Details of the Target

General Information of Target

Target ID LDTP13924
Target Name Mediator of RNA polymerase II transcription subunit 16 (MED16)
Gene Name MED16
Gene ID 10025
Synonyms
DRIP92; THRAP5; Mediator of RNA polymerase II transcription subunit 16; Mediator complex subunit 16; Thyroid hormone receptor-associated protein 5; Thyroid hormone receptor-associated protein complex 95 kDa component; Trap95; Vitamin D3 receptor-interacting protein complex 92 kDa component; DRIP92
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGS
DSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQ
FFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDG
YITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQ
KDENIMSSMQLFENVI
Target Bioclass
Other
Family
Mediator complex subunit 16 family
Subcellular location
Nucleus
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Uniprot ID
Q9Y2X0
Ensemble ID
ENST00000312090.10
HGNC ID
HGNC:17556

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A144V DBIA    Probe Info 
CCK81 SNV: p.R42Q DBIA    Probe Info 
HCT15 SNV: p.L134M DBIA    Probe Info 
HUH1 SNV: p.V188L DBIA    Probe Info 
JURKAT SNV: p.E510D .
OCIAML2 SNV: p.P705Q DBIA    Probe Info 
RL952 SNV: p.A46T DBIA    Probe Info 
SNGM SNV: p.D388G DBIA    Probe Info 
SUPT1 SNV: p.I180T DBIA    Probe Info 
SW756 SNV: p.R656Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C545(1.12)  LDD2104  [2]
DBIA
 Probe Info  		C253(4.12)  LDD0204  [3]
HHS-475
 Probe Info  		Y547(0.85)  LDD0264  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C539(0.00); C584(0.00); C107(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C253(0.00); C245(0.00); C107(0.00); C267(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C107(0.00); C539(0.00); C584(0.00); C245(0.00)  LDD0037  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
ENE
 Probe Info  		N.A.  LDD0006  [6]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
AOyne
 Probe Info  		14.80  LDD0443  [9]
HHS-465
 Probe Info  		N.A.  LDD2240  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		2.80  LDD0213  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C545(1.00); C539(0.99); C584(0.90); C245(1.00)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C545(0.96); C539(0.97); C584(0.92); C245(0.93)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C545(0.95); C539(0.99); C584(0.92); C245(0.93)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C545(1.16); C539(0.94); C584(0.91); C245(0.91)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C545(1.03); C539(0.95); C584(0.96); C245(1.05)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C545(1.00); C539(0.92); C584(0.88); C245(0.99)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C545(1.06); C539(1.01); C584(0.99); C245(0.93)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C545(0.96); C539(0.99); C584(1.02); C245(1.00)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C545(1.46); C539(1.29); C584(1.14); C245(0.89)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C545(0.91); C539(0.92); C584(0.98); C245(1.02)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C545(0.92); C539(0.99); C584(0.95); C245(0.92)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C545(1.08); C539(1.02); C584(0.94); C245(1.05)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C545(1.02); C539(0.96); C584(0.92); C245(0.95)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C545(1.03); C539(0.95); C584(0.95); C245(1.09)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C545(0.97); C539(1.05); C584(0.96); C245(0.98)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C545(1.04); C539(1.06); C584(0.96); C245(1.07)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C545(0.92); C539(1.02); C584(1.01); C245(1.01)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C545(1.04); C539(1.08); C584(0.99); C245(0.98)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C545(1.05); C539(1.00); C584(0.97); C245(0.98)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C545(1.05); C539(1.01); C584(1.00); C245(1.06)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C545(1.03); C539(1.03); C584(0.96); C245(0.90)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C545(0.98); C539(0.93); C584(0.93); C245(1.04)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C545(0.99); C539(1.00); C584(0.96); C245(0.98)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C545(1.02); C539(0.96); C584(0.94); C245(1.02)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C545(1.02); C539(0.94); C584(0.91); C245(0.93)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C545(0.98); C539(0.97); C584(0.91); C245(0.93)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C545(0.97); C539(1.04); C584(0.94); C245(0.97)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C545(0.97); C539(1.03); C584(0.91); C245(0.95)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C545(0.85); C539(0.99); C584(0.93); C245(1.05)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C545(0.98); C539(0.95); C584(0.93); C245(1.04)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C545(0.86); C539(1.01); C584(0.91); C245(0.97)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C545(1.01); C539(0.94); C584(0.93); C245(0.95)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C545(1.09); C539(0.98); C584(0.92); C245(0.94)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C545(1.00); C539(1.04); C584(0.93); C245(0.90)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C545(0.96); C539(0.99); C584(0.98); C245(0.96)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C545(0.98); C539(1.07); C584(1.00); C245(1.05)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C545(1.05); C539(0.96); C584(0.90); C245(0.98)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C545(0.85); C539(0.99); C584(0.91); C245(1.01)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C545(1.10); C539(0.99); C584(0.94); C245(0.95)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C545(1.06); C539(0.97); C584(0.91); C245(0.94)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C545(1.00); C539(0.97); C584(0.92); C245(0.96)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C545(0.98); C539(1.00); C584(0.90); C245(0.89)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C545(0.88); C539(0.99); C584(0.91); C245(0.96)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C545(0.92); C539(0.95); C584(0.93); C245(1.04)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C545(0.94); C539(0.96); C584(0.95); C245(0.98)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C545(0.94); C539(0.98); C584(0.96); C245(0.94)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C545(0.97); C539(1.00); C584(0.85); C245(1.06)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C545(0.91); C539(0.97); C584(0.92); C245(0.97)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C545(1.09); C539(0.98); C584(0.88); C245(0.98)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C545(1.05); C539(1.00); C584(0.93); C245(0.96)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C545(1.03); C539(1.03); C584(0.96); C245(0.96)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C545(0.92); C539(0.99); C584(0.95); C245(1.01)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C545(0.99); C539(0.99); C584(0.95); C245(1.04)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C545(0.99); C539(0.95); C584(0.95); C245(1.00)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C545(1.00); C539(1.01); C584(0.93); C245(0.96)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C545(1.12); C539(1.05); C584(0.92); C245(1.03)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C545(0.97); C539(0.98); C584(0.94); C245(0.98)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C545(0.93); C539(1.04); C584(0.93); C245(1.02)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C545(1.00); C539(0.94); C584(0.92); C245(0.96)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C545(1.05); C539(0.95); C584(0.98); C245(1.03)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C545(1.05); C539(0.99); C584(0.91); C245(0.90)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C545(1.06); C539(0.97); C584(0.92); C245(1.02)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C545(1.02); C539(0.98); C584(0.88); C245(0.99)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C545(1.09); C539(0.96); C584(0.88); C245(0.93)  LDD1514  [12]
 LDCM0102  BDHI 8 Jurkat C253(4.12)  LDD0204  [3]
 LDCM0367  CL1 HEK-293T C545(0.89); C539(1.14); C584(0.88); C245(0.97)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C545(1.95); C539(1.82); C584(1.12); C245(0.98)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C545(0.89); C539(1.07); C584(0.91); C245(0.96)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C545(0.99); C539(1.05); C584(0.92); C245(0.99)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C545(0.96); C539(1.26); C584(0.99); C245(0.89)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C545(0.85); C539(0.97); C584(0.99); C245(1.00)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C545(0.92); C539(1.01); C584(0.90); C245(0.96)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C545(0.94); C539(1.02); C584(0.93); C245(1.00)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C545(0.93); C539(1.06); C584(0.99); C245(0.98)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C545(0.95); C539(0.95); C584(0.96); C245(1.02)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C545(0.94); C539(0.99); C584(1.05); C245(0.98)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C545(1.10); C539(1.12); C584(0.97); C245(0.98)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C545(1.29); C539(1.21); C584(1.01); C245(1.11)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C545(0.99); C539(1.29); C584(1.01); C245(0.86)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C545(1.07); C539(1.17); C584(1.01); C245(0.94)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C545(0.88); C539(1.18); C584(1.01); C245(0.93)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C545(0.94); C539(1.01); C584(0.95); C245(1.01)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C545(1.04); C539(1.41); C584(1.02); C245(0.90)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C545(0.88); C539(0.98); C584(0.93); C245(0.99)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C545(0.90); C539(0.90); C584(0.85); C245(1.03)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C545(1.06); C539(0.94); C584(0.92); C245(0.96)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C545(0.99); C539(0.98); C584(0.98); C245(0.98)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C545(0.92); C539(0.99); C584(0.95); C245(1.02)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C545(1.08); C539(1.17); C584(0.94); C245(1.03)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C545(0.88); C539(0.98); C584(0.92); C245(0.96)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C545(0.90); C539(1.02); C584(0.88); C245(1.04)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C545(1.00); C539(1.06); C584(0.94); C245(0.96)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C545(1.29); C539(1.31); C584(1.00); C245(0.91)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C545(1.01); C539(1.15); C584(0.88); C245(0.96)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C545(0.91); C539(1.01); C584(0.94); C245(0.98)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C545(0.96); C539(1.10); C584(0.99); C245(1.00)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C545(0.91); C539(0.99); C584(0.99); C245(1.02)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C545(0.86); C539(0.97); C584(0.91); C245(0.97)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C545(1.00); C539(1.08); C584(0.90); C245(1.01)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C545(0.98); C539(0.95); C584(0.87); C245(1.00)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C545(1.20); C539(1.47); C584(1.00); C245(0.94)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C545(0.94); C539(0.90); C584(0.82); C245(1.08)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C545(1.29); C539(1.45); C584(0.97); C245(0.87)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C545(1.09); C539(0.96); C584(0.86); C245(1.06)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C545(1.01); C539(1.04); C584(0.91); C245(1.03)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C545(0.99); C539(0.95); C584(0.97); C245(0.98)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C545(1.10); C539(0.96); C584(0.92); C245(1.05)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C545(1.35); C539(1.45); C584(1.00); C245(0.94)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C545(1.04); C539(1.14); C584(0.94); C245(1.10)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C545(1.11); C539(1.12); C584(0.90); C245(1.11)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C545(1.11); C539(1.11); C584(0.93); C245(0.99)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C545(1.11); C539(1.44); C584(0.97); C245(0.95)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C545(0.96); C539(1.01); C584(0.96); C245(0.99)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C545(1.03); C539(0.97); C584(0.97); C245(1.02)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C545(0.97); C539(1.00); C584(0.89); C245(0.98)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C545(1.01); C539(1.00); C584(0.87); C245(1.09)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C545(1.02); C539(1.00); C584(0.92); C245(0.98)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C545(0.97); C539(0.98); C584(0.98); C245(1.06)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C545(1.15); C539(1.06); C584(0.98); C245(1.01)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C545(1.02); C539(0.98); C584(0.93); C245(0.98)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C545(1.90); C539(2.60); C584(1.15); C245(0.93)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C545(1.05); C539(1.24); C584(0.96); C245(1.04)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C545(1.16); C539(1.12); C584(0.97); C245(1.15)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C545(1.15); C539(1.20); C584(0.98); C245(0.97)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C545(0.97); C539(1.00); C584(0.90); C245(1.10)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C545(1.11); C539(0.97); C584(0.89); C245(1.04)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C545(0.88); C539(1.04); C584(0.88); C245(0.92)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C545(0.88); C539(0.98); C584(0.91); C245(0.96)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C545(1.02); C539(1.18); C584(0.98); C245(0.95)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C545(0.95); C539(0.92); C584(1.00); C245(1.09)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C545(1.02); C539(1.06); C584(0.94); C245(1.05)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C545(1.05); C539(1.07); C584(0.99); C245(0.97)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C545(1.02); C539(1.30); C584(1.01); C245(0.92)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C545(1.17); C539(1.15); C584(1.01); C245(1.02)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C545(1.08); C539(1.15); C584(1.01); C245(1.24)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C545(1.14); C539(1.23); C584(1.02); C245(1.03)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C545(0.88); C539(1.05); C584(0.88); C245(1.04)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C545(1.09); C539(0.96); C584(0.88); C245(1.02)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C545(0.97); C539(1.10); C584(0.96); C245(0.96)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C545(0.91); C539(0.94); C584(0.89); C245(1.02)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C545(1.14); C539(1.27); C584(0.91); C245(0.89)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C545(1.38); C539(1.47); C584(0.94); C245(0.88)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C545(0.95); C539(1.03); C584(0.94); C245(1.02)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C545(0.94); C539(1.05); C584(0.88); C245(1.06)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C545(1.15); C539(1.28); C584(0.94); C245(0.98)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C545(1.15); C539(1.20); C584(0.93); C245(0.94)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C545(1.36); C539(1.14); C584(0.88); C245(1.09)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C545(1.19); C539(1.47); C584(0.93); C245(1.02)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C545(1.17); C539(1.24); C584(0.94); C245(0.99)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C545(0.91); C539(0.97); C584(0.87); C245(1.14)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C545(0.89); C539(0.93); C584(0.94); C245(1.03)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C545(0.91); C539(0.94); C584(0.93); C245(1.04)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C545(0.93); C539(1.18); C584(0.90); C245(0.87)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C545(0.95); C539(0.96); C584(0.85); C245(0.98)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C545(0.98); C539(1.02); C584(0.90); C245(0.99)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C545(1.06); C539(1.07); C584(0.94); C245(1.02)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C545(1.09); C539(1.06); C584(0.89); C245(1.04)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C545(1.15); C539(1.13); C584(0.90); C245(1.05)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C545(1.01); C539(1.03); C584(0.95); C245(0.99)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C545(1.01); C539(1.06); C584(0.99); C245(1.14)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C545(1.25); C539(1.16); C584(0.94); C245(1.16)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C545(1.07); C539(1.10); C584(0.95); C245(0.97)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C545(1.07); C539(1.09); C584(0.90); C245(1.06)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C545(0.94); C539(0.93); C584(0.95); C245(1.08)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C545(0.99); C539(0.94); C584(0.91); C245(0.94)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C545(1.02); C539(1.14); C584(0.90); C245(0.91)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C545(0.94); C539(0.95); C584(0.91); C245(1.02)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C545(1.04); C539(0.96); C584(0.91); C245(1.07)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C545(2.36); C539(3.58); C584(1.48); C245(0.81)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C545(0.93); C539(1.00); C584(0.91); C245(1.07)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C545(1.02); C539(1.03); C584(0.83); C245(1.03)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C545(0.93); C539(1.05); C584(0.97); C245(1.14)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C545(1.13); C539(1.21); C584(0.94); C245(1.10)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C545(1.15); C539(1.26); C584(0.98); C245(1.01)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C545(0.84); C539(0.93); C584(0.85); C245(1.10)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C545(0.97); C539(0.98); C584(0.92); C245(1.02)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C545(0.93); C539(1.04); C584(0.88); C245(1.04)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C545(0.86); C539(0.98); C584(0.88); C245(1.05)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C545(1.02); C539(0.91); C584(0.86); C245(1.04)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C545(1.06); C539(1.08); C584(0.90); C245(0.95)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C545(1.76); C539(2.17); C584(1.10); C245(0.89)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C545(0.97); C539(0.99); C584(0.93); C245(1.05)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C545(1.19); C539(1.23); C584(0.91); C245(0.98)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C545(1.00); C539(1.41); C584(0.92); C245(1.07)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C545(1.07); C539(1.08); C584(0.94); C245(1.02)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C545(1.79); C539(2.26); C584(1.27); C245(0.92)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C545(1.28); C539(1.20); C584(0.92); C245(1.03)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C545(1.01); C539(1.16); C584(0.96); C245(0.99)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C545(0.98); C539(1.04); C584(0.95); C245(0.97)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C545(0.95); C539(1.03); C584(1.00); C245(1.01)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C545(0.86); C539(0.98); C584(0.84); C245(0.97)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C545(3.36); C795(2.28); C790(0.96)  LDD1702  [2]
 LDCM0625  F8 Ramos C545(10.27); 1.72; C539(1.05)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos 0.92  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C545(20.00); 1.58  LDD2190  [13]
 LDCM0574  Fragment12 Ramos 0.62; C539(3.63)  LDD2191  [13]
 LDCM0576  Fragment14 Ramos C545(1.16); 0.74  LDD2193  [13]
 LDCM0579  Fragment20 Ramos 1.40  LDD2194  [13]
 LDCM0580  Fragment21 Ramos 0.49; C539(2.02)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C539(1.81)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C539(1.02)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C545(0.87); 0.93  LDD2198  [13]
 LDCM0588  Fragment30 Ramos 0.92; C539(3.46)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C539(1.41)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C539(7.78)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C545(0.88); C539(1.04); C584(0.88); C245(0.98)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos 0.35; C539(2.01)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C545(0.90); 1.03; C539(1.63)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C545(0.96); C539(0.97); C584(0.98); C245(1.05)  LDD1631  [12]
 LDCM0614  Fragment56 Ramos C539(1.32)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C545(1.28); 0.69  LDD2186  [13]
 LDCM0116  HHS-0101 DM93 Y547(0.85)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y547(0.72)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y547(0.69)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y547(1.07)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y547(0.66)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C545(0.92); C539(0.89); C584(0.90); C245(0.98)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C19(28.54); C584(7.67); C539(194.75); C545(5.04)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C539(4.57)  LDD3310  [14]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C545(1.12)  LDD2104  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C539(0.66)  LDD2125  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C539(0.60)  LDD2207  [15]
 LDCM0090  Rapamycin JHH-7 2.80  LDD0213  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 14 (MED14) Mediator complex subunit 14 family O60244
Mediator of RNA polymerase II transcription subunit 23 (MED23) Mediator complex subunit 23 family Q9ULK4
Mediator of RNA polymerase II transcription subunit 24 (MED24) Mediator complex subunit 24 family O75448
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.