Details of the Target

General Information of Target

Target ID LDTP00931
Target Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)
Gene Name SMARCA5
Gene ID 8467
Synonyms
SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; EC 3.6.4.-; Sucrose nonfermenting protein 2 homolog; hSNF2H
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSAAEPPPPPPPESAPSKPAASIASGGSNSSNKGGPEGVAAQAVASAASAGPADAEMEE
IFDDASPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKM
KPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKL
RDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKST
LHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKF
NWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFN
SADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQ
REWYTRILMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVT
NSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQD
SINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTK
TVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATH
VFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYR
EKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPR
LFELLEKEILFYRKTIGYKVPRNPELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQ
GFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKI
MAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLH
KLGFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEK
AEKKKRGPKPSTQKRKMDGAPDGRGRKKKLKL
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family, ISWI subfamily
Subcellular location
Nucleus
Function
Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails . Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template. Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes. The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase. Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
Uniprot ID
O60264
Ensemble ID
ENST00000283131.4
HGNC ID
HGNC:11101

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y712(20.00); Y742(14.36); Y947(8.37); Y928(5.06)  LDD0257  [1]
STPyne
 Probe Info  		K176(9.09); K249(7.69); K328(5.57); K600(10.00)  LDD0277  [2]
ONAyne
 Probe Info  		K176(0.68)  LDD0275  [2]
Probe 1
 Probe Info  		Y80(28.24); Y174(9.65); Y545(28.07); Y712(15.64)  LDD3495  [3]
BTD
 Probe Info  		C259(1.69)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C165(4.45)  LDD0172  [5]
DBIA
 Probe Info  		C165(0.92)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C891(0.00); C259(0.00); C519(0.00); C165(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C1001(0.00); C456(0.00); C519(0.00); C891(0.00)  LDD0032  [8]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [9]
IPIAA_L
 Probe Info  		C891(0.00); C1001(0.00); C957(0.00)  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C891(0.00); C1001(0.00); C374(0.00); C957(0.00)  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
TFBX
 Probe Info  		C891(0.00); C259(0.00); C165(0.00)  LDD0027  [10]
WYneN
 Probe Info  		C259(0.00); C165(0.00); C527(0.00)  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
Compound 10
 Probe Info  		C165(0.00); C259(0.00); C891(0.00)  LDD2216  [12]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
NHS
 Probe Info  		K814(0.00); K176(0.00)  LDD0010  [11]
SF
 Probe Info  		Y742(0.00); Y928(0.00); Y94(0.00)  LDD0028  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
Acrolein
 Probe Info  		C259(0.00); H535(0.00); H656(0.00); C957(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		H535(0.00); H656(0.00); C527(0.00); H311(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C259(0.00); C165(0.00); C957(0.00); H535(0.00)  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
NAIA_5
 Probe Info  		C165(0.00); C891(0.00); C1001(0.00); C957(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.35  LDD0472  [19]
FFF probe13
 Probe Info  		9.27  LDD0475  [19]
FFF probe14
 Probe Info  		12.42  LDD0477  [19]
FFF probe3
 Probe Info  		12.62  LDD0464  [19]
STS-1
 Probe Info  		N.A.  LDD0136  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]
Alk-rapa
 Probe Info  		3.80  LDD0213  [22]
Photonaproxen
 Probe Info  		N.A.  LDD0157  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C165(0.55)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C259(0.74)  LDD2112  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C165(0.93)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C259(0.81); C165(0.70); C527(1.30)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C259(1.22); C165(1.01)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C259(0.93); C165(1.06)  LDD2103  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C259(0.63)  LDD2131  [4]
 LDCM0025  4SU-RNA HEK-293T C165(4.45)  LDD0172  [5]
 LDCM0214  AC1 HCT 116 C1001(1.23); C259(1.07); C456(0.69); C457(0.69)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C1001(0.67); C165(1.09); C259(1.03); C519(0.79)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C1001(0.49); C165(0.70); C259(0.99); C456(0.55)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C1001(0.64); C165(1.11); C259(0.79); C456(0.62)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C1001(0.47); C165(1.24); C259(0.88); C456(0.63)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C1001(0.42); C165(0.92); C259(0.78); C456(0.49)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C1001(0.39); C165(0.92); C259(0.84); C456(0.61)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C1001(0.53); C165(1.06); C259(0.85); C456(0.50)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C1001(0.62); C165(0.85); C259(0.88); C456(0.49)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C1001(0.68); C165(1.11); C259(0.88); C456(0.46)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C1001(0.40); C165(0.99); C259(1.04); C456(0.75)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C1001(0.61); C165(0.75); C259(0.88); C456(0.92)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C1001(0.53); C165(0.96); C259(1.05); C519(0.78)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C1001(0.42); C165(1.03); C259(0.95); C456(0.86)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C1001(0.51); C165(1.22); C259(0.90); C456(0.69)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C1001(0.61); C165(1.45); C259(0.82); C456(0.49)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C1001(1.60); C165(1.47); C259(0.96); C456(0.92)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C1001(1.09); C165(1.62); C259(0.84); C456(0.75)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C1001(0.98); C165(1.10); C259(0.79); C456(0.72)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C1001(1.16); C165(1.29); C259(0.78); C456(0.77)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C1001(1.11); C165(1.35); C259(0.92); C456(0.78)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C1001(1.13); C165(1.45); C259(0.91); C456(0.82)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C1001(1.10); C165(1.35); C259(0.93); C456(0.80)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C1001(0.76); C165(1.15); C259(1.04); C519(0.89)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C1001(1.06); C165(1.34); C259(0.83); C456(1.04)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C1001(0.96); C165(1.39); C259(1.12); C456(1.01)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C1001(1.28); C165(1.28); C259(1.03); C456(0.80)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C1001(0.86); C165(1.27); C259(1.25); C456(0.85)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C1001(0.93); C165(1.13); C259(1.01); C456(0.89)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C1001(1.06); C165(1.39); C259(0.89); C456(0.74)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C1001(1.23); C165(1.26); C259(0.87); C456(0.78)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C1001(1.13); C165(1.33); C259(0.93); C456(0.71)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C1001(1.46); C165(0.98); C259(1.35); C456(1.01)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C1001(2.11); C165(0.98); C259(1.04); C456(1.00)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C1001(1.60); C165(1.04); C259(1.15); C456(0.68)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C1001(1.58); C165(0.95); C259(0.89); C456(1.04)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C1001(2.39); C165(1.05); C259(1.07); C456(0.79)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C1001(1.57); C165(1.03); C259(1.11); C456(0.73)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C1001(1.57); C165(1.22); C259(1.09); C456(0.86)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C1001(1.74); C165(1.04); C259(1.16); C456(0.76)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C1001(1.16); C165(1.29); C259(1.07); C456(0.88)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C1001(1.37); C165(1.62); C259(1.08); C456(0.98)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C1001(1.52); C165(1.89); C259(1.11); C456(1.01)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C1001(1.80); C165(1.19); C259(1.03); C456(0.88)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C1001(1.08); C165(0.94); C259(1.03); C519(0.90)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C1001(1.96); C165(1.43); C259(1.10); C456(0.84)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C1001(1.86); C165(1.20); C259(1.06); C456(0.77)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C1001(3.74); C165(1.19); C259(1.21); C456(1.02)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C456(0.84); C457(0.84); C519(0.91); C259(0.98)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C519(0.55); C1001(0.67); C456(0.78); C457(0.78)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C519(0.71); C1001(0.79); C165(0.84); C259(1.03)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C519(0.63); C1001(0.78); C259(0.88); C456(0.94)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C519(0.55); C1001(0.70); C456(0.79); C457(0.79)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C519(0.68); C1001(0.72); C165(0.99); C456(1.05)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C519(0.59); C1001(0.74); C456(0.86); C457(0.86)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C1001(0.61); C519(0.80); C165(0.96); C259(1.02)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C519(0.75); C1001(0.80); C259(0.86); C456(0.94)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C519(0.73); C456(0.83); C457(0.83); C259(0.86)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C1001(0.54); C519(0.55); C259(0.87); C456(1.05)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C519(0.74); C456(0.85); C457(0.85); C1001(0.88)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C1001(0.55); C165(0.98); C259(0.86); C456(0.94)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C1001(0.53); C165(1.42); C259(0.86); C456(0.80)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C1001(1.13); C165(1.20); C259(0.96); C456(0.97)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C1001(1.01); C165(0.83); C259(0.96); C456(1.03)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C519(0.81); C456(0.82); C457(0.82); C165(0.85)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C1001(0.34); C519(0.71); C165(0.82); C456(0.86)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C456(0.71); C457(0.71); C1001(0.75); C519(0.77)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C456(0.66); C457(0.66); C519(0.88); C259(0.94)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C519(0.79); C1001(0.89); C259(0.94); C165(0.95)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C1001(0.63); C519(0.76); C165(0.86); C456(0.93)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C456(0.83); C457(0.83); C519(0.89); C1001(0.91)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C456(0.81); C457(0.81); C519(0.83); C1001(0.87)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C456(0.70); C457(0.70); C519(0.83); C165(0.88)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C456(0.80); C457(0.80); C519(0.82); C1001(0.88)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C456(0.61); C457(0.61); C519(0.76); C1001(0.77)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C456(0.65); C457(0.65); C1001(0.66); C519(0.72)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C1001(0.56); C456(0.73); C457(0.73); C519(0.82)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C456(0.73); C457(0.73); C519(0.80); C259(0.87)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C456(0.69); C457(0.69); C519(0.94); C259(1.03)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C456(0.63); C457(0.63); C259(0.74); C1001(0.75)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C456(0.68); C457(0.68); C519(0.71); C1001(0.83)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C456(0.57); C457(0.57); C1001(0.61); C519(0.61)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C1001(0.61); C456(0.64); C457(0.64); C519(0.67)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C1001(0.50); C519(0.64); C456(0.70); C457(0.70)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C1001(0.85); C165(0.96); C259(1.07); C456(1.25)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C165(0.99); C259(1.11); C456(1.13); C457(1.13)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C165(0.95); C456(0.96); C457(0.96); C519(1.03)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C165(1.01); C259(1.02); C519(1.12); C456(1.17)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C1001(0.99); C456(1.04); C457(1.04); C165(1.07)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C456(0.68); C457(0.68); C1001(0.75); C519(0.83)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C519(0.95); C456(0.98); C457(0.98); C165(1.05)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C456(0.92); C457(0.92); C259(1.07); C519(1.09)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C456(0.98); C457(0.98); C1001(0.98); C519(1.04)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C456(1.00); C457(1.00); C165(1.06); C519(1.13)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C165(0.88); C456(0.93); C457(0.93); C519(0.99)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C165(0.94); C456(0.95); C457(0.95); C519(0.99)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C456(0.85); C457(0.85); C519(0.92); C259(1.04)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C456(0.82); C457(0.82); C519(0.92); C259(1.05)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C456(0.87); C457(0.87); C519(1.15); C259(1.22)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C1001(0.84); C165(0.87); C519(1.01); C456(1.03)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C1001(0.70); C456(0.74); C457(0.74); C519(0.79)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C456(0.82); C457(0.82); C165(0.93); C519(0.94)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C456(0.96); C457(0.96); C259(1.17); C519(1.17)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C456(0.82); C457(0.82); C519(0.86); C1001(0.98)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C519(0.82); C456(0.82); C457(0.82); C1001(0.94)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C1001(0.78); C519(0.82); C456(0.96); C457(0.96)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C456(0.82); C457(0.82); C519(0.95); C259(1.19)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C456(0.96); C457(0.96); C1001(1.19); C165(1.20)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C1001(0.57); C519(0.62); C456(0.78); C457(0.78)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C519(0.62); C1001(0.65); C456(0.91); C457(0.91)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C1001(0.50); C519(0.64); C456(0.78); C457(0.78)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C1001(0.69); C519(0.78); C259(0.95); C165(1.06)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C1001(0.66); C519(0.75); C456(0.80); C457(0.80)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C519(0.68); C456(0.99); C457(0.99); C165(1.05)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C519(0.62); C1001(0.69); C456(0.70); C457(0.70)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C1001(0.60); C519(0.66); C456(0.82); C457(0.82)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C1001(0.59); C519(0.71); C165(0.78); C456(0.79)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C456(0.69); C457(0.69); C519(0.72); C1001(0.76)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C456(0.70); C457(0.70); C1001(0.71); C519(0.79)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C1001(0.61); C519(0.77); C456(0.79); C457(0.79)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C165(0.86); C519(0.91); C1001(1.01); C456(1.08)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C165(0.89); C519(0.91); C1001(1.01); C456(1.14)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C165(0.86); C259(0.87); C1001(0.90); C519(0.98)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C519(0.87); C1001(0.91); C165(0.91); C456(1.04)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C519(1.03); C165(1.05); C259(1.13); C1001(1.15)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C519(0.79); C1001(0.87); C456(0.94); C457(0.94)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C519(1.07); C165(1.08); C456(1.08); C457(1.08)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C519(1.10); C165(1.11); C1001(1.21); C456(1.49)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C165(1.01); C456(1.14); C457(1.14); C519(1.18)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C519(0.83); C456(0.96); C457(0.96); C1001(1.12)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C519(0.80); C456(0.89); C457(0.89); C165(1.04)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C519(0.94); C456(0.96); C457(0.96); C165(1.10)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C519(0.93); C1001(0.97); C456(1.03); C457(1.03)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C1001(0.48); C519(0.89); C259(0.92); C165(1.01)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C519(0.83); C456(0.89); C457(0.89); C1001(0.93)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C1001(0.80); C165(1.09); C519(1.13); C259(1.24)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C1001(1.16); C165(1.27); C456(1.50); C457(1.50)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C1001(0.47); C519(0.81); C456(0.86); C457(0.86)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C1001(0.37); C519(0.83); C456(0.90); C457(0.90)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C1001(0.49); C456(0.85); C457(0.85); C259(0.87)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C1001(0.49); C259(0.83); C456(0.84); C457(0.84)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C1001(0.69); C456(0.92); C457(0.92); C259(0.97)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C1001(0.49); C519(0.83); C259(0.86); C456(0.95)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C1001(0.44); C456(0.75); C457(0.75); C519(0.77)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C456(0.86); C457(0.86); C259(1.07); C1001(1.09)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C1001(0.43); C456(0.79); C457(0.79); C519(0.83)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C1001(0.40); C456(0.70); C457(0.70); C519(0.75)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C1001(0.42); C519(0.81); C259(0.84); C456(0.85)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C1001(0.49); C519(0.94); C259(1.01); C165(1.05)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C165(0.89); C259(0.91); C519(0.94); C456(0.95)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C1001(0.49); C519(0.80); C259(0.99); C456(1.03)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C1001(0.37); C456(0.72); C457(0.72); C519(0.78)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C1001(0.44); C519(0.51); C456(0.57); C457(0.57)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C456(0.61); C457(0.61); C519(0.68); C1001(0.77)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C259(0.36); C165(0.28)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C259(0.92); C165(1.33)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C1001(1.34); C165(0.96); C259(0.97); C519(1.03)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C1001(0.79); C519(0.86); C259(0.97); C165(0.99)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C1001(0.47); C519(0.66); C165(0.92); C259(1.00)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C165(0.92)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C259(0.00); H535(0.00); C957(0.00); H656(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C259(2.44)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C259(0.93); C165(1.05); C1001(1.12); C519(1.16)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C519(0.74); C1001(0.88); C259(1.06); C165(1.35)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C456(0.68); C457(0.68); C519(0.77); C1001(0.81)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C1001(0.60); C519(0.73); C165(0.93); C259(0.94)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C165(0.79); C519(0.87); C259(0.94); C1001(1.07)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C165(0.71); C1001(0.84); C519(0.87); C259(1.04)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C165(0.79); C519(0.86); C1001(0.94); C259(1.01)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C1001(0.59); C519(0.69); C456(0.77); C457(0.77)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C1001(0.54); C519(0.68); C165(0.94); C456(1.05)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C1001(0.46); C519(0.66); C456(0.82); C457(0.82)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C1001(0.42); C519(0.65); C456(0.78); C457(0.78)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C1001(0.58); C519(0.71); C456(0.82); C457(0.82)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C519(0.82); C1001(1.01); C259(1.21); C165(1.57)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C1001(0.50); C519(0.63); C456(0.74); C457(0.74)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C1001(0.62); C519(0.75); C456(0.90); C457(0.90)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C1001(0.65); C259(0.85); C519(0.89); C456(0.90)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C1001(0.51); C456(0.62); C457(0.62); C519(0.69)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C456(0.76); C457(0.76); C1001(0.78); C519(0.78)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C456(0.76); C457(0.76); C259(0.79); C519(0.81)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C456(0.79); C457(0.79); C1001(0.81); C519(0.84)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C165(1.05); C1001(1.08); C519(1.27); C259(1.46)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C1001(0.97); C456(1.01); C457(1.01); C165(1.02)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C1001(0.83); C519(0.98); C456(1.00); C457(1.00)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C519(0.80); C1001(1.01); C259(1.14); C165(1.50)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C456(0.95); C457(0.95); C519(1.05); C259(1.06)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C519(0.71); C259(0.96); C165(1.21); C456(1.27)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C456(0.90); C457(0.90); C519(0.93); C259(1.09)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C519(0.81); C456(0.82); C457(0.82); C1001(0.83)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C456(0.79); C457(0.79); C165(0.95); C519(0.97)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C519(0.81); C456(0.91); C457(0.91); C1001(0.94)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C1001(0.58); C456(0.84); C457(0.84); C519(0.85)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C456(0.71); C457(0.71); C1001(0.77); C519(0.83)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C1001(0.54); C519(0.60); C456(0.77); C457(0.77)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C519(0.84); C259(1.00); C1001(1.08); C165(1.24)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C519(0.82); C259(0.86); C165(1.11); C1001(1.14)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C519(0.92); C259(1.02); C165(1.25); C1001(1.36)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C259(0.80); C1001(0.83); C165(0.85); C519(0.86)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C456(0.72); C457(0.72); C519(0.77); C259(0.98)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C519(0.75); C456(0.79); C457(0.79); C259(1.04)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C519(0.74); C456(0.79); C457(0.79); C259(0.98)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C259(0.97); C519(1.04); C165(1.04); C1001(1.39)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C456(0.59); C457(0.59); C519(0.60); C1001(0.70)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C519(0.66); C1001(0.71); C456(0.74); C457(0.74)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C1001(0.82); C456(0.94); C457(0.94); C519(1.01)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C1001(0.62); C519(0.70); C456(0.70); C457(0.70)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C1001(0.65); C165(1.14); C259(1.10); C456(0.76)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C1001(0.66); C165(1.05); C259(1.03); C456(0.68)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C1001(0.60); C165(1.00); C259(0.95); C456(0.74)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C1001(0.79); C165(1.04); C259(0.87); C456(0.69)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C1001(0.64); C165(1.00); C259(0.93); C456(0.71)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C1001(0.85); C165(1.10); C259(0.96); C456(0.69)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C1001(1.00); C165(0.97); C259(0.98); C519(0.90)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C1001(0.95); C165(0.98); C259(1.01); C456(0.89)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C1001(0.77); C165(1.24); C259(0.88); C456(0.93)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C1001(0.98); C259(1.02); C456(0.78); C457(0.78)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C1001(0.94); C259(0.87); C456(0.73); C457(0.73)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C1001(0.70); C259(0.91); C456(0.77); C457(0.77)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C1001(0.71); C259(0.88); C456(0.70); C457(0.70)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C1001(0.81); C259(0.87); C456(0.65); C457(0.65)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C1001(0.83); C259(0.99); C456(0.63); C457(0.63)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C1001(0.78); C259(0.97); C456(0.68); C457(0.68)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C1001(1.15); C165(0.96); C259(0.85); C519(0.83)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C1001(0.85); C259(0.87); C456(0.68); C457(0.68)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C1001(0.74); C259(0.82); C456(0.61); C457(0.61)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C1001(0.92); C259(1.27); C456(0.94); C457(0.94)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C1001(0.79); C259(0.99); C456(0.77); C457(0.77)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C1001(0.76); C259(0.91); C456(0.75); C457(0.75)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C1001(0.69); C259(1.07); C456(0.75); C457(0.75)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C1001(1.90); C165(0.98); C259(0.95); C456(0.78)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C1001(1.44); C165(1.20); C259(0.99); C456(0.82)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C1001(1.44); C165(1.22); C259(1.12); C456(0.86)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C1001(0.93); C165(1.16); C259(1.00); C456(0.76)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C1001(0.91); C165(1.40); C259(0.94); C519(0.85)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C1001(1.48); C165(1.16); C259(0.91); C456(0.75)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C1001(1.67); C165(0.98); C259(0.87); C456(0.72)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C1001(1.65); C165(1.32); C259(0.91); C456(0.72)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C1001(1.37); C165(1.53); C259(0.84); C456(0.94)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C1001(1.48); C165(1.00); C259(0.92); C456(0.84)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C1001(1.49); C165(1.09); C259(1.09); C456(0.91)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C1001(1.02); C165(1.21); C259(0.93); C456(0.86)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C1001(1.56); C165(1.18); C259(0.81); C456(0.82)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C1001(1.56); C165(1.26); C259(0.96); C456(0.84)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C1001(1.04); C165(1.31); C259(0.92); C456(0.81)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C1001(1.19); C165(0.94); C259(0.99); C519(0.88)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C1001(0.97); C165(1.20); C259(0.85); C456(0.76)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C1001(1.12); C165(1.02); C259(0.89); C456(0.79)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C1001(1.03); C165(1.15); C259(0.99); C456(0.79)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C1001(0.78); C165(1.12); C259(0.90); C456(0.75)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C1001(0.63); C165(1.30); C259(0.85); C456(0.77)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C1001(0.86); C165(1.24); C259(0.94); C456(0.92)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C1001(0.58); C165(1.48); C259(1.02); C456(0.96)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C1001(0.49); C165(1.35); C259(0.87); C456(0.82)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C1001(0.84); C165(1.23); C259(0.90); C456(0.87)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C1001(1.63); C165(1.00); C259(0.93); C456(0.89)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C1001(0.94); C165(1.34); C259(1.05); C519(0.87)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C1001(0.95); C165(1.18); C259(0.93); C456(0.86)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C1001(0.59); C165(1.29); C259(0.91); C456(0.74)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C1001(0.96); C165(1.11); C259(0.88); C456(1.00)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C1001(0.65); C165(1.01); C259(0.80); C456(0.84)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C1001(0.73); C165(1.44); C259(0.82); C456(0.77)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C1001(0.93); C165(0.87); C259(0.90); C456(1.05)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C1001(0.77); C165(1.10); C259(0.83); C456(1.11)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C1001(0.69); C165(0.93); C259(0.91); C456(0.87)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C1001(0.59); C165(0.85); C259(0.87); C456(0.74)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C1001(0.97); C165(1.37); C259(1.03); C519(0.78)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C1001(0.96); C165(0.98); C259(0.98); C456(1.05)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C1001(0.60); C165(0.70); C259(0.88); C456(0.76)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C1001(0.58); C165(0.79); C259(1.05); C456(1.00)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C1001(0.61); C165(0.82); C259(0.96); C456(0.81)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C1001(0.65); C165(0.86); C259(1.18); C456(0.93)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C1001(0.65); C165(0.81); C259(0.92); C456(0.94)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C1001(0.64); C165(0.86); C259(0.97); C456(0.99)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C1001(0.57); C165(1.35); C259(0.85); C456(0.94)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C1001(0.63); C165(0.76); C259(0.95); C456(0.94)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C1001(0.62); C165(0.86); C259(1.35); C456(1.23)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C1001(0.81); C165(1.15); C259(0.96); C519(0.72)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C1001(0.94); C165(0.61); C259(0.94); C456(1.10)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C1001(1.08); C259(0.96); C456(0.75); C457(0.75)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C1001(1.17); C259(1.02); C456(0.79); C457(0.79)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C1001(1.08); C259(1.07); C456(0.82); C457(0.82)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C1001(0.87); C259(0.82); C456(0.60); C457(0.60)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C1001(0.89); C259(0.85); C456(0.64); C457(0.64)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C1001(0.78); C259(0.93); C456(0.65); C457(0.65)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C1001(0.85); C259(0.89); C456(0.64); C457(0.64)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C1001(0.75); C259(0.96); C456(0.68); C457(0.68)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C1001(0.63); C259(0.98); C456(0.67); C457(0.67)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C165(1.13); C259(0.89); C1001(0.82); C519(1.08)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C165(3.35); C1001(1.05); C527(0.97)  LDD1702  [4]
 LDCM0625  F8 Ramos C165(1.33); C259(1.32); 0.73  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C165(2.13); C259(1.31)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C165(0.40); C259(0.35); C976(0.96); 2.94  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C165(1.94); C259(2.65)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C165(0.92); C259(1.03)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C165(1.21); C259(2.20); C976(0.70); 4.11  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C165(3.58); C259(3.57)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C165(0.92); C259(1.16)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C165(0.88); C259(1.07)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C165(0.83); C259(0.84)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C165(0.82); C259(0.91)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C165(1.19); C259(1.13)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C165(0.84); C259(1.09)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C165(2.85); C259(2.11)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C1001(0.67); C165(1.07); C259(0.82); C456(0.85)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C165(0.98); C259(1.16)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C165(2.28); C259(1.92); C976(0.51)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C1001(0.81); C259(1.06); C456(0.85); C457(0.85)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C165(1.11); C259(1.44)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C165(1.38); C259(1.05)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C165(2.87); C259(2.32); C976(0.26); 0.71  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C165(3.63); C259(3.67)  LDD2188  [25]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C259(1.54); C165(1.34)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C259(2.68); C165(1.23)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C259(1.91); C165(1.26)  LDD0082  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C259(1.25)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C259(0.53); C165(0.32)  LDD2121  [4]
 LDCM0109  NEM HeLa H535(0.00); H656(0.00); H933(0.00); H660(0.00)  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C259(0.47); C165(0.34)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C165(1.47)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C259(1.03)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C165(0.72); C374(0.86)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C259(1.23)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C259(0.09); C165(0.60)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C259(1.19); C165(0.52)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C259(0.97); C165(0.76); C527(1.21)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C259(0.44)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C165(0.82)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C259(0.82); C165(0.93)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C259(1.58); C165(1.98); C374(2.48)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C259(1.00); C165(0.79)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C259(0.23)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C259(0.73); C527(0.93); C1001(0.48)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C259(0.96); C165(0.56)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C259(0.76)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C165(1.14)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C259(0.19); C165(0.86)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C259(2.12); C165(2.69)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C165(0.79)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C259(0.13); C165(1.06)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C259(0.84); C1001(1.18)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C259(0.08); C165(0.73)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C259(0.75); C165(0.66); C527(0.93); C1001(0.75)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C259(0.16); C165(0.87)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C259(1.06); C165(0.64)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C259(0.65); C165(1.02)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C259(1.15); C165(0.68)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C259(0.68)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C165(0.66)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C259(1.41); C165(0.93); C1001(1.84)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C259(0.89); C527(1.10); C1001(0.99)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C259(1.69)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C259(0.73); C374(0.81)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C259(0.70); C165(0.28)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C165(1.18)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C259(2.34); C165(2.77)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C259(0.64); C165(2.67)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C259(0.98); C165(0.49); C527(1.01)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C165(3.63)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C259(0.71); C165(0.78)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C165(0.92)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C259(0.40)  LDD2150  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C259(1.15); C165(1.60)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C259(0.43)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C259(1.03); C165(0.85); C165(0.82)  LDD2207  [26]
 LDCM0090  Rapamycin JHH-7 3.80  LDD0213  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase BAZ1B (BAZ1B) WAL family Q9UIG0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) WAL family Q9NRL2
Remodeling and spacing factor 1 (RSF1) . Q96T23

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Beta-d-glucose Small molecular drug DB02379
4-deoxy-alpha-d-glucose . DB02670

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
23 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.