Details of the Target

General Information of Target

Target ID LDTP05098
Target Name Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)
Gene Name EIF4G2
Gene ID 1982
Synonyms
DAP5; Eukaryotic translation initiation factor 4 gamma 2; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; Death-associated protein 5; DAP-5; p97
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDD
NSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVD
KALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTR
NVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKK
RVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQD
TVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPR
MKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQS
QFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSF
LMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPS
KEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKA
SSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISE
LAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILE
GKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYI
SSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYN
SNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEE
ESEEEAD
Target Bioclass
Other
Family
Eukaryotic initiation factor 4G family
Function Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.
Uniprot ID
P78344
Ensemble ID
ENST00000339995.11
HGNC ID
HGNC:3297

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.P574S DBIA    Probe Info 
DOTC24510 SNV: p.R360S DBIA    Probe Info 
HCT15 SNV: p.E174D .
JURKAT SNV: p.V853L .
MEWO SNV: p.P194L DBIA    Probe Info 
MFE319 SNV: p.L208S DBIA    Probe Info 
NCIH1793 SNV: p.M378I DBIA    Probe Info 
SW756 SNV: p.Q344E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.54  LDD0215  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
C-Sul
 Probe Info  		3.20  LDD0066  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K170(10.00); K187(0.96); K31(5.73); K313(5.26)  LDD0277  [5]
IPM
 Probe Info  		N.A.  LDD0241  [6]
Probe 1
 Probe Info  		Y185(37.45); Y555(4.04)  LDD3495  [7]
m-APA
 Probe Info  		10.85  LDD0403  [8]
BTD
 Probe Info  		C282(1.86)  LDD2093  [9]
HHS-475
 Probe Info  		Y29(0.30); Y439(0.69)  LDD0264  [10]
HHS-465
 Probe Info  		Y439(0.77)  LDD2237  [11]
DBIA
 Probe Info  		C282(0.99)  LDD0078  [12]
ATP probe
 Probe Info  		K92(0.00); K31(0.00); K230(0.00); K233(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C97(0.00); C629(0.00); C136(0.00); C282(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C97(0.00); C282(0.00); C629(0.00); C136(0.00)  LDD0037  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
TFBX
 Probe Info  		C136(0.00); C282(0.00); C253(0.00)  LDD0148  [20]
1c-yne
 Probe Info  		K41(0.00); K158(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
NAIA_5
 Probe Info  		C231(0.00); C97(0.00); C282(0.00); C629(0.00)  LDD2223  [22]
HHS-482
 Probe Info  		Y29(0.94); Y439(1.18)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.15  LDD0476  [23]
FFF probe3
 Probe Info  		6.32  LDD0465  [23]
STS-2
 Probe Info  		1.00  LDD0139  [24]
Alk-rapa
 Probe Info  		4.01  LDD0213  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C282(0.69)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C282(0.86)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C282(1.49)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C282(1.50)  LDD2152  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C282(0.57)  LDD2131  [9]
 LDCM0214  AC1 HCT 116 C136(0.82); C253(1.00); C255(1.04); C282(1.00)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C136(0.83); C253(0.88); C255(0.96); C282(1.07)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C136(0.57); C253(0.48); C255(0.46); C282(0.83)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C136(0.59); C253(0.54); C255(0.49); C282(0.82)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C136(0.62); C253(0.54); C255(0.51); C282(0.87)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C136(0.55); C253(0.56); C255(0.50); C282(0.84)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C136(0.64); C253(0.54); C255(0.53); C282(0.88)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C136(0.59); C253(0.51); C255(0.46); C282(0.83)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C136(0.56); C253(0.50); C255(0.49); C282(0.85)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C136(0.59); C253(0.60); C255(0.72); C282(1.09)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C136(0.60); C253(0.58); C255(0.73); C282(0.83)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C136(0.76); C253(0.61); C255(0.85); C282(1.02)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C136(0.93); C253(0.78); C255(0.89); C282(1.09)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C136(0.62); C253(0.57); C255(0.79); C282(1.03)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C136(0.66); C253(0.58); C255(0.82); C282(1.00)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C136(0.57); C253(0.51); C255(0.70); C282(1.03)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C136(0.89); C253(1.02); C255(1.00); C282(1.04)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C136(0.96); C253(0.88); C255(0.89); C282(1.01)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C136(0.78); C253(0.94); C255(0.98); C282(1.00)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C136(0.90); C253(0.89); C255(0.93); C282(0.99)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C136(0.80); C253(1.03); C255(0.99); C282(1.15)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C136(1.04); C253(0.98); C255(0.96); C282(1.09)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C136(0.88); C253(1.01); C255(0.96); C282(1.01)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C136(0.89); C253(0.95); C255(0.97); C282(1.08)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C136(0.88); C253(0.80); C255(0.82); C282(1.01)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C136(0.87); C253(1.05); C255(1.04); C282(1.11)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C136(1.10); C253(1.10); C255(1.07); C282(1.00)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C136(0.65); C253(1.02); C255(1.02); C282(1.31)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C136(0.86); C253(1.04); C255(1.04); C282(1.06)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C136(0.92); C253(0.96); C255(0.98); C282(0.94)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C136(0.81); C253(1.03); C255(1.03); C282(0.96)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C136(0.87); C253(0.96); C255(0.99); C282(0.99)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C136(1.57); C253(1.39); C255(1.37); C282(0.94)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C136(1.61); C253(1.36); C255(1.23); C282(1.07)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C136(1.22); C253(1.26); C255(1.17); C282(1.10)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C136(1.15); C253(0.99); C255(1.06); C282(0.99)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C136(1.02); C253(1.12); C255(1.12); C282(1.07)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C136(1.20); C253(1.16); C255(1.05); C282(1.10)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C136(1.07); C253(1.19); C255(1.17); C282(1.02)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C136(1.07); C253(1.14); C255(1.22); C282(0.97)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C136(1.15); C253(1.12); C255(1.12); C282(1.05)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C136(1.04); C253(1.10); C255(1.15); C282(1.04)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C136(1.30); C253(1.12); C255(1.04); C282(1.15)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C136(1.05); C253(1.14); C255(1.08); C282(1.09)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C136(1.01); C253(0.97); C255(0.96); C282(1.07)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C136(1.04); C253(1.08); C255(1.08); C282(1.11)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C136(1.10); C253(1.19); C255(1.12); C282(1.05)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C136(1.02); C253(1.21); C255(1.26); C282(1.16)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C136(0.75); C253(0.80); C255(0.75); C282(1.08)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C255(0.75); C253(0.85); C136(0.87); C282(1.04)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C136(0.72); C255(0.80); C253(0.84); C282(1.07)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C255(0.78); C136(0.79); C253(0.81); C282(0.95)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C136(0.71); C253(0.85); C255(0.90); C282(1.14)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C255(0.94); C282(0.96); C253(0.97); C136(0.98)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C136(0.68); C255(0.78); C253(0.79); C282(0.94)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C97(0.81); C253(0.86); C255(0.94); C136(1.03)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C255(0.74); C253(0.77); C136(0.84); C282(1.13)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C255(0.76); C253(0.77); C136(0.86); C282(1.09)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C136(0.74); C255(0.75); C253(0.86); C282(1.12)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C136(0.83); C255(0.92); C282(0.96); C253(1.03)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C136(0.78); C253(0.75); C255(0.71); C282(1.05)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C136(0.72); C253(0.77); C255(0.71); C282(0.91)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C136(0.91); C253(0.84); C255(0.80); C282(1.04)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C136(0.77); C253(0.91); C255(0.85); C282(0.99)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C255(0.80); C97(0.81); C253(0.81); C136(0.92)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C253(0.76); C97(0.77); C255(0.86); C136(0.90)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C255(0.80); C253(0.81); C97(0.86); C136(0.89)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C136(0.67); C253(0.81); C255(0.85); C282(0.95)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C136(0.85); C255(0.85); C253(0.87); C97(0.89)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C97(0.65); C255(0.84); C253(0.85); C136(0.92)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C97(0.75); C136(0.87); C253(0.88); C255(0.91)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C97(0.72); C255(0.80); C253(0.82); C136(0.83)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C253(0.88); C255(0.91); C97(0.96); C282(0.98)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C255(0.56); C253(0.57); C136(0.79); C282(0.84)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C255(0.57); C136(0.61); C253(0.62); C282(0.89)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C255(0.52); C253(0.55); C136(0.64); C282(0.90)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C255(0.49); C253(0.51); C136(0.62); C282(0.93)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C255(0.46); C253(0.49); C136(0.66); C282(0.92)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C136(0.62); C282(0.92); C253(1.14); C255(1.19)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C253(0.50); C255(0.51); C136(0.64); C282(0.87)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C255(0.54); C253(0.56); C136(0.63); C282(0.87)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C255(0.51); C253(0.55); C136(0.59); C282(0.91)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C255(0.56); C253(0.57); C136(0.66); C282(0.88)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C255(0.50); C253(0.54); C136(0.81); C282(1.02)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C97(0.86); C282(0.95); C136(1.04); C253(1.10)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C282(0.97); C253(1.03); C97(1.05); C136(1.13)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C97(1.01); C282(1.06); C136(1.13); C253(1.21)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C253(0.95); C282(0.96); C255(0.98); C97(1.20)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C282(0.99); C97(1.02); C253(1.06); C255(1.11)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C136(0.69); C282(0.98); C253(1.01); C255(1.04)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C97(0.93); C253(1.07); C282(1.10); C136(1.10)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C97(0.93); C253(1.03); C255(1.04); C136(1.08)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C97(0.92); C282(0.95); C253(1.00); C255(1.01)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C282(1.02); C253(1.06); C255(1.07); C97(1.12)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C282(1.03); C97(1.09); C253(1.22); C255(1.24)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C97(1.06); C282(1.11); C136(1.21); C253(1.31)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C255(0.99); C253(1.02); C282(1.06); C136(1.07)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C136(0.88); C255(0.89); C253(0.94); C282(1.07)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C136(1.10); C282(1.11); C255(1.16); C253(1.27)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C255(1.05); C253(1.11); C282(1.20); C136(1.30)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C136(0.66); C253(0.90); C255(0.94); C282(1.01)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C136(1.08); C255(1.11); C282(1.16); C253(1.16)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C255(0.92); C282(1.01); C136(1.03); C253(1.06)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C255(0.86); C136(0.90); C253(0.99); C282(1.10)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C255(1.02); C282(1.04); C136(1.07); C253(1.09)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C255(0.93); C253(1.05); C136(1.06); C282(1.16)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C136(1.02); C255(1.04); C253(1.12); C282(1.20)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C255(1.22); C253(1.29); C136(1.36); C282(1.49)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C97(0.74); C253(0.76); C136(0.77); C255(0.82)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C253(0.70); C97(0.77); C255(0.78); C136(0.90)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C97(0.76); C253(0.80); C136(0.85); C255(0.87)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C97(0.75); C253(0.80); C255(0.88); C136(0.95)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C253(0.78); C97(0.79); C136(0.82); C255(0.85)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C253(0.78); C97(0.82); C255(0.83); C136(0.90)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C253(0.83); C136(0.84); C97(0.85); C255(0.89)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C97(0.74); C136(0.78); C253(0.79); C255(0.85)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C97(0.82); C136(0.82); C253(0.85); C255(0.90)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C136(0.72); C253(0.77); C255(0.88); C97(1.01)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C253(0.72); C255(0.78); C136(0.88); C97(0.99)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C136(0.76); C97(0.83); C253(0.87); C255(0.94)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C136(0.97); C282(1.02); C253(1.03); C255(1.03)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C282(1.02); C136(1.09); C253(1.14); C255(1.14)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C97(0.77); C136(0.89); C253(0.93); C255(1.00)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C136(0.95); C253(1.02); C255(1.02); C282(1.05)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C282(0.97); C253(1.04); C255(1.04); C136(1.11)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C282(0.91); C253(0.96); C255(0.96); C136(0.99)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C282(0.95); C136(1.16); C253(1.24); C255(1.24)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C282(0.99); C253(1.30); C255(1.30); C136(1.31)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C282(1.03); C136(1.29); C253(1.39); C255(1.39)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C282(0.96); C136(1.01); C253(1.19); C255(1.19)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C136(0.96); C282(1.03); C253(1.16); C255(1.16)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C136(0.98); C253(1.03); C255(1.03); C282(1.10)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C253(0.97); C255(0.97); C136(1.00); C282(1.05)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C97(0.70); C253(0.82); C255(0.91); C136(1.03)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C282(1.00); C136(1.04); C253(1.07); C255(1.07)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C136(0.99); C253(1.07); C255(1.07); C282(1.10)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C282(1.03); C136(1.27); C253(1.46); C255(1.46)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C253(0.76); C136(0.83); C255(0.87); C282(1.26)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C253(0.71); C255(0.80); C136(0.88); C282(1.11)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C253(0.69); C136(0.74); C255(0.79); C282(1.03)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C253(0.70); C255(0.76); C136(0.87); C282(1.01)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C253(0.82); C136(0.86); C255(0.91); C282(0.99)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C253(0.65); C255(0.71); C136(0.83); C282(0.99)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C253(0.69); C255(0.74); C136(0.77); C282(1.02)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C136(0.89); C282(0.95); C253(0.97); C255(1.01)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C136(0.80); C253(0.86); C255(0.90); C282(1.19)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C253(0.69); C136(0.77); C255(0.78); C282(1.14)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C253(0.63); C255(0.72); C136(0.82); C282(0.96)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C253(0.69); C136(0.74); C255(0.78); C282(0.94)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C136(0.79); C253(0.88); C255(0.93); C282(0.96)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C253(0.78); C136(0.79); C255(0.83); C282(0.98)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C253(0.64); C136(0.72); C255(0.75); C282(1.02)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C255(0.53); C136(0.56); C253(0.58); C282(0.97)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C255(0.48); C253(0.52); C136(0.63); C282(0.85)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C136(1.05); C253(0.95); C255(1.05); C282(1.03)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C97(0.80); C253(0.84); C136(0.90); C255(0.95)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C97(0.82); C253(0.84); C136(0.88); C255(0.91)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 10.85  LDD0403  [8]
 LDCM0020  ARS-1620 HCC44 C282(0.99)  LDD0078  [12]
 LDCM0108  Chloroacetamide HeLa H576(0.00); H74(0.00); H224(0.00); H28(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C282(1.67)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C136(0.85); C282(0.93); C255(0.97); C253(1.05)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C136(0.98); C255(1.01); C253(1.03); C282(1.05)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C136(0.79); C253(0.92); C255(0.94); C282(0.98)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C97(0.76); C253(0.77); C136(0.86); C255(0.87)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C136(0.84); C253(0.85); C255(0.89); C97(0.97)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C97(0.85); C136(0.89); C255(0.95); C282(0.96)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C97(0.86); C253(0.90); C136(0.95); C255(0.99)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C97(0.74); C255(0.79); C253(0.82); C136(0.91)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C97(0.78); C255(0.94); C136(0.95); C253(0.98)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C97(0.69); C255(0.81); C253(0.90); C136(0.94)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C255(0.86); C97(0.87); C253(0.94); C136(1.05)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C97(0.72); C255(0.74); C253(0.77); C136(0.83)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C136(1.06); C282(1.10); C255(1.12); C253(1.26)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C97(0.63); C255(0.82); C253(0.83); C136(0.86)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C97(0.67); C255(0.73); C253(0.78); C136(0.84)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C253(0.64); C255(0.67); C282(0.83); C136(0.88)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C255(0.47); C253(0.49); C136(0.71); C282(0.84)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C255(0.52); C253(0.55); C136(0.66); C282(0.82)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C255(0.43); C253(0.48); C136(0.69); C282(0.85)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C255(0.52); C253(0.55); C136(0.67); C282(0.90)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C253(1.18); C282(1.22); C97(1.25); C255(1.29)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C282(0.97); C253(1.04); C136(1.10); C255(1.11)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C282(0.99); C253(1.03); C97(1.05); C255(1.09)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C136(1.05); C255(1.21); C282(1.26); C253(1.29)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C136(0.93); C253(0.96); C282(0.99); C255(1.03)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C136(0.64); C253(1.12); C282(1.23); C255(1.62)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C255(0.99); C136(1.06); C253(1.06); C282(1.10)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C255(0.95); C253(1.03); C136(1.05); C282(1.05)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C255(1.00); C136(1.05); C253(1.14); C282(1.15)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C253(0.68); C136(0.74); C255(0.76); C97(0.93)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C253(0.66); C97(0.67); C255(0.70); C136(0.78)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C253(0.72); C255(0.77); C136(0.78); C97(0.79)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C253(0.71); C136(0.72); C255(0.76); C97(0.82)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C136(0.88); C282(1.00); C255(1.02); C253(1.17)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C136(0.88); C253(0.91); C282(0.93); C255(0.99)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C136(0.80); C282(0.99); C253(1.00); C255(1.04)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C255(0.89); C253(0.89); C97(0.90); C136(0.93)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C97(0.91); C255(0.92); C136(0.93); C253(0.98)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C255(1.01); C253(1.04); C97(1.07); C282(1.09)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C97(0.87); C255(0.93); C136(0.94); C253(1.00)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C136(0.82); C282(0.93); C253(0.94); C255(0.98)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C97(0.84); C255(0.88); C136(0.90); C253(0.93)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C136(0.92); C97(0.95); C255(0.99); C253(1.02)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C136(1.04); C97(1.17); C255(1.21); C253(1.24)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C255(0.81); C253(0.87); C97(0.92); C136(1.07)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C97(0.93); C255(0.97); C136(1.02); C253(1.07)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C136(0.93); C253(1.00); C255(0.94); C282(1.07)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C136(1.00); C253(0.85); C255(0.87); C282(1.10)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C136(0.88); C253(1.03); C255(1.01); C282(1.05)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C136(0.98); C253(0.93); C255(0.86); C282(1.04)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C136(0.96); C253(1.01); C255(1.02); C282(1.11)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C136(0.91); C253(0.86); C255(0.93); C282(0.92)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C136(1.03); C253(0.89); C255(0.84); C282(1.06)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C136(0.97); C253(0.86); C255(0.87); C282(0.99)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C136(1.10); C253(0.95); C255(0.96); C282(1.25)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C136(0.88); C253(0.86); C255(0.84); C282(1.04)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C136(1.03); C253(0.94); C255(0.95); C282(1.07)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C136(1.02); C253(0.90); C255(0.92); C282(1.02)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C136(1.09); C253(0.86); C255(0.92); C282(1.06)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C136(1.00); C253(0.93); C255(0.88); C282(1.08)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C136(0.97); C253(0.90); C255(0.88); C282(1.10)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C136(0.78); C253(1.01); C255(0.90); C282(0.94)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C136(0.82); C253(0.85); C255(0.83); C282(1.11)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C136(1.14); C253(0.83); C255(0.86); C282(1.05)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C136(1.14); C253(1.02); C255(1.02); C282(1.41)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C136(1.17); C253(0.93); C255(0.91); C282(1.08)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C136(1.06); C253(0.89); C255(0.85); C282(0.99)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C136(1.15); C253(0.94); C255(1.00); C282(1.01)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C136(1.06); C253(1.07); C255(1.08); C282(0.91)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C136(0.97); C253(0.98); C255(0.96); C282(0.95)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C136(1.16); C253(1.00); C255(0.99); C282(0.94)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C136(1.09); C253(0.91); C255(0.97); C282(0.91)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C136(0.77); C253(0.96); C255(1.06); C282(1.02)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C136(0.98); C253(1.05); C255(1.03); C282(0.85)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C136(1.02); C253(1.04); C255(1.05); C282(0.85)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C136(1.04); C253(1.03); C255(1.04); C282(0.86)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C136(1.07); C253(0.96); C255(0.95); C282(0.86)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C136(1.03); C253(1.20); C255(1.18); C282(0.86)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C136(1.04); C253(0.99); C255(0.95); C282(0.87)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C136(0.92); C253(0.93); C255(0.95); C282(0.92)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C136(1.01); C253(0.96); C255(0.95); C282(0.87)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C136(1.08); C253(1.04); C255(1.05); C282(0.90)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C136(0.90); C253(0.94); C255(0.95); C282(0.88)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C136(1.02); C253(1.05); C255(1.02); C282(0.97)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C136(1.01); C253(0.92); C255(0.89); C282(0.92)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C136(0.66); C253(1.08); C255(1.06); C282(0.96)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C136(0.74); C253(0.83); C255(0.84); C282(1.03)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C136(0.66); C253(0.96); C255(0.96); C282(0.97)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C136(0.68); C253(0.81); C255(0.80); C282(0.93)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C136(0.82); C253(0.90); C255(0.89); C282(1.02)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C136(0.74); C253(1.05); C255(1.10); C282(1.11)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C136(0.86); C253(0.83); C255(0.85); C282(1.01)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C136(0.95); C253(0.95); C255(0.94); C282(1.02)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C136(0.68); C253(1.04); C255(1.06); C282(0.98)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C136(1.03); C253(1.12); C255(1.15); C282(1.16)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C136(0.88); C253(0.81); C255(0.83); C282(1.04)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C136(0.76); C253(0.76); C255(0.76); C282(1.02)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C136(0.67); C253(0.92); C255(0.94); C282(1.00)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C136(0.89); C253(0.76); C255(0.76); C282(0.93)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C136(0.82); C253(0.88); C255(0.90); C282(0.94)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C136(0.93); C253(0.99); C255(0.93); C282(0.97)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C136(2.02); C253(0.89); C255(0.83); C282(0.95)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C136(0.77); C253(0.99); C255(0.98); C282(1.00)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C136(0.89); C253(1.03); C255(0.94); C282(1.03)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C136(0.98); C253(1.13); C255(1.08); C282(1.16)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C136(1.18); C253(0.99); C255(1.03); C282(1.06)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C136(0.86); C253(0.92); C255(0.99); C282(0.94)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C136(1.08); C253(1.12); C255(1.06); C282(1.16)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C136(1.05); C253(1.02); C255(1.13); C282(1.15)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C136(1.14); C253(1.24); C255(1.20); C282(1.37)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C136(0.81); C253(0.85); C255(0.88); C282(0.99)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C136(0.90); C253(0.82); C255(0.86); C282(0.99)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C136(0.89); C253(0.95); C255(1.05); C282(0.92)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C136(1.03); C253(1.09); C255(0.99); C282(1.04)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C136(1.23); C253(1.29); C255(1.28); C282(1.52)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C136(0.84); C253(0.93); C255(0.98); C282(0.97)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C136(0.99); C253(0.93); C255(1.00); C282(0.88)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C136(0.59); C253(0.89); C255(0.89); C282(1.01)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C136(0.74); C253(0.91); C255(0.91); C282(0.91)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C136(0.91); C253(0.97); C255(1.00); C282(0.90)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C136(0.93); C253(0.82); C255(0.83); C282(0.90)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C136(0.67); C253(0.79); C255(0.81); C282(0.88)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C136(0.51); C253(0.88); C255(0.89); C282(0.97)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C136(0.69); C253(0.78); C255(0.79); C282(0.97)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C136(0.56); C253(0.82); C255(0.83); C282(0.96)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C136(0.58); C253(0.94); C255(0.95); C282(1.01)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C282(1.00); C97(0.94); C629(1.08); C253(1.18)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C282(1.45)  LDD1702  [9]
 LDCM0625  F8 Ramos C282(1.76)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C282(2.38)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C282(0.64)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C282(0.44)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C282(0.85)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C282(0.63)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C282(0.86)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C282(0.48)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C282(0.50)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C282(1.03)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C282(1.14)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C282(0.97)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C282(0.81)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C282(0.42)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C136(0.74); C253(0.82); C255(0.85); C282(1.06)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C282(0.76)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C282(1.35)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C136(1.12); C253(1.01); C255(1.01); C282(1.13)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C282(0.88)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C282(0.83)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C282(0.69)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C282(0.66)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y29(0.30); Y439(0.69)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y29(0.20); Y439(0.99)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y29(0.15); Y439(0.62)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y29(0.29); Y439(0.69)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y29(0.62); Y439(1.06)  LDD0268  [10]
 LDCM0107  IAA HeLa H576(0.00); H74(0.00); H229(0.00); H28(0.00)  LDD0221  [21]
 LDCM0022  KB02 HCT 116 C253(12.70); C255(12.70)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C253(20.00); C255(20.00)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C253(20.00); C255(20.00)  LDD0082  [12]
 LDCM0109  NEM HeLa H576(0.00); H224(0.00); H74(0.00)  LDD0223  [21]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C282(1.86)  LDD2093  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C282(1.73)  LDD2099  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C282(1.47)  LDD2107  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C282(0.92)  LDD2109  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C282(1.63)  LDD2119  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C282(1.09)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C282(1.24)  LDD2123  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C282(1.32)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C282(1.43)  LDD2127  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C282(1.86)  LDD2129  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C282(1.28)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C282(1.71)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C282(1.21)  LDD2137  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C282(1.52)  LDD2140  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C282(1.66)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C282(1.16)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C282(1.67)  LDD2148  [9]
 LDCM0090  Rapamycin JHH-7 4.01  LDD0213  [25]
 LDCM0021  THZ1 HCT 116 C282(1.34)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic initiation factor 4A-I (EIF4A1) DEAD box helicase family P60842
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) EIF-2-beta/eIF-5 family P20042
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578