Details of the Target

General Information of Target

Target ID LDTP01430
Target Name E3 ubiquitin-protein ligase listerin (LTN1)
Gene Name LTN1
Gene ID 26046
Synonyms
C21orf10; C21orf98; KIAA0714; RNF160; ZNF294; E3 ubiquitin-protein ligase listerin; EC 2.3.2.27; RING finger protein 160; RING-type E3 ubiquitin transferase listerin; Zinc finger protein 294
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSL
VDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRR
VREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQP
EAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLP
DNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPS
VLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIY
PYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIM
QQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTA
HNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVR
FADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADI
SINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQ
FLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIE
KACPSSDKHALVTPWLKGDILGEKLVNLADCLCNEDLESRVSSESHFSERWTLLSLVLSQ
HVKNDYLIGDVYVERIIVRLHETLFKTKKLSEAESSDSSVSFICDVAYNYFSSAKGCLLM
PSSEDLLLTLFQLCAQSKEKTHLPDFLICKLKNTWLSGVNLLVHQTDSSYKESTFLHLSA
LWLKNQVQASSLDINSLQVLLSAVDDLLNTLLESEDSYLMGVYIGSVMPNDSEWEKMRQS
LPMQWLHRPLLEGRLSLNYECFKTDFKEQDIKTLPSHLCTSALLSKMVLIALRKETVLEN
NELEKIIAELLYSLQWCEELDNPPIFLIGFCEILQKMNITYDNLRVLGNTSGLLQLLFNR
SREHGTLWSLIIAKLILSRSISSDEVKPHYKRKESFFPLTEGNLHTIQSLCPFLSKEEKK
EFSAQCIPALLGWTKKDLCSTNGGFGHLAIFNSCLQTKSIDDGELLHGILKIIISWKKEH
EDIFLFSCNLSEASPEVLGVNIEIIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTSE
NQALYSIPLVQLFACVSCDLACDLSAFFDSTTLDTIGNLPVNLISEWKEFFSQGIHSLLL
PILVTVTGENKDVSETSFQNAMLKPMCETLTYISKEQLLSHKLPARLVADQKTNLPEYLQ
TLLNTLAPLLLFRARPVQIAVYHMLYKLMPELPQYDQDNLKSYGDEEEEPALSPPAALMS
LLSIQEDLLENVLGCIPVGQIVTIKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYS
MYLRKTKSLNKLLYHLFRLMPENPTYAETAVEVPNKDPKTFFTEELQLSIRETTMLPYHI
PHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSSVLSFQEISSVQTSTQL
FNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSIIVESGKRVGVAVQQWRNWM
LQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKK
FHSACLYKWFTSSNKSTCPLCRETFF
Target Bioclass
Enzyme
Family
LTN1 family
Subcellular location
Cytoplasm, cytosol
Function
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product.
Uniprot ID
O94822
Ensemble ID
ENST00000361371.10
HGNC ID
HGNC:13082

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II SNV: p.V486I .
COLO792 SNV: p.S1312F DBIA    Probe Info 
HCT116 SNV: p.V499A; p.A1744T .
HT115 SNV: p.R108I; p.V1217A; p.E1309Ter DBIA    Probe Info 
IPC298 SNV: p.S623F DBIA    Probe Info 
K562 Deletion: p.I199Ter .
KARPAS422 SNV: p.G1454R DBIA    Probe Info 
KASUMI2 Insertion: p.T479NfsTer26 .
KMRC20 SNV: p.T1553K DBIA    Probe Info 
MCAS SNV: p.T1640I DBIA    Probe Info 
MCC13 SNV: p.P440S DBIA    Probe Info 
MDAMB453 SNV: p.D695N DBIA    Probe Info 
MFE319 SNV: p.A1564V DBIA    Probe Info 
NCIH1048 Insertion: p.L1239FfsTer5 .
NCIH2172 SNV: p.E1544D DBIA    Probe Info 
NCIH2286 SNV: p.L529Ter; p.L666R; p.K1355Q .
PC9 Substitution: p.S531K; p.S532K .
SKMEL30 SNV: p.L867V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.90  LDD0402  [1]
TH211
 Probe Info  		Y1514(20.00)  LDD0257  [2]
STPyne
 Probe Info  		K233(5.39); K609(7.18); K80(10.00)  LDD0277  [3]
BTD
 Probe Info  		C227(1.01)  LDD2117  [4]
AHL-Pu-1
 Probe Info  		C869(2.50); C555(4.89); C237(2.91)  LDD0168  [5]
DBIA
 Probe Info  		C595(90.49); C981(4.91); C1146(33.70); C498(72.81)  LDD0209  [6]
HHS-475
 Probe Info  		Y1514(0.62)  LDD0266  [7]
Acrolein
 Probe Info  		C498(0.00); C981(0.00); C237(0.00)  LDD0222  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1131(0.00); C283(0.00); C1146(0.00); C869(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C498(0.00); C999(0.00); C555(0.00); C981(0.00)  LDD0037  [9]
IPM
 Probe Info  		C595(0.00); C91(0.00); C498(0.00); C227(0.00)  LDD0005  [11]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
TFBX
 Probe Info  		C869(0.00); C999(0.00); C498(0.00); C981(0.00)  LDD0148  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		6.60  LDD0443  [15]
NAIA_5
 Probe Info  		C91(0.00); C555(0.00); C227(0.00); C283(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C280
 Probe Info  		8.82  LDD1950  [17]
C293
 Probe Info  		21.11  LDD1963  [17]
C296
 Probe Info  		12.64  LDD1966  [17]
Alk-rapa
 Probe Info  		2.23  LDD0213  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C227(1.01)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C869(2.50); C555(4.89); C237(2.91)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C869(2.33); C751(2.05); C555(6.56); C237(3.13)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C723(0.99); C555(0.95); C91(1.06); C1745(0.97)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C723(0.98); C555(1.04); C91(0.93); C1745(0.94)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C723(0.99); C555(1.08); C91(1.01); C1745(0.94)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C723(0.93); C555(1.00); C91(0.99); C1745(0.98)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C723(0.99); C555(1.01); C91(0.93); C1745(0.98)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C723(1.00); C555(0.89); C91(1.01); C498(0.94)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C723(0.94); C555(0.97); C91(1.06); C1745(0.99)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C723(0.98); C555(0.98); C91(1.02); C1745(1.01)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C723(1.34); C555(1.14); C91(1.16); C1745(0.87)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C723(0.93); C555(0.99); C91(0.97); C1745(0.96)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C723(1.04); C555(0.98); C91(0.98); C1745(1.00)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C723(1.05); C555(1.00); C91(0.98); C1745(0.96)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C723(1.00); C555(1.00); C91(0.97); C1745(0.99)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C723(1.03); C555(0.98); C91(1.00); C498(1.01)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C723(1.00); C555(0.97); C91(1.04); C1745(0.98)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C723(1.02); C555(0.95); C91(1.06); C1745(0.96)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C723(0.98); C555(1.02); C91(1.06); C1745(1.00)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C723(1.07); C555(1.01); C91(1.00); C1745(0.93)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C723(0.98); C555(0.90); C91(0.92); C1745(1.01)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C723(1.02); C555(1.03); C91(0.91); C1745(1.01)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C723(0.95); C555(0.88); C91(0.92); C1745(1.00)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C723(1.06); C555(1.07); C91(0.90); C1745(0.99)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C723(0.98); C555(1.06); C91(1.00); C498(0.96)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C723(1.01); C555(0.97); C91(0.95); C1745(0.97)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C723(0.94); C555(0.95); C91(1.07); C1745(0.98)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C723(0.94); C555(0.92); C91(1.04); C1745(0.93)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C723(0.92); C555(0.90); C91(1.08); C1745(1.00)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C723(0.89); C555(0.94); C91(0.96); C1745(0.98)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C723(0.90); C555(1.01); C91(0.98); C1745(0.95)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C723(0.94); C555(1.00); C91(0.92); C1745(0.95)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C723(0.99); C555(0.81); C91(1.08); C498(0.96)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C723(0.90); C555(0.97); C91(0.99); C1745(0.99)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C723(0.83); C555(0.89); C91(0.93); C1745(1.04)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C723(0.91); C555(0.92); C91(1.12); C1745(0.95)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C723(0.93); C555(1.00); C91(1.07); C1745(0.93)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C723(0.92); C555(0.94); C91(1.02); C1745(0.92)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C723(0.89); C555(0.93); C91(0.92); C1745(0.95)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C723(0.88); C555(1.03); C91(1.02); C1745(0.90)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C723(0.96); C555(1.03); C91(0.94); C1745(0.99)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C723(0.93); C555(0.77); C91(0.92); C498(0.94)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C723(0.91); C555(0.96); C91(0.91); C1745(1.06)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C723(0.98); C555(0.87); C91(1.16); C1745(0.95)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C723(0.90); C555(0.98); C91(1.08); C1745(1.05)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C723(0.92); C555(0.93); C91(0.90); C1745(0.92)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C723(0.93); C555(0.93); C91(1.00); C1745(0.96)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C723(0.85); C555(0.90); C91(0.92); C1745(0.97)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C723(0.92); C555(1.01); C91(1.05); C1745(0.96)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C723(0.87); C555(0.94); C91(0.91); C1745(0.97)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C723(0.94); C555(0.97); C91(0.95); C498(0.91)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C723(0.89); C555(0.94); C91(1.05); C1745(1.03)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C723(0.99); C555(0.91); C91(1.07); C1745(0.95)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C723(0.95); C555(0.93); C91(0.95); C1745(0.93)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C723(0.98); C555(0.96); C91(0.89); C1745(0.97)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C723(1.01); C555(1.08); C91(0.98); C1745(0.98)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C723(0.98); C555(0.94); C91(1.07); C1745(0.96)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C723(0.93); C555(1.03); C91(0.98); C1745(0.94)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C723(0.95); C555(0.96); C91(0.91); C1745(0.99)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C723(0.97); C555(0.93); C91(1.08); C498(0.97)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C723(0.97); C555(0.89); C91(0.93); C1745(1.08)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C723(0.93); C555(0.96); C91(0.94); C498(1.03)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C723(1.01); C555(0.88); C91(1.01); C1745(1.03)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C723(0.98); C555(1.01); C91(0.96); C1745(0.95)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C723(0.98); C555(0.88); C91(1.01); C1745(1.00)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C723(0.99); C555(0.97); C91(1.04); C1745(1.00)  LDD1514  [19]
 LDCM0108  Chloroacetamide HeLa C498(0.00); C981(0.00); C237(0.00)  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C595(20.00); C869(1.36); C555(0.93); C981(0.85)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C723(0.91); C555(0.71); C91(0.90); C1745(1.12)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C723(1.29); C555(0.79); C91(1.27); C1745(1.54)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C723(0.95); C555(0.84); C91(1.11); C1745(1.01)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C723(0.92); C555(0.87); C91(0.93); C1745(1.00)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C723(1.04); C555(0.97); C91(1.04); C1745(1.03)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C723(0.95); C555(0.94); C91(0.94); C1745(0.95)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C723(0.96); C555(0.90); C91(1.05); C1745(1.04)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C723(0.94); C555(1.00); C91(0.94); C1745(1.01)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C723(1.01); C555(1.00); C91(1.04); C1745(1.05)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C723(0.96); C555(0.99); C91(0.84); C1745(1.01)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C723(0.91); C555(0.92); C91(0.92); C1745(1.01)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C723(1.04); C555(0.95); C91(0.97); C1745(1.02)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C723(0.89); C555(0.90); C91(1.13); C498(1.10)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C723(1.12); C555(1.02); C91(1.11); C1745(1.07)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C723(1.06); C555(0.97); C91(1.03); C1745(1.05)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C723(0.93); C555(1.00); C91(1.07); C1745(0.99)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C723(0.91); C555(0.86); C91(0.92); C1745(0.94)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C723(1.13); C555(0.94); C91(1.15); C1745(1.16)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C723(0.89); C555(0.80); C91(0.84); C1745(1.01)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C723(0.95); C555(0.90); C91(0.94); C1745(0.99)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C723(0.89); C555(0.96); C91(0.97); C1745(0.98)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C723(0.98); C555(0.99); C91(1.15); C1745(0.93)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C723(0.86); C555(0.89); C91(0.79); C1745(0.93)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C723(1.03); C555(0.85); C91(1.03); C1745(0.82)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C723(0.99); C555(0.92); C91(0.98); C1745(0.98)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C723(0.99); C555(0.90); C91(0.92); C1745(0.97)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C723(1.00); C555(1.00); C91(1.02); C1745(1.07)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C723(1.64); C555(0.84); C91(0.89); C1745(1.20)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C723(0.98); C555(0.95); C91(0.99); C1745(1.00)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C723(0.95); C555(0.90); C91(0.96); C1745(0.93)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C723(1.01); C555(1.00); C91(0.97); C1745(0.97)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C723(0.97); C555(0.91); C91(1.03); C1745(0.97)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C723(0.93); C555(0.98); C91(0.89); C1745(0.98)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C723(0.89); C555(0.86); C91(0.97); C1745(0.92)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C723(0.92); C555(0.91); C91(1.00); C1745(0.94)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C723(1.43); C555(0.78); C91(1.14); C1745(1.10)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C723(0.94); C555(0.90); C91(0.95); C1745(0.97)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C723(1.49); C555(0.77); C91(1.14); C1745(1.17)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C723(0.91); C555(0.93); C91(1.02); C1745(0.94)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C723(0.88); C555(0.95); C91(1.08); C1745(1.00)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C723(0.94); C555(0.92); C91(1.11); C1745(1.01)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C723(0.98); C555(1.11); C91(1.12); C1745(1.02)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C723(1.14); C555(1.06); C91(1.16); C1745(1.24)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C723(0.82); C555(0.89); C91(1.07); C1745(1.11)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C723(0.81); C555(0.91); C91(1.13); C498(1.07)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C723(0.94); C555(0.91); C91(0.96); C1745(0.79)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C723(1.21); C555(0.91); C91(0.90); C1745(1.20)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C723(0.96); C555(1.01); C91(1.05); C1745(1.07)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C723(0.95); C555(0.95); C91(0.92); C1745(1.02)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C723(1.07); C555(0.90); C91(0.96); C1745(1.02)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C723(0.97); C555(0.93); C91(1.13); C1745(1.02)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C723(0.97); C555(0.79); C91(0.94); C1745(1.02)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C723(0.91); C555(0.97); C91(1.01); C1745(0.99)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C723(1.00); C555(1.09); C91(0.97); C1745(1.12)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C723(0.93); C555(1.00); C91(0.96); C1745(1.08)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C723(1.90); C555(0.93); C91(1.19); C1745(1.38)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C723(1.00); C555(1.03); C91(1.13); C1745(1.32)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C723(0.90); C555(1.13); C91(1.09); C498(1.05)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C723(0.96); C555(1.09); C91(1.00); C1745(0.72)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C723(0.93); C555(1.05); C91(0.90); C1745(1.03)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C723(0.96); C555(0.89); C91(0.96); C1745(1.16)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C723(1.06); C555(0.82); C91(1.08); C1745(1.10)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C723(0.97); C555(0.97); C91(1.23); C1745(0.97)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C723(0.92); C555(0.85); C91(0.95); C1745(1.07)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C723(0.92); C555(0.99); C91(0.93); C1745(0.96)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C723(1.01); C555(0.96); C91(1.03); C1745(1.05)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C723(0.91); C555(1.02); C91(1.05); C1745(1.03)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C723(1.06); C555(1.01); C91(1.14); C1745(1.16)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C723(0.97); C555(1.02); C91(1.09); C1745(1.17)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C723(0.89); C555(0.94); C91(1.12); C498(1.05)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C723(0.91); C555(0.98); C91(1.11); C1745(0.73)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C723(0.91); C555(0.76); C91(0.92); C1745(0.99)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C723(0.92); C555(0.84); C91(1.04); C1745(1.03)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C723(1.02); C555(0.96); C91(1.03); C1745(1.06)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C723(0.87); C555(0.90); C91(0.97); C1745(1.02)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C723(1.03); C555(0.80); C91(1.24); C1745(1.14)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C723(1.64); C555(0.85); C91(0.98); C1745(1.27)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C723(0.93); C555(0.97); C91(1.05); C1745(1.01)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C723(0.85); C555(0.90); C91(0.99); C1745(1.09)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C723(1.18); C555(1.04); C91(1.09); C1745(1.25)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C723(0.87); C555(0.98); C91(1.15); C1745(1.31)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C723(0.83); C555(0.89); C91(1.03); C498(1.05)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C723(1.04); C555(0.83); C91(1.09); C1745(1.08)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C723(0.97); C555(0.91); C91(0.97); C1745(0.79)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C723(0.88); C555(0.76); C91(0.90); C1745(0.90)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C723(0.93); C555(1.00); C91(0.92); C1745(0.94)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C723(0.92); C555(0.91); C91(0.83); C1745(0.93)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C723(1.08); C555(0.86); C91(1.12); C1745(1.13)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C723(1.02); C555(0.92); C91(0.98); C1745(0.95)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C723(1.05); C555(0.97); C91(1.10); C1745(0.94)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C723(0.97); C555(0.96); C91(1.01); C1745(0.98)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C723(0.98); C555(0.95); C91(1.02); C1745(1.08)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C723(1.06); C555(1.11); C91(1.00); C1745(1.03)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C723(0.88); C555(0.88); C91(1.07); C1745(1.01)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C723(0.84); C555(0.98); C91(1.15); C1745(1.10)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C723(0.79); C555(1.07); C91(0.96); C498(0.97)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C723(0.99); C555(0.99); C91(1.12); C1745(0.82)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C723(0.94); C555(0.79); C91(1.01); C1745(1.09)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C723(0.94); C555(0.95); C91(1.00); C1745(0.96)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C723(1.00); C555(0.89); C91(0.95); C1745(0.98)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C723(1.07); C555(0.85); C91(1.12); C1745(1.09)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C723(0.96); C555(0.95); C91(0.94); C1745(0.96)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C723(0.94); C555(1.02); C91(0.95); C1745(1.08)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C723(3.07); C555(0.78); C91(1.68); C1745(1.35)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C723(0.86); C555(0.87); C91(1.05); C1745(1.02)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C723(0.90); C555(1.14); C91(0.91); C1745(1.04)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C723(0.80); C555(0.87); C91(1.01); C1745(1.08)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C723(0.86); C555(0.93); C91(1.09); C498(0.98)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C723(0.99); C555(0.95); C91(1.11); C1745(0.92)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C723(0.88); C555(0.82); C91(0.93); C1745(0.95)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C723(0.92); C555(0.98); C91(0.99); C1745(0.95)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C723(0.91); C555(0.92); C91(0.81); C1745(0.93)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C723(0.95); C555(0.87); C91(1.13); C1745(0.98)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C723(0.96); C555(0.85); C91(1.21); C1745(0.94)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C723(0.94); C555(1.04); C91(1.09); C1745(1.17)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C723(2.44); C555(0.81); C91(1.23); C1745(1.35)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C723(0.94); C555(0.85); C91(0.92); C1745(1.03)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C723(1.02); C555(0.92); C91(0.97); C1745(1.11)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C723(1.20); C555(0.96); C91(1.08); C1745(1.15)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C723(0.91); C555(0.98); C91(0.92); C1745(1.11)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C723(1.34); C555(0.81); C91(1.34); C498(1.07)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C723(0.96); C555(0.88); C91(1.07); C1745(1.03)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C723(0.93); C555(0.80); C91(1.06); C1745(1.09)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C723(0.97); C555(0.96); C91(1.00); C1745(1.05)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C723(0.93); C555(0.90); C91(0.90); C1745(1.00)  LDD1697  [19]
 LDCM0634  CY-0357 Hep-G2 C869(0.31)  LDD2228  [16]
 LDCM0495  E2913 HEK-293T C723(0.83); C555(0.82); C91(0.91); C1745(0.93)  LDD1698  [19]
 LDCM0204  EV-97 T cell C723(20.00)  LDD0525  [20]
 LDCM0625  F8 Ramos C869(1.20)  LDD2187  [21]
 LDCM0573  Fragment11 Ramos C498(8.97); C869(20.00)  LDD2190  [21]
 LDCM0586  Fragment28 Ramos C869(1.23)  LDD2198  [21]
 LDCM0468  Fragment33 HEK-293T C723(0.87); C555(0.91); C91(0.82); C1745(1.01)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C723(0.93); C555(1.03); C91(1.14); C1745(0.92)  LDD1631  [19]
 LDCM0569  Fragment7 Ramos C498(0.81); C869(3.12)  LDD2186  [21]
 LDCM0118  HHS-0301 DM93 Y1514(0.62)  LDD0266  [7]
 LDCM0120  HHS-0701 DM93 Y1514(0.31)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C723(0.88); C555(0.90); C91(1.00); C595(0.92)  LDD1492  [19]
 LDCM0023  KB03 Jurkat C595(90.49); C981(4.91); C1146(33.70); C498(72.81)  LDD0209  [6]
 LDCM0024  KB05 G361 C769(9.42); C232(3.11)  LDD3311  [22]
 LDCM0090  Rapamycin JHH-7 2.23  LDD0213  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP) . P58753
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 7 (IRF7) IRF family Q92985

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840