Details of the Target

General Information of Target

Target ID LDTP10213
Target Name Anaphase-promoting complex subunit 16 (ANAPC16)
Gene Name ANAPC16
Gene ID 119504
Synonyms
C10orf104; CENP-27; Anaphase-promoting complex subunit 16; APC16; Cyclosome subunit 16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGARRLELGEALALGSGWRHACHALLYAPDPGMLFGRIPLRYAILMQMRFDGRLGFPGG
FVDTQDRSLEDGLNRELREELGEAAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEEL
LAVEAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFIGSAREQLLEALQDLGL
LQSGSISGLKIPAHH
Target Bioclass
Other
Family
APC16 family
Subcellular location
Cytoplasm
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Uniprot ID
Q96DE5
Ensemble ID
ENST00000299381.5
HGNC ID
HGNC:26976

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K33(10.00); K71(7.83)  LDD0277  [1]
DBIA
 Probe Info  		C55(4.73)  LDD3331  [2]
AHL-Pu-1
 Probe Info  		C55(2.51)  LDD0168  [3]
IA-alkyne
 Probe Info  		4.00  LDD0433  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
SF
 Probe Info  		N.A.  LDD0028  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C161
 Probe Info  		9.78  LDD1841  [10]
C178
 Probe Info  		14.93  LDD1857  [10]
C243
 Probe Info  		11.47  LDD1916  [10]
C244
 Probe Info  		16.45  LDD1917  [10]
C249
 Probe Info  		16.68  LDD1922  [10]
C313
 Probe Info  		16.34  LDD1980  [10]
C338
 Probe Info  		11.63  LDD2001  [10]
C429
 Probe Info  		12.21  LDD2084  [10]
C431
 Probe Info  		15.45  LDD2086  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C55(2.51)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C55(2.14)  LDD0169  [3]
 LDCM0214  AC1 PaTu 8988t C55(0.80)  LDD1093  [11]
 LDCM0215  AC10 PaTu 8988t C55(1.89)  LDD1094  [11]
 LDCM0216  AC100 PaTu 8988t C55(1.45)  LDD1095  [11]
 LDCM0217  AC101 PaTu 8988t C55(1.19)  LDD1096  [11]
 LDCM0218  AC102 PaTu 8988t C55(1.45)  LDD1097  [11]
 LDCM0219  AC103 PaTu 8988t C55(1.41)  LDD1098  [11]
 LDCM0220  AC104 PaTu 8988t C55(1.00)  LDD1099  [11]
 LDCM0221  AC105 PaTu 8988t C55(1.12)  LDD1100  [11]
 LDCM0222  AC106 PaTu 8988t C55(1.30)  LDD1101  [11]
 LDCM0223  AC107 PaTu 8988t C55(1.04)  LDD1102  [11]
 LDCM0224  AC108 PaTu 8988t C55(1.60)  LDD1103  [11]
 LDCM0225  AC109 PaTu 8988t C55(1.73)  LDD1104  [11]
 LDCM0226  AC11 PaTu 8988t C55(1.64)  LDD1105  [11]
 LDCM0227  AC110 PaTu 8988t C55(2.29)  LDD1106  [11]
 LDCM0228  AC111 PaTu 8988t C55(1.99)  LDD1107  [11]
 LDCM0229  AC112 PaTu 8988t C55(1.52)  LDD1108  [11]
 LDCM0230  AC113 PaTu 8988t C55(0.89)  LDD1109  [11]
 LDCM0231  AC114 PaTu 8988t C55(1.15)  LDD1110  [11]
 LDCM0232  AC115 PaTu 8988t C55(0.86)  LDD1111  [11]
 LDCM0233  AC116 PaTu 8988t C55(0.91)  LDD1112  [11]
 LDCM0234  AC117 PaTu 8988t C55(0.82)  LDD1113  [11]
 LDCM0235  AC118 PaTu 8988t C55(1.35)  LDD1114  [11]
 LDCM0236  AC119 PaTu 8988t C55(1.04)  LDD1115  [11]
 LDCM0237  AC12 PaTu 8988t C55(1.49)  LDD1116  [11]
 LDCM0238  AC120 PaTu 8988t C55(0.91)  LDD1117  [11]
 LDCM0239  AC121 PaTu 8988t C55(1.19)  LDD1118  [11]
 LDCM0240  AC122 PaTu 8988t C55(1.02)  LDD1119  [11]
 LDCM0241  AC123 PaTu 8988t C55(0.81)  LDD1120  [11]
 LDCM0242  AC124 PaTu 8988t C55(1.23)  LDD1121  [11]
 LDCM0243  AC125 PaTu 8988t C55(1.04)  LDD1122  [11]
 LDCM0244  AC126 PaTu 8988t C55(0.79)  LDD1123  [11]
 LDCM0245  AC127 PaTu 8988t C55(1.03)  LDD1124  [11]
 LDCM0246  AC128 PaTu 8988t C55(1.39)  LDD1125  [11]
 LDCM0247  AC129 PaTu 8988t C55(1.91)  LDD1126  [11]
 LDCM0249  AC130 PaTu 8988t C55(1.54)  LDD1128  [11]
 LDCM0250  AC131 PaTu 8988t C55(1.51)  LDD1129  [11]
 LDCM0251  AC132 PaTu 8988t C55(1.32)  LDD1130  [11]
 LDCM0252  AC133 PaTu 8988t C55(1.80)  LDD1131  [11]
 LDCM0253  AC134 PaTu 8988t C55(1.91)  LDD1132  [11]
 LDCM0254  AC135 PaTu 8988t C55(2.04)  LDD1133  [11]
 LDCM0255  AC136 PaTu 8988t C55(1.55)  LDD1134  [11]
 LDCM0256  AC137 PaTu 8988t C55(1.41)  LDD1135  [11]
 LDCM0257  AC138 PaTu 8988t C55(1.53)  LDD1136  [11]
 LDCM0258  AC139 PaTu 8988t C55(1.41)  LDD1137  [11]
 LDCM0259  AC14 PaTu 8988t C55(1.68)  LDD1138  [11]
 LDCM0260  AC140 PaTu 8988t C55(1.30)  LDD1139  [11]
 LDCM0261  AC141 PaTu 8988t C55(1.39)  LDD1140  [11]
 LDCM0262  AC142 PaTu 8988t C55(1.49)  LDD1141  [11]
 LDCM0263  AC143 PaTu 8988t C55(1.35)  LDD1142  [11]
 LDCM0264  AC144 PaTu 8988t C55(1.22)  LDD1143  [11]
 LDCM0265  AC145 PaTu 8988t C55(1.26)  LDD1144  [11]
 LDCM0266  AC146 PaTu 8988t C55(2.03)  LDD1145  [11]
 LDCM0267  AC147 PaTu 8988t C55(1.65)  LDD1146  [11]
 LDCM0268  AC148 PaTu 8988t C55(1.38)  LDD1147  [11]
 LDCM0269  AC149 PaTu 8988t C55(1.56)  LDD1148  [11]
 LDCM0270  AC15 PaTu 8988t C55(1.90)  LDD1149  [11]
 LDCM0271  AC150 PaTu 8988t C55(2.08)  LDD1150  [11]
 LDCM0272  AC151 PaTu 8988t C55(2.90)  LDD1151  [11]
 LDCM0273  AC152 PaTu 8988t C55(1.52)  LDD1152  [11]
 LDCM0274  AC153 PaTu 8988t C55(2.34)  LDD1153  [11]
 LDCM0621  AC154 PaTu 8988t C55(2.39)  LDD2166  [11]
 LDCM0622  AC155 PaTu 8988t C55(2.08)  LDD2167  [11]
 LDCM0623  AC156 PaTu 8988t C55(2.02)  LDD2168  [11]
 LDCM0624  AC157 PaTu 8988t C55(2.23)  LDD2169  [11]
 LDCM0276  AC17 HEK-293T C55(2.25)  LDD0874  [11]
 LDCM0277  AC18 HEK-293T C55(1.81)  LDD0875  [11]
 LDCM0278  AC19 HEK-293T C55(2.09)  LDD0876  [11]
 LDCM0279  AC2 PaTu 8988t C55(0.43)  LDD1158  [11]
 LDCM0280  AC20 HEK-293T C55(1.41)  LDD0878  [11]
 LDCM0281  AC21 HEK-293T C55(1.50)  LDD0879  [11]
 LDCM0282  AC22 HEK-293T C55(1.45)  LDD0880  [11]
 LDCM0283  AC23 HEK-293T C55(2.16)  LDD0881  [11]
 LDCM0284  AC24 HEK-293T C55(1.24)  LDD0882  [11]
 LDCM0285  AC25 HEK-293T C55(0.86)  LDD0883  [11]
 LDCM0286  AC26 HEK-293T C55(1.33)  LDD0884  [11]
 LDCM0287  AC27 HEK-293T C55(0.88)  LDD0885  [11]
 LDCM0288  AC28 HEK-293T C55(0.63)  LDD0886  [11]
 LDCM0289  AC29 HEK-293T C55(1.37)  LDD0887  [11]
 LDCM0290  AC3 PaTu 8988t C55(0.73)  LDD1169  [11]
 LDCM0291  AC30 HEK-293T C55(0.93)  LDD0889  [11]
 LDCM0292  AC31 HEK-293T C55(0.81)  LDD0890  [11]
 LDCM0293  AC32 HEK-293T C55(0.85)  LDD0891  [11]
 LDCM0294  AC33 HEK-293T C55(1.02)  LDD0892  [11]
 LDCM0295  AC34 HEK-293T C55(0.66)  LDD0893  [11]
 LDCM0296  AC35 PaTu 8988t C55(1.37)  LDD1175  [11]
 LDCM0297  AC36 PaTu 8988t C55(1.58)  LDD1176  [11]
 LDCM0298  AC37 PaTu 8988t C55(1.57)  LDD1177  [11]
 LDCM0299  AC38 PaTu 8988t C55(1.46)  LDD1178  [11]
 LDCM0300  AC39 PaTu 8988t C55(1.88)  LDD1179  [11]
 LDCM0301  AC4 PaTu 8988t C55(0.51)  LDD1180  [11]
 LDCM0302  AC40 PaTu 8988t C55(2.15)  LDD1181  [11]
 LDCM0303  AC41 PaTu 8988t C55(1.42)  LDD1182  [11]
 LDCM0304  AC42 PaTu 8988t C55(1.75)  LDD1183  [11]
 LDCM0305  AC43 PaTu 8988t C55(1.36)  LDD1184  [11]
 LDCM0306  AC44 PaTu 8988t C55(2.04)  LDD1185  [11]
 LDCM0307  AC45 PaTu 8988t C55(1.78)  LDD1186  [11]
 LDCM0308  AC46 HEK-293T C55(1.31)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C55(1.44)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C55(1.35)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C55(1.29)  LDD1550  [12]
 LDCM0312  AC5 PaTu 8988t C55(0.74)  LDD1191  [11]
 LDCM0313  AC50 HEK-293T C55(1.15)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C55(1.10)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C55(1.29)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C55(1.10)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C55(1.37)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C55(1.25)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C55(1.17)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C55(1.03)  LDD0918  [11]
 LDCM0321  AC58 HEK-293T C55(1.23)  LDD0919  [11]
 LDCM0322  AC59 HEK-293T C55(1.33)  LDD0920  [11]
 LDCM0323  AC6 PaTu 8988t C55(1.28)  LDD1202  [11]
 LDCM0324  AC60 HEK-293T C55(1.36)  LDD0922  [11]
 LDCM0325  AC61 HEK-293T C55(1.05)  LDD0923  [11]
 LDCM0326  AC62 HEK-293T C55(1.18)  LDD0924  [11]
 LDCM0327  AC63 HEK-293T C55(1.64)  LDD0925  [11]
 LDCM0328  AC64 HEK-293T C55(0.98)  LDD0926  [11]
 LDCM0329  AC65 HEK-293T C55(1.46)  LDD0927  [11]
 LDCM0330  AC66 HEK-293T C55(1.10)  LDD0928  [11]
 LDCM0331  AC67 HEK-293T C55(1.13)  LDD0929  [11]
 LDCM0332  AC68 PaTu 8988t C55(0.91)  LDD1211  [11]
 LDCM0333  AC69 PaTu 8988t C55(0.98)  LDD1212  [11]
 LDCM0334  AC7 PaTu 8988t C55(0.90)  LDD1213  [11]
 LDCM0335  AC70 PaTu 8988t C55(1.01)  LDD1214  [11]
 LDCM0336  AC71 PaTu 8988t C55(0.85)  LDD1215  [11]
 LDCM0337  AC72 PaTu 8988t C55(0.81)  LDD1216  [11]
 LDCM0338  AC73 PaTu 8988t C55(0.99)  LDD1217  [11]
 LDCM0339  AC74 PaTu 8988t C55(1.10)  LDD1218  [11]
 LDCM0340  AC75 PaTu 8988t C55(0.92)  LDD1219  [11]
 LDCM0341  AC76 PaTu 8988t C55(1.06)  LDD1220  [11]
 LDCM0342  AC77 PaTu 8988t C55(1.03)  LDD1221  [11]
 LDCM0343  AC78 PaTu 8988t C55(0.91)  LDD1222  [11]
 LDCM0344  AC79 PaTu 8988t C55(1.22)  LDD1223  [11]
 LDCM0345  AC8 PaTu 8988t C55(1.37)  LDD1224  [11]
 LDCM0346  AC80 PaTu 8988t C55(1.16)  LDD1225  [11]
 LDCM0347  AC81 PaTu 8988t C55(1.17)  LDD1226  [11]
 LDCM0348  AC82 PaTu 8988t C55(1.20)  LDD1227  [11]
 LDCM0349  AC83 PaTu 8988t C55(0.86)  LDD1228  [11]
 LDCM0350  AC84 PaTu 8988t C55(0.65)  LDD1229  [11]
 LDCM0351  AC85 PaTu 8988t C55(0.65)  LDD1230  [11]
 LDCM0352  AC86 PaTu 8988t C55(0.71)  LDD1231  [11]
 LDCM0353  AC87 PaTu 8988t C55(0.65)  LDD1232  [11]
 LDCM0354  AC88 PaTu 8988t C55(1.05)  LDD1233  [11]
 LDCM0355  AC89 PaTu 8988t C55(0.80)  LDD1234  [11]
 LDCM0357  AC90 PaTu 8988t C55(1.07)  LDD1236  [11]
 LDCM0358  AC91 PaTu 8988t C55(0.86)  LDD1237  [11]
 LDCM0359  AC92 PaTu 8988t C55(0.88)  LDD1238  [11]
 LDCM0360  AC93 PaTu 8988t C55(0.69)  LDD1239  [11]
 LDCM0361  AC94 PaTu 8988t C55(0.80)  LDD1240  [11]
 LDCM0362  AC95 PaTu 8988t C55(0.92)  LDD1241  [11]
 LDCM0363  AC96 PaTu 8988t C55(0.94)  LDD1242  [11]
 LDCM0364  AC97 PaTu 8988t C55(0.99)  LDD1243  [11]
 LDCM0365  AC98 PaTu 8988t C55(1.51)  LDD1244  [11]
 LDCM0366  AC99 PaTu 8988t C55(1.19)  LDD1245  [11]
 LDCM0248  AKOS034007472 PaTu 8988t C55(1.88)  LDD1127  [11]
 LDCM0356  AKOS034007680 PaTu 8988t C55(1.37)  LDD1235  [11]
 LDCM0275  AKOS034007705 PaTu 8988t C55(1.70)  LDD1154  [11]
 LDCM0020  ARS-1620 HCC44 C55(0.95)  LDD2171  [11]
 LDCM0630  CCW28-3 231MFP C55(1.25)  LDD2214  [13]
 LDCM0367  CL1 PaTu 8988t C55(0.97)  LDD1246  [11]
 LDCM0368  CL10 PaTu 8988t C55(1.88)  LDD1247  [11]
 LDCM0369  CL100 PaTu 8988t C55(0.57)  LDD1248  [11]
 LDCM0370  CL101 PaTu 8988t C55(1.42)  LDD1249  [11]
 LDCM0371  CL102 PaTu 8988t C55(1.18)  LDD1250  [11]
 LDCM0372  CL103 PaTu 8988t C55(2.23)  LDD1251  [11]
 LDCM0373  CL104 PaTu 8988t C55(1.49)  LDD1252  [11]
 LDCM0374  CL105 HEK-293T C55(0.95)  LDD0972  [11]
 LDCM0375  CL106 HEK-293T C55(1.04)  LDD0973  [11]
 LDCM0376  CL107 HEK-293T C55(1.49)  LDD0974  [11]
 LDCM0377  CL108 HEK-293T C55(1.26)  LDD0975  [11]
 LDCM0378  CL109 HEK-293T C55(1.87)  LDD0976  [11]
 LDCM0379  CL11 PaTu 8988t C55(1.06)  LDD1258  [11]
 LDCM0380  CL110 HEK-293T C55(1.35)  LDD0978  [11]
 LDCM0381  CL111 HEK-293T C55(1.69)  LDD0979  [11]
 LDCM0382  CL112 HEK-293T C55(1.07)  LDD0980  [11]
 LDCM0383  CL113 HEK-293T C55(0.77)  LDD0981  [11]
 LDCM0384  CL114 HEK-293T C55(1.13)  LDD0982  [11]
 LDCM0385  CL115 HEK-293T C55(1.28)  LDD0983  [11]
 LDCM0386  CL116 HEK-293T C55(1.28)  LDD0984  [11]
 LDCM0387  CL117 PaTu 8988t C55(1.44)  LDD1266  [11]
 LDCM0388  CL118 PaTu 8988t C55(1.50)  LDD1267  [11]
 LDCM0389  CL119 PaTu 8988t C55(1.48)  LDD1268  [11]
 LDCM0390  CL12 PaTu 8988t C55(1.19)  LDD1269  [11]
 LDCM0391  CL120 PaTu 8988t C55(1.53)  LDD1270  [11]
 LDCM0392  CL121 HEK-293T C55(1.30)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C55(1.20)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C55(1.13)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C55(1.15)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C55(2.58)  LDD0994  [11]
 LDCM0397  CL126 HEK-293T C55(1.54)  LDD0995  [11]
 LDCM0398  CL127 HEK-293T C55(1.08)  LDD0996  [11]
 LDCM0399  CL128 HEK-293T C55(1.47)  LDD0997  [11]
 LDCM0400  CL13 PaTu 8988t C55(2.27)  LDD1279  [11]
 LDCM0401  CL14 PaTu 8988t C55(2.59)  LDD1280  [11]
 LDCM0402  CL15 PaTu 8988t C55(1.87)  LDD1281  [11]
 LDCM0403  CL16 HEK-293T C55(1.18)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C55(1.34)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C55(1.14)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C55(1.07)  LDD1610  [12]
 LDCM0407  CL2 PaTu 8988t C55(1.07)  LDD1286  [11]
 LDCM0408  CL20 HEK-293T C55(1.15)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C55(1.16)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C55(1.15)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C55(1.01)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C55(1.02)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C55(1.43)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C55(1.20)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C55(1.18)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C55(1.09)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C55(1.26)  LDD1621  [12]
 LDCM0418  CL3 PaTu 8988t C55(1.36)  LDD1297  [11]
 LDCM0419  CL30 HEK-293T C55(1.03)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C55(1.51)  LDD1018  [11]
 LDCM0421  CL32 HEK-293T C55(1.79)  LDD1019  [11]
 LDCM0422  CL33 HEK-293T C55(4.78)  LDD1020  [11]
 LDCM0423  CL34 HEK-293T C55(1.64)  LDD1021  [11]
 LDCM0424  CL35 HEK-293T C55(1.43)  LDD1022  [11]
 LDCM0425  CL36 HEK-293T C55(1.47)  LDD1023  [11]
 LDCM0426  CL37 HEK-293T C55(2.02)  LDD1024  [11]
 LDCM0428  CL39 HEK-293T C55(3.29)  LDD1026  [11]
 LDCM0429  CL4 PaTu 8988t C55(1.91)  LDD1308  [11]
 LDCM0430  CL40 HEK-293T C55(1.42)  LDD1028  [11]
 LDCM0431  CL41 HEK-293T C55(1.77)  LDD1029  [11]
 LDCM0432  CL42 HEK-293T C55(2.37)  LDD1030  [11]
 LDCM0433  CL43 HEK-293T C55(2.30)  LDD1031  [11]
 LDCM0434  CL44 HEK-293T C55(1.49)  LDD1032  [11]
 LDCM0435  CL45 HEK-293T C55(2.12)  LDD1033  [11]
 LDCM0436  CL46 HEK-293T C55(1.19)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C55(1.34)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C55(1.40)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C55(1.23)  LDD1643  [12]
 LDCM0440  CL5 PaTu 8988t C55(1.71)  LDD1319  [11]
 LDCM0441  CL50 HEK-293T C55(1.40)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C55(0.95)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C55(1.40)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C55(0.97)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C55(1.16)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C55(1.15)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C55(1.15)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C55(1.24)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C55(1.23)  LDD1653  [12]
 LDCM0451  CL6 PaTu 8988t C55(1.43)  LDD1330  [11]
 LDCM0452  CL60 HEK-293T C55(1.35)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C55(1.23)  LDD1051  [11]
 LDCM0454  CL62 HEK-293T C55(1.01)  LDD1052  [11]
 LDCM0455  CL63 HEK-293T C55(1.26)  LDD1053  [11]
 LDCM0456  CL64 HEK-293T C55(1.52)  LDD1054  [11]
 LDCM0457  CL65 HEK-293T C55(1.73)  LDD1055  [11]
 LDCM0458  CL66 HEK-293T C55(1.18)  LDD1056  [11]
 LDCM0459  CL67 HEK-293T C55(1.12)  LDD1057  [11]
 LDCM0460  CL68 HEK-293T C55(1.38)  LDD1058  [11]
 LDCM0461  CL69 HEK-293T C55(1.50)  LDD1059  [11]
 LDCM0462  CL7 PaTu 8988t C55(1.98)  LDD1341  [11]
 LDCM0463  CL70 HEK-293T C55(1.18)  LDD1061  [11]
 LDCM0464  CL71 HEK-293T C55(1.32)  LDD1062  [11]
 LDCM0465  CL72 HEK-293T C55(2.65)  LDD1063  [11]
 LDCM0466  CL73 HEK-293T C55(1.34)  LDD1064  [11]
 LDCM0467  CL74 HEK-293T C55(1.57)  LDD1065  [11]
 LDCM0469  CL76 HEK-293T C55(1.03)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C55(1.27)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C55(1.07)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C55(0.95)  LDD1675  [12]
 LDCM0473  CL8 PaTu 8988t C55(2.26)  LDD1352  [11]
 LDCM0474  CL80 HEK-293T C55(1.00)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C55(1.14)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C55(0.98)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C55(1.02)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C55(1.14)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C55(1.34)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C55(1.23)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C55(1.36)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C55(1.31)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C55(1.41)  LDD1686  [12]
 LDCM0484  CL9 PaTu 8988t C55(1.75)  LDD1363  [11]
 LDCM0485  CL90 HEK-293T C55(1.28)  LDD1688  [12]
 LDCM0486  CL91 PaTu 8988t C55(0.42)  LDD1365  [11]
 LDCM0487  CL92 PaTu 8988t C55(0.40)  LDD1366  [11]
 LDCM0488  CL93 PaTu 8988t C55(0.53)  LDD1367  [11]
 LDCM0489  CL94 PaTu 8988t C55(0.47)  LDD1368  [11]
 LDCM0490  CL95 PaTu 8988t C55(1.26)  LDD1369  [11]
 LDCM0491  CL96 PaTu 8988t C55(0.95)  LDD1370  [11]
 LDCM0492  CL97 PaTu 8988t C55(0.54)  LDD1371  [11]
 LDCM0493  CL98 PaTu 8988t C55(0.87)  LDD1372  [11]
 LDCM0494  CL99 PaTu 8988t C55(0.54)  LDD1373  [11]
 LDCM0495  E2913 HEK-293T C55(1.53)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C55(1.64)  LDD1066  [11]
 LDCM0427  Fragment51 HEK-293T C55(1.66)  LDD1025  [11]
 LDCM0022  KB02 HEK-293T C55(1.01)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C55(1.25)  LDD1497  [12]
 LDCM0024  KB05 MKN-1 C55(4.73)  LDD3331  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C55(0.29); C55(0.10)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C55(1.08)  LDD2207  [14]
 LDCM0170  Structure8 Ramos 4.00  LDD0433  [4]
 LDCM0021  THZ1 HCT 116 C55(0.95)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.