.94)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C38(1.06); C279(1.26)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C38(0.97); C279(1.17); C131(1.04)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C38(1.13); C279(0.95); C131(1.04)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C38(1.06); C279(1.22)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C38(1.21); C279(1.09)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C38(1.13); C279(1.22)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C38(1.14); C279(1.18)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C38(1.05); C279(1.27)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C38(1.08); C279(0.92)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C38(0.97); C131(0.70)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C38(1.27); C279(1.02)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C38(1.16); C279(1.11)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C38(0.90); C279(1.17)  LDD1671  [15]
 LDCM0427  Fragment51 HEK-293T C38(1.05); C131(1.03)  LDD1631  [15]
 LDCM0022  KB02 HEK-293T C38(0.94); C131(1.26)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C38(0.96); C131(1.06)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C6(4.01)  LDD3310  [3]
 LDCM0014  Panhematin HEK-293T 3.70  LDD0062  [4]
 LDCM0090  Rapamycin JHH-7 2.63  LDD0213  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) 5'-AMP-activated protein kinase beta subunit family Q9Y478
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
Caspase-6 (CASP6) Peptidase C14A family P55212
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Homeobox protein MOX-1 (MEOX1) . P50221
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 10-11 (KRTAP10-11) KRTAP type 10 family P60412
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Tektin-1 (TEKT1) Tektin family Q969V4
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetylsalicylic Acid Small molecular drug DB00945
Adenosine Phosphate Small molecular drug DB00131
Fostamatinib Small molecular drug DB12010
Topiramate Small molecular drug DB00273

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402