Details of the Target

General Information of Target

Target ID LDTP06983
Target Name Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3)
Gene Name PPP6R3
Gene ID 55291
Synonyms
C11orf23; KIAA1558; PP6R3; SAPL; SAPS3; Serine/threonine-protein phosphatase 6 regulatory subunit 3; SAPS domain family member 3; Sporulation-induced transcript 4-associated protein SAPL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSF
IIEEPPQDMDEKIRYKYPNISCELLTSDVSQMNDRLGEDESLLMKLYSFLLNDSPLNPLL
ASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLA
TLEKQEIIEQLLSNIFHKEKNESAIVSAIQILLTLLETRRPTFEGHIEICPPGMSHSACS
VNKSVLEAIRGRLGSFHELLLEPPKKSVMKTTWGVLDPPVGNTRLNVIRLISSLLQTNTS
SINGDLMELNSIGVILNMFFKYTWNNFLHTQVEICIALILASPFENTENATITDQDSTGD
NLLLKHLFQKCQLIERILEAWEMNEKKQAEGGRRHGYMGHLTRIANCIVHSTDKGPNSAL
VQQLIKDLPDEVRERWETFCTSSLGETNKRNTVDLVTTCHIHSSSDDEIDFKETGFSQDS
SLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIAL
FEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQD
LFEPSSANTEDKMEVDLSEPPNWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGW
ASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGE
EDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKSEEGKLSTSQDAACKDAEECPETA
EAKCAAPRPPSSSPEQRTGQPSAPGDTSVNGPV
Target Bioclass
Other
Family
SAPS family
Subcellular location
Cytoplasm
Function Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.
Uniprot ID
Q5H9R7
Ensemble ID
ENST00000265636.9
HGNC ID
HGNC:1173
ChEMBL ID
CHEMBL4105773

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R495Ter DBIA    Probe Info 
HCT15 SNV: p.A845T DBIA    Probe Info 
HT SNV: p.L423S DBIA    Probe Info 
MEWO Substitution: p.A545V .
MKN45 SNV: p.T839A DBIA    Probe Info 
PF382 SNV: p.R344Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.51  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
DBIA
 Probe Info  		C850(1.50); C836(1.34)  LDD3311  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
BTD
 Probe Info  		C830(1.24)  LDD1700  [5]
DA-P3
 Probe Info  		4.61  LDD0184  [6]
AHL-Pu-1
 Probe Info  		C290(2.73); C172(3.43); C830(6.14)  LDD0168  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C53(0.00); C836(0.00); C37(0.00); C216(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C53(0.00); C37(0.00); C500(0.00); C216(0.00)  LDD0036  [8]
IPIAA_L
 Probe Info  		C37(0.00); C500(0.00)  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C53(0.00); C836(0.00); C37(0.00); C500(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		C172(0.00); C431(0.00); C844(0.00)  LDD0027  [11]
WYneN
 Probe Info  		C844(0.00); C830(0.00)  LDD0021  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
Compound 10
 Probe Info  		C216(0.00); C830(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		C830(0.00); C844(0.00); C467(0.00)  LDD0005  [12]
NPM
 Probe Info  		N.A.  LDD0016  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
VSF
 Probe Info  		C467(0.00); C844(0.00); C830(0.00)  LDD0007  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
Acrolein
 Probe Info  		C216(0.00); H200(0.00); C830(0.00); H627(0.00)  LDD0217  [16]
Methacrolein
 Probe Info  		C830(0.00); C836(0.00); C37(0.00); C500(0.00)  LDD0218  [16]
W1
 Probe Info  		C830(0.00); C467(0.00); C836(0.00); C172(0.00)  LDD0236  [17]
AOyne
 Probe Info  		10.60  LDD0443  [18]
NAIA_5
 Probe Info  		C844(0.00); C500(0.00); C216(0.00); C467(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.31  LDD0476  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
Alk-rapa
 Probe Info  		7.11  LDD0213  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C467(0.75)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C844(0.92); C467(1.08)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C844(0.97); C467(0.70)  LDD2095  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C844(0.75); C830(1.00)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C844(1.38); C467(1.20); C830(1.01); C172(1.11)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C467(1.63); C830(0.62)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C830(0.93)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C844(0.53); C467(0.56)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C844(0.71); C467(0.91)  LDD2131  [5]
 LDCM0025  4SU-RNA HEK-293T C290(2.73); C172(3.43); C830(6.14)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C172(10.15); C830(18.00)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C844(0.98); C836(1.08); C216(0.96); C830(1.02)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C844(1.03); C836(0.93); C216(1.06); C830(0.97)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C844(1.04); C836(0.77); C216(0.91); C830(0.99)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C844(1.04); C836(1.04); C216(1.11); C830(0.99)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C844(1.07); C836(1.01); C216(1.08); C830(0.96)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C844(0.99); C836(1.09); C216(1.16); C830(0.99)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C844(1.02); C836(1.07); C216(1.01); C830(1.06)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C844(1.00); C836(0.99); C216(1.00); C830(1.02)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C844(1.19); C836(1.34); C216(0.99); C830(1.29)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C844(0.95); C836(0.88); C216(0.92); C830(0.98)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C844(1.05); C836(1.05); C216(0.99); C830(1.06)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C844(1.06); C836(1.01); C216(1.03); C830(0.96)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C844(1.10); C836(1.10); C216(1.08); C830(1.06)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C844(1.04); C836(1.04); C216(1.24); C830(1.06)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C844(1.06); C836(0.99); C216(0.97); C830(0.99)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C844(1.05); C836(1.20); C216(1.01); C830(1.04)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C844(0.96); C836(0.97); C216(0.97); C830(1.00)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C844(0.98); C836(1.26); C216(1.03); C830(1.07)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C844(1.00); C836(1.00); C216(1.00); C830(1.04)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C844(1.05); C836(0.94); C216(1.03); C830(1.00)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C844(1.00); C836(0.91); C216(0.91); C830(1.03)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C844(0.95); C836(0.82); C216(1.09); C830(0.96)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C844(1.01); C836(1.01); C216(1.06); C830(1.07)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C844(1.09); C836(1.00); C216(0.94); C830(0.99)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C844(1.07); C836(1.16); C216(1.01); C830(1.12)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C844(1.05); C836(0.89); C216(1.14); C830(1.03)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C844(1.08); C836(0.89); C216(1.08); C830(1.07)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C844(1.09); C836(1.01); C216(1.06); C830(1.06)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C844(1.05); C836(0.90); C216(1.03); C830(0.94)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C844(1.15); C836(1.00); C216(1.13); C830(0.99)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C844(1.06); C836(1.05); C216(1.15); C830(1.05)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C844(0.97); C836(0.95); C216(0.96); C830(0.88)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C844(1.25); C836(0.93); C216(1.14); C830(1.02)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C844(1.02); C836(1.19); C216(1.13); C830(1.04)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C844(1.07); C836(0.95); C216(1.05); C830(1.04)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C844(1.13); C836(1.08); C216(0.94); C830(1.05)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C844(1.11); C836(1.08); C216(1.12); C830(0.95)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C844(1.14); C836(0.95); C216(1.00); C830(0.99)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C844(1.21); C836(0.92); C216(1.08); C830(0.93)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C844(1.08); C836(1.05); C216(1.17); C830(1.05)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C844(1.10); C836(0.96); C216(1.01); C830(1.00)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C844(1.08); C836(1.08); C216(0.97); C830(1.02)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C844(1.00); C836(0.93); C216(0.95); C830(0.94)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C844(1.02); C836(0.95); C216(1.01); C830(0.94)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C844(1.19); C836(1.00); C216(0.91); C830(1.03)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C844(1.04); C836(1.06); C216(1.12); C830(0.98)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C844(1.04); C836(0.95); C216(0.97); C830(0.95)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C844(1.19); C836(0.95); C216(1.17); C830(1.05)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C844(1.04); C836(1.07); C216(1.07); C830(1.07)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C844(1.18); C836(0.95); C216(1.01); C830(1.05)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C844(0.98); C836(1.03); C216(0.89); C830(1.09)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C844(0.97); C836(0.93); C216(1.01); C830(0.96)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C844(1.05); C836(1.09); C216(0.88); C830(1.10)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C844(1.02); C836(0.91); C216(1.05); C830(0.92)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C844(1.00); C836(1.01); C216(1.08); C830(1.04)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C844(1.15); C836(0.95); C216(0.96); C830(0.96)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C844(1.14); C836(0.95); C216(1.03); C830(1.00)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C844(1.04); C836(1.00); C216(1.15); C830(0.97)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C844(0.96); C836(0.91); C216(1.02); C830(0.97)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C844(0.94); C836(0.96); C216(1.03); C830(0.99)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C844(1.11); C836(0.99); C216(1.10); C830(1.02)  LDD1569  [21]
 LDCM0545  Acetamide MDA-MB-231 C844(0.62); C467(0.71)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C467(0.79)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C844(1.17); C836(0.97); C216(1.01); C830(0.94)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C844(0.96); C836(1.14); C216(1.06); C830(1.08)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C844(1.08); C836(1.02); C216(1.00); C830(0.99)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 11.58  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C844(0.66); C467(0.91); C830(0.80)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C500(0.00); C82(0.00); C216(0.00); C37(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C500(20.00); C216(1.42); C467(1.04)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C844(1.00); C836(0.86); C216(1.13); C830(0.86)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C844(0.92); C836(0.76); C216(1.40); C830(0.90)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C844(1.00); C836(1.13); C216(1.07); C830(1.08)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C844(1.06); C836(0.91); C216(1.10); C830(0.91)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C844(0.97); C836(0.99); C216(1.12); C830(0.98)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C844(1.08); C836(1.10); C216(0.99); C830(1.01)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C844(0.99); C836(1.08); C216(1.08); C830(1.04)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C844(1.03); C836(0.99); C216(1.05); C830(1.02)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C844(1.00); C836(1.15); C216(1.16); C830(1.12)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C844(1.03); C836(0.92); C216(1.03); C830(1.05)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C844(1.06); C836(1.12); C216(0.97); C830(1.09)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C844(1.02); C836(0.76); C216(1.25); C830(0.91)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C844(1.07); C836(1.10); C216(1.62); C830(0.93)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C844(0.97); C836(1.09); C216(1.14); C830(0.93)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C844(0.93); C836(1.02); C216(1.15); C830(0.96)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C844(1.08); C836(1.12); C216(1.13); C830(0.99)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C844(1.10); C836(1.13); C216(1.11); C830(0.96)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C844(0.99); C836(0.89); C216(1.10); C830(0.93)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C844(1.13); C836(1.05); C216(1.12); C830(0.91)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C844(1.09); C836(1.20); C216(1.06); C830(1.08)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C844(1.08); C836(1.00); C216(1.08); C830(1.03)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C844(1.13); C836(1.44); C216(1.04); C830(1.17)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C844(1.05); C836(0.97); C216(1.03); C830(0.94)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C844(1.10); C836(0.90); C216(1.46); C830(0.99)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C844(1.06); C836(1.11); C216(1.10); C830(1.02)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C844(1.09); C836(1.07); C216(1.01); C830(1.08)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C844(1.11); C836(0.88); C216(1.01); C830(1.10)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C844(0.99); C836(0.92); C216(1.20); C830(0.89)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C844(1.15); C836(1.14); C216(1.04); C830(0.99)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C844(1.05); C836(0.94); C216(0.88); C830(0.93)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C844(1.02); C836(0.96); C216(1.01); C830(1.02)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C844(1.05); C836(0.95); C216(0.94); C830(0.92)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C844(1.08); C836(1.13); C216(1.00); C830(1.19)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C844(1.07); C836(1.10); C216(1.07); C830(1.16)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C844(1.03); C836(0.94); C216(1.04); C830(0.98)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C844(1.00); C836(1.06); C216(1.28); C830(1.01)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C844(1.09); C836(1.00); C216(1.05); C830(1.09)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C844(1.03); C836(1.19); C216(1.50); C830(1.10)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C844(0.98); C836(0.88); C216(1.04); C830(0.94)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C844(1.19); C836(1.01); C216(0.98); C830(1.05)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C844(0.93); C836(0.90); C216(1.08); C830(0.92)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C844(1.09); C836(0.99); C216(1.30); C830(1.06)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C844(1.19); C836(1.07); C216(1.50); C830(1.06)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C844(1.26); C836(0.95); C216(1.26); C830(1.02)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C844(1.18); C836(1.11); C216(1.29); C830(1.15)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C844(1.17); C836(0.95); C216(1.18); C830(1.01)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C844(0.99); C836(0.83); C216(1.03); C830(0.90)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C844(1.01); C836(1.03); C216(0.98); C830(1.03)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C844(0.96); C836(0.95); C216(1.05); C830(0.96)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C844(1.17); C836(1.05); C216(1.08); C830(1.04)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C844(1.02); C836(1.28); C216(1.12); C830(1.06)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C844(1.10); C836(0.82); C216(1.08); C830(0.91)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C844(1.06); C836(0.94); C216(1.00); C830(0.99)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C844(1.22); C836(0.93); C216(1.23); C830(1.04)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C844(1.07); C836(1.04); C216(1.16); C830(1.10)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C844(1.00); C836(1.04); C216(1.33); C830(0.94)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C844(1.18); C836(1.04); C216(1.31); C830(0.99)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C844(1.10); C836(1.11); C216(1.55); C830(1.14)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C844(0.96); C836(0.93); C216(1.28); C830(0.97)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C844(1.00); C836(0.92); C216(0.99); C830(1.01)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C844(0.97); C836(0.93); C216(1.08); C830(0.96)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C844(0.99); C836(1.04); C216(1.09); C830(1.16)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C844(1.13); C836(0.98); C216(1.14); C830(1.03)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C844(0.98); C836(1.07); C216(1.28); C830(1.01)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C844(1.05); C836(0.97); C216(1.00); C830(1.03)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C844(1.07); C836(0.97); C216(1.12); C830(1.00)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C844(1.05); C836(1.05); C216(1.22); C830(1.14)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C844(1.10); C836(1.14); C216(1.09); C830(0.98)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C844(1.00); C836(1.10); C216(1.23); C830(0.94)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C844(1.04); C836(1.09); C216(1.20); C830(0.98)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C844(1.19); C836(1.03); C216(1.08); C830(1.07)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C844(1.00); C836(0.88); C216(0.91); C830(0.92)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C844(1.00); C836(0.98); C216(0.96); C830(1.12)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C844(1.06); C836(0.95); C216(1.17); C830(0.98)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C844(0.98); C836(1.10); C216(1.02); C830(1.09)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C844(1.00); C836(1.10); C216(1.28); C830(1.00)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C844(1.06); C836(1.00); C216(1.30); C830(0.94)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C844(1.12); C836(1.39); C216(1.01); C830(1.01)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C844(1.09); C836(1.07); C216(1.27); C830(1.00)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C844(1.04); C836(1.05); C216(1.29); C830(1.03)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C844(1.13); C836(0.91); C216(1.19); C830(0.94)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C844(1.02); C836(1.09); C216(1.30); C830(0.93)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C844(0.91); C836(0.96); C216(1.28); C830(0.93)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C844(1.11); C836(1.02); C216(1.37); C830(1.10)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C844(1.04); C836(0.86); C216(0.89); C830(0.84)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C844(1.01); C836(0.93); C216(1.00); C830(0.98)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C844(1.11); C836(0.99); C216(1.03); C830(0.94)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C844(1.02); C836(1.03); C216(1.20); C830(1.07)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C844(1.11); C836(1.15); C216(1.07); C830(1.15)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C844(1.07); C836(0.98); C216(1.05); C830(1.01)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C844(1.07); C836(0.88); C216(1.04); C830(1.06)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C844(1.10); C836(1.10); C216(1.25); C830(1.00)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C844(1.02); C836(0.98); C216(1.15); C830(0.99)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C844(1.03); C836(0.79); C216(0.96); C830(1.01)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C844(1.26); C836(0.71); C216(1.16); C830(1.00)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C844(1.08); C836(1.11); C216(1.23); C830(1.07)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C844(1.04); C836(0.99); C216(1.27); C830(1.06)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C844(1.00); C836(0.94); C216(1.00); C830(0.98)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C844(0.97); C836(0.90); C216(0.94); C830(1.01)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C844(1.06); C836(1.05); C216(0.94); C830(1.05)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C844(1.08); C836(1.02); C216(1.15); C830(0.98)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C844(1.00); C836(0.91); C216(1.00); C830(0.96)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C844(1.08); C836(0.90); C216(1.04); C830(1.02)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C844(0.79); C836(0.93); C216(1.68); C830(0.83)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C844(1.03); C836(1.12); C216(1.22); C830(0.89)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C844(1.33); C836(1.01); C216(1.14); C830(1.03)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C844(1.09); C836(0.93); C216(1.12); C830(0.94)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C844(1.01); C836(1.01); C216(1.38); C830(1.01)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C844(1.00); C836(0.84); C216(1.22); C830(0.99)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C844(0.97); C836(0.84); C216(0.88); C830(0.94)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C844(0.94); C836(0.98); C216(0.97); C830(1.01)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C844(0.94); C836(0.79); C216(0.88); C830(0.92)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C844(0.95); C836(1.09); C216(0.86); C830(1.00)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C844(1.08); C836(1.00); C216(0.86); C830(1.02)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C844(0.97); C836(0.93); C216(1.18); C830(0.89)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C844(0.87); C836(0.93); C216(1.55); C830(0.92)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C844(1.01); C836(0.92); C216(0.76); C830(1.07)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C844(1.01); C836(1.04); C216(1.17); C830(1.07)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C844(0.97); C836(1.04); C216(1.12); C830(0.92)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C844(1.07); C836(0.83); C216(1.13); C830(0.95)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C844(1.02); C836(1.18); C216(1.54); C830(1.06)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C844(0.85); C836(0.94); C216(1.06); C830(0.99)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C844(1.00); C836(0.99); C216(1.29); C830(0.96)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C844(0.93); C836(1.08); C216(1.06); C830(1.01)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C844(1.06); C836(0.95); C216(0.91); C830(0.89)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C844(1.14); C836(0.97); C216(1.09); C830(0.94)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C216(2.78); C172(1.66); C467(1.10); C844(1.00)  LDD1702  [5]
 LDCM0625  F8 Ramos C844(1.37); C172(0.59); C37(1.15)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C844(1.57); C172(0.65); C37(1.03)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C844(1.19); C172(0.02); C467(1.76)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C844(1.66); C172(0.68); C37(0.78); C467(0.96)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C844(1.64); C172(1.15); C37(0.89)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C844(0.78); C172(0.68); C467(0.67)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C844(1.71); C172(0.68); C37(0.94)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C844(1.45); C172(0.65); C37(1.31)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C844(1.72); C172(0.64); C37(0.86); C467(2.88)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C844(1.52); C172(0.76); C37(1.09); C467(1.69)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C844(0.58); C172(0.73)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C844(2.03); C172(0.85); C37(1.05)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C844(2.19); C172(0.83); C37(1.06)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C844(2.13); C172(0.63); C37(0.75); C467(0.96)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C844(0.95); C836(1.01); C216(1.06); C830(0.88)  LDD1671  [21]
 LDCM0596  Fragment38 Ramos C844(1.64); C172(0.81); C37(1.09)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C844(1.09); C172(0.77); C37(0.84); C467(1.13)  LDD2184  [22]
 LDCM0427  Fragment51 HEK-293T C844(1.00); C836(1.05); C216(1.04); C830(1.10)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C844(3.05); C172(1.00); C467(1.73)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C844(3.76); C172(0.98)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C844(1.23); C172(0.35); C37(0.63); C467(0.62)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C844(1.56); C172(0.55); C37(0.91); C467(0.41)  LDD2188  [22]
 LDCM0149  GA MCF-7 C844(2.06)  LDD0379  [23]
 LDCM0107  IAA HeLa H627(0.00); H200(0.00); C216(0.00)  LDD0221  [16]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HEK-293T C836(0.94); C830(0.99); C216(0.90); C467(0.99)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C836(1.01); C830(0.96); C216(0.85); C467(0.92)  LDD1497  [21]
 LDCM0024  KB05 G361 C850(1.50); C836(1.34)  LDD3311  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C467(0.97); C830(1.02)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C844(0.83); C467(1.00)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C844(0.85); C467(0.96); C830(0.64)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C467(1.00); C830(1.07)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C467(1.08)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C467(1.28)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C467(0.51); C216(0.61)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C467(0.96); C216(2.17)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C467(0.73)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C844(0.76); C467(1.11); C216(1.08)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C844(0.72); C830(0.97)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C830(0.38)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C844(0.92); C467(0.60)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C467(1.40); C830(1.22)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C844(0.80); C830(1.08)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C844(0.78); C467(1.26); C172(0.89); C431(0.98)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C467(0.80); C830(1.19)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C844(0.73); C467(0.54); C830(0.72)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C467(1.33)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C467(1.35); C830(0.80); C216(0.90)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C844(0.62)  LDD2114  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C216(0.83)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C467(2.29); C216(2.10)  LDD2119  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C467(1.05); C830(1.02); C216(0.40)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C844(0.75); C467(0.90); C830(0.82); C431(0.98)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C216(1.20)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C467(0.96); C830(0.81); C172(0.97)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C844(0.80); C467(1.17); C830(0.95)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C844(0.75)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C467(1.12); C830(0.94)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C467(0.56)  LDD2133  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C467(1.60)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C844(1.24); C830(0.90); C172(1.24)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C844(0.95); C467(1.02); C830(0.87)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C830(1.24)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C844(0.65); C467(0.90); C431(0.89)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C844(1.15); C830(0.84)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C844(0.77)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C467(2.09); C172(1.48)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C467(1.02); C216(0.76)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C830(1.10); C216(0.42)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C830(1.32)  LDD2153  [5]
 LDCM0032  Oleacein HEK-293T 4.61  LDD0184  [6]
 LDCM0090  Rapamycin JHH-7 7.11  LDD0213  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C) PPP phosphatase family O00743
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) . O15084

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.