Details of the Target

General Information of Target

Target ID LDTP05625
Target Name AP-1 complex subunit beta-1 (AP1B1)
Gene Name AP1B1
Gene ID 162
Synonyms
ADTB1; BAM22; CLAPB2; AP-1 complex subunit beta-1; Adaptor protein complex AP-1 subunit beta-1; Adaptor-related protein complex 1 subunit beta-1; Beta-1-adaptin; Beta-adaptin 1; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT
DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE
YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA
VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI
CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY
VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK
YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV
VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS
ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG
GGLDSLMGDEPEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPK
AVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQ
VHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGK
MDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSL
KLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN
Target Bioclass
Transporter and channel
Family
Adaptor complexes large subunit family
Subcellular location
Golgi apparatus
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Uniprot ID
Q10567
Ensemble ID
ENST00000317368.11
HGNC ID
HGNC:554
ChEMBL ID
CHEMBL4630824

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.N857S DBIA    Probe Info 
HCT15 SNV: p.C144Y DBIA    Probe Info 
HEC1 SNV: p.S826G DBIA    Probe Info 
HEC1B SNV: p.S826G .
HT1080 SNV: p.D657Y DBIA    Probe Info 
JURKAT Deletion: p.G585AfsTer57
SNV: p.D150N		 Compound 10    Probe Info 
LNCaP clone FGC SNV: p.A356S; p.E357Ter DBIA    Probe Info 
MOLT4 SNV: p.A859S IA-alkyne    Probe Info 
NCIH1155 SNV: p.Q860Ter DBIA    Probe Info 
PC3 SNV: p.P796T .
PF382 SNV: p.N769S DBIA    Probe Info 
RL952 SNV: p.Y300H DBIA    Probe Info 
TOV21G SNV: p.R520L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.45  LDD0402  [1]
TH211
 Probe Info  		Y121(13.23); Y136(7.85)  LDD0257  [2]
TH214
 Probe Info  		Y121(17.16)  LDD0258  [2]
TH216
 Probe Info  		Y121(8.60)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K318(10.00); K728(4.78); K730(9.09); K887(7.97)  LDD0277  [4]
Probe 1
 Probe Info  		Y6(15.90)  LDD3495  [5]
BTD
 Probe Info  		C112(3.96); C144(2.84); C241(1.98); C866(0.93)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C123(10.39)  LDD0168  [7]
HHS-475
 Probe Info  		Y136(1.11); Y121(1.26)  LDD0264  [8]
HHS-465
 Probe Info  		Y121(7.66); Y136(10.00)  LDD2237  [9]
Acrolein
 Probe Info  		N.A.  LDD0221  [10]
DBIA
 Probe Info  		C144(1.15); C95(1.26); C241(2.32); C123(1.39)  LDD0080  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C866(0.00); C57(0.00); C921(0.00); C433(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C144(0.00); C129(0.00); C380(0.00); C123(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		C123(0.00); C57(0.00); C241(0.00); C95(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C930(0.00); C866(0.00); C57(0.00); C921(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		C866(0.00); C380(0.00)  LDD0026  [17]
TFBX
 Probe Info  		C380(0.00); C391(0.00); C129(0.00); C144(0.00)  LDD0027  [17]
Compound 10
 Probe Info  		C144(0.00); C866(0.00)  LDD2216  [18]
ENE
 Probe Info  		C95(0.00); C241(0.00); C866(0.00); C112(0.00)  LDD0006  [19]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NHS
 Probe Info  		K282(0.00); K887(0.00); K5(0.00)  LDD0010  [19]
SF
 Probe Info  		N.A.  LDD0028  [20]
VSF
 Probe Info  		C241(0.00); C391(0.00); C95(0.00); C123(0.00)  LDD0007  [19]
1c-yne
 Probe Info  		K876(0.00); K283(0.00)  LDD0228  [21]
W1
 Probe Info  		C866(0.00); C921(0.00)  LDD0236  [22]
AOyne
 Probe Info  		5.70  LDD0443  [23]
NAIA_5
 Probe Info  		C930(0.00); C866(0.00); C57(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C266
 Probe Info  		7.73  LDD1937  [25]
C270
 Probe Info  		6.54  LDD1940  [25]
FFF probe13
 Probe Info  		13.13  LDD0475  [26]
FFF probe2
 Probe Info  		5.61  LDD0463  [26]
FFF probe3
 Probe Info  		12.24  LDD0464  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
Alk-rapa
 Probe Info  		4.14  LDD0213  [28]
DA-2
 Probe Info  		N.A.  LDD0071  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C866(0.77)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C866(0.74)  LDD2130  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C123(1.59); C241(1.19)  LDD2103  [6]
 LDCM0025  4SU-RNA HEK-293T C123(10.39)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C123(10.60); C112(3.13)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C866(1.19)  LDD0531  [11]
 LDCM0215  AC10 HEK-293T C866(1.32)  LDD0813  [11]
 LDCM0216  AC100 HEK-293T C866(0.77)  LDD0814  [11]
 LDCM0217  AC101 HEK-293T C866(0.80)  LDD0815  [11]
 LDCM0218  AC102 HEK-293T C866(0.66)  LDD0816  [11]
 LDCM0219  AC103 HEK-293T C866(1.13)  LDD0817  [11]
 LDCM0220  AC104 HEK-293T C866(0.87)  LDD0818  [11]
 LDCM0221  AC105 HEK-293T C866(0.69)  LDD0819  [11]
 LDCM0222  AC106 HEK-293T C866(0.93)  LDD0820  [11]
 LDCM0223  AC107 HEK-293T C866(0.92)  LDD0821  [11]
 LDCM0224  AC108 HEK-293T C866(0.79)  LDD0822  [11]
 LDCM0225  AC109 HEK-293T C866(0.74)  LDD0823  [11]
 LDCM0226  AC11 HEK-293T C866(1.17)  LDD0824  [11]
 LDCM0227  AC110 HEK-293T C866(0.75)  LDD0825  [11]
 LDCM0228  AC111 HEK-293T C866(1.01)  LDD0826  [11]
 LDCM0229  AC112 HEK-293T C866(0.80)  LDD0827  [11]
 LDCM0230  AC113 HEK-293T C866(1.13)  LDD0828  [11]
 LDCM0231  AC114 HEK-293T C866(0.87)  LDD0829  [11]
 LDCM0232  AC115 HEK-293T C866(1.03)  LDD0830  [11]
 LDCM0233  AC116 HEK-293T C866(0.91)  LDD0831  [11]
 LDCM0234  AC117 HEK-293T C866(0.94)  LDD0832  [11]
 LDCM0235  AC118 HEK-293T C866(0.91)  LDD0833  [11]
 LDCM0236  AC119 HEK-293T C866(1.04)  LDD0834  [11]
 LDCM0237  AC12 HEK-293T C866(1.06)  LDD0835  [11]
 LDCM0238  AC120 HEK-293T C866(0.88)  LDD0836  [11]
 LDCM0239  AC121 HEK-293T C866(0.96)  LDD0837  [11]
 LDCM0240  AC122 HEK-293T C866(1.09)  LDD0838  [11]
 LDCM0241  AC123 HEK-293T C866(0.97)  LDD0839  [11]
 LDCM0242  AC124 HEK-293T C866(0.95)  LDD0840  [11]
 LDCM0243  AC125 HEK-293T C866(1.14)  LDD0841  [11]
 LDCM0244  AC126 HEK-293T C866(1.10)  LDD0842  [11]
 LDCM0245  AC127 HEK-293T C866(1.12)  LDD0843  [11]
 LDCM0246  AC128 HEK-293T C866(0.83)  LDD0844  [11]
 LDCM0247  AC129 HEK-293T C866(0.86)  LDD0845  [11]
 LDCM0249  AC130 HEK-293T C866(0.81)  LDD0847  [11]
 LDCM0250  AC131 HEK-293T C866(0.85)  LDD0848  [11]
 LDCM0251  AC132 HEK-293T C866(0.77)  LDD0849  [11]
 LDCM0252  AC133 HEK-293T C866(0.89)  LDD0850  [11]
 LDCM0253  AC134 HEK-293T C866(0.89)  LDD0851  [11]
 LDCM0254  AC135 HEK-293T C866(0.80)  LDD0852  [11]
 LDCM0255  AC136 HEK-293T C866(1.12)  LDD0853  [11]
 LDCM0256  AC137 HEK-293T C866(0.90)  LDD0854  [11]
 LDCM0257  AC138 HEK-293T C866(0.91)  LDD0855  [11]
 LDCM0258  AC139 HEK-293T C866(0.86)  LDD0856  [11]
 LDCM0259  AC14 HEK-293T C866(1.10)  LDD0857  [11]
 LDCM0260  AC140 HEK-293T C866(0.91)  LDD0858  [11]
 LDCM0261  AC141 HEK-293T C866(0.93)  LDD0859  [11]
 LDCM0262  AC142 HEK-293T C866(0.91)  LDD0860  [11]
 LDCM0263  AC143 HEK-293T C866(1.13)  LDD0861  [11]
 LDCM0264  AC144 HEK-293T C866(1.54)  LDD0862  [11]
 LDCM0265  AC145 HEK-293T C866(1.33)  LDD0863  [11]
 LDCM0266  AC146 HEK-293T C866(0.97)  LDD0864  [11]
 LDCM0267  AC147 HEK-293T C866(1.82)  LDD0865  [11]
 LDCM0268  AC148 HEK-293T C866(1.51)  LDD0866  [11]
 LDCM0269  AC149 HEK-293T C866(1.58)  LDD0867  [11]
 LDCM0270  AC15 HEK-293T C866(1.19)  LDD0868  [11]
 LDCM0271  AC150 HEK-293T C866(1.38)  LDD0869  [11]
 LDCM0272  AC151 HEK-293T C866(1.03)  LDD0870  [11]
 LDCM0273  AC152 HEK-293T C866(1.27)  LDD0871  [11]
 LDCM0274  AC153 HEK-293T C866(1.13)  LDD0872  [11]
 LDCM0621  AC154 HEK-293T C866(1.23)  LDD2162  [11]
 LDCM0622  AC155 HEK-293T C866(1.10)  LDD2163  [11]
 LDCM0623  AC156 HEK-293T C866(2.15)  LDD2164  [11]
 LDCM0624  AC157 HEK-293T C866(1.36)  LDD2165  [11]
 LDCM0276  AC17 HEK-293T C866(0.95); C144(0.94); C95(0.88); C123(0.97)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C866(0.86); C144(1.01); C95(1.02); C123(0.83)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C866(0.82); C95(1.09); C123(1.11); C921(0.95)  LDD1517  [30]
 LDCM0279  AC2 HCT 116 C866(0.87)  LDD0596  [11]
 LDCM0280  AC20 HEK-293T C866(1.01); C144(1.01); C95(0.89); C123(0.89)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C866(1.04); C144(0.97); C95(1.00); C123(0.98)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C866(0.98); C95(1.00); C123(0.94); C921(1.10)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C866(0.96); C95(0.97); C123(0.90); C921(1.00)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C866(0.98); C144(1.02); C95(0.98); C123(0.98)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C866(0.85)  LDD0883  [11]
 LDCM0286  AC26 HEK-293T C866(0.80)  LDD0884  [11]
 LDCM0287  AC27 HEK-293T C866(1.09)  LDD0885  [11]
 LDCM0288  AC28 HEK-293T C866(0.96)  LDD0886  [11]
 LDCM0289  AC29 HEK-293T C866(1.07)  LDD0887  [11]
 LDCM0290  AC3 HCT 116 C866(1.28)  LDD0607  [11]
 LDCM0291  AC30 HEK-293T C866(1.02)  LDD0889  [11]
 LDCM0292  AC31 HEK-293T C866(1.20)  LDD0890  [11]
 LDCM0293  AC32 HEK-293T C866(1.06)  LDD0891  [11]
 LDCM0294  AC33 HEK-293T C866(1.06)  LDD0892  [11]
 LDCM0295  AC34 HEK-293T C866(0.83)  LDD0893  [11]
 LDCM0296  AC35 HEK-293T C866(0.92); C95(0.93); C123(0.89); C921(0.96)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C866(1.01); C144(0.88); C95(0.90); C123(0.85)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C866(1.09); C144(0.98); C95(1.02); C123(0.85)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C866(1.01); C95(0.97); C123(0.88); C921(0.94)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C866(0.91); C95(1.05); C123(0.93); C921(1.09)  LDD1539  [30]
 LDCM0301  AC4 HCT 116 C866(1.20)  LDD0618  [11]
 LDCM0302  AC40 HEK-293T C866(1.00); C144(0.97); C95(1.09); C123(1.00)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C866(0.97); C144(0.95); C95(0.97); C123(0.82)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C866(0.87); C144(0.96); C95(1.00); C123(0.90)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C866(0.91); C95(0.97); C123(0.90); C921(0.94)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C866(0.93); C144(0.97); C95(0.96); C123(0.89)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C866(1.03); C144(1.00); C95(1.00); C123(0.95)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C866(0.99); C95(0.95); C123(0.90); C921(1.00)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C866(0.98); C95(1.04); C123(0.86); C921(1.03)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C866(0.97); C144(0.99); C95(1.04); C123(1.00)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C866(0.93); C144(0.91); C95(0.92); C123(0.89)  LDD1550  [30]
 LDCM0312  AC5 HCT 116 C866(1.19)  LDD0629  [11]
 LDCM0313  AC50 HEK-293T C866(0.92); C144(0.99); C95(0.97); C123(0.89)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C866(0.93); C95(0.91); C123(0.97); C921(1.05)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C866(0.94); C144(0.95); C95(0.98); C123(0.90)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C866(1.05); C144(1.02); C95(1.01); C123(0.95)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C866(1.04); C95(1.03); C123(0.90); C921(1.08)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C866(0.94); C95(0.99); C123(0.86); C921(0.89)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C866(1.00); C144(0.98); C95(1.04); C123(0.96)  LDD1558  [30]
 LDCM0320  AC57 HCT 116 C866(0.84)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C866(0.98)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C866(0.78)  LDD0639  [11]
 LDCM0323  AC6 HEK-293T C866(1.07)  LDD0921  [11]
 LDCM0324  AC60 HCT 116 C866(0.68)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C866(0.71)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C866(0.69)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C866(0.64)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C866(0.64)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C866(0.74)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C866(0.94)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C866(0.53)  LDD0648  [11]
 LDCM0332  AC68 HEK-293T C866(1.19)  LDD0930  [11]
 LDCM0333  AC69 HEK-293T C866(2.00)  LDD0931  [11]
 LDCM0334  AC7 HEK-293T C866(1.11)  LDD0932  [11]
 LDCM0335  AC70 HEK-293T C866(1.28)  LDD0933  [11]
 LDCM0336  AC71 HEK-293T C866(1.06)  LDD0934  [11]
 LDCM0337  AC72 HEK-293T C866(1.11)  LDD0935  [11]
 LDCM0338  AC73 HEK-293T C866(1.36)  LDD0936  [11]
 LDCM0339  AC74 HEK-293T C866(1.88)  LDD0937  [11]
 LDCM0340  AC75 HEK-293T C866(1.13)  LDD0938  [11]
 LDCM0341  AC76 HEK-293T C866(1.54)  LDD0939  [11]
 LDCM0342  AC77 HEK-293T C866(0.88)  LDD0940  [11]
 LDCM0343  AC78 HEK-293T C866(1.30)  LDD0941  [11]
 LDCM0344  AC79 HEK-293T C866(1.60)  LDD0942  [11]
 LDCM0345  AC8 HEK-293T C866(1.09)  LDD0943  [11]
 LDCM0346  AC80 HEK-293T C866(1.11)  LDD0944  [11]
 LDCM0347  AC81 HEK-293T C866(1.14)  LDD0945  [11]
 LDCM0348  AC82 HEK-293T C866(1.01)  LDD0946  [11]
 LDCM0349  AC83 HCT 116 C866(1.07)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C866(0.99)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C866(0.75)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C866(0.92)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C866(1.13)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C866(1.01)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C866(0.99)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C866(1.08)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C866(0.88)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C866(0.92)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C866(0.99)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C866(1.08)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C866(1.15)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C866(1.08)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C866(1.12)  LDD0681  [11]
 LDCM0365  AC98 HEK-293T C866(0.80)  LDD0963  [11]
 LDCM0366  AC99 HEK-293T C866(0.66)  LDD0964  [11]
 LDCM0545  Acetamide MDA-MB-231 C866(0.38); C144(0.56)  LDD2138  [6]
 LDCM0248  AKOS034007472 HEK-293T C866(1.11)  LDD0846  [11]
 LDCM0356  AKOS034007680 HEK-293T C866(1.16)  LDD0954  [11]
 LDCM0275  AKOS034007705 HEK-293T C866(1.15)  LDD0873  [11]
 LDCM0498  BS-3668 MDA-MB-231 C866(0.55)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C57(0.00); H149(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C391(20.00); C57(2.86); C380(2.50); C57(1.65)  LDD2227  [24]
 LDCM0367  CL1 HEK-293T C866(1.47)  LDD0965  [11]
 LDCM0368  CL10 HEK-293T C866(1.40)  LDD0966  [11]
 LDCM0369  CL100 HCT 116 C866(0.89)  LDD0686  [11]
 LDCM0370  CL101 HEK-293T C866(1.05)  LDD0968  [11]
 LDCM0371  CL102 HEK-293T C866(1.00)  LDD0969  [11]
 LDCM0372  CL103 HEK-293T C866(1.02)  LDD0970  [11]
 LDCM0373  CL104 HEK-293T C866(1.54)  LDD0971  [11]
 LDCM0374  CL105 HEK-293T C866(0.96); C144(0.98); C95(1.00); C123(1.08)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C866(0.97); C95(0.93); C123(1.03); C921(0.98)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C866(0.99); C144(0.95); C95(0.94); C123(0.87)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C866(0.91); C144(0.91); C95(0.99); C123(0.96)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C866(0.92); C144(0.96); C95(1.00); C123(1.17)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C866(1.41)  LDD0977  [11]
 LDCM0380  CL110 HEK-293T C866(1.02); C95(0.93); C123(1.14); C921(0.90)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C866(1.02); C144(1.02); C95(1.00); C123(0.96)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C866(0.98)  LDD0980  [11]
 LDCM0383  CL113 HEK-293T C866(1.08)  LDD0981  [11]
 LDCM0384  CL114 HEK-293T C866(1.01)  LDD0982  [11]
 LDCM0385  CL115 HEK-293T C866(0.93)  LDD0983  [11]
 LDCM0386  CL116 HEK-293T C866(0.96)  LDD0984  [11]
 LDCM0387  CL117 HEK-293T C866(0.95); C144(0.92); C95(0.99); C123(1.01)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C866(0.90); C95(0.92); C123(0.90); C921(0.95)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C866(0.98); C144(1.23); C95(0.98); C123(0.81)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C866(1.50)  LDD0988  [11]
 LDCM0391  CL120 HEK-293T C866(0.94); C144(0.91); C95(0.92); C123(0.91)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C866(1.04); C144(0.93); C95(0.98); C123(0.99)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C866(0.96); C95(0.97); C123(0.95); C921(0.94)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C866(1.03); C144(1.05); C95(1.06); C123(1.02)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C866(0.90); C144(0.91); C95(0.98); C123(1.12)  LDD1599  [30]
 LDCM0396  CL125 HCT 116 C866(0.71)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C866(0.92)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C866(0.79)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C866(0.78)  LDD0716  [11]
 LDCM0400  CL13 HEK-293T C866(1.18)  LDD0998  [11]
 LDCM0401  CL14 HEK-293T C866(1.13)  LDD0999  [11]
 LDCM0402  CL15 HEK-293T C866(1.01)  LDD1000  [11]
 LDCM0403  CL16 HCT 116 C866(0.70)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C866(1.08)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C866(0.95)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C866(1.03)  LDD0723  [11]
 LDCM0407  CL2 HEK-293T C866(1.41)  LDD1005  [11]
 LDCM0408  CL20 HCT 116 C866(0.83)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C866(0.90)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C866(1.02)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C866(0.99)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C866(0.85)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C866(0.96)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C866(0.81)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C866(0.99)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C866(0.76)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C866(0.94)  LDD0734  [11]
 LDCM0418  CL3 HEK-293T C866(0.96)  LDD1016  [11]
 LDCM0419  CL30 HCT 116 C866(0.88)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C866(0.93)  LDD0737  [11]
 LDCM0421  CL32 HEK-293T C866(0.50)  LDD1019  [11]
 LDCM0422  CL33 HEK-293T C866(1.14)  LDD1020  [11]
 LDCM0423  CL34 HEK-293T C866(1.09)  LDD1021  [11]
 LDCM0424  CL35 HEK-293T C866(0.51)  LDD1022  [11]
 LDCM0425  CL36 HEK-293T C866(0.43)  LDD1023  [11]
 LDCM0426  CL37 HEK-293T C866(0.57)  LDD1024  [11]
 LDCM0428  CL39 HEK-293T C866(0.50)  LDD1026  [11]
 LDCM0429  CL4 HEK-293T C866(1.81)  LDD1027  [11]
 LDCM0430  CL40 HEK-293T C866(0.60)  LDD1028  [11]
 LDCM0431  CL41 HEK-293T C866(0.45)  LDD1029  [11]
 LDCM0432  CL42 HEK-293T C866(0.68)  LDD1030  [11]
 LDCM0433  CL43 HEK-293T C866(0.84)  LDD1031  [11]
 LDCM0434  CL44 HEK-293T C866(0.51)  LDD1032  [11]
 LDCM0435  CL45 HEK-293T C866(0.48)  LDD1033  [11]
 LDCM0436  CL46 HCT 116 C866(0.93)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C866(0.88)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C866(0.83)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C866(1.20)  LDD0756  [11]
 LDCM0440  CL5 HEK-293T C866(1.68)  LDD1038  [11]
 LDCM0441  CL50 HCT 116 C866(0.92)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C866(0.92)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C866(0.80)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C866(0.66)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C866(0.87)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C866(0.83)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C866(0.67)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C866(0.93)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C866(0.79)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C866(0.86)  LDD0767  [11]
 LDCM0451  CL6 HEK-293T C866(1.20)  LDD1049  [11]
 LDCM0452  CL60 HCT 116 C866(0.90)  LDD0769  [11]
 LDCM0453  CL61 HEK-293T C866(0.89); C144(0.97); C95(1.06); C123(1.10)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C866(1.02); C95(0.93); C123(0.63); C921(0.94)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C866(1.02); C144(1.14); C95(1.07); C123(0.77)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C866(0.98); C144(0.88); C95(1.02); C123(0.99)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C866(0.97); C144(0.93); C95(1.00); C123(0.80)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C866(0.99); C144(0.91); C95(1.06); C123(0.99)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C866(0.94); C95(1.03); C123(0.81); C921(1.17)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C866(1.06); C144(0.92); C95(1.02); C123(0.87)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C866(1.14); C144(0.95); C95(1.06); C123(1.02)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C866(1.43)  LDD1060  [11]
 LDCM0463  CL70 HEK-293T C866(1.11); C95(1.06); C123(0.85); C921(1.07)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C866(1.13); C95(1.19); C123(1.21); C921(0.98)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C866(1.01); C144(0.97); C95(1.11); C123(0.89)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C866(1.00); C144(0.93); C95(1.05); C123(1.12)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C866(1.09); C95(0.88); C123(0.90); C921(0.99)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C866(0.93); C144(0.89); C95(0.97); C123(0.93)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C866(1.06); C144(0.84); C95(1.02); C123(1.07)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C866(0.92); C144(0.95); C95(1.05); C123(1.10)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C866(1.02); C95(0.99); C123(0.86); C921(1.06)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C866(0.80)  LDD1071  [11]
 LDCM0474  CL80 HEK-293T C866(1.12); C144(0.97); C95(1.06); C123(0.88)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C866(1.18); C144(0.98); C95(1.12); C123(1.04)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C866(1.16); C95(0.96); C123(0.84); C921(0.97)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C866(1.09); C95(1.06); C123(1.14); C921(0.98)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C866(1.14); C144(0.94); C95(1.18); C123(1.12)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C866(0.90); C144(0.93); C95(1.03); C123(1.09)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C866(0.94); C95(0.83); C123(0.95); C921(0.97)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C866(1.04); C144(1.08); C95(0.89); C123(0.91)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C866(0.97); C144(0.87); C95(0.95); C123(1.04)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C866(0.98); C144(0.93); C95(0.87); C123(0.93)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C866(0.99)  LDD1082  [11]
 LDCM0485  CL90 HEK-293T C866(0.95); C144(1.18); C95(1.52); C123(1.33)  LDD1688  [30]
 LDCM0486  CL91 HCT 116 C866(1.13)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C866(1.16)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C866(1.22)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C866(1.03)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C866(1.07)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C866(1.15)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C866(1.01)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C866(0.80)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C866(0.91)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C129(2.06); C57(1.84); C123(0.83)  LDD2228  [24]
 LDCM0495  E2913 HEK-293T C866(1.05); C144(1.01); C95(0.95); C123(0.74)  LDD1698  [30]
 LDCM0625  F8 Ramos C391(0.50); C921(1.36); C144(0.73); C95(0.72)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C391(0.72); C921(0.64); C144(1.04); C95(1.66)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C391(20.00); C921(5.74); C144(3.25); C380(16.13)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C391(0.80); C921(0.80); C144(1.17); C95(1.75)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C391(1.04); C921(0.94); C144(1.13); C95(0.90)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C391(2.77); C921(1.06); C95(3.50); C380(1.16)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C391(0.82); C921(0.56); C144(0.96); C95(1.48)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C391(0.56); C921(1.10); C144(0.98); C95(0.78)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C391(0.99); C921(1.23); C144(1.45); C95(0.69)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C391(0.87); C921(1.02); C144(1.05); C95(1.20)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C391(0.51); C921(0.90); C144(0.47); C95(0.84)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C391(1.01); C921(1.08); C144(1.00); C95(1.01)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C391(1.71); C921(0.98); C144(1.58); C380(2.66)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C391(0.59); C921(0.72); C144(0.92); C95(1.63)  LDD2201  [31]
 LDCM0468  Fragment33 HEK-293T C866(0.97); C144(0.97); C95(1.01); C123(0.87)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C391(0.65); C921(0.76); C144(1.37); C95(0.81)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C391(0.63); C921(0.86); C144(1.07); C95(1.51)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C866(0.59)  LDD1025  [11]
 LDCM0610  Fragment52 Ramos C391(0.55); C921(1.17); C95(1.27); C380(1.08)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C391(0.83); C921(1.27); C144(1.75); C95(1.12)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C391(0.88); C921(0.57); C144(1.26); C95(1.18)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C391(0.75); C921(0.68); C144(0.85); C95(2.01)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y136(1.11); Y121(1.26)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y136(0.85); Y121(1.08)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y121(0.79); Y136(0.95)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y121(0.94); Y136(0.99)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y121(0.78); Y136(1.06)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HCT 116 C144(1.15); C95(1.26); C241(2.32); C123(1.39)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C144(2.61); C95(3.50); C241(2.61); C123(2.26)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C144(2.58); C95(2.52); C241(2.31); C123(1.58)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C123(1.16); C241(1.72)  LDD2102  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C866(0.38)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C123(0.87); C241(1.07)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C123(1.42); C112(1.50); C144(0.99); C241(1.01)  LDD2093  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C866(1.23)  LDD2099  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C123(0.55); C241(0.61)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C866(0.92)  LDD2107  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C123(0.73); C241(0.92)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C123(1.32); C112(1.22); C241(1.02)  LDD2111  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C144(0.57); C129(0.65)  LDD2116  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C123(1.32); C112(2.29); C144(2.22); C241(2.46)  LDD2119  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C123(1.69); C112(1.42); C144(1.08); C241(0.92)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C123(1.90); C112(1.72); C241(0.94)  LDD2135  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C112(3.96); C144(2.84); C241(1.98); C866(0.93)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C866(0.88)  LDD2140  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C241(2.15)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C123(0.94); C112(1.00); C241(0.89)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C866(0.36)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C930(1.00)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C123(1.69); C241(2.26)  LDD2153  [6]
 LDCM0090  Rapamycin JHH-7 4.14  LDD0213  [28]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 3 (AGR3) AGR family Q8TD06
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
RING finger protein 39 (RNF39) . Q9H2S5
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adaptin ear-binding coat-associated protein 1 (NECAP1) NECAP family Q8NC96
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mesogenin-1 (MSGN1) . A6NI15
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-crystallin B1 (CRYBB1) Beta/gamma-crystallin family P53674
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Splicing factor U2AF 35 kDa subunit (U2AF1) Splicing factor SR family Q01081
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Low density lipoprotein receptor adapter protein 1 (LDLRAP1) . Q5SW96
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

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Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD041264
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578