Details of the Target

General Information of Target

Target ID LDTP13019
Target Name Vacuolar protein sorting-associated protein 18 homolog (VPS18)
Gene Name VPS18
Gene ID 57617
Synonyms
KIAA1475; Vacuolar protein sorting-associated protein 18 homolog; hVPS18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVLGLLVAGAADGCELVPRHLRGRRATGSAATAASSPAAAAGDSPALMTDPCMSLSPPC
FTEEDRFSLEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHIT
IEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMI
SQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKT
SKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEE
ACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHE
VEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKAL
SELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGG
VDDLDEDTPPIVSQFPGTMAKPPGSLARSSSLCRSRRSIVPSSPQPQRAQLAPHAPHPSH
PRHPHHPQHTPHSLPSPDPDILSVSSCPALYRNEEEEEAIYFSAEKQWEVPDTASECDSL
NSSIGRKQSPPLSLEIYQTLSPRKISRDEVSLEDSSRGDSPVTVDVSWGSPDCVGLTETK
SMIFSPASKVYNGILEKSCSMNQLSSGIPVPKPRHTSCSSAGNDSKPVQEAPSVARISSI
PHDLCHNGEKSKKPSKIKSLFKKKSK
Target Bioclass
Other
Family
VPS18 family
Subcellular location
Late endosome membrane
Function
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in dendrite development of Pukinje cells.
Uniprot ID
Q9P253
Ensemble ID
ENST00000220509.10
HGNC ID
HGNC:15972

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.92  LDD0402  [1]
STPyne
 Probe Info  		K46(10.00); K476(4.76); K698(10.00); K758(10.00)  LDD0277  [2]
BTD
 Probe Info  		C415(1.33)  LDD2135  [3]
Johansson_61
 Probe Info  		_(12.73)  LDD1485  [4]
YY4-yne
 Probe Info  		2.17  LDD0400  [5]
AHL-Pu-1
 Probe Info  		C22(2.35)  LDD0168  [6]
DBIA
 Probe Info  		C776(3.23); C780(3.23)  LDD0080  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C806(0.00); C421(0.00); C22(0.00); C433(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C445(0.00); C433(0.00); C421(0.00); C704(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C433(0.00); C421(0.00); C741(0.00); C22(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C22(0.00); C421(0.00)  LDD2226  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
Compound 10
 Probe Info  		C22(0.00); C433(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		N.A.  LDD0005  [10]
TFBX
 Probe Info  		C22(0.00); C704(0.00); C433(0.00); C421(0.00)  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [10]
AOyne
 Probe Info  		13.40  LDD0443  [13]
NAIA_5
 Probe Info  		C421(0.00); C704(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C072
 Probe Info  		7.52  LDD1768  [14]
C206
 Probe Info  		15.45  LDD1881  [14]
C243
 Probe Info  		20.39  LDD1916  [14]
C249
 Probe Info  		14.42  LDD1922  [14]
C284
 Probe Info  		27.10  LDD1954  [14]
C296
 Probe Info  		13.83  LDD1966  [14]
C338
 Probe Info  		14.72  LDD2001  [14]
C355
 Probe Info  		22.94  LDD2016  [14]
C383
 Probe Info  		13.45  LDD2042  [14]
C390
 Probe Info  		21.71  LDD2049  [14]
C391
 Probe Info  		18.38  LDD2050  [14]
C429
 Probe Info  		14.72  LDD2084  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C22(2.35)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C806(2.08); C421(4.17); C22(2.95)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C433(1.12); C445(1.27); C704(1.06); C806(0.81)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C433(0.99); C806(1.07)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C433(0.92); C704(0.75)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C433(1.01); C704(0.93)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C433(1.06); C704(0.72)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C433(1.10); C704(0.73)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C433(1.05); C704(0.64)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C433(1.03); C704(0.75)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C433(1.10); C704(0.83)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C433(1.11); C704(0.92)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C433(0.95); C704(0.91)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C433(0.93); C704(0.69)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C433(0.95); C806(1.28)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C433(0.97); C704(0.60)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C433(0.93); C704(0.68)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C433(0.94); C704(0.66)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C433(1.10); C704(0.78)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C433(0.98); C704(0.70)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C433(1.11); C704(0.85)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C433(1.04); C704(0.77)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C433(1.24); C704(0.82)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C433(1.08); C704(0.76)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C433(1.12); C704(0.77)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C433(1.10); C806(1.11)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C433(1.02); C704(0.61)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C433(1.36); C704(0.84)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C433(1.15); C704(0.75)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C433(1.71); C704(0.82)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C433(1.03); C704(0.94)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C433(0.99); C704(0.83)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C433(1.25); C704(0.72)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C433(1.25); C704(0.70)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C433(1.21); C704(1.68)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C433(0.93); C704(1.11)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C433(1.11); C704(0.99)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C433(0.93); C704(2.04)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C433(0.91); C704(1.61)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C433(0.97); C704(1.42)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C433(1.06); C704(1.37)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C433(1.10); C704(1.29)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C433(1.02); C704(1.58)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C433(0.94); C704(1.27)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C433(1.04); C704(1.42)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C433(1.05); C704(1.10)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C433(0.87); C806(1.46)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C433(1.04); C704(1.08)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C433(1.08); C704(1.68)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C433(0.86); C704(1.59)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C433(1.09)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C433(0.97)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C433(1.06)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C433(1.11)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C433(1.15)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C433(1.37)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C433(1.21)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C433(1.13); C806(1.21)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C433(0.99)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C433(1.05)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C433(1.10)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C433(1.78)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C433(1.22)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C433(1.33)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C433(1.31)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C433(1.03)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C433(0.87); C704(1.19)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C433(0.98); C704(1.26)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C433(0.84); C704(1.11)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C433(1.02); C806(1.06); C445(1.09); C704(1.21)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C433(0.91); C704(0.97)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C433(0.89); C704(1.03)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C433(0.94); C704(0.95)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C433(0.88); C704(0.97)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C433(0.90); C704(1.09)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C433(1.11); C806(1.26)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C433(1.12); C806(1.31)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C433(1.04); C806(1.26)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C433(1.10); C806(1.32)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C433(1.03); C806(1.28)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C806(0.99); C433(1.00); C445(1.12); C704(1.22)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C433(1.09); C806(1.45)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C433(1.07); C806(1.31)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C433(1.05); C806(1.47)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C433(1.01); C806(1.25)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C433(1.15); C806(1.25)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C806(0.85); C445(0.93); C433(1.03)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C445(0.86); C806(0.93); C433(1.00)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C445(0.79); C806(1.00); C433(1.06)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C445(0.80); C806(0.97); C433(0.99)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C445(0.89); C806(0.93); C433(1.07)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C806(0.88); C433(1.23); C704(1.24); C445(1.26)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C806(1.04); C433(1.09); C445(1.19)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C445(0.79); C806(0.98); C433(1.01)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C445(0.95); C806(1.00); C433(1.05)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C445(0.94); C806(1.04); C433(1.04)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C806(0.93); C445(0.94); C433(1.10)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C445(1.00); C433(1.08); C806(1.16)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C433(0.97); C445(0.98); C704(1.14)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C445(0.88); C704(1.02); C433(1.05)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C445(0.93); C704(1.04); C433(1.10)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C704(1.14); C433(1.19); C445(1.26)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C806(0.95); C445(1.16); C704(1.25); C433(1.30)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C704(1.07); C433(1.15); C445(1.16)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C445(1.02); C704(1.03); C433(1.07)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C445(0.97); C704(0.97); C433(1.01)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C704(0.73); C433(1.05); C445(1.09)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C445(1.03); C704(1.10); C433(1.14)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C445(1.06); C704(1.07); C433(1.22)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C704(1.26); C445(1.34); C433(1.39)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C704(0.86); C433(1.09)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C433(0.85); C704(0.99)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C704(0.81); C433(1.04)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C433(0.87); C806(1.29)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C704(0.82); C433(0.95)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C704(0.94); C433(0.98)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C704(0.97); C433(1.04)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C704(0.80); C433(0.95)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C704(0.96); C433(1.00)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C704(1.05); C433(1.08)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C704(0.85); C433(1.00)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C704(0.81); C433(1.12)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C806(0.77); C445(0.89); C704(1.02); C433(1.18)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C445(0.80); C704(1.01); C806(1.02); C433(1.21)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C433(0.88); C806(1.18)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C806(0.94); C445(1.00); C704(1.07); C433(1.40)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C806(0.82); C445(0.84); C704(0.98); C433(1.14)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C806(0.85); C445(0.93); C704(0.99); C433(1.32)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C445(0.91); C806(1.13); C704(1.30); C433(1.37)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C806(0.81); C445(0.86); C704(1.26); C433(1.44)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C806(1.01); C445(1.01); C704(1.26); C433(1.77)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C806(0.64); C445(0.79); C704(1.11); C433(1.43)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C445(0.88); C806(0.89); C704(1.16); C433(1.17)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C445(0.90); C704(1.03); C433(1.17); C806(1.19)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C806(0.80); C445(0.86); C704(1.19); C433(1.24)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C806(0.95); C433(0.99)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C806(0.80); C445(0.82); C704(0.98); C433(1.30)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C445(0.90); C433(1.12); C704(1.16); C806(1.28)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C445(0.85); C806(0.87); C704(1.26); C433(1.82)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C704(1.13); C806(1.15); C433(1.42)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C704(1.03); C806(1.22); C433(1.25)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C704(1.01); C433(1.12); C806(1.13)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C704(0.84); C806(1.06); C433(1.12)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C704(0.83); C806(1.01); C433(1.05)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C704(0.86); C806(1.02); C433(1.06)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C806(1.01); C704(1.05); C433(1.14)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C704(0.82); C433(1.01); C806(1.03)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C806(0.90); C704(1.16); C433(1.24)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C704(0.94); C806(1.06); C433(1.31)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C704(0.83); C806(1.05); C433(1.12)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C704(0.98); C806(1.03); C433(1.07)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C704(0.87); C806(1.01); C433(1.03)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C704(0.89); C806(1.05); C433(1.10)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C704(0.92); C806(1.05); C433(1.18)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C704(0.69); C433(1.33)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C704(0.77); C433(0.98)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C433(1.02); C806(1.01)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C433(1.01); C806(1.35)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C433(0.95); C806(1.69)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C776(1.20); C780(1.20); C433(1.09)  LDD2171  [7]
 LDCM0632  CL-Sc Hep-G2 C421(0.77)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C433(0.99); C445(1.02); C704(1.08)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C433(1.01); C704(1.08); C445(1.36)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C806(0.82); C433(1.00); C445(1.13); C704(1.18)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C433(0.87); C806(1.29)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C433(0.91); C806(1.22)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C433(0.93); C806(1.34)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C433(1.00); C806(1.35)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C433(0.91); C704(1.14)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C433(1.02); C704(1.10)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C433(1.01); C704(1.15)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C433(0.98); C704(1.28)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C433(0.88); C704(1.18)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C433(1.10); C704(1.14); C445(1.22)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C433(0.89); C704(0.97)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C433(0.84); C704(1.01)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C433(0.98); C806(1.14)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C433(1.03); C806(1.29)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C433(1.07); C806(1.29)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C433(0.99); C806(1.21)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C433(1.08); C806(1.29)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C806(1.13); C445(1.27); C433(1.32)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C445(0.95); C806(1.01); C433(1.07)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C445(1.05); C433(1.12); C806(1.13)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C704(1.13); C433(1.17); C445(1.40)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C445(0.91); C806(0.97); C433(1.04)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C433(0.84); C704(0.89); C445(0.91)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C704(0.90); C445(1.09); C433(1.11)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C704(0.70); C445(1.12); C433(1.22)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C704(0.95); C445(1.09); C433(1.14)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C704(0.95); C433(1.00)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C704(0.74); C433(0.91)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C433(0.83); C704(0.95)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C704(0.91); C433(1.03)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C704(0.86); C433(1.08); C445(1.09)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C433(1.16); C704(1.16); C445(1.16)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C445(1.07); C704(1.25); C433(1.25)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C704(0.88); C433(0.91); C806(1.14)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C806(0.85); C704(0.96); C433(1.04)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C704(0.85); C806(0.96); C433(0.99)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C704(0.89); C433(0.98); C806(1.04)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C445(0.98); C704(1.05); C433(1.12)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C704(0.89); C433(1.01); C806(1.15)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C704(0.97); C433(1.10); C806(1.53)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C704(1.01); C433(1.27); C806(1.30)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C704(0.87); C806(1.01); C433(1.11)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C433(1.10); C704(0.87); C806(0.95)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C433(1.10); C704(0.86); C806(0.94)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C433(1.05); C704(0.79); C806(1.39)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C433(1.04); C704(0.73); C806(0.94)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C433(1.00); C704(0.79); C806(1.07)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C433(1.01); C704(0.81); C806(0.96)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C433(1.00); C445(1.04); C704(1.04)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C433(0.89); C704(0.81); C806(0.96)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C433(1.05); C704(0.88); C806(0.89)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C433(1.34); C806(0.75)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C433(1.07); C806(1.06)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C433(1.07); C806(0.92)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C433(1.36); C806(0.95)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C433(1.16); C806(1.02)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C433(1.21); C806(0.88)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C433(1.30); C806(0.78)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C433(0.92); C445(0.97); C704(0.96)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C433(1.23); C806(0.83)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C433(1.05); C806(0.93)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C433(1.18); C806(0.97)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C433(1.29); C806(0.82)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C433(1.44); C806(0.88)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C433(1.18); C806(1.40)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C433(1.08)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C433(1.06)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C433(1.09)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C433(1.13)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C433(1.06); C445(1.02); C704(0.84)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C433(1.05)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C433(0.98)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C433(1.03)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C433(0.99)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C433(0.95)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C433(1.15)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C433(1.02)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C433(0.96)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C433(1.12)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C433(1.09)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C433(1.10); C445(1.02); C704(1.05)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C433(1.12)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C433(1.14); C445(1.03); C704(1.01)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C433(1.04); C445(1.00); C704(1.00)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C433(1.03); C445(0.99); C704(0.96)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C433(1.19); C445(1.35); C704(1.10)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C433(1.08); C445(1.03); C704(0.90)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C433(1.14); C445(1.24); C704(0.96)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C433(1.07); C445(1.20); C704(0.83)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C433(1.14); C445(1.04); C704(1.01)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C433(1.07); C445(0.99); C704(1.13)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C433(1.16); C445(1.19); C704(1.16)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C433(1.00); C445(1.06); C704(1.06)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C433(1.15); C445(0.89); C704(0.82)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C433(1.17); C445(0.94); C704(1.11)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C433(1.06); C445(1.07); C704(0.99)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C433(1.13); C445(1.27); C704(0.95)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C433(0.92); C704(0.96); C806(0.86)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C433(0.82); C704(0.78); C806(1.08)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C433(0.83); C704(0.74); C806(1.36)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C433(0.90); C704(0.91); C806(0.91)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C433(1.26); C445(1.67); C704(1.24)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C433(0.92); C704(1.18); C806(1.38)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C433(0.93); C704(0.92); C806(1.35)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C433(0.97); C704(0.87); C806(1.01)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C433(1.03); C704(1.09); C806(1.69)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C433(1.13); C704(1.17); C806(1.22)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C433(0.91); C704(0.80); C806(1.11)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C433(0.85); C704(1.21); C806(0.65)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C433(0.85); C704(1.26); C806(0.71)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C433(0.91); C704(0.92); C806(0.69)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C433(1.21); C704(1.12); C806(0.77)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C433(1.07); C445(1.12); C704(0.95)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C433(0.86); C704(1.05); C806(0.76)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C433(0.92); C445(1.00); C704(0.83); C806(1.13)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C433(1.21); C445(1.10); C704(0.91); C806(1.39)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C433(1.18); C445(0.98); C704(1.09); C806(1.12)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C433(1.04); C445(1.08); C704(1.12); C806(1.19)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C433(1.00); C445(1.04); C704(0.90); C806(1.24)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C433(0.95); C445(0.91); C704(1.00); C806(1.25)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C433(0.97); C445(1.17); C704(1.12); C806(1.18)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C433(1.06); C445(1.32); C704(1.02); C806(0.88)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C433(1.00); C445(1.11); C704(1.10); C806(0.83)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C741(0.90); C421(0.78); C806(0.84); C433(0.98)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C806(3.20); C421(2.37)  LDD1702  [3]
 LDCM0625  F8 Ramos C22(1.29); C433(0.86); C522(1.03)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C22(2.87); C433(0.77); C522(1.19)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C22(1.27); C433(0.59)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C22(2.27); C433(1.10); C522(0.66)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C22(1.08); C433(0.73); C522(0.61)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C22(1.72); C522(0.96)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C22(1.83); C433(1.00); C522(0.49)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C22(0.71); C433(1.08); C522(0.64)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C22(1.25); C433(0.58); C522(1.34)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C22(0.81); C433(0.81); C522(1.46)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C22(1.00); C433(0.89); C522(0.53)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C22(1.10); C433(1.34); C522(0.99)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C22(1.09); C433(0.96); C522(0.69)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C22(3.27)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C433(1.01); C445(1.22); C704(0.87)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C22(0.56); C433(0.97); C522(0.79)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C22(2.24); C433(1.11); C522(0.65)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C433(1.62); C806(0.99)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C22(0.94); C433(1.04); C522(0.44)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C22(0.96); C433(0.88); C522(0.42)  LDD2205  [18]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [4]
 LDCM0569  Fragment7 Jurkat _(12.73)  LDD1485  [4]
 LDCM0571  Fragment9 Ramos C22(3.40); C522(0.54)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C776(3.23); C780(3.23)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C776(5.60); C780(5.60)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C776(3.10); C780(3.10)  LDD0082  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C415(1.33)  LDD2135  [3]
 LDCM0021  THZ1 HCT 116 C776(1.20); C780(1.20); C433(1.09)  LDD2173  [7]
 LDCM0154  YY4 T cell 2.17  LDD0400  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar fusion protein MON1 homolog B (MON1B) MON1/SAND family Q7L1V2
Vacuolar protein sorting-associated protein 33A (VPS33A) STXBP/unc-18/SEC1 family Q96AX1
Syntaxin-7 (STX7) Syntaxin family O15400
Vam6/Vps39-like protein (VPS39) VAM6/VPS39 family Q96JC1
Vacuolar protein sorting-associated protein 11 homolog (VPS11) VPS11 family Q9H270
Vacuolar protein sorting-associated protein 16 homolog (VPS16) VPS16 family Q9H269
Vacuolar protein sorting-associated protein 41 homolog (VPS41) VPS41 family P49754

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578