Details of the Target

General Information of Target

Target ID LDTP13408
Target Name Cell division cycle protein 23 homolog (CDC23)
Gene Name CDC23
Gene ID 8697
Synonyms
ANAPC8; Cell division cycle protein 23 homolog; Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKPDAIHPHPLLQRKLTEA
PGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRKEHAIPHV
VLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKRRGLRNSRATAGDIAHYYR
DYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQDSSPLFQVSGFLTRNQAQQPFSLWAR
NVVLATGTFDSPARLGIPGEALPFIHHELSALEAATRVGAVTPASDPVLIIGAGLSAADA
VLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMMREQSILSPSPYEGYRS
LPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPL
SAKRNPIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALAVASSLLRKETRKPP
Target Bioclass
Enzyme
Family
APC8/CDC23 family
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Uniprot ID
Q9UJX2
Ensemble ID
ENST00000394884.7
HGNC ID
HGNC:1724

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.M1? DBIA    Probe Info 
EFO27 SNV: p.R557Q DBIA    Probe Info 
HGC27 Deletion: p.K130del DBIA    Probe Info 
HT29 SNV: p.E245Ter .
KP4 SNV: p.Q82R DBIA    Probe Info 
KYSE410 SNV: p.R330C DBIA    Probe Info 
MCC13 SNV: p.S304F DBIA    Probe Info 
MFE319 SNV: p.G139A DBIA    Probe Info 
NCIN87 Substitution: p.H426T DBIA    Probe Info 
SW1271 SNV: p.D293Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.77  LDD0402  [1]
TH211
 Probe Info  		Y460(5.21)  LDD0257  [2]
STPyne
 Probe Info  		K453(0.85)  LDD0277  [3]
IPM
 Probe Info  		C489(0.00); C532(0.00); C536(0.00); C537(0.00)  LDD0241  [4]
BTD
 Probe Info  		C109(1.21)  LDD2093  [5]
AHL-Pu-1
 Probe Info  		C500(2.69)  LDD0168  [6]
DBIA
 Probe Info  		C536(1.17); C537(1.17); C334(0.90); C335(0.90)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C109(0.00); C489(0.00); C532(0.00); C500(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C489(0.00); C532(0.00); C324(0.00); C442(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C324(0.00); C442(0.00); C532(0.00); C418(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C489(0.00); C532(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		C532(0.00); C442(0.00)  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [4]
AOyne
 Probe Info  		14.60  LDD0443  [12]
NAIA_5
 Probe Info  		C109(0.00); C532(0.00); C442(0.00); C324(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C161
 Probe Info  		19.56  LDD1841  [13]
C165
 Probe Info  		13.45  LDD1845  [13]
C196
 Probe Info  		10.78  LDD1872  [13]
C228
 Probe Info  		25.81  LDD1901  [13]
C293
 Probe Info  		27.28  LDD1963  [13]
C350
 Probe Info  		26.91  LDD2011  [13]
C429
 Probe Info  		11.39  LDD2084  [13]
FFF probe13
 Probe Info  		17.81  LDD0476  [14]
FFF probe3
 Probe Info  		20.00  LDD0465  [14]
Alk-rapa
 Probe Info  		6.49  LDD0213  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C109(1.27)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C500(2.69)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C500(3.46)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C109(1.33); C489(1.05); C532(1.14); C536(1.03)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C418(1.45); C489(1.03); C536(1.42); C537(0.99)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C109(0.50); C418(0.87); C489(0.84); C536(0.75)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C109(0.56); C418(0.70); C489(0.79); C536(0.80)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C109(0.58); C418(0.82); C489(0.87); C536(0.73)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C109(0.50); C418(0.73); C489(0.81); C536(0.74)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C109(0.56); C418(0.70); C489(0.81); C536(0.64)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C109(0.48); C418(0.81); C489(0.85); C536(0.82)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C109(0.56); C418(0.78); C489(0.83); C536(0.81)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C109(0.57); C418(0.83); C489(0.79); C536(0.72)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C109(0.58); C418(0.69); C489(0.87); C536(0.72)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C109(0.60); C418(0.92); C489(0.91); C536(0.79)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C418(1.55); C489(1.02); C536(1.11); C537(0.89)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C109(0.54); C418(0.91); C489(0.97); C536(0.69)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C109(0.57); C418(0.88); C489(0.85); C536(0.66)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C109(0.51); C418(0.88); C489(0.75); C536(0.73)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C109(1.07); C418(0.96); C489(0.99); C536(1.12)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C109(1.15); C418(0.92); C489(0.89); C536(1.17)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C109(0.93); C418(0.92); C489(0.89); C536(1.01)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C109(0.98); C418(0.71); C489(1.09); C536(1.01)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C109(1.17); C418(0.55); C489(1.06); C536(1.10)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C109(1.14); C418(0.64); C489(0.97); C536(1.18)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C109(1.75); C418(0.44); C489(1.08); C536(1.02)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C418(1.13); C489(1.03); C536(1.07); C537(0.89)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C109(1.24); C418(2.19); C489(1.08); C536(0.75)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C109(1.63); C418(1.43); C489(0.98); C536(1.10)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C109(0.98); C418(0.82); C489(1.05); C536(1.02)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C109(2.90); C418(1.64); C489(1.04); C536(1.20)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C109(1.33); C418(0.90); C489(1.10); C536(1.09)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C109(1.01); C418(1.56); C489(0.99); C536(1.24)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C109(1.21); C418(1.14); C489(1.13); C536(1.10)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C109(1.22); C418(0.89); C489(1.02); C536(1.22)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C109(1.11); C418(0.87); C489(1.01); C536(1.33)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C109(0.89); C418(0.74); C489(0.86); C536(1.63)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C109(0.84); C418(0.70); C489(0.87); C536(1.40)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C109(0.86); C418(1.26); C489(0.89); C536(1.33)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C109(1.20); C418(0.73); C489(1.05); C536(1.62)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C109(0.98); C418(0.62); C489(0.95); C536(1.36)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C109(1.06); C418(0.74); C489(0.96); C536(1.65)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C109(1.09); C418(0.83); C489(0.80); C536(1.52)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C109(1.14); C418(0.67); C489(0.93); C536(1.20)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C109(1.17); C418(0.70); C489(1.05); C536(1.21)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C109(1.17); C418(1.07); C489(1.02); C536(1.32)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C109(1.13); C418(0.76); C489(0.97); C536(1.51)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C418(2.21); C489(1.03); C536(1.15); C537(1.00)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C109(1.16); C418(0.75); C489(0.96); C536(1.72)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C109(1.14); C418(1.05); C489(0.91); C536(1.26)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C109(1.13); C418(0.65); C489(0.94); C536(1.40)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C109(0.77); C418(1.23); C489(0.89); C532(0.89)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C109(0.49); C489(0.61); C532(0.73); C418(0.91)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C109(0.60); C489(0.89); C532(0.90); C536(1.18)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C109(0.52); C489(0.83); C532(0.95); C536(1.15)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C109(0.54); C489(0.62); C532(0.79); C537(0.97)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C109(0.48); C489(0.77); C532(0.80); C537(1.19)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C109(0.52); C489(0.77); C532(1.01); C537(1.14)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C489(0.96); C537(1.11); C536(1.33); C418(1.84)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C109(0.75); C489(0.83); C537(0.98); C532(1.01)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C489(0.64); C109(0.69); C532(0.82); C418(0.83)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C109(0.57); C532(0.80); C489(0.84); C536(0.96)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C109(0.49); C532(0.90); C489(0.97); C418(1.07)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C109(0.52); C418(1.22); C489(0.75); C532(0.80)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C109(0.54); C418(0.82); C489(0.69); C532(0.81)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C109(0.68); C418(1.25); C489(0.84); C532(0.85)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C109(0.71); C418(1.29); C489(0.68); C532(0.80)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C537(0.88); C109(0.90); C536(0.95); C500(1.01)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C537(0.80); C536(0.84); C109(0.98); C500(1.15)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C109(0.85); C537(0.91); C536(0.96); C489(1.09)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C536(0.99); C109(1.02); C489(1.05); C537(1.05)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C109(0.86); C489(0.89); C536(1.00); C537(1.01)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C537(0.83); C536(0.84); C109(0.97); C489(0.99)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C537(0.83); C536(0.86); C109(0.90); C489(0.94)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C109(0.88); C500(0.89); C489(0.92); C537(1.00)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C109(0.85); C489(1.02); C500(1.07); C536(1.14)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C109(0.89); C489(0.95); C536(1.13); C532(1.23)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C109(0.79); C489(0.96); C532(1.07); C536(1.07)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C109(0.80); C532(0.87); C489(0.98); C536(1.13)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C109(0.81); C537(1.00); C536(1.01); C489(1.01)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C109(0.75); C489(0.94); C532(0.98); C536(1.07)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C532(1.11); C109(1.14); C489(1.15); C536(1.23)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C109(0.77); C536(1.00); C489(1.00); C532(1.01)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C109(0.71); C532(0.94); C489(1.05); C536(1.22)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C109(0.71); C489(0.97); C532(1.03); C536(1.17)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C109(0.72); C489(0.94); C532(0.97); C536(1.02)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C109(0.71); C532(0.97); C489(1.00); C537(1.01)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C500(0.66); C537(0.70); C536(0.72); C532(0.90)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C500(0.66); C532(0.88); C537(0.92); C489(0.92)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C500(0.54); C489(0.87); C532(0.97); C537(0.98)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C500(0.78); C532(0.89); C537(0.91); C489(0.91)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C500(0.67); C532(0.86); C489(0.90); C537(0.95)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C536(1.18); C537(1.20); C489(1.20); C532(1.25)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C500(0.74); C532(0.92); C489(0.94); C109(1.08)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C500(0.68); C489(0.88); C537(0.89); C532(0.90)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C500(0.65); C532(0.87); C489(0.95); C536(0.97)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C500(0.74); C537(0.83); C536(0.86); C489(0.87)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C500(0.79); C489(0.92); C537(1.04); C536(1.05)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C500(0.71); C537(0.91); C489(0.93); C536(0.97)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C532(0.86); C109(0.93); C537(0.99); C489(1.03)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C418(0.72); C532(0.88); C109(0.98); C489(1.00)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C418(0.68); C109(0.79); C489(0.81); C532(0.89)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C532(0.81); C537(0.92); C418(0.96); C536(0.99)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C537(1.07); C536(1.10); C489(1.23); C532(1.25)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C418(0.75); C532(0.82); C109(0.89); C489(0.97)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C532(0.77); C489(0.99); C537(1.08); C109(1.13)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C418(0.68); C532(0.73); C489(0.97); C109(1.03)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C532(0.81); C418(0.88); C109(0.89); C489(1.05)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C532(0.86); C537(0.88); C418(0.91); C536(0.95)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C418(0.72); C532(0.84); C109(0.88); C489(1.00)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C418(0.78); C109(0.85); C532(0.90); C537(1.20)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C109(0.88); C500(0.94); C536(1.06); C537(1.06)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C109(0.77); C418(0.79); C500(0.90); C536(1.12)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C489(0.77); C109(0.91); C500(0.97); C418(0.99)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C537(0.74); C489(0.91); C536(1.13); C418(1.30)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C489(0.68); C109(0.71); C536(1.06); C418(1.08)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C109(0.73); C500(0.93); C489(1.06); C536(1.07)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C489(0.76); C109(0.88); C500(0.99); C418(1.04)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C109(0.77); C418(0.83); C489(0.87); C500(1.03)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C489(0.82); C109(0.84); C500(1.00); C537(1.08)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C489(0.80); C109(0.96); C500(1.09); C536(1.19)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C489(0.89); C109(0.92); C500(0.98); C418(1.03)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C109(0.68); C489(0.96); C500(0.97); C537(1.07)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C500(0.89); C109(0.99); C418(1.01); C537(1.04)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C500(0.94); C109(1.00); C418(1.03); C489(1.04)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C489(0.88); C537(0.97); C418(1.33); C536(1.45)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C418(0.44); C536(0.99); C537(1.04); C109(1.10)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C418(0.78); C500(0.88); C109(1.11); C537(1.17)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C418(0.66); C109(1.03); C500(1.04); C537(1.16)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C418(0.58); C109(0.93); C500(1.17); C536(1.34)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C418(0.72); C500(0.95); C109(1.03); C537(1.24)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C418(0.70); C109(0.89); C500(0.97); C537(1.21)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C418(0.78); C500(0.91); C109(0.99); C537(1.28)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C109(0.89); C500(0.96); C489(1.01); C418(1.08)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C418(0.73); C500(0.97); C109(0.98); C536(1.14)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C418(0.64); C109(1.02); C500(1.12); C537(1.23)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C537(0.92); C489(0.95); C536(1.08); C418(1.39)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C418(0.72); C109(0.89); C500(0.97); C489(1.06)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C418(0.82); C500(1.06); C536(1.08); C537(1.11)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C418(0.58); C109(0.93); C500(1.08); C537(1.30)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C418(0.29); C536(0.76); C109(0.77); C537(0.80)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C536(0.60); C537(0.63); C418(0.64); C109(0.77)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C418(0.40); C536(0.60); C537(0.63); C109(0.86)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C418(0.31); C109(0.82); C536(0.88); C537(0.89)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C418(0.37); C109(0.94); C537(0.95); C536(0.96)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C418(0.35); C536(0.66); C537(0.67); C109(0.87)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C418(0.24); C109(0.81); C537(1.13); C536(1.14)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C418(0.31); C537(0.77); C536(0.81); C109(0.88)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C418(0.31); C536(0.75); C537(0.75); C109(0.81)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C418(0.23); C537(0.77); C109(0.77); C536(0.80)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C418(0.71); C537(0.74); C536(0.74); C109(0.81)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C537(0.62); C536(0.66); C109(0.85); C418(0.89)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C418(0.34); C536(0.74); C537(0.74); C109(0.81)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C537(0.76); C109(0.81); C418(0.83); C536(0.83)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C418(0.22); C537(0.61); C536(0.65); C109(0.79)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C109(0.36); C537(0.62); C536(0.68); C418(0.69)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C537(0.69); C109(0.71); C536(0.75); C418(0.81)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C418(1.31); C489(1.04); C536(1.21); C537(0.88)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C489(0.91); C537(1.06); C418(1.21); C536(1.53)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C489(1.01); C537(1.04); C536(1.16); C418(1.83)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C536(1.17); C537(1.17); C334(0.90); C335(0.90)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa C324(0.00); C442(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C532(20.00); C324(0.47)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C532(0.93); C489(1.03); C109(1.15); C536(1.18)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C532(0.87); C109(0.87); C489(0.97); C537(1.11)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C536(1.05); C489(1.12); C537(1.13); C532(1.17)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C537(0.83); C489(0.89); C536(1.09); C418(2.53)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C489(0.90); C537(0.96); C536(1.20); C418(2.67)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C489(1.00); C537(1.14); C536(1.16); C418(2.61)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C489(0.98); C537(1.04); C536(1.17); C418(2.36)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C109(1.03); C500(1.04); C489(1.08); C537(1.12)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C537(0.81); C536(0.90); C109(1.06); C489(1.33)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C489(0.90); C537(0.95); C536(0.97); C109(0.99)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C537(0.86); C536(0.91); C489(1.05); C109(1.13)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C109(0.80); C537(0.92); C536(0.95); C489(0.99)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C109(0.88); C532(0.90); C489(0.93); C537(1.12)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C109(0.84); C537(0.91); C536(0.95); C489(1.13)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C537(0.78); C109(0.80); C536(0.80); C489(1.07)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C109(0.86); C536(0.89); C489(0.94); C532(0.96)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C109(0.71); C537(0.98); C532(0.98); C536(1.03)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C109(0.76); C532(0.91); C489(0.92); C536(1.18)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C109(0.80); C489(0.94); C536(0.98); C532(1.07)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C532(0.89); C109(0.89); C489(1.01); C536(1.24)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C532(0.84); C536(0.92); C537(0.92); C489(1.02)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C537(0.85); C532(0.85); C536(0.86); C489(0.90)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C500(0.76); C537(0.79); C536(0.83); C489(0.87)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C532(0.99); C489(1.04); C109(1.05); C537(1.13)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C489(0.88); C537(0.90); C536(0.93); C532(0.97)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C418(0.54); C109(0.76); C489(0.78); C532(0.88)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C532(0.77); C418(0.82); C109(0.87); C537(1.00)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C532(0.75); C109(0.90); C489(1.09); C537(1.14)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C532(0.83); C537(0.87); C418(0.92); C109(0.94)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C489(0.83); C418(0.91); C537(1.01); C536(1.02)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C418(0.85); C109(0.88); C489(0.91); C500(0.93)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C500(0.91); C109(0.96); C418(1.00); C537(1.06)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C109(0.89); C537(1.06); C536(1.07); C500(1.08)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C109(0.78); C489(0.88); C532(1.02); C537(1.09)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C489(0.99); C532(0.99); C109(1.08); C537(1.21)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C109(0.83); C489(0.93); C532(0.99); C537(1.36)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C109(0.74); C532(0.77); C418(0.79); C536(0.84)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C418(0.62); C532(0.70); C109(0.78); C489(0.95)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C109(0.51); C532(0.65); C489(0.71); C418(0.74)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C109(0.63); C532(0.65); C489(0.81); C418(0.81)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C532(0.83); C489(1.00); C109(1.04); C537(1.13)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C109(0.66); C489(0.82); C418(0.86); C532(0.91)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C109(0.57); C532(0.76); C489(0.86); C418(0.95)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C109(0.61); C532(0.82); C536(0.98); C489(1.13)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C109(0.72); C532(0.77); C489(0.80); C536(0.89)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C109(0.63); C532(0.73); C489(0.87); C418(0.90)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C109(0.68); C418(0.77); C489(0.81); C532(0.89)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C109(0.65); C418(0.91); C489(0.82); C532(0.81)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C109(0.67); C418(0.78); C489(0.80); C532(0.90)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C109(0.58); C418(0.70); C489(0.86); C532(0.84)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C109(0.64); C418(1.02); C489(0.97); C532(0.78)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C109(1.05); C489(0.91); C532(1.02); C536(1.07)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C109(0.67); C418(0.97); C489(0.91); C532(0.65)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C109(0.92); C418(0.75); C489(1.01); C532(0.82)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C109(0.85); C489(0.97); C532(0.86); C536(1.02)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C109(0.80); C489(0.93); C532(0.83); C536(1.30)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C109(0.88); C489(1.18); C532(0.78); C536(1.08)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C109(0.80); C489(1.06); C532(0.74); C536(1.19)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C109(0.75); C489(1.02); C532(0.82); C536(1.11)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C109(0.76); C489(1.08); C532(0.74); C536(1.19)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C109(0.87); C489(1.07); C532(0.85); C536(1.20)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C109(1.07); C489(1.01); C532(1.01); C536(1.16)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C109(0.77); C489(1.03); C532(0.78); C536(1.11)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C109(0.71); C489(1.07); C532(1.00); C536(1.20)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C109(0.82); C489(1.16); C532(0.71); C536(1.13)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C109(0.68); C489(1.09); C532(0.78); C536(1.14)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C109(0.75); C489(1.05); C532(0.83); C536(1.18)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C109(0.82); C489(0.92); C532(0.77); C536(1.05)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C418(0.55); C489(0.81); C536(1.33); C537(1.19)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C418(0.61); C489(0.72); C536(1.17); C537(1.13)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C418(1.00); C489(0.79); C536(1.04); C537(1.10)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C418(0.63); C489(0.82); C536(1.22); C537(1.13)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C109(1.06); C489(1.00); C532(1.04); C536(1.20)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C418(1.25); C489(0.70); C536(1.34); C537(1.23)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C418(0.57); C489(0.79); C536(1.29); C537(1.31)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C418(1.17); C489(0.74); C536(1.53); C537(1.48)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C418(3.05); C489(0.84); C536(1.21); C537(1.28)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C418(2.14); C489(0.68); C536(1.92); C537(1.55)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C418(1.24); C489(0.70); C536(1.21); C537(1.19)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C418(2.59); C489(0.95); C536(1.16); C537(1.21)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C418(1.33); C489(0.94); C536(1.36); C537(1.40)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C418(2.97); C489(0.72); C536(1.17); C537(1.13)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C418(1.19); C489(0.97); C536(1.23); C537(1.22)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C109(0.92); C489(0.91); C532(0.91); C536(1.00)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C418(1.14); C489(0.83); C536(1.06); C537(1.02)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C109(0.86); C489(1.07); C500(1.03); C536(1.15)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C109(0.92); C489(0.98); C500(0.95); C536(1.09)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C109(0.93); C489(1.12); C500(1.25); C536(1.15)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C109(0.89); C489(1.13); C500(1.53); C536(1.19)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C109(0.96); C489(1.08); C500(1.46); C536(1.27)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C109(0.90); C489(1.23); C500(1.59); C536(1.10)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C109(0.95); C489(1.27); C500(1.18); C536(1.22)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C109(0.82); C489(1.06); C500(1.59); C536(1.24)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C109(0.78); C489(0.95); C500(0.88); C536(1.11)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C109(0.97); C489(1.02); C532(0.89); C536(1.21)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C109(0.77); C489(1.06); C500(1.17); C536(1.24)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C109(0.86); C489(1.08); C500(1.55); C536(1.03)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C109(0.92); C489(1.13); C500(1.12); C536(1.11)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C109(0.83); C489(1.26); C500(1.54); C536(1.16)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C109(0.88); C489(1.18); C500(1.19); C536(1.13)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C109(0.71); C418(1.84); C489(1.01); C536(0.89)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C109(0.78); C418(2.98); C489(0.94); C536(0.76)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C109(0.78); C418(1.93); C489(0.93); C536(0.77)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C109(0.75); C418(1.24); C489(0.99); C536(0.94)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C109(1.01); C489(1.05); C532(1.00); C536(1.14)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C109(0.75); C418(0.89); C489(0.96); C536(0.87)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C109(0.81); C418(0.97); C489(0.96); C536(0.90)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C109(0.73); C418(0.88); C489(1.05); C536(0.74)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C109(0.72); C418(1.01); C489(1.00); C536(0.83)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C109(0.71); C418(0.98); C489(1.05); C536(0.95)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C109(0.77); C418(1.46); C489(0.98); C536(0.88)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C109(0.84); C418(1.78); C489(0.95); C536(0.94)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C109(0.82); C418(1.72); C489(0.95); C536(0.87)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C109(0.70); C418(2.33); C489(1.06); C536(0.86)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C109(0.69); C418(1.58); C489(1.31); C536(0.99)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C109(1.09); C489(1.00); C532(0.98); C536(1.04)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C109(0.95); C418(1.42); C489(1.15); C536(0.96)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C109(0.99); C489(1.07); C532(0.95); C536(1.01)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C109(1.00); C489(0.97); C532(0.81); C536(1.04)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C109(1.21); C489(0.97); C532(1.08); C536(0.96)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C109(1.15); C489(0.99); C532(1.12); C536(1.14)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C109(1.02); C489(0.98); C532(0.93); C536(1.00)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C109(1.08); C489(0.90); C532(0.95); C536(1.01)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C109(0.97); C489(1.04); C532(0.98); C536(0.93)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C109(1.11); C489(1.13); C532(1.12); C536(1.07)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C109(1.12); C489(1.13); C532(0.92); C536(1.04)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C109(0.99); C532(0.91); C442(1.02); C324(0.85)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C536(5.79); C489(2.97)  LDD1702  [5]
 LDCM0625  F8 Ramos C532(1.41)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C532(0.57)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C532(1.46); 1.45; C489(2.17)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C532(1.02)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C532(0.97); C489(1.13)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C532(0.89); C489(1.34)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C532(0.97)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C532(0.92); 0.79; C489(1.00)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C532(0.90); C489(0.73)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C532(0.92); C489(1.26)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C532(1.03); C489(1.24)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C532(0.98); C489(1.23)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C532(0.90); C489(1.20)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C532(0.55); C489(0.97)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C109(0.88); C489(1.07); C500(1.17); C536(0.95)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C532(1.01); 0.62; C489(1.25)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C532(0.99)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C109(0.72); C489(0.94); C532(0.79); C536(1.01)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C532(1.56); C489(2.47)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C532(1.26); C489(0.99)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C532(1.04)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C532(0.76)  LDD2188  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C500(1.32); C536(1.45); C537(1.45)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C500(1.48); C536(1.88); C537(1.88)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C500(1.49); C536(1.22); C537(1.22)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C109(1.21)  LDD2093  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C109(1.04)  LDD2111  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C109(1.19)  LDD2119  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C109(0.90)  LDD2140  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C489(1.35)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C489(0.19)  LDD2207  [18]
 LDCM0090  Rapamycin JHH-7 6.49  LDD0213  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH-cytochrome b5 reductase 2 (CYB5R2) Flavoprotein pyridine nucleotide cytochrome reductase family Q6BCY4
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
Caspase-6 (CASP6) Peptidase C14A family P55212
Retinol-binding protein 3 (RBP3) Peptidase S41A family P10745
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) Phosphoglycerate mutase family Q16877
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) PhyH family O14832
MTRF1L release factor glutamine methyltransferase (HEMK1) Protein N5-glutamine methyltransferase family Q9Y5R4
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
GTP-binding protein 8 (GTPBP8) EngB GTPase family Q8N3Z3
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Single-strand selective monofunctional uracil DNA glycosylase (SMUG1) SMUG1 family Q53HV7
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L1 (APOL1) Apolipoprotein L family O14791
Eukaryotic translation initiation factor 5A-2 (EIF5A2) EIF-5A family Q9GZV4
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Solute carrier family 52, riboflavin transporter, member 2 (SLC52A2) Riboflavin transporter family Q9HAB3
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
TSC22 domain family protein 4 (TSC22D4) TSC-22/Dip/Bun family Q9Y3Q8
Forkhead box protein N1 (FOXN1) . O15353
Transcription factor SOX-5 (SOX5) . P35711
Other
Click To Hide/Show 37 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Anaphase-promoting complex subunit 13 (ANAPC13) APC13 family Q9BS18
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
ATR-interacting protein (ATRIP) ATRIP family Q8WXE1
Ataxin-1 (ATXN1) ATXN1 family P54253
BCAS3 microtubule associated cell migration factor (BCAS3) BCAS3 family Q9H6U6
Bystin (BYSL) Bystin family Q13895
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Coilin (COIL) Coilin family P38432
EF-hand calcium-binding domain-containing protein 4B (CRACR2A) EFCAB4 family Q9BSW2
Probable ribosome biogenesis protein RLP24 (RSL24D1) Eukaryotic ribosomal protein eL24 family Q9UHA3
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Protein INCA1 (INCA1) INCA family Q0VD86
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
CREB-regulated transcription coactivator 2 (CRTC2) TORC family Q53ET0
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
Fibrinogen silencer-binding protein (FSBP) . O95073
INO80 complex subunit E (INO80E) . Q8NBZ0
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Nuclear receptor-binding factor 2 (NRBF2) . Q96F24
Proline and serine-rich protein 3 (PROSER3) . Q2NL68
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Vinexin (SORBS3) . O60504

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.