Details of the Target

General Information of Target

Target ID LDTP05914
Target Name Serine/threonine-protein kinase ATR (ATR)
Gene Name ATR
Gene ID 545
Synonyms
FRP1; Serine/threonine-protein kinase ATR; EC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTD
SQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLH
KKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG
SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIK
TLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENL
SSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYS
GLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIY
SHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWAL
QSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL
AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDG
FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVR
KQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQ
LNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS
SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV
RCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKD
FTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGH
QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT
KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDD
QHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVST
VDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLY
AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVV
KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTW
SVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCEL
EHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV
GECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV
ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF
YLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTK
AYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVL
MEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTD
KLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANH
ASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLME
FNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVY
MTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRS
TAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMV
NGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNET
GEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGW
TPYM
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family, ATM subfamily
Subcellular location
Nucleus
Function
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q . Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis . Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2. Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress. Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1. Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly. Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture. The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex.
TTD ID
T97155
Uniprot ID
Q13535
DrugMap ID
TT8ZYBQ
Ensemble ID
ENST00000350721.9
HGNC ID
HGNC:882
ChEMBL ID
CHEMBL5024

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.F2513I .
CCSW1 SNV: p.W1962Ter .
CORL88 SNV: p.R1351L .
DEL SNV: p.A1206T .
HCT15 SNV: p.T1798A; p.I1851V .
HGC27 Deletion: p.G2316AfsTer9 .
HS936T SNV: p.S2207F .
HT3 SNV: p.R796T .
Ishikawa (Heraklio) 02 ER SNV: p.Q2408R .
JEKO1 SNV: p.T1751A .
JURKAT SNV: p.I1264M .
KASUMI2 SNV: p.Y1651C .
KNS42 SNV: p.H2517L .
KYSE150 SNV: p.F982V .
KYSE510 SNV: p.E2034K .
LNCaP clone FGC SNV: p.K1379N .
MCC13 SNV: p.H2361Y .
MEWO Substitution: p.V666K .
MSTO211H SNV: p.V1338L .
NCIH1048 SNV: p.S1693G .
NCIH1944 SNV: p.R2363Ter; p.A2366T .
NCIH2170 SNV: p.R2190C .
NCIH2286 SNV: p.D1634Y .
NCIH3122 Substitution: p.L770K .
NCIH661 SNV: p.L2428F .
OCUG1 SNV: p.D1915G .
OVK18 SNV: p.T1663A; p.R1959M .
OVKATE SNV: p.S2449L .
PC9 SNV: p.L769Q
Substitution: p.L770K		 .
RCC10RGB SNV: p.G2W .
SNU1079 SNV: p.T1799K .
SUPT1 SNV: p.I2068V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y2102(8.73)  LDD0257  [2]
HHS-475
 Probe Info  		Y2067(3.79)  LDD0266  [3]
HHS-465
 Probe Info  		Y2067(1.80)  LDD2237  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C1042(0.99); C1044(0.99); C1721(0.93); C790(0.91)  LDD0078  [6]
N1
 Probe Info  		D2118(0.00); N2123(0.00)  LDD0245  [7]
IA-alkyne
 Probe Info  		C1343(0.00); C1430(0.00); C753(0.00); C763(0.00)  LDD0162  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
NAIA_4
 Probe Info  		C2031(0.00); C2348(0.00); C2374(0.00)  LDD2226  [11]
IPM
 Probe Info  		C763(0.00); C1198(0.00)  LDD0005  [12]
TFBX
 Probe Info  		C1343(0.00); C790(0.00); C1983(0.00); C763(0.00)  LDD0148  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		10.50  LDD0443  [15]
NAIA_5
 Probe Info  		C763(0.00); C753(0.00); C1354(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [16]
Alk-rapa
 Probe Info  		3.94  LDD0213  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1192(1.03); C1193(1.03); C1198(1.14); C1343(1.50)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C1192(1.00); C1193(1.00); C1198(1.32); C1343(0.75)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C1042(1.11); C1044(1.11); C1192(1.24); C1193(1.24)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C1042(1.11); C1044(1.11); C1192(1.03); C1193(1.03)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C1042(1.12); C1044(1.12); C1192(1.19); C1193(1.19)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C1042(0.96); C1044(0.96); C1192(0.87); C1193(0.87)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C1042(1.36); C1044(1.36); C1192(1.12); C1193(1.12)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C1042(0.93); C1044(0.93); C1192(1.13); C1193(1.13)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C1042(1.04); C1044(1.04); C1192(1.05); C1193(1.05)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C1042(1.27); C1044(1.27); C1192(1.17); C1193(1.17)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C1042(1.04); C1044(1.04); C1192(1.14); C1193(1.14)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C1042(1.57); C1044(1.57); C1192(1.20); C1193(1.20)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C1192(0.98); C1193(0.98); C1198(1.28); C1343(0.75)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C1042(1.03); C1044(1.03); C1192(1.22); C1193(1.22)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C1042(1.03); C1044(1.03); C1192(1.00); C1193(1.00)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C1042(0.88); C1044(0.88); C1192(0.96); C1193(0.96)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C1042(0.94); C1044(0.94); C1192(0.96); C1193(0.96)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C1042(0.88); C1044(0.92); C1192(0.83); C1193(0.83)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C1042(1.03); C1044(1.10); C1192(0.85); C1193(0.85)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C1042(1.00); C1044(1.11); C1192(0.93); C1193(0.93)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C1042(0.92); C1044(0.97); C1192(0.84); C1193(0.84)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C1042(0.97); C1044(0.99); C1192(0.88); C1193(0.88)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C1042(1.04); C1044(1.08); C1192(0.87); C1193(0.87)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C1192(0.96); C1193(0.96); C1198(1.28); C1343(0.93)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C1042(1.18); C1044(1.17); C1192(0.85); C1193(0.85)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C1042(0.98); C1044(1.06); C1192(1.12); C1193(1.12)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C1042(0.99); C1044(1.02); C1192(0.89); C1193(0.89)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C1042(0.98); C1044(1.19); C1192(0.94); C1193(0.94)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C1042(1.02); C1044(0.99); C1192(1.03); C1193(1.03)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C1042(0.91); C1044(0.88); C1192(0.85); C1193(0.85)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C1042(0.97); C1044(0.99); C1192(0.99); C1193(0.99)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C1042(0.93); C1044(0.99); C1192(0.88); C1193(0.88)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C1192(1.31); C1193(1.31); C1198(1.24); C1343(0.55)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C1192(1.03); C1193(1.03); C1198(0.95); C1343(1.76)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C1192(1.13); C1193(1.13); C1198(1.17); C1343(0.70)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C1192(1.09); C1193(1.09); C1198(0.98); C1343(0.78)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C1192(1.36); C1193(1.36); C1198(1.14); C1343(1.23)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C1192(1.30); C1193(1.30); C1198(1.24); C1343(0.83)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C1192(1.18); C1193(1.18); C1198(1.26); C1343(0.85)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C1192(1.17); C1193(1.17); C1198(1.26); C1343(0.70)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C1192(1.18); C1193(1.18); C1198(1.14); C1343(0.84)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C1192(1.03); C1193(1.03); C1198(1.04); C1343(1.03)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C1192(1.08); C1193(1.08); C1198(1.24); C1343(0.73)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C1192(1.30); C1193(1.30); C1198(1.20); C1343(0.72)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C1192(0.98); C1193(0.98); C1198(1.35); C1343(0.77)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C1192(1.37); C1193(1.37); C1198(1.15); C1343(0.65)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C1192(1.18); C1193(1.18); C1198(1.22); C1343(0.76)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C1192(1.21); C1193(1.21); C1198(1.05); C1343(1.20)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C1042(0.88); C1044(0.88); C1192(0.97); C1193(0.97)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C1343(0.15); C1198(0.89); C790(0.90); C1192(0.91)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C1343(0.27); C1042(0.87); C1044(0.87); C790(0.91)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C1343(0.23); C790(0.91); C1042(0.94); C1044(0.94)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C1343(0.21); C38(0.90); C790(0.95); C1042(1.00)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C1343(0.18); C1198(0.90); C790(1.04); C1192(1.19)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C1343(0.20); C1192(0.94); C1193(0.94); C790(0.97)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C1343(0.75); C2490(0.80); C2497(0.80); C2536(0.92)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C1343(0.29); C790(0.86); C636(0.91); C38(0.93)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C1343(0.22); C790(0.88); C636(1.02); C1042(1.08)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C1343(0.20); C1198(0.94); C790(0.96); C636(1.03)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C1343(0.18); C1198(1.00); C790(1.13); C1042(1.20)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C1042(1.00); C1044(1.00); C1192(0.96); C1193(0.96)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C1042(1.02); C1044(1.02); C1192(1.11); C1193(1.11)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C1042(0.91); C1044(0.91); C1192(1.06); C1193(1.06)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C1042(0.86); C1044(0.86); C1192(1.15); C1193(1.15)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C1343(0.77); C1192(0.85); C1193(0.85); C1721(0.89)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C1343(0.32); C1354(0.62); C1357(0.62); C636(0.72)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C1343(0.46); C636(0.86); C1192(0.86); C1193(0.86)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C671(0.84); C685(0.84); C1343(0.93); C96(0.96)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C1343(0.35); C636(0.91); C1721(0.93); C790(0.95)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C1343(0.56); C636(0.75); C1192(0.90); C1193(0.90)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C1343(0.51); C1721(0.81); C96(0.91); C1192(0.92)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C1343(0.46); C1923(0.86); C1192(0.86); C1193(0.86)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C1343(0.48); C1192(0.87); C1193(0.87); C1923(0.95)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C1354(0.48); C1357(0.48); C1343(0.68); C38(0.83)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C1343(0.66); C1192(0.77); C1193(0.77); C38(0.83)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C1343(0.47); C1354(0.63); C1357(0.63); C1192(0.77)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C1354(0.50); C1357(0.50); C1343(0.50); C1192(0.82)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C1343(0.53); C1354(0.69); C1357(0.69); C1192(0.86)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C671(0.70); C685(0.70); C1192(0.91); C1193(0.91)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C1343(0.46); C1354(0.68); C1357(0.68); C1192(0.78)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C1343(0.58); C96(0.78); C1354(0.81); C1357(0.81)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C1343(0.40); C1354(0.53); C1357(0.53); C1192(0.74)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C1343(0.40); C1354(0.55); C1357(0.55); C1192(0.72)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C1343(0.36); C1354(0.48); C1357(0.48); C1192(0.82)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C1198(0.91); C1923(1.06); C790(1.08); C671(1.09)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C1198(0.88); C1923(0.89); C790(0.92); C671(0.96)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C1923(0.84); C1198(0.91); C790(0.91); C1192(1.03)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C790(0.88); C1198(0.93); C1354(1.01); C1357(1.01)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C671(0.88); C685(0.88); C1923(0.93); C1192(0.96)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C96(0.90); C671(0.93); C685(0.93); C790(1.00)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C1923(0.94); C790(0.99); C1343(1.00); C1198(1.01)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C1923(0.80); C1192(0.85); C1193(0.85); C790(0.88)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C1923(0.87); C790(0.95); C1198(1.01); C1354(1.04)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C1923(0.89); C790(0.94); C671(0.97); C685(0.97)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C1923(0.90); C790(0.97); C1198(1.07); C1343(1.07)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C1923(0.93); C1343(0.99); C1354(1.03); C1357(1.03)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C2490(0.87); C2497(0.87); C1192(0.92); C1193(0.92)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C1343(0.91); C1354(0.92); C1357(0.92); C790(0.95)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C790(0.93); C2490(0.93); C2497(0.93); C1192(0.95)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C1343(0.73); C1354(0.79); C1357(0.79); C790(0.92)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C96(0.89); C38(1.01); C790(1.04); C2536(1.07)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C1343(0.74); C1354(0.80); C1357(0.80); C790(0.88)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C1721(0.86); C1198(0.88); C790(0.90); C1192(0.91)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C1343(0.80); C1923(0.88); C790(0.89); C1192(0.93)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C1343(0.75); C1354(0.81); C1357(0.81); C790(0.82)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C1343(0.75); C790(0.81); C1354(0.82); C1357(0.82)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C1343(0.77); C790(0.93); C1354(0.95); C1357(0.95)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C1343(0.78); C790(0.87); C1354(0.89); C1357(0.89)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C1343(0.53); C2536(0.77); C1192(0.94); C1193(0.94)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C1343(0.53); C2536(0.80); C1192(0.92); C1193(0.92)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C1343(0.60); C2536(0.93); C790(0.93); C1192(0.95)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C1343(0.50); C38(0.87); C2536(0.89); C1923(0.92)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C1343(0.63); C790(0.87); C2536(0.88); C1192(0.88)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C1343(0.86); C790(0.97); C671(1.00); C685(1.00)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C1343(0.50); C790(0.81); C1192(0.86); C1193(0.86)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C1343(0.50); C1192(0.75); C1193(0.75); C2536(0.81)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C1343(0.58); C1192(0.91); C1193(0.91); C790(0.93)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C1343(0.61); C790(0.85); C1192(0.89); C1193(0.89)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C1343(0.70); C1192(0.89); C1193(0.89); C790(0.92)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C1343(0.56); C790(0.88); C1192(0.92); C1193(0.92)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C2536(0.66); C1343(0.84); C38(0.86); C2490(0.91)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C2536(0.73); C1721(0.74); C38(0.83); C1923(0.86)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C2536(0.72); C1343(0.80); C38(0.82); C1721(0.92)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C1343(0.49); C2536(0.80); C2490(0.85); C2497(0.85)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C1923(0.77); C2536(0.83); C1721(0.84); C2490(0.89)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C1343(0.70); C2490(0.79); C2497(0.79); C2536(0.85)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C1343(0.71); C1721(0.75); C2490(0.89); C2497(0.89)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C1343(0.79); C2536(0.85); C1721(0.92); C38(0.92)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C1343(0.76); C1923(0.84); C38(0.91); C1192(1.01)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C1343(0.76); C38(0.81); C1721(0.82); C2536(0.91)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C1343(0.59); C38(0.89); C1923(0.93); C2536(0.94)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C2490(0.60); C2497(0.60); C2536(0.82); C38(0.86)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C2536(0.82); C1923(0.82); C1343(0.85); C38(0.85)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C1343(0.77); C2536(0.81); C38(0.87); C671(0.94)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C2536(0.61); C1343(0.63); C2490(0.69); C2497(0.69)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C1923(0.81); C2536(0.83); C1721(0.90); C38(0.93)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C1923(0.65); C1343(0.74); C38(0.83); C1721(0.89)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C96(0.70); C1042(0.84); C1044(0.84); C1721(0.90)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C96(0.70); C1042(0.82); C1044(0.82); C1721(0.88)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C96(0.76); C1042(0.80); C1044(0.80); C1923(0.94)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C96(0.84); C1192(0.96); C1193(0.96); C1721(0.98)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C671(0.83); C685(0.83); C96(0.86); C1042(0.88)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C96(0.79); C1198(0.91); C1042(0.92); C1044(0.92)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C1923(0.77); C96(0.82); C1042(0.91); C1044(0.91)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C96(0.73); C1923(0.80); C1042(0.99); C1044(0.99)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C96(0.65); C1042(0.78); C1044(0.78); C1923(0.85)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C96(0.71); C1042(0.90); C1044(0.90); C1721(0.94)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C1042(0.81); C1044(0.81); C790(0.89); C1721(0.90)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C96(0.68); C1042(0.79); C1044(0.79); C1192(0.88)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C1042(0.82); C1044(0.82); C96(0.82); C1192(0.93)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C96(0.65); C1042(0.72); C1044(0.72); C1721(0.97)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C96(0.77); C1042(0.86); C1044(0.86); C1923(0.87)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C1343(0.23); C671(0.65); C685(0.65); C1192(0.96)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C1343(0.64); C671(0.71); C685(0.71); C1198(0.72)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C1192(1.15); C1193(1.15); C1198(1.07); C1343(1.15)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C1343(0.78); C2490(0.81); C2497(0.81); C38(0.83)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C1343(0.46); C38(0.89); C2536(1.02); C1192(1.04)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C1042(0.99); C1044(0.99); C1721(0.93); C790(0.91)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C790(20.00)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C2490(0.65); C2497(0.65); C1923(0.85); C790(0.96)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C2490(0.82); C2497(0.82); C1354(0.90); C1357(0.90)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C96(0.90); C671(0.94); C685(0.94); C790(1.00)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C1343(0.71); C2490(0.86); C2497(0.86); C38(0.89)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C671(0.83); C685(0.83); C38(0.86); C1343(0.91)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C38(0.91); C790(0.93); C96(1.00); C1192(1.00)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C1343(0.86); C1192(0.88); C1193(0.88); C38(0.91)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C1343(0.43); C1354(0.80); C1357(0.80); C38(0.91)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C1343(0.31); C1354(0.83); C1357(0.83); C636(1.00)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C1343(0.34); C1354(0.85); C1357(0.85); C1192(0.93)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C1343(0.29); C1354(0.79); C1357(0.79); C1192(0.93)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C1343(0.36); C1192(0.84); C1193(0.84); C671(0.95)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C1354(0.61); C1357(0.61); C2490(0.86); C2497(0.86)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C1343(0.35); C636(0.80); C96(0.89); C1192(0.92)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C1343(0.52); C636(0.80); C1192(0.84); C1193(0.84)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C1343(0.66); C1354(0.73); C1357(0.73); C1192(0.82)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C1343(0.41); C1354(0.46); C1357(0.46); C1192(0.76)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C1343(0.67); C1354(0.80); C1357(0.80); C1192(0.87)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C1343(0.56); C1192(0.62); C1193(0.62); C1354(0.66)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C1343(0.59); C1192(0.76); C1193(0.76); C1354(0.79)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C790(1.03); C1343(1.05); C1354(1.06); C1357(1.06)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C790(0.85); C1923(0.89); C1198(0.91); C1192(0.97)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C1923(0.93); C1343(0.96); C790(0.97); C1192(1.01)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C1354(0.66); C1357(0.66); C2490(0.81); C2497(0.81)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C1923(0.83); C790(0.90); C1192(0.94); C1193(0.94)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C1343(0.83); C790(0.92); C1923(0.94); C96(1.03)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C1923(0.87); C790(0.87); C1192(0.94); C1193(0.94)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C1343(0.71); C1354(0.78); C1357(0.78); C1923(0.81)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C1343(0.73); C790(0.86); C1354(0.94); C1357(0.94)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C2536(0.76); C790(0.86); C1042(0.87); C1044(0.87)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C1343(0.64); C2536(0.72); C1192(0.84); C1193(0.84)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C2536(0.76); C1192(0.83); C1193(0.83); C1042(0.87)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C1343(0.51); C1354(0.87); C1357(0.87); C2536(0.94)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C1354(0.80); C1357(0.80); C1192(0.93); C1193(0.93)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C1923(0.84); C1354(0.85); C1357(0.85); C1192(0.87)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C2490(0.82); C2497(0.82); C1192(1.00); C1193(1.00)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C38(0.84); C636(0.84); C790(0.99); C1198(1.01)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C38(0.83); C1042(0.89); C1044(0.89); C790(0.94)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C38(0.73); C1721(0.80); C1042(0.85); C1044(0.85)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C1721(0.84); C1192(0.93); C1193(0.93); C96(0.93)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C2490(0.73); C2497(0.73); C1354(0.93); C1357(0.93)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C38(0.83); C1042(0.90); C1044(0.90); C1192(0.91)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C38(0.97); C1192(0.98); C1193(0.98); C790(1.01)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C38(0.87); C790(1.19); C1042(1.19); C1044(1.19)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C38(0.66); C1721(0.89); C1042(0.94); C1044(0.94)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C38(0.82); C96(0.91); C1721(0.91); C1923(0.97)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C1042(0.89); C1044(0.89); C1192(1.16); C1193(1.16)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C1042(0.90); C1044(0.90); C1192(0.97); C1193(0.97)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C1042(0.92); C1044(0.92); C1192(0.95); C1193(0.95)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C1042(1.01); C1044(1.01); C1192(0.99); C1193(0.99)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C1042(0.92); C1044(0.92); C1192(0.94); C1193(0.94)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C1192(0.84); C1193(0.84); C1198(0.99); C1343(1.07)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C1042(0.96); C1044(0.96); C1192(1.11); C1193(1.11)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C1042(0.89); C1044(0.89); C1192(1.04); C1193(1.04)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C1192(1.13); C1193(1.13); C1198(1.17); C1343(1.17)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C1192(1.17); C1193(1.17); C1198(1.13); C1343(0.91)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C1192(1.22); C1193(1.22); C1198(1.37); C1343(0.47)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C1192(1.11); C1193(1.11); C1198(1.18); C1343(0.42)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C1192(1.04); C1193(1.04); C1198(1.19); C1343(0.47)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C1192(1.28); C1193(1.28); C1198(1.11); C1343(0.46)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C1192(1.09); C1193(1.09); C1198(1.34); C1343(0.47)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C1192(1.03); C1193(1.03); C1198(1.11); C1343(1.23)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C1192(1.22); C1193(1.22); C1198(1.20); C1343(0.35)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C1192(1.01); C1193(1.01); C1198(1.11); C1343(0.36)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C1192(1.43); C1193(1.43); C1198(1.50); C1343(0.55)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C1192(1.15); C1193(1.15); C1198(1.44); C1343(0.38)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C1192(1.16); C1193(1.16); C1198(1.31); C1343(0.42)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C1192(1.08); C1193(1.08); C1198(1.44); C1343(0.53)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C1042(0.74); C1044(0.74); C1198(0.83); C1343(1.35)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C1042(0.81); C1044(0.81); C1198(0.87); C1343(1.30)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C1042(0.76); C1044(0.76); C1198(0.78); C1343(1.48)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C1042(0.83); C1044(0.83); C1198(0.90); C1343(1.03)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C1192(0.92); C1193(0.92); C1198(1.03); C1343(1.16)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C1042(0.72); C1044(0.72); C1198(0.82); C1343(0.88)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C1042(0.73); C1044(0.73); C1198(0.89); C1343(1.33)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C1042(0.73); C1044(0.73); C1198(0.80); C1343(0.92)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C1042(0.72); C1044(0.72); C1198(0.77); C1343(1.03)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C1042(0.75); C1044(0.75); C1198(0.80); C1343(1.55)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C1042(0.54); C1044(0.54); C1198(0.80); C1343(1.28)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C1042(0.87); C1044(0.87); C1198(0.89); C1343(0.90)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C1042(0.73); C1044(0.73); C1198(0.90); C1343(1.36)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C1042(0.80); C1044(0.80); C1198(0.89); C1343(1.57)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C1042(0.86); C1044(0.86); C1198(0.86); C1343(1.15)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C1192(0.88); C1193(0.88); C1198(1.06); C1343(1.13)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C1042(0.84); C1044(0.84); C1198(0.83); C1343(1.08)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C1042(0.90); C1044(0.90); C1192(1.02); C1193(1.02)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C1042(0.92); C1044(0.92); C1192(0.96); C1193(0.96)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C1042(0.90); C1044(0.90); C1192(0.97); C1193(0.97)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C1042(1.09); C1044(1.09); C1192(1.06); C1193(1.06)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C1042(1.03); C1044(1.03); C1192(1.02); C1193(1.02)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C1042(1.25); C1044(1.25); C1192(1.12); C1193(1.12)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C1042(1.15); C1044(1.15); C1192(1.00); C1193(1.00)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C1042(1.07); C1044(1.07); C1192(1.01); C1193(1.01)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C1042(0.78); C1044(0.78); C1192(0.92); C1193(0.92)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C1192(0.97); C1193(0.97); C1198(1.22); C1343(1.06)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C1042(1.03); C1044(1.03); C1192(0.90); C1193(0.90)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C1042(1.01); C1044(1.01); C1192(0.92); C1193(0.92)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C1042(1.06); C1044(1.06); C1192(1.05); C1193(1.05)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C1042(1.00); C1044(1.00); C1192(0.96); C1193(0.96)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C1042(0.95); C1044(0.95); C1192(0.92); C1193(0.92)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C1042(1.07); C1044(1.07); C1192(0.99); C1193(0.99)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C1042(0.92); C1044(0.92); C1192(0.83); C1193(0.83)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C1042(1.12); C1044(1.12); C1192(0.99); C1193(0.99)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C1042(1.31); C1044(1.31); C1192(1.06); C1193(1.06)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C1192(1.26); C1193(1.26); C1198(1.41); C1343(0.86)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C1042(1.09); C1044(1.09); C1192(0.91); C1193(0.91)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C1042(0.94); C1044(0.94); C1192(0.94); C1193(0.94)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C1042(1.42); C1044(1.42); C1192(1.00); C1193(1.00)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C1042(1.33); C1044(1.33); C1192(0.90); C1193(0.90)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C1042(1.19); C1044(1.19); C1192(1.18); C1193(1.18)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C1042(1.01); C1044(1.01); C1192(0.88); C1193(0.88)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C1042(1.20); C1044(1.20); C1192(0.96); C1193(0.96)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C1042(1.21); C1044(1.21); C1192(0.97); C1193(0.97)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C1042(1.05); C1044(1.05); C1192(1.12); C1193(1.12)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C1042(1.16); C1044(1.16); C1192(1.13); C1193(1.13)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C1192(1.00); C1193(1.00); C1198(1.25); C1343(0.90)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C1042(1.05); C1044(1.05); C1192(1.01); C1193(1.01)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C1192(0.92); C1193(0.92); C1198(0.91); C1343(0.74)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C1192(1.08); C1193(1.08); C1198(0.81); C1343(0.68)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C1192(1.15); C1193(1.15); C1198(1.09); C1343(1.03)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C1192(0.97); C1193(0.97); C1198(1.01); C1343(1.05)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C1192(0.88); C1193(0.88); C1198(0.91); C1343(0.97)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C1192(1.03); C1193(1.03); C1198(1.08); C1343(0.84)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C1192(1.12); C1193(1.12); C1198(1.18); C1343(0.70)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C1192(1.21); C1193(1.21); C1198(1.23); C1343(1.12)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C1192(1.04); C1193(1.04); C1198(1.21); C1343(1.49)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C753(1.11); C1721(1.01); C2536(1.04); C1198(0.96)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C753(5.23)  LDD1702  [19]
 LDCM0625  F8 Ramos C1343(0.84); C753(1.86)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C1343(0.81); C376(1.92)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C1343(13.00); C753(6.70)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C1343(0.88); C753(3.24)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C1343(1.05); C753(1.05)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C1343(1.31)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C1343(0.87)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C1343(0.92); C376(0.65)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C1343(0.76); C376(1.40); C753(0.76)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C1343(1.09); C753(1.19)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C1343(0.62); C376(0.64); C753(0.75)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C1343(1.52); C753(1.78)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C1343(1.27); C753(1.41)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C1343(0.97); C376(1.36); C753(3.66)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C1042(1.05); C1044(1.05); C1192(0.97); C1193(0.97)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C1343(1.12); C376(1.09); C753(1.76)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C1343(0.72)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C1192(1.19); C1193(1.19); C1198(1.63); C1343(0.39)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C1343(1.63)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C1343(1.81); C753(2.81)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C1343(0.60)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C1343(0.89)  LDD2188  [20]
 LDCM0118  HHS-0301 DM93 Y2067(3.79)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y2067(2.06)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y2067(5.32)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C1721(2.91); C685(1.39); C96(3.99)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C1721(2.39); C685(4.58); C96(4.68)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C1721(2.63); C685(2.23); C96(1.56)  LDD0082  [6]
 LDCM0090  Rapamycin JHH-7 3.94  LDD0213  [17]
 LDCM0021  THZ1 HCT 116 C1198(1.09); C1721(0.86); C671(1.02); C685(1.02)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 9 (CDK9) CMGC Ser/Thr protein kinase family P50750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATR-interacting protein (ATRIP) ATRIP family Q8WXE1
Cyclin-dependent kinase 2-interacting protein (CINP) CINP family Q9BW66
TELO2-interacting protein 1 homolog (TTI1) Tti1 family O43156
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azd6738 Small molecular drug D0H9DA
Rp-3500 Small molecular drug DAD65R
Phase 1
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
M1774 Small molecular drug D3OWG9
Bay1895344 . D03BYM
M4344 . D0IE9L
Vx-970 . D06DMQ
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Az20 Small molecular drug D02TSN
Cgk733 Small molecular drug D00PXO
Ve-821 Small molecular drug D0G0BJ
Ceralasertib . DB14917

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578