Details of the Target

General Information of Target

Target ID LDTP00822
Target Name Trafficking protein particle complex subunit 3 (TRAPPC3)
Gene Name TRAPPC3
Gene ID 27095
Synonyms
BET3; Trafficking protein particle complex subunit 3; BET3 homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRQANRGTESKKMSSELFTLTYGALVTQLCKDYENDEDVNKQLDKMGFNIGVRLIEDFL
ARSNVGRCHDFRETADVIAKVAFKMYLGITPSITNWSPAGDEFSLILENNPLVDFVELPD
NHSSLIYSNLLCGVLRGALEMVQMAVEAKFVQDTLKGDGVTEIRMRFIRRIEDNLPAGEE
Target Bioclass
Other
Family
TRAPP small subunits family, BET3 subfamily
Subcellular location
Golgi apparatus, cis-Golgi network
Function May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Uniprot ID
O43617
Ensemble ID
ENST00000373162.5
HGNC ID
HGNC:19942

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.T9A .
IGROV1 SNV: p.L44P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y34(106.57)  LDD3495  [1]
DBIA
 Probe Info  		C31(1.59)  LDD3310  [2]
BTD
 Probe Info  		C31(1.02)  LDD2117  [3]
HPAP
 Probe Info  		4.31  LDD0063  [4]
HHS-465
 Probe Info  		Y34(10.00)  LDD2237  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		C68(0.00); C31(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		6.27  LDD0213  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C31(1.02)  LDD2117  [3]
 LDCM0214  AC1 PaTu 8988t C31(0.96)  LDD1093  [12]
 LDCM0215  AC10 PaTu 8988t C31(0.96)  LDD1094  [12]
 LDCM0226  AC11 PaTu 8988t C31(0.98)  LDD1105  [12]
 LDCM0237  AC12 PaTu 8988t C31(1.08)  LDD1116  [12]
 LDCM0259  AC14 PaTu 8988t C31(1.31)  LDD1138  [12]
 LDCM0270  AC15 PaTu 8988t C31(0.98)  LDD1149  [12]
 LDCM0276  AC17 HEK-293T C31(1.03)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C31(0.98)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C31(0.81)  LDD1517  [13]
 LDCM0279  AC2 PaTu 8988t C31(1.00)  LDD1158  [12]
 LDCM0280  AC20 HEK-293T C31(1.00)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C31(0.91)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C31(0.99)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C31(1.04)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C31(1.02)  LDD1523  [13]
 LDCM0285  AC25 PaTu 8988t C31(1.00)  LDD1164  [12]
 LDCM0286  AC26 PaTu 8988t C31(0.98)  LDD1165  [12]
 LDCM0287  AC27 PaTu 8988t C31(1.15)  LDD1166  [12]
 LDCM0288  AC28 PaTu 8988t C31(1.18)  LDD1167  [12]
 LDCM0289  AC29 PaTu 8988t C31(1.07)  LDD1168  [12]
 LDCM0290  AC3 PaTu 8988t C31(1.02)  LDD1169  [12]
 LDCM0291  AC30 PaTu 8988t C31(1.05)  LDD1170  [12]
 LDCM0292  AC31 PaTu 8988t C31(1.01)  LDD1171  [12]
 LDCM0293  AC32 PaTu 8988t C31(0.84)  LDD1172  [12]
 LDCM0294  AC33 PaTu 8988t C31(1.17)  LDD1173  [12]
 LDCM0295  AC34 PaTu 8988t C31(1.01)  LDD1174  [12]
 LDCM0296  AC35 PaTu 8988t C31(0.98)  LDD1175  [12]
 LDCM0297  AC36 PaTu 8988t C31(0.98)  LDD1176  [12]
 LDCM0298  AC37 PaTu 8988t C31(1.18)  LDD1177  [12]
 LDCM0299  AC38 PaTu 8988t C31(1.01)  LDD1178  [12]
 LDCM0300  AC39 PaTu 8988t C31(0.97)  LDD1179  [12]
 LDCM0301  AC4 PaTu 8988t C31(1.00)  LDD1180  [12]
 LDCM0302  AC40 PaTu 8988t C31(1.07)  LDD1181  [12]
 LDCM0303  AC41 PaTu 8988t C31(0.95)  LDD1182  [12]
 LDCM0304  AC42 PaTu 8988t C31(0.98)  LDD1183  [12]
 LDCM0305  AC43 PaTu 8988t C31(1.05)  LDD1184  [12]
 LDCM0306  AC44 PaTu 8988t C31(1.05)  LDD1185  [12]
 LDCM0307  AC45 PaTu 8988t C31(1.15)  LDD1186  [12]
 LDCM0308  AC46 PaTu 8988t C31(0.88)  LDD1187  [12]
 LDCM0309  AC47 PaTu 8988t C31(0.86)  LDD1188  [12]
 LDCM0310  AC48 PaTu 8988t C31(0.86)  LDD1189  [12]
 LDCM0311  AC49 PaTu 8988t C31(0.90)  LDD1190  [12]
 LDCM0312  AC5 PaTu 8988t C31(1.13)  LDD1191  [12]
 LDCM0313  AC50 PaTu 8988t C31(0.84)  LDD1192  [12]
 LDCM0314  AC51 PaTu 8988t C31(1.21)  LDD1193  [12]
 LDCM0315  AC52 PaTu 8988t C31(0.96)  LDD1194  [12]
 LDCM0316  AC53 PaTu 8988t C31(0.98)  LDD1195  [12]
 LDCM0317  AC54 PaTu 8988t C31(0.97)  LDD1196  [12]
 LDCM0318  AC55 PaTu 8988t C31(0.90)  LDD1197  [12]
 LDCM0319  AC56 PaTu 8988t C31(1.27)  LDD1198  [12]
 LDCM0320  AC57 HEK-293T C31(1.13)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C31(1.07)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C31(1.04)  LDD1561  [13]
 LDCM0323  AC6 PaTu 8988t C31(1.07)  LDD1202  [12]
 LDCM0324  AC60 HEK-293T C31(1.05)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C31(0.94)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C31(1.02)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C31(1.00)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C31(1.08)  LDD1567  [13]
 LDCM0334  AC7 PaTu 8988t C31(0.92)  LDD1213  [12]
 LDCM0345  AC8 PaTu 8988t C31(0.74)  LDD1224  [12]
 LDCM0248  AKOS034007472 PaTu 8988t C31(1.04)  LDD1127  [12]
 LDCM0356  AKOS034007680 PaTu 8988t C31(0.96)  LDD1235  [12]
 LDCM0275  AKOS034007705 PaTu 8988t C31(0.87)  LDD1154  [12]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 PaTu 8988t C31(0.97)  LDD1246  [12]
 LDCM0368  CL10 PaTu 8988t C31(0.93)  LDD1247  [12]
 LDCM0369  CL100 PaTu 8988t C31(0.97)  LDD1248  [12]
 LDCM0370  CL101 PaTu 8988t C31(0.94)  LDD1249  [12]
 LDCM0371  CL102 PaTu 8988t C31(0.86)  LDD1250  [12]
 LDCM0372  CL103 PaTu 8988t C31(1.27)  LDD1251  [12]
 LDCM0373  CL104 PaTu 8988t C31(0.95)  LDD1252  [12]
 LDCM0374  CL105 HEK-293T C31(0.99)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C31(0.96)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C31(0.97)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C31(0.97)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C31(0.96)  LDD1582  [13]
 LDCM0379  CL11 PaTu 8988t C31(0.88)  LDD1258  [12]
 LDCM0380  CL110 HEK-293T C31(0.89)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C31(0.95)  LDD1585  [13]
 LDCM0382  CL112 PaTu 8988t C31(1.11)  LDD1261  [12]
 LDCM0383  CL113 PaTu 8988t C31(1.07)  LDD1262  [12]
 LDCM0384  CL114 PaTu 8988t C31(1.16)  LDD1263  [12]
 LDCM0385  CL115 PaTu 8988t C31(1.01)  LDD1264  [12]
 LDCM0386  CL116 PaTu 8988t C31(1.36)  LDD1265  [12]
 LDCM0387  CL117 PaTu 8988t C31(0.96)  LDD1266  [12]
 LDCM0388  CL118 PaTu 8988t C31(0.92)  LDD1267  [12]
 LDCM0389  CL119 PaTu 8988t C31(0.95)  LDD1268  [12]
 LDCM0390  CL12 PaTu 8988t C31(0.99)  LDD1269  [12]
 LDCM0391  CL120 PaTu 8988t C31(0.96)  LDD1270  [12]
 LDCM0392  CL121 PaTu 8988t C31(0.88)  LDD1271  [12]
 LDCM0393  CL122 PaTu 8988t C31(1.70)  LDD1272  [12]
 LDCM0394  CL123 PaTu 8988t C31(0.88)  LDD1273  [12]
 LDCM0395  CL124 PaTu 8988t C31(0.82)  LDD1274  [12]
 LDCM0396  CL125 HEK-293T C31(1.17)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C31(1.01)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C31(0.92)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C31(1.00)  LDD1603  [13]
 LDCM0400  CL13 PaTu 8988t C31(0.94)  LDD1279  [12]
 LDCM0401  CL14 PaTu 8988t C31(0.97)  LDD1280  [12]
 LDCM0402  CL15 PaTu 8988t C31(0.82)  LDD1281  [12]
 LDCM0403  CL16 HEK-293T C31(1.02)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C31(0.97)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C31(1.01)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C31(1.01)  LDD1610  [13]
 LDCM0407  CL2 PaTu 8988t C31(0.99)  LDD1286  [12]
 LDCM0408  CL20 HEK-293T C31(1.01)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C31(0.90)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C31(1.05)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C31(1.10)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C31(1.12)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C31(0.99)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C31(1.04)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C31(1.05)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C31(1.02)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C31(1.02)  LDD1621  [13]
 LDCM0418  CL3 PaTu 8988t C31(0.87)  LDD1297  [12]
 LDCM0419  CL30 HEK-293T C31(1.02)  LDD1623  [13]
 LDCM0420  CL31 PaTu 8988t C31(1.06)  LDD1299  [12]
 LDCM0421  CL32 PaTu 8988t C31(1.11)  LDD1300  [12]
 LDCM0422  CL33 PaTu 8988t C31(0.93)  LDD1301  [12]
 LDCM0423  CL34 PaTu 8988t C31(1.06)  LDD1302  [12]
 LDCM0424  CL35 PaTu 8988t C31(1.29)  LDD1303  [12]
 LDCM0425  CL36 PaTu 8988t C31(0.35)  LDD1304  [12]
 LDCM0426  CL37 PaTu 8988t C31(0.95)  LDD1305  [12]
 LDCM0428  CL39 PaTu 8988t C31(1.05)  LDD1307  [12]
 LDCM0429  CL4 PaTu 8988t C31(1.13)  LDD1308  [12]
 LDCM0430  CL40 PaTu 8988t C31(1.10)  LDD1309  [12]
 LDCM0431  CL41 PaTu 8988t C31(1.08)  LDD1310  [12]
 LDCM0432  CL42 PaTu 8988t C31(1.13)  LDD1311  [12]
 LDCM0433  CL43 PaTu 8988t C31(1.28)  LDD1312  [12]
 LDCM0434  CL44 PaTu 8988t C31(1.13)  LDD1313  [12]
 LDCM0435  CL45 PaTu 8988t C31(1.16)  LDD1314  [12]
 LDCM0436  CL46 PaTu 8988t C31(0.97)  LDD1315  [12]
 LDCM0437  CL47 PaTu 8988t C31(0.93)  LDD1316  [12]
 LDCM0438  CL48 PaTu 8988t C31(1.06)  LDD1317  [12]
 LDCM0439  CL49 PaTu 8988t C31(1.01)  LDD1318  [12]
 LDCM0440  CL5 PaTu 8988t C31(1.06)  LDD1319  [12]
 LDCM0441  CL50 PaTu 8988t C31(0.98)  LDD1320  [12]
 LDCM0442  CL51 PaTu 8988t C31(0.87)  LDD1321  [12]
 LDCM0443  CL52 PaTu 8988t C31(0.95)  LDD1322  [12]
 LDCM0444  CL53 PaTu 8988t C31(0.79)  LDD1323  [12]
 LDCM0445  CL54 PaTu 8988t C31(0.75)  LDD1324  [12]
 LDCM0446  CL55 PaTu 8988t C31(0.79)  LDD1325  [12]
 LDCM0447  CL56 PaTu 8988t C31(0.90)  LDD1326  [12]
 LDCM0448  CL57 PaTu 8988t C31(0.93)  LDD1327  [12]
 LDCM0449  CL58 PaTu 8988t C31(0.96)  LDD1328  [12]
 LDCM0450  CL59 PaTu 8988t C31(1.00)  LDD1329  [12]
 LDCM0451  CL6 PaTu 8988t C31(0.92)  LDD1330  [12]
 LDCM0452  CL60 PaTu 8988t C31(1.07)  LDD1331  [12]
 LDCM0453  CL61 HEK-293T C31(1.05)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C31(1.02)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C31(0.97)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C31(1.00)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C31(1.02)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C31(0.98)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C31(0.98)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C31(1.04)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C31(0.97)  LDD1664  [13]
 LDCM0462  CL7 PaTu 8988t C31(1.03)  LDD1341  [12]
 LDCM0463  CL70 HEK-293T C31(1.03)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C31(1.00)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C31(0.95)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C31(0.96)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C31(1.01)  LDD1670  [13]
 LDCM0469  CL76 PaTu 8988t C31(0.82)  LDD1348  [12]
 LDCM0470  CL77 PaTu 8988t C31(0.88)  LDD1349  [12]
 LDCM0471  CL78 PaTu 8988t C31(0.86)  LDD1350  [12]
 LDCM0472  CL79 PaTu 8988t C31(1.13)  LDD1351  [12]
 LDCM0473  CL8 PaTu 8988t C31(0.84)  LDD1352  [12]
 LDCM0474  CL80 PaTu 8988t C31(0.86)  LDD1353  [12]
 LDCM0475  CL81 PaTu 8988t C31(0.79)  LDD1354  [12]
 LDCM0476  CL82 PaTu 8988t C31(0.74)  LDD1355  [12]
 LDCM0477  CL83 PaTu 8988t C31(0.92)  LDD1356  [12]
 LDCM0478  CL84 PaTu 8988t C31(0.94)  LDD1357  [12]
 LDCM0479  CL85 PaTu 8988t C31(0.79)  LDD1358  [12]
 LDCM0480  CL86 PaTu 8988t C31(0.97)  LDD1359  [12]
 LDCM0481  CL87 PaTu 8988t C31(0.84)  LDD1360  [12]
 LDCM0482  CL88 PaTu 8988t C31(0.94)  LDD1361  [12]
 LDCM0483  CL89 PaTu 8988t C31(0.85)  LDD1362  [12]
 LDCM0484  CL9 PaTu 8988t C31(1.00)  LDD1363  [12]
 LDCM0485  CL90 PaTu 8988t C31(0.89)  LDD1364  [12]
 LDCM0486  CL91 PaTu 8988t C31(1.16)  LDD1365  [12]
 LDCM0487  CL92 PaTu 8988t C31(0.97)  LDD1366  [12]
 LDCM0488  CL93 PaTu 8988t C31(1.09)  LDD1367  [12]
 LDCM0489  CL94 PaTu 8988t C31(1.57)  LDD1368  [12]
 LDCM0490  CL95 PaTu 8988t C31(1.16)  LDD1369  [12]
 LDCM0491  CL96 PaTu 8988t C31(1.01)  LDD1370  [12]
 LDCM0492  CL97 PaTu 8988t C31(0.91)  LDD1371  [12]
 LDCM0493  CL98 PaTu 8988t C31(0.93)  LDD1372  [12]
 LDCM0494  CL99 PaTu 8988t C31(0.98)  LDD1373  [12]
 LDCM0495  E2913 HEK-293T C31(0.91)  LDD1698  [13]
 LDCM0625  F8 Ramos C68(7.60)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C68(2.66)  LDD2190  [14]
 LDCM0575  Fragment13 Ramos C68(0.99)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C68(3.33)  LDD2193  [14]
 LDCM0580  Fragment21 Ramos C68(0.79)  LDD2195  [14]
 LDCM0586  Fragment28 Ramos C68(0.91)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C68(0.64)  LDD2199  [14]
 LDCM0468  Fragment33 HEK-293T C31(0.96)  LDD1671  [13]
 LDCM0566  Fragment4 Ramos C68(1.48)  LDD2184  [14]
 LDCM0427  Fragment51 PaTu 8988t C31(1.12)  LDD1306  [12]
 LDCM0610  Fragment52 Ramos C68(1.23)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C68(0.50)  LDD2205  [14]
 LDCM0022  KB02 HEK-293T C31(0.97)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C31(4.72)  LDD0315  [15]
 LDCM0024  KB05 COLO792 C31(1.59)  LDD3310  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C31(0.91)  LDD2125  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C31(0.96)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C31(0.83)  LDD2137  [3]
 LDCM0014  Panhematin K562 4.31  LDD0063  [4]
 LDCM0090  Rapamycin JHH-7 6.27  LDD0213  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Trafficking protein particle complex subunit 5 (TRAPPC5) TRAPP small subunits family Q8IUR0
Trafficking protein particle complex subunit 6A (TRAPPC6A) TRAPP small subunits family O75865
Trafficking protein particle complex subunit 6B (TRAPPC6B) TRAPP small subunits family Q86SZ2
Trafficking protein particle complex subunit 1 (TRAPPC1) TRAPP small subunits family Q9Y5R8
Trafficking protein particle complex subunit 2-like protein (TRAPPC2L) TRAPP small subunits family Q9UL33
Trafficking protein particle complex subunit 13 (TRAPPC13) TRAPPC13 family A5PLN9
Trafficking protein particle complex subunit 8 (TRAPPC8) TRS85 family Q9Y2L5
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Palmitic Acid Small molecular drug DB03796
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Myristic Acid Small molecular drug DB08231
S-palmitoyl-l-cysteine . DB08342

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060