Details of the Target

General Information of Target

Target ID LDTP08300
Target Name Reticulophagy regulator 3 (RETREG3)
Gene Name RETREG3
Gene ID 162427
Synonyms
FAM134C; Reticulophagy regulator 3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAAL
VWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVCIDQWKNKIWPEIKVPRPD
ALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFL
AVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRE
RQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTF
NLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINMDPAGLDDEDDTSIGMPSLMYRS
PPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQGMIQLALSGASQPGPSG
APAQRATRGFLRSPSSDLDTDAEGDDFELLDQSELSQLDPASSRSH
Target Bioclass
Other
Family
RETREG family
Subcellular location
Endoplasmic reticulum membrane
Function
Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes. Required for collagen quality control in a LIR motif-dependent manner. Mediates NRF1-enhanced neurite outgrowth.
Uniprot ID
Q86VR2
Ensemble ID
ENST00000309428.10
HGNC ID
HGNC:27258

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.V401I .
KMRC3 SNV: p.V217M .
KYSE410 SNV: p.R210Q .
LNCaP clone FGC SNV: p.L431I .
MOLT4 SNV: p.L450M .
REH SNV: p.A58T .
SKMEL5 SNV: p.P388S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y233(16.57); Y49(9.50)  LDD0260  [1]
TH216
 Probe Info  		Y233(20.00); Y49(17.92)  LDD0259  [1]
STPyne
 Probe Info  		K237(10.00)  LDD0277  [2]
m-APA
 Probe Info  		12.15  LDD0403  [3]
IA-alkyne
 Probe Info  		C268(2.02)  LDD2184  [4]
Acrolein
 Probe Info  		N.A.  LDD0225  [5]
DBIA
 Probe Info  		C268(0.97)  LDD1492  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
AOyne
 Probe Info  		13.90  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		6.36  LDD1733  [9]
C094
 Probe Info  		28.84  LDD1785  [9]
C218
 Probe Info  		11.47  LDD1892  [9]
C228
 Probe Info  		14.72  LDD1901  [9]
C231
 Probe Info  		14.03  LDD1904  [9]
C235
 Probe Info  		24.08  LDD1908  [9]
C243
 Probe Info  		10.56  LDD1916  [9]
C246
 Probe Info  		14.83  LDD1919  [9]
C362
 Probe Info  		29.65  LDD2023  [9]
C388
 Probe Info  		40.50  LDD2047  [9]
Alk-rapa
 Probe Info  		4.12  LDD0213  [10]
OEA-DA
 Probe Info  		6.56  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C141(0.97)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C141(0.89); C268(0.91)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C141(1.18)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C141(1.15); C268(1.00)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C141(0.86); C294(1.18)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C141(0.93)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C141(0.86); C268(1.05)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C141(0.89)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C141(1.08)  LDD1519  [6]
 LDCM0282  AC22 HEK-293T C141(0.80); C268(0.99)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C141(0.91); C294(0.88)  LDD1522  [6]
 LDCM0286  AC26 HEK-293T C141(0.88)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C141(0.87); C268(1.00)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C141(0.99)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C141(0.90); C268(0.98)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C141(0.85); C268(1.17)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C141(0.78); C294(0.84)  LDD1531  [6]
 LDCM0295  AC34 HEK-293T C141(1.01)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C141(0.92); C268(1.18)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C141(0.95)  LDD1536  [6]
 LDCM0299  AC38 HEK-293T C141(0.99); C268(1.16)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C141(0.88); C294(0.79)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C141(0.86)  LDD1540  [6]
 LDCM0304  AC42 HEK-293T C141(0.93)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C141(0.95); C268(1.00)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C141(1.07)  LDD1545  [6]
 LDCM0308  AC46 HEK-293T C141(0.93); C268(1.24)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C141(0.87); C294(0.93)  LDD1548  [6]
 LDCM0313  AC50 HEK-293T C141(0.85)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C141(0.91); C268(0.97)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C141(1.11)  LDD1554  [6]
 LDCM0317  AC54 HEK-293T C141(1.05); C268(1.16)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C141(0.95); C294(1.08)  LDD1557  [6]
 LDCM0321  AC58 HEK-293T C141(0.94)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C141(0.87); C268(1.04)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C141(1.33); C268(1.12)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C141(1.16)  LDD1563  [6]
 LDCM0326  AC62 HEK-293T C141(0.89); C268(1.13)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C141(0.98); C294(1.06)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C141(0.91); C294(0.90)  LDD1568  [6]
 LDCM0156  Aniline NCI-H1299 12.15  LDD0403  [3]
 LDCM0367  CL1 HEK-293T C268(1.15)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C141(1.65); C268(1.11)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C141(0.73)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C268(1.12)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C141(1.01)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C141(0.98)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C141(0.62)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C268(0.96)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C141(1.07)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C141(0.99)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C141(0.56)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C268(1.19)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C141(1.53); C294(1.03)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C141(0.51)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C141(0.83)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C141(0.52)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C268(1.09)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C141(1.20)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C141(0.93)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C141(0.59)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C268(1.08)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C141(0.99)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C141(1.06)  LDD1593  [6]
 LDCM0391  CL120 HEK-293T C141(0.60)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C268(1.13)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C141(1.12)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C141(1.68)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C141(0.62)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C268(1.22)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C141(1.01)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C141(1.03)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C141(0.57)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C268(1.10)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C141(1.18)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C141(1.44)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C141(0.62)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C141(0.91)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C141(1.12); C268(1.15)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C141(1.04)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C141(1.20)  LDD1612  [6]
 LDCM0410  CL22 HEK-293T C141(1.30); C268(1.30)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C141(1.63); C294(0.96)  LDD1615  [6]
 LDCM0413  CL25 HEK-293T C268(1.01)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C141(1.13)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C141(0.97)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C141(0.49)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C141(1.16)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C141(0.91)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C141(0.97); C268(1.08)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C141(1.08)  LDD1625  [6]
 LDCM0423  CL34 HEK-293T C141(1.23); C268(1.07)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C141(1.61); C294(1.07)  LDD1628  [6]
 LDCM0426  CL37 HEK-293T C268(0.98)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C141(0.91)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C141(0.65)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C141(0.51)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C141(1.14)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C141(1.02); C268(1.07)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C141(1.05)  LDD1638  [6]
 LDCM0436  CL46 HEK-293T C141(1.17); C268(1.28)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C141(1.23); C294(1.15)  LDD1641  [6]
 LDCM0439  CL49 HEK-293T C268(1.14)  LDD1643  [6]
 LDCM0441  CL50 HEK-293T C141(1.01)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C141(0.75)  LDD1646  [6]
 LDCM0445  CL54 HEK-293T C141(1.17)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C141(1.11); C268(1.11)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C141(1.35)  LDD1650  [6]
 LDCM0449  CL58 HEK-293T C141(1.37); C268(1.33)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C141(1.27); C294(1.16)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C141(1.22)  LDD1654  [6]
 LDCM0453  CL61 HEK-293T C268(1.11)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C141(1.09)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C141(0.89)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C141(0.77)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C141(1.14)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C141(0.88); C268(1.12)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C141(1.09)  LDD1663  [6]
 LDCM0462  CL7 HEK-293T C141(0.99); C268(1.04)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C141(1.01); C268(1.25)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C141(1.29); C294(1.34)  LDD1667  [6]
 LDCM0466  CL73 HEK-293T C268(1.09)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C141(1.04)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C141(0.68)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C141(1.05)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C141(1.03); C268(1.10)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C141(1.78)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C141(0.97)  LDD1677  [6]
 LDCM0476  CL82 HEK-293T C141(1.02); C268(1.23)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C141(1.15); C294(1.03)  LDD1680  [6]
 LDCM0479  CL85 HEK-293T C268(0.96)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C141(1.20)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C141(1.10)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C141(0.86)  LDD1685  [6]
 LDCM0485  CL90 HEK-293T C141(1.28)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C141(0.89); C268(0.95)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C141(1.07)  LDD1690  [6]
 LDCM0489  CL94 HEK-293T C141(1.01); C268(0.93)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C141(1.73); C294(0.90)  LDD1693  [6]
 LDCM0492  CL97 HEK-293T C268(1.09)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C141(1.02)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C141(0.93)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C141(1.08)  LDD1698  [6]
 LDCM0625  F8 Ramos C268(2.04)  LDD2187  [4]
 LDCM0574  Fragment12 Ramos C268(1.73)  LDD2191  [4]
 LDCM0576  Fragment14 Ramos C268(2.66)  LDD2193  [4]
 LDCM0580  Fragment21 Ramos C268(1.42)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C268(0.58)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C268(0.89)  LDD2197  [4]
 LDCM0588  Fragment30 Ramos C268(1.19)  LDD2199  [4]
 LDCM0590  Fragment32 Ramos C268(0.62)  LDD2201  [4]
 LDCM0468  Fragment33 HEK-293T C141(0.98)  LDD1671  [6]
 LDCM0596  Fragment38 Ramos C268(0.83)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C268(2.02)  LDD2184  [4]
 LDCM0427  Fragment51 HEK-293T C141(0.98)  LDD1631  [6]
 LDCM0614  Fragment56 Ramos C268(0.68)  LDD2205  [4]
 LDCM0022  KB02 HEK-293T C268(0.97)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C268(0.99)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C268(1.06)  LDD1502  [6]
 LDCM0109  NEM HeLa N.A.  LDD0225  [5]
 LDCM0090  Rapamycin JHH-7 4.12  LDD0213  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ5
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q7L5N7
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) Lipase family P54315
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) ATP-dependent AMP-binding enzyme family Q9ULC5
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Phosphatidate cytidylyltransferase 1 (CDS1) CDS family Q92903
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) Chondroitin N-acetylgalactosaminyltransferase family Q8N6G5
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
FAST kinase domain-containing protein 4 (TBRG4) FAST kinase family Q969Z0
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Transmembrane protein with metallophosphoesterase domain (TMPPE) LOC643853 family Q6ZT21
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) PA-phosphatase related phosphoesterase family Q8IY26
Sentrin-specific protease 2 (SENP2) Peptidase C48 family Q9HC62
Inactive ubiquitin thioesterase OTULINL (OTULINL) Peptidase C65 family Q9NUU6
Dehydrogenase/reductase SDR family member on chromosome X (DHRSX) Short-chain dehydrogenases/reductases (SDR) family Q8N5I4
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) V-ATPase proteolipid subunit family P27449
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Transporter and channel
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
Interferon-induced transmembrane protein 3 (IFITM3) CD225/Dispanin family Q01628
Derlin-1 (DERL1) Derlin family Q9BUN8
PRA1 family protein 2 (PRAF2) PRA1 family O60831
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Syntaxin-5 (STX5) Syntaxin family Q13190
Transmembrane protein 176A (TMEM176A) TMEM176 family Q96HP8
Transmembrane protein 218 (TMEM218) TMEM218 family A2RU14
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Protein YIPF1 (YIPF1) YIP1 family Q9Y548
Optineurin (OPTN) . Q96CV9
Proteolipid protein 2 (PLP2) . Q04941
Transmembrane protein 100 (TMEM100) . Q9NV29
Transmembrane protein 203 (TMEM203) . Q969S6
Transmembrane protein 60 (TMEM60) . Q9H2L4
Transmembrane protein 65 (TMEM65) . Q6PI78
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) Chemokine-like factor family Q96FZ5
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Other
Click To Hide/Show 43 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Actin-related protein 2/3 complex subunit 3 (ARPC3) ARPC3 family O15145
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492
BET1 homolog (BET1) BET1 family O15155
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
MAL-like protein (MALL) MAL family Q13021
Protein MAL2 (MAL2) MAL family Q969L2
MOB kinase activator 2 (MOB2) MOB1/phocein family Q70IA6
Nurim (NRM) Nurim family Q8IXM6
ORM1-like protein 2 (ORMDL2) ORM family Q53FV1
ORM1-like protein 3 (ORMDL3) ORM family Q8N138
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Vesicle transport protein SEC20 (BNIP1) SEC20 family Q12981
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Sideroflexin-3 (SFXN3) Sideroflexin family Q9BWM7
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Syntaxin-7 (STX7) Syntaxin family O15400
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Tumor protein p63-regulated gene 1 protein (TPRG1) TPRG1 family Q6ZUI0
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Coiled-coil domain-containing protein 167 (CCDC167) . Q9P0B6
Fertilization-influencing membrane protein (FIMP) . Q96LL3
LEM domain-containing protein 1 (LEMD1) . Q68G75
Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4) . O75427
Microspherule protein 1 (MCRS1) . Q96EZ8
Motile sperm domain-containing protein 3 (MOSPD3) . O75425
Signal-transducing adaptor protein 1 (STAP1) . Q9ULZ2
Transmembrane protein 222 (TMEM222) . Q9H0R3
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 42 (TMEM42) . Q69YG0

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570