Details of the Target

General Information of Target

Target ID LDTP13851
Target Name Exocyst complex component 6B (EXOC6B)
Gene Name EXOC6B
Gene ID 23233
Synonyms
KIAA0919; SEC15B; SEC15L2; Exocyst complex component 6B; Exocyst complex component Sec15B; SEC15-like protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFANLKYVSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAELLKIMACILLVYK
DSKCSLRALNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLK
ILTTALFSVSMLSKKLGVYQWLSLVILMTGVAFVQWPSDSQLDSKELSAGSQFVGLMAVL
TACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYIYDGELVSKNGFFQGY
NRLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTLISYFWLQDFVPTSVFFL
GAILVITATFLYGYDPKPAGNPTKA
Target Bioclass
Other
Family
SEC15 family
Function Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Uniprot ID
Q9Y2D4
Ensemble ID
ENST00000272427.11
HGNC ID
HGNC:17085

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L397H .
CAL148 SNV: p.R228T DBIA    Probe Info 
COLO678 SNV: p.R320G DBIA    Probe Info 
HT SNV: p.M6V .
IGROV1 SNV: p.Y594H DBIA    Probe Info 
IM95 SNV: p.R689W .
KARPAS422 SNV: p.S39A .
KPL1 SNV: p.G4A DBIA    Probe Info 
KYSE180 SNV: p.T381S DBIA    Probe Info 
KYSE30 SNV: p.I253V DBIA    Probe Info 
LN18 SNV: p.I405M DBIA    Probe Info 
LS180 SNV: p.Q698R DBIA    Probe Info 
MCF7 SNV: p.G4A .
NCIH1299 SNV: p.R689W .
NCIH1703 SNV: p.R121G .
OVCAR8 SNV: p.G349D .
PF382 SNV: p.D721G .
SUDHL6 SNV: p.D514Y .
SUIT2 SNV: p.V304I .
UACC257 SNV: p.P585L .
YSCCC SNV: p.E720Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K467(0.66); K547(9.09); K600(5.56); K770(8.61)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C32(2.03)  LDD0169  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C32(0.91)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C298(0.00); C137(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C298(0.00); C137(0.00); C68(0.00); C32(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C298(0.00); C706(0.00); C32(0.00); C137(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		C298(0.00); C706(0.00)  LDD0005  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C346
 Probe Info  		11.31  LDD2007  [11]
Alk-rapa
 Probe Info  		5.00  LDD0213  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C32(2.03)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C668(0.82); C672(0.82)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C668(0.89); C672(0.89); C706(0.83)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C32(0.93); C668(0.90); C706(0.93)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C32(0.87); C668(0.90); C706(0.87)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C32(0.96); C668(0.93); C706(0.96)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C32(0.91); C668(0.80); C706(0.91)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C32(0.95); C668(0.94); C706(0.95)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C32(0.93); C668(1.04); C706(0.93)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C32(1.20); C668(0.95); C706(1.20)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C32(0.99); C668(0.88); C706(0.99)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C32(0.88); C668(1.05); C706(0.88)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C32(0.94); C668(0.92); C706(0.94)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C668(0.78); C672(0.78); C706(0.80)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C32(1.11); C668(0.84); C706(1.11)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C32(1.44); C668(0.99); C706(1.44)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C32(1.14); C668(0.95); C706(1.14)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C668(0.89); C672(0.89)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C668(1.00); C672(1.00)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C668(1.07); C672(1.07)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C668(0.88); C672(0.88)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C668(0.95); C672(0.95)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C668(0.99); C672(0.99)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C668(0.97); C672(0.97)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C668(1.01); C672(1.01); C706(0.83)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C668(0.99); C672(0.99)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C668(1.41); C672(1.41)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C668(1.04); C672(1.04)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C668(1.21); C672(1.21)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C668(1.31); C672(1.31)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C668(1.10); C672(1.10)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C668(1.31); C672(1.31)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C668(1.29); C672(1.29)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C32(0.80); C668(0.83); C672(0.86); C706(0.80)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C32(0.71); C668(0.84); C672(0.73); C706(0.71)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C32(0.75); C668(0.86); C672(0.89); C706(0.75)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C32(0.95); C668(0.96); C672(1.00); C706(0.95)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C32(0.97); C668(0.79); C672(0.75); C706(0.97)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C32(0.76); C668(0.94); C672(1.11); C706(0.76)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C32(0.88); C668(0.94); C672(0.91); C706(0.88)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C32(0.73); C668(0.93); C672(1.03); C706(0.73)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C32(0.76); C668(0.95); C672(0.92); C706(0.76)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C32(0.80); C668(0.77); C672(0.87); C706(0.80)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C32(0.74); C668(0.80); C672(0.88); C706(0.74)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C32(0.78); C668(0.79); C672(0.84); C706(0.78)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C668(1.00); C672(1.00); C706(0.77)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C32(0.73); C668(0.82); C672(0.85); C706(0.73)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C32(0.75); C668(0.76); C672(0.76); C706(0.75)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C32(0.75); C668(0.78); C672(0.80); C706(0.75)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C32(1.09); C668(1.08); C672(1.34); C706(1.09)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C32(0.92); C668(0.89); C672(1.02); C706(0.92)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C32(0.88); C668(0.84); C672(0.95); C706(0.88)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C32(0.92); C668(0.99); C672(1.19); C706(0.92)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C32(0.80); C668(1.17); C672(1.59); C706(0.80)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C32(0.91); C668(1.03); C672(1.36); C706(0.91)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C32(0.80); C668(1.20); C672(1.49); C706(0.80)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C706(0.87); C668(1.08); C672(1.08)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C32(0.70); C668(1.05); C672(1.41); C706(0.70)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C32(0.81); C668(0.97); C672(1.16); C706(0.81)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C32(0.86); C668(1.09); C672(1.25); C706(0.86)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C32(0.83); C668(0.97); C672(1.14); C706(0.83)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C32(0.85); C668(1.31); C672(1.39); C706(0.85)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C32(0.86); C668(0.98); C672(1.08); C706(0.86)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C32(0.93); C668(0.84); C672(1.06); C706(0.93)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C32(1.30); C668(1.14); C672(1.45); C706(1.30)  LDD2165  [5]
 LDCM0276  AC17 HCT 116 C706(0.97); C668(1.04); C672(1.04)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C706(0.99); C668(0.99); C672(0.99)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C668(1.00); C672(1.00); C706(1.05)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C668(0.88); C672(0.88)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C706(0.92); C668(1.17); C672(1.17)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C706(0.85); C668(1.04); C672(1.04)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C706(0.96); C668(1.08); C672(1.08)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C706(0.87); C668(1.06); C672(1.06)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C706(0.90); C668(1.17); C672(1.17)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C706(1.00); C668(1.01); C672(1.01)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C668(0.95); C672(0.95); C706(1.21)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C668(0.93); C672(0.93); C706(1.01)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C668(0.97); C672(0.97); C706(1.18)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C668(0.79); C672(0.79); C706(1.05)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C668(0.90); C672(0.90)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C668(0.92); C672(0.92); C706(1.26)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C668(0.91); C672(0.91); C706(1.07)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C668(0.84); C672(0.84); C706(1.06)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C668(0.91); C672(0.91); C706(1.13)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C668(0.88); C672(0.88); C706(1.14)  LDD0612  [5]
 LDCM0296  AC35 PaTu 8988t C668(0.77); C672(0.77)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C668(0.74); C672(0.74)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C668(0.79); C672(0.79)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C668(0.81); C672(0.81)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C668(0.78); C672(0.78)  LDD1179  [5]
 LDCM0301  AC4 HCT 116 C668(0.78); C672(0.78)  LDD0618  [5]
 LDCM0302  AC40 PaTu 8988t C668(0.72); C672(0.72)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C668(0.91); C672(0.91)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C668(0.93); C672(0.93)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C668(0.80); C672(0.80)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C668(0.84); C672(0.84)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C668(0.82); C672(0.82)  LDD1186  [5]
 LDCM0308  AC46 HCT 116 C668(1.07); C672(1.07); C706(1.09)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C706(0.90); C668(1.09); C672(1.09)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C706(1.01); C668(1.18); C672(1.18)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C668(0.99); C672(0.99); C706(1.07)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C668(0.80); C672(0.80)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C706(0.76); C668(1.08); C672(1.08)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C706(0.86); C668(1.19); C672(1.19)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C668(0.95); C672(0.95); C706(1.08)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C706(0.86); C668(1.30); C672(1.30)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C706(0.95); C668(1.36); C672(1.36)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C706(0.88); C668(1.25); C672(1.25)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C706(0.83); C668(1.28); C672(1.28)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C668(1.08); C672(1.08)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C668(1.05); C672(1.05)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C668(0.97); C672(0.97)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C706(0.76); C668(0.78); C672(0.78)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C668(0.91); C672(0.91)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C668(1.21); C672(1.21)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C668(1.09); C672(1.09)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C668(1.15); C672(1.15)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C668(1.14); C672(1.14)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C668(0.98); C672(0.98)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C668(1.12); C672(1.12)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C668(0.92); C672(0.92)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C32(0.82); C668(0.97); C672(0.97)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C32(0.56); C668(1.17); C672(1.17)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C668(0.89); C672(0.89); C706(0.93)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C32(0.78); C668(1.01); C672(1.01)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C32(0.69); C668(1.17); C672(1.17)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C32(0.78); C668(0.90); C672(0.90)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C668(0.84); C672(0.84); C32(0.92)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C32(0.73); C668(1.06); C672(1.06)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C32(0.73); C668(1.30); C672(1.30)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C32(0.65); C668(0.96); C672(0.96)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C32(1.02); C668(1.04); C672(1.04)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C32(0.76); C668(1.09); C672(1.09)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C32(0.75); C668(1.14); C672(1.14)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C668(0.97); C672(0.97); C706(0.99)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C32(1.07); C668(1.22); C672(1.22)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C32(0.77); C668(1.02); C672(1.02)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C32(0.94); C668(1.18); C672(1.18)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C668(0.93); C672(0.93); C32(1.09)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C668(0.94); C672(0.94); C32(0.97)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C668(0.97); C672(0.97); C32(1.01)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C668(0.91); C672(0.91); C32(0.96)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C32(0.85); C668(1.00); C672(1.00)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C32(0.82); C668(1.07); C672(1.07)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C32(0.83); C668(0.96); C672(0.96)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C668(0.94); C672(0.94); C32(0.96)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C32(0.97); C668(1.12); C672(1.12)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C32(1.03); C668(1.20); C672(1.20)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C668(1.07); C672(1.07); C32(1.20)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C32(0.97); C668(1.20); C672(1.20)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C668(0.89); C672(0.89); C32(0.96)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C32(1.10); C668(1.18); C672(1.18)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C668(0.87); C672(0.87); C32(1.00)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C32(1.20); C668(0.99); C706(1.20)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C32(0.98); C668(1.04); C706(0.98)  LDD0964  [5]
 LDCM0248  AKOS034007472 HCT 116 C668(1.00); C672(1.00); C706(1.05)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C706(0.78); C668(0.99); C672(0.99)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C668(0.93); C672(0.93); C706(1.17)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C32(0.91)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C668(0.71); C672(0.71); C706(1.20)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C668(0.90); C672(0.90); C706(0.96)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C668(0.84); C672(0.84)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C706(0.83); C668(0.86); C672(0.86)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C706(0.72); C668(0.98); C672(0.98)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C706(0.96); C668(1.01); C672(1.01)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C706(0.78); C668(1.02); C672(1.02)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C706(0.80); C668(0.96); C672(0.96)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C668(0.98); C672(0.98); C706(0.99)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C668(0.97); C672(0.97); C706(1.09)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C706(0.95); C668(0.98); C672(0.98)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C706(0.92); C668(0.95); C672(0.95)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C668(0.98); C672(0.98); C706(1.12)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C668(0.99); C672(0.99); C706(1.02)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C706(0.92); C668(1.01); C672(1.01)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C668(1.02); C672(1.02); C706(1.09)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C668(0.87); C672(0.87); C706(1.13)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C668(0.83); C672(0.83); C706(1.18)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C668(0.84); C672(0.84); C706(1.09)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C668(0.95); C672(0.95); C706(1.23)  LDD0703  [5]
 LDCM0387  CL117 PaTu 8988t C668(0.85); C672(0.85)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C668(1.18); C672(1.18)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C668(0.91); C672(0.91)  LDD1268  [5]
 LDCM0390  CL12 HCT 116 C706(1.32); C668(1.32); C672(1.32)  LDD0707  [5]
 LDCM0391  CL120 PaTu 8988t C668(0.75); C672(0.75)  LDD1270  [5]
 LDCM0392  CL121 HCT 116 C706(0.75); C668(1.22); C672(1.22)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C706(0.86); C668(1.24); C672(1.24)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C706(0.86); C668(1.47); C672(1.47)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C706(0.93); C668(1.20); C672(1.20)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C668(0.95); C672(0.95)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C668(0.92); C672(0.92)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C668(0.99); C672(0.99)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C668(1.05); C672(1.05)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C668(0.79); C672(0.79); C706(1.05)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C668(0.74); C672(0.74); C706(0.95)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C668(0.77); C672(0.77); C706(1.04)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C706(0.89); C32(0.95); C668(0.99); C672(0.99)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C668(0.82); C672(0.82); C706(1.18)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C668(0.82); C672(0.82); C706(1.03)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C668(0.97); C672(0.97); C706(1.02)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C668(0.90); C672(0.90); C706(0.91)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C668(0.93); C672(0.93); C706(1.11)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C668(1.03); C672(1.03); C706(1.16)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C706(1.23); C668(1.29); C672(1.29)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C706(0.90); C668(0.90); C672(0.90)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C668(1.07); C672(1.07); C706(1.25)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C668(1.03); C672(1.03); C706(1.12)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C668(0.90); C672(0.90); C706(1.17)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C668(0.94); C672(0.94); C706(1.12)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C668(1.05); C672(1.05); C706(0.96)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C668(0.93); C672(0.93); C706(1.45)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C668(0.84); C672(0.84); C706(0.89)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C668(0.94); C672(0.94); C706(1.08)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C32(0.70); C668(0.71); C672(0.71); C706(0.82)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C32(0.86); C668(0.67); C672(0.67); C706(0.97)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C32(0.83); C668(0.72); C672(0.72); C706(0.54)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C32(0.80); C668(0.81); C672(0.81); C706(0.76)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C32(0.89); C668(0.94); C672(0.94); C706(1.08)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C32(0.84); C668(0.78); C672(0.78); C706(1.18)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C32(0.99); C668(0.87); C672(0.87); C706(0.67)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C32(0.84); C668(0.88); C672(0.88); C706(0.87)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C668(1.04); C672(1.04); C706(0.88)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C32(0.94); C668(0.85); C672(0.85); C706(0.85)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C32(0.86); C668(0.73); C672(0.73); C706(0.84)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C32(0.78); C668(0.98); C672(0.98); C706(1.29)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C32(0.83); C668(0.96); C672(0.96); C706(0.87)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C32(0.87); C668(0.79); C672(0.79); C706(0.95)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C32(0.84); C668(0.85); C672(0.85); C706(1.19)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C32(0.89); C706(1.17)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C32(1.11); C706(0.97)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C32(1.10); C706(0.93)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C32(0.86); C706(1.38)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C668(1.12); C672(1.12); C706(1.13)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C32(0.88); C706(1.06)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C32(0.89); C706(1.08)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C32(0.91); C706(0.91)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C32(0.94); C706(1.15)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C32(1.20); C706(1.25)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C32(0.72); C706(0.99)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C32(0.88); C706(1.01)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C32(1.02); C706(0.73)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C32(0.85); C706(1.16)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C32(0.82); C706(0.88)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C668(0.67); C672(0.67); C706(1.11)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C32(0.97); C706(1.13)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C668(0.93); C672(0.93); C706(0.92)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C668(0.87); C672(0.87); C706(0.91)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C668(0.86); C672(0.86); C706(0.86)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C668(0.91); C672(0.91); C706(0.76)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C668(0.92); C672(0.92); C706(1.05)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C668(0.99); C672(0.99); C706(0.82)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C668(0.90); C672(0.90); C706(0.75)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C668(0.68); C672(0.68); C706(0.76)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C668(0.72); C672(0.72); C706(0.95)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C668(0.94); C672(0.94); C706(1.03)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C668(0.74); C672(0.74); C706(0.83)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C668(0.77); C672(0.77); C706(0.95)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C668(1.01); C672(1.01); C706(1.13)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C668(0.94); C672(0.94); C706(1.10)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C668(0.80); C672(0.80); C706(0.86)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C668(0.63); C672(0.63); C706(1.07)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C668(0.75); C672(0.75); C706(1.41)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C668(0.70); C672(0.70); C706(1.53)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C668(0.81); C672(0.81); C706(1.23)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C668(0.92); C672(0.92); C706(1.17)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C668(0.70); C672(0.70); C706(1.40)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C668(0.80); C672(0.80); C706(1.44)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C668(0.90); C672(0.90); C706(1.39)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C668(0.75); C672(0.75); C706(1.09)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C668(0.91); C672(0.91); C706(1.35)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C668(0.80); C672(0.80); C706(1.29)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C668(0.77); C672(0.77); C706(1.19)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C668(0.79); C672(0.79); C706(1.18)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C668(0.84); C672(0.84); C706(1.23)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C668(1.04); C672(1.04); C706(1.32)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C668(0.75); C672(0.75); C706(1.03)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C668(0.79); C672(0.79); C706(1.30)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C668(0.91); C672(0.91)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C668(0.88); C672(0.88)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C668(0.88); C672(0.88)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C668(0.78); C672(0.78)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C668(0.82); C672(0.82)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C668(0.86); C672(0.86)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C668(0.88); C672(0.88)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C668(0.80); C672(0.80)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C668(0.90); C672(0.90)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C32(0.94); C68(0.86); C137(0.87)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C298(3.06); C392(0.72)  LDD1702  [14]
 LDCM0468  Fragment33 HCT 116 C668(0.86); C672(0.86); C706(0.91)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C32(0.67); C668(0.95); C672(0.95); C706(1.25)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C32(1.70)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C32(1.52)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C32(1.40)  LDD0082  [5]
 LDCM0090  Rapamycin JHH-7 5.00  LDD0213  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 5 (EXOC5) SEC10 family O00471

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761