Details of the Target

General Information of Target

Target ID LDTP04013
Target Name Neutral amino acid transporter A (SLC1A4)
Gene Name SLC1A4
Gene ID 6509
Synonyms
ASCT1; SATT; Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA
ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY
FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP
SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL
GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA
SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN
GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA
AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK
ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
Target Bioclass
Transporter and channel
Family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A4 subfamily
Subcellular location
Membrane
Function Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine.
Uniprot ID
P43007
Ensemble ID
ENST00000234256.4
HGNC ID
HGNC:10942
ChEMBL ID
CHEMBL2315

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A673 SNV: p.L93P DBIA    Probe Info 
CAL148 SNV: p.I139M DBIA    Probe Info 
CCK81 SNV: p.F320L DBIA    Probe Info 
JURKAT SNV: p.A119T .
KYSE510 SNV: p.Q71K DBIA    Probe Info 
NCIH446 SNV: p.E524D DBIA    Probe Info 
OVISE SNV: p.G37D .
SKNSH SNV: p.P162T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-5
 Probe Info  		5.81  LDD0394  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
OPA-S-S-alkyne
 Probe Info  		K239(1.94)  LDD3494  [3]
m-APA
 Probe Info  		12.37  LDD0403  [4]
AHL-Pu-1
 Probe Info  		C500(2.48)  LDD0169  [5]
DBIA
 Probe Info  		C500(0.77)  LDD0531  [6]
IA-alkyne
 Probe Info  		C355(0.00); C500(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
VSF
 Probe Info  		N.A.  LDD0007  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
VE-P
 Probe Info  		N.A.  LDD0396  [13]
Alk-rapa
 Probe Info  		2.29  LDD0213  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C500(2.00)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C500(2.48)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C500(0.77)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C355(1.05); C500(0.94)  LDD1508  [15]
 LDCM0216  AC100 HEK-293T C500(0.86)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C500(0.71)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C500(0.80)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C500(1.27)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C500(1.10)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C500(0.62)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C500(0.66)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C500(0.58)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C500(0.90)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C500(0.65)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C355(1.10); C500(0.97)  LDD1509  [15]
 LDCM0227  AC110 HEK-293T C500(1.04)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C500(1.09)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C500(1.18)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C500(0.90)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C500(0.92)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C500(0.88)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C500(0.77)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C500(0.96)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C500(0.95)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C500(0.85)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C355(1.07); C500(0.91)  LDD1510  [15]
 LDCM0238  AC120 HEK-293T C500(0.75)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C500(0.80)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C500(0.85)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C500(0.91)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C500(0.76)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C500(0.75)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C500(0.87)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C500(1.02)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C500(1.50)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C500(1.12)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C500(1.09)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C500(1.28)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C500(1.30)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C500(1.30)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C500(1.31)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C500(1.25)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C500(1.27)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C500(1.26)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C500(1.38)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C500(1.35)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C355(1.03); C500(0.89)  LDD1512  [15]
 LDCM0260  AC140 HEK-293T C500(1.24)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C500(1.35)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C500(1.18)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C500(0.89)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C500(0.98)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C500(0.98)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C500(0.93)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C500(1.08)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C500(0.88)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C500(1.03)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C355(1.03); C500(0.90)  LDD1513  [15]
 LDCM0271  AC150 HEK-293T C500(0.94)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C500(0.88)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C500(0.96)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C500(0.89)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C500(0.94)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C500(1.01)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C500(0.99)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C500(1.10)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C500(0.72)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C500(0.81)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C500(0.82)  LDD0876  [6]
 LDCM0279  AC2 HCT 116 C500(1.11)  LDD0596  [6]
 LDCM0280  AC20 HEK-293T C500(0.83)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C500(0.76)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C500(0.74)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C500(0.61)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C500(0.98)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C500(0.63)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C500(0.57)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C500(0.67)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C500(0.50)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C500(0.54)  LDD0887  [6]
 LDCM0290  AC3 HCT 116 C500(1.04)  LDD0607  [6]
 LDCM0291  AC30 HEK-293T C500(0.57)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C500(0.45)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C500(0.72)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C500(0.69)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C500(0.81)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C500(0.75)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C500(0.76)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C500(0.77)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C500(0.84)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C500(0.88)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C500(1.07)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C500(0.97)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C500(0.75)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C500(0.80)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C500(0.84)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C500(0.81)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C500(0.82)  LDD0905  [6]
 LDCM0308  AC46 HCT 116 C500(1.24)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C500(1.04)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C500(1.16)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C500(1.29)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C500(1.08)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C500(1.24)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C500(1.15)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C500(1.14)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C500(0.86)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C500(1.19)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C500(0.82)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C500(1.03)  LDD0636  [6]
 LDCM0320  AC57 PaTu 8988t C500(0.89)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C500(0.88)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C500(0.86)  LDD1201  [6]
 LDCM0323  AC6 HEK-293T C355(1.02); C500(0.94)  LDD1562  [15]
 LDCM0324  AC60 PaTu 8988t C500(0.84)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C500(0.92)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C500(0.89)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C500(0.82)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C500(0.88)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C500(0.74)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C500(0.77)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C500(0.98)  LDD1210  [6]
 LDCM0334  AC7 HEK-293T C355(1.00); C500(0.91)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C355(1.00); C500(0.93)  LDD1569  [15]
 LDCM0349  AC83 HEK-293T C500(1.14)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C500(0.74)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C500(0.92)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C500(0.91)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C500(0.81)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C500(0.95)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C500(0.87)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C500(0.78)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C500(0.85)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C500(0.76)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C500(0.83)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C500(0.87)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C500(0.87)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C500(0.71)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C500(1.03)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C500(0.67)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C500(0.97)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C355(0.94); C500(0.98)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C355(1.10); C500(0.97)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C355(0.97); C500(0.91)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 12.37  LDD0403  [4]
 LDCM0367  CL1 HCT 116 C500(1.27)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C500(0.99)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C500(0.76)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C355(1.07); C500(1.01)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C355(1.13); C500(0.86)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C355(1.02); C500(0.88)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C355(1.03); C500(0.93)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C500(0.86)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C500(1.03)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C500(0.90)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C500(0.87)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C500(0.91)  LDD0976  [6]
 LDCM0379  CL11 HCT 116 C500(0.95)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C500(0.77)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C500(0.97)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C500(0.57)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C500(0.71)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C500(0.64)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C500(0.62)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C500(0.77)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C500(0.88)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C500(0.78)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C500(0.83)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C500(1.19)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C500(0.91)  LDD0989  [6]
 LDCM0392  CL121 HCT 116 C500(1.08)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C500(1.08)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C500(1.06)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C500(1.09)  LDD0712  [6]
 LDCM0396  CL125 PaTu 8988t C500(0.85)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C500(0.96)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C500(0.90)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C500(0.84)  LDD1278  [6]
 LDCM0400  CL13 HCT 116 C500(1.00)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C500(1.42)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C500(0.99)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C500(1.06)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C500(1.09)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C500(1.36)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C500(1.31)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C500(0.98)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C500(1.48)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C500(1.31)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C500(1.25)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C500(1.28)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C500(1.43)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C500(1.52)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C500(1.65)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C500(1.46)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C500(1.61)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C500(1.34)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C500(1.02)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C500(1.47)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C500(1.17)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C500(1.29)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C500(1.08)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C500(1.25)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C500(1.33)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C500(1.02)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C500(1.36)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C500(1.40)  LDD1307  [6]
 LDCM0429  CL4 HCT 116 C500(1.22)  LDD0746  [6]
 LDCM0430  CL40 PaTu 8988t C500(1.39)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C500(1.31)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C500(1.35)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C500(1.52)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C500(1.60)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C500(1.60)  LDD1314  [6]
 LDCM0436  CL46 HCT 116 C500(1.04)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C500(1.04)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C500(1.02)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C500(0.99)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C500(1.18)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C500(0.95)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C500(1.07)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C500(1.05)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C500(1.35)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C500(1.02)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C500(1.02)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C500(1.06)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C500(1.10)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C500(0.97)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C500(1.01)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C500(1.14)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C500(1.07)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C500(0.89)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C500(0.98)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C500(1.01)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C500(0.98)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C500(0.95)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C500(0.91)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C500(0.90)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C500(1.08)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C500(0.96)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C500(1.39)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C500(0.95)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C500(0.88)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C500(0.98)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C500(0.99)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C500(0.95)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C500(1.10)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C500(1.09)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C500(0.89)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C500(1.12)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C500(1.19)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C500(0.96)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C500(0.93)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C500(1.13)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C500(0.95)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C500(0.89)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C500(1.06)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C500(0.97)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C500(1.11)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C500(1.04)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C500(0.88)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C500(1.00)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C500(0.94)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C500(1.16)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C500(0.85)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C500(0.83)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C500(0.88)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C500(1.08)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C500(1.06)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C500(1.21)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C500(1.05)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C500(1.01)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C355(0.99); C500(0.84)  LDD1698  [15]
 LDCM0625  F8 Ramos C35(0.41); C500(0.84)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C500(1.11)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C35(0.18); C500(0.00)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C500(1.10)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C500(0.82)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C500(0.46)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C500(0.80)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C500(0.93)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C500(1.21)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C500(0.86)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C35(1.35); C500(0.66)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C500(1.07)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C500(0.77)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C500(0.97)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C500(1.01)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C500(0.95)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C500(0.74)  LDD2184  [16]
 LDCM0427  Fragment51 PaTu 8988t C500(1.46)  LDD1306  [6]
 LDCM0610  Fragment52 Ramos C500(1.33)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C500(1.04)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C500(0.84)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C500(1.19)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C355(0.94); C500(1.04)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C355(0.95); C500(1.06)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C500(1.13)  LDD3310  [17]
 LDCM0627  NUDT7-COV-1 HEK-293T C355(0.93)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C355(0.72)  LDD2207  [18]
 LDCM0131  RA190 MM1.R C500(1.60)  LDD0304  [19]
 LDCM0090  Rapamycin JHH-7 2.29  LDD0213  [14]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alanine Small molecular drug DB00160

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.