Details of the Target

General Information of Target

Target ID LDTP09410
Target Name Protein bicaudal D homolog 2 (BICD2)
Gene Name BICD2
Gene ID 23299
Synonyms
KIAA0699; Protein bicaudal D homolog 2; Bic-D 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ
FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE
LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD
YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL
EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV
NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA
GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE
DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA
LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH
VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG
GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE
LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA
MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS
LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL
Target Bioclass
Other
Family
BicD family
Subcellular location
Golgi apparatus
Function
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex. Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis.
Uniprot ID
Q8TD16
Ensemble ID
ENST00000356884.11
HGNC ID
HGNC:17208

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K371(5.42); K386(9.40); K701(1.34); K712(9.13)  LDD0277  [3]
Probe 1
 Probe Info  		Y114(15.21)  LDD3495  [4]
DBIA
 Probe Info  		C437(6.45)  LDD0209  [5]
Acrolein
 Probe Info  		N.A.  LDD0225  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
IPM
 Probe Info  		C437(0.00); C754(0.00)  LDD2156  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		13.93  LDD1713  [12]
C087
 Probe Info  		9.00  LDD1779  [12]
C106
 Probe Info  		17.88  LDD1793  [12]
C158
 Probe Info  		9.92  LDD1838  [12]
C210
 Probe Info  		48.84  LDD1884  [12]
C244
 Probe Info  		13.83  LDD1917  [12]
C249
 Probe Info  		12.04  LDD1922  [12]
C265
 Probe Info  		14.12  LDD1936  [12]
C278
 Probe Info  		49.87  LDD1948  [12]
C280
 Probe Info  		9.19  LDD1950  [12]
C282
 Probe Info  		16.11  LDD1952  [12]
C284
 Probe Info  		40.50  LDD1954  [12]
C313
 Probe Info  		13.18  LDD1980  [12]
C346
 Probe Info  		10.34  LDD2007  [12]
C348
 Probe Info  		11.39  LDD2009  [12]
C350
 Probe Info  		22.63  LDD2011  [12]
C353
 Probe Info  		6.11  LDD2014  [12]
C354
 Probe Info  		9.25  LDD2015  [12]
C362
 Probe Info  		25.63  LDD2023  [12]
C390
 Probe Info  		21.71  LDD2049  [12]
C391
 Probe Info  		17.39  LDD2050  [12]
C403
 Probe Info  		13.83  LDD2061  [12]
C407
 Probe Info  		11.63  LDD2064  [12]
C429
 Probe Info  		13.09  LDD2084  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C437(1.02); C754(0.94)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C437(1.04); C754(1.18)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C437(1.04); C754(1.17)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C437(0.99); C754(1.00)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C437(1.08); C754(1.04)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C437(0.96); C754(1.03)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C437(1.03); C754(1.01)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C437(0.98); C754(0.92)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C437(1.31); C754(0.96)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C437(1.05); C754(0.97)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C437(0.99); C754(1.03)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C437(1.08); C754(1.13)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C437(1.14); C754(0.92)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C437(1.02); C754(0.97)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C437(0.92); C754(1.06)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C437(1.00); C754(1.17)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C437(0.98); C754(1.04)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C437(0.94); C754(1.05)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C437(0.98); C754(1.00)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C437(1.09); C754(1.09)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C437(1.16); C754(1.10)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C437(1.00); C754(0.91)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C437(0.96); C754(0.97)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C437(0.83); C754(1.11)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C437(0.99); C754(1.11)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C437(1.16); C754(1.05)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C437(1.15); C754(1.03)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C437(1.04); C754(1.08)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C437(1.06); C754(1.16)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C437(1.03); C754(0.97)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C437(1.00); C754(1.00)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C437(1.07); C754(1.00)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C437(0.89); C754(0.83)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C437(0.96); C754(1.16)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C437(0.98); C754(1.28)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C437(1.07); C754(1.16)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C437(1.14); C754(1.05)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C437(1.06); C754(1.29)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C437(1.02); C754(0.82)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C437(0.99); C754(1.03)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C437(1.01); C754(1.23)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C437(1.05); C754(1.12)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C437(1.05); C754(1.08)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C437(0.98); C754(1.05)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C437(0.92); C754(1.07)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C437(1.01); C754(1.07)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C437(1.10); C754(1.06)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C437(1.00); C754(1.28)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C437(0.98); C754(1.10)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C437(1.02); C754(1.36)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C437(1.02); C754(1.18)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C437(1.06); C754(1.13)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C437(1.05); C754(0.87)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C437(1.21); C754(0.86)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C437(1.05); C754(1.00)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C437(1.16); C754(1.10)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C437(1.16); C754(0.93)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C437(1.04); C754(0.93)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C437(1.07); C754(1.05)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C437(1.02); C754(1.02)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C437(0.96); C754(0.96)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C437(1.05); C754(1.12)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C437(1.00); C754(1.03)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C437(1.06); C754(0.95)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 12.09  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C437(1.01)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C437(1.23); C754(0.75)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C754(1.22)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C437(1.15)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C754(0.96)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C437(1.04); C754(1.12)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C754(1.20)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C437(1.03)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C754(1.16)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C437(0.91); C754(0.96)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C754(1.31)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C437(0.93)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C437(0.96); C754(0.92)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C754(1.11)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C437(1.02); C754(1.05)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C754(1.03)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C437(0.96)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C754(0.99)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C437(0.92); C754(1.20)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C754(1.25)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C437(1.05)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C754(1.37)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C437(1.06); C754(1.02)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C437(1.16); C754(0.80)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C754(1.24)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C437(0.93)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C754(1.29)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C437(0.90); C754(0.99)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C754(1.11)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C437(1.09)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C754(1.10)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C437(1.11); C754(1.18)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C754(0.81)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C437(1.38)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C754(1.30)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C437(1.15); C754(1.00)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C754(1.03)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C437(1.06); C754(0.91)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C437(1.05); C754(1.04)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C437(0.92); C754(1.17)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C754(1.21)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C437(1.08); C754(1.05)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C437(1.06); C754(1.10)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C437(1.28); C754(0.98)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C437(0.89); C754(1.01)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C437(1.14); C754(1.20)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C437(0.92)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C754(1.15)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C437(0.98); C754(0.97)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C754(1.21)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C437(1.02); C754(1.39)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C437(1.10); C754(0.98)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C437(0.98); C754(1.04)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C437(1.02); C754(0.95)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C437(0.98); C754(1.00)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C437(1.02); C754(0.93)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C437(1.20); C754(0.92)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C437(0.85); C754(1.07)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C437(1.09); C754(1.11)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C437(0.86)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C437(1.23); C754(1.12)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C754(0.99)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C754(0.98)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C437(0.98); C754(1.10)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C437(0.99); C754(1.05)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C437(1.06); C754(1.02)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C437(1.10); C754(0.95)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C437(1.18); C754(0.97)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C437(1.06); C754(1.04)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C437(0.85); C754(0.99)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C437(0.88); C754(1.07)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C437(0.88)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C437(1.10); C754(0.94)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C754(1.14)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C754(1.13)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C437(1.03); C754(1.13)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C437(1.00); C754(0.98)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C437(1.04); C754(1.09)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C437(1.08); C754(0.93)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C437(1.35); C754(1.03)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C437(1.23); C754(1.09)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C437(0.93); C754(1.04)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C437(1.01); C754(1.04)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C437(1.09); C754(1.08)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C437(1.03)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C754(1.09)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C437(0.99); C754(1.44)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C754(1.05)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C437(0.98); C754(1.13)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C437(1.00); C754(0.93)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C437(0.97); C754(1.24)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C437(1.04); C754(0.96)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C437(1.18); C754(1.22)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C437(1.20); C754(1.03)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C437(1.02); C754(0.97)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C437(0.93); C754(1.12)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C437(0.91); C754(1.09)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C437(1.06)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C754(1.49)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C754(1.25)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C437(1.09); C754(1.07)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C437(1.05); C754(0.94)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C437(0.91); C754(1.20)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C437(1.07); C754(0.84)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C437(1.09); C754(0.89)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C437(1.06); C754(1.10)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C437(0.99); C754(1.00)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C437(0.89); C754(1.06)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C437(1.02); C754(1.20)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C437(1.07)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C754(1.14)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C437(1.08); C754(1.04)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C754(1.07)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C437(0.99); C754(1.02)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C437(1.12); C754(1.03)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C437(0.99); C754(0.90)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C437(0.95); C754(0.94)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C437(1.02); C754(0.90)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C437(1.10); C754(0.99)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C437(1.16); C754(1.05)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C437(1.10); C754(0.88)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C437(0.99); C754(0.83)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C437(1.05)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C754(1.13)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C437(1.10); C754(1.31)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C437(0.98); C754(1.07)  LDD1698  [13]
 LDCM0625  F8 Ramos C754(1.10)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C754(0.87)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C754(1.72)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C754(0.90)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C754(0.67)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C754(1.07)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C754(0.79)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C754(1.12)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C754(0.91)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C754(1.00)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C754(0.79)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C754(0.98)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C754(0.84)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C754(0.72)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C437(0.98); C754(0.95)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C754(0.52)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C754(0.82)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C754(1.02)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C754(0.72)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C754(0.79)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C754(0.97)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C754(0.72)  LDD2188  [14]
 LDCM0022  KB02 HEK-293T C754(1.00); C437(1.07)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C437(6.45)  LDD0209  [5]
 LDCM0024  KB05 HEK-293T C754(0.88); C437(1.10)  LDD1502  [13]
 LDCM0109  NEM HeLa N.A.  LDD0225  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FAST kinase domain-containing protein 4 (TBRG4) FAST kinase family Q969Z0
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
E3 SUMO-protein ligase RanBP2 (RANBP2) RanBP2 E3 ligase family P49792
Carbonyl reductase [NADPH] 3 (CBR3) Short-chain dehydrogenases/reductases (SDR) family O75828
Ras-related protein Rab-6A (RAB6A) Rab family P20340
Ras-related protein Rab-6B (RAB6B) Rab family Q9NRW1
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) Krueppel C2H2-type zinc-finger protein family Q3MJ62
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 624 (ZNF624) Krueppel C2H2-type zinc-finger protein family Q9P2J8
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 669 (ZNF669) Krueppel C2H2-type zinc-finger protein family Q96BR6
Zinc finger protein 670 (ZNF670) Krueppel C2H2-type zinc-finger protein family Q9BS34
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1) Dynein intermediate chain family O14576
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
Phostensin (PPP1R18) . Q6NYC8
Polyamine-modulated factor 1 (PMF1) . Q6P1K2
Rho GTPase-activating protein 45 (ARHGAP45) . Q92619
RNA-binding protein 41 (RBM41) . Q96IZ5
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578