Details of the Target

General Information of Target

Target ID LDTP03350
Target Name DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Gene Name DNMT1
Gene ID 1786
Synonyms
AIM; CXXC9; DNMT; DNA; cytosine-5)-methyltransferase 1; Dnmt1; EC 2.1.1.37; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; MCMT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
GMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEK
EEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPE
EKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYL
DDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLC
PIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFS
TSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGL
NLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQAR
RQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQ
QPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQ
GKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVT
ALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS
ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLA
EMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPR
KEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNK
FYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGP
NRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLR
TLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMA
GETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRP
RFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAP
GEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNG
ASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLP
NIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCL
PHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFP
DTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Subcellular location
Nucleus
Function
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth.
TTD ID
T88304
Uniprot ID
P26358
DrugMap ID
TTOX4TW
Ensemble ID
ENST00000340748.8
HGNC ID
HGNC:2976
ChEMBL ID
CHEMBL1993

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.31  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y1457(20.00)  LDD0260  [3]
Probe 1
 Probe Info  		Y78(10.98); Y923(27.58); Y924(11.66); Y969(4.13)  LDD3495  [4]
P11
 Probe Info  		10.81  LDD0201  [5]
BTD
 Probe Info  		C62(2.01); C41(1.45)  LDD1700  [6]
Johansson_61
 Probe Info  		_(20.00)  LDD1490  [7]
AHL-Pu-1
 Probe Info  		C1499(4.09); C751(4.44); C1071(2.13)  LDD0168  [8]
DBIA
 Probe Info  		C1071(52.30)  LDD0209  [9]
HHS-475
 Probe Info  		Y976(0.99); Y99(0.99); Y979(1.11); Y367(1.62)  LDD0264  [10]
HHS-465
 Probe Info  		Y976(10.00); Y979(10.00); Y99(5.25)  LDD2237  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1485(0.00); C1339(0.00); C580(0.00); C420(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C1125(0.00); C1339(0.00); C1001(0.00); C1499(0.00)  LDD0032  [13]
IPIAA_L
 Probe Info  		C1339(0.00); C62(0.00); C1125(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C1339(0.00); C41(0.00); C580(0.00); C420(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		C62(0.00); C1125(0.00)  LDD2226  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [17]
Compound 10
 Probe Info  		C1125(0.00); C1191(0.00); C1339(0.00); C1499(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		C1125(0.00); C1339(0.00); C1499(0.00); C62(0.00)  LDD2213  [18]
ENE
 Probe Info  		C62(0.00); C1125(0.00)  LDD0006  [16]
IPM
 Probe Info  		C62(0.00); C1478(0.00); C896(0.00)  LDD0005  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
PF-06672131
 Probe Info  		N.A.  LDD0017  [19]
SF
 Probe Info  		Y99(0.00); Y924(0.00); Y1405(0.00)  LDD0028  [20]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
TFBX
 Probe Info  		C686(0.00); C62(0.00); C420(0.00); C41(0.00)  LDD0148  [21]
VSF
 Probe Info  		N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info  		C41(0.00); C62(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		K83(0.00); K586(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C1125(0.00); C1191(0.00); C62(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		C1125(0.00); C62(0.00); C1485(0.00); C1499(0.00)  LDD0236  [24]
NAIA_5
 Probe Info  		C1339(0.00); C1414(0.00); C62(0.00); C1255(0.00)  LDD2223  [15]
HHS-482
 Probe Info  		Y99(0.71)  LDD2239  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C62(1.01); C41(0.81)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C62(0.86); C41(1.02)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C62(0.68); C1485(0.53); C1339(0.45)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C62(1.00); C1485(0.92); C41(0.68)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C62(1.07); C1485(1.02); C41(0.95); C686(0.95)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C62(0.92); C893(1.24)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C62(0.98); C41(0.74)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1339(0.42)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1485(0.48)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C1499(4.09); C751(4.44); C1071(2.13)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1499(6.34); C1191(3.71); C751(4.32); C62(2.42)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C1485(0.94); C1125(1.10); C1339(0.93); C1191(1.01)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C1485(1.03); C1125(0.82); C580(1.16); C1339(1.00)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C1125(1.07); C580(1.04); C1339(1.07); C751(1.05)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C1125(1.00); C580(0.99); C691(1.05); C1339(0.95)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C1485(1.10); C1125(0.93); C1339(1.10); C1255(1.02)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C1485(1.07); C1125(1.02); C580(1.11); C1339(1.01)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C1485(1.11); C1125(1.05); C1339(0.98); C1191(0.95)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C1485(1.04); C1125(1.07); C580(1.18); C1339(1.03)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C1125(1.66); C580(0.91); C1339(0.82); C751(0.88)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C1485(1.07); C1125(0.90); C580(1.06); C1339(1.08)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C1125(0.97); C580(1.05); C691(1.09); C1339(1.00)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C1485(0.91); C1125(1.00); C1148(1.40); C1339(1.01)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C1485(0.99); C1125(0.96); C1339(1.05); C1255(1.01)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C1485(1.03); C1125(0.96); C580(1.15); C1339(0.98)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C1485(1.04); C1125(1.06); C580(1.08); C1339(1.06)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C1485(0.98); C1125(0.98); C1339(0.97); C1191(1.02)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C1485(1.04); C1125(0.86); C580(1.24); C1339(1.00)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C1125(1.07); C580(1.12); C1339(1.03); C751(1.04)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C1125(0.95); C580(0.76); C691(1.03); C1339(0.97)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C1485(1.04); C1125(0.97); C1148(0.78); C1339(1.05)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C1125(1.08); C580(1.12); C1339(1.00); C751(0.95)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C1485(1.02); C1125(0.95); C1339(1.05); C1255(0.94)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C1485(1.07); C1125(0.99); C580(1.56); C1339(1.03)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C1485(1.07); C1125(0.92); C580(1.08); C1339(1.08)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C1485(0.92); C1125(1.04); C1339(1.03); C1191(1.06)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C1485(1.14); C1125(0.87); C580(1.08); C1339(1.03)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C1125(1.11); C580(0.92); C1339(1.00); C751(0.91)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C1125(0.96); C580(1.18); C691(0.96); C1339(0.95)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C1485(1.04); C1125(0.94); C1148(1.36); C1339(1.14)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C1485(1.07); C1125(0.85); C1339(1.12); C1255(0.86)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C1485(1.06); C1125(1.02); C580(1.25); C1339(1.02)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C1125(1.03); C580(0.89); C691(0.91); C1339(0.98)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C1485(1.04); C1125(0.88); C580(0.97); C1339(1.11)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C1485(1.09); C1125(1.17); C1339(0.93); C1191(1.04)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C1485(1.04); C1125(0.84); C580(1.26); C1339(0.95)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C1125(1.12); C580(1.02); C1339(1.03); C751(0.98)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C1125(0.98); C580(1.07); C691(0.98); C1339(1.00)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C1485(0.96); C1125(0.98); C1148(1.04); C1339(1.02)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C1485(1.01); C1125(0.91); C1339(1.12); C1255(1.02)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C1485(1.07); C1125(1.00); C580(0.90); C1339(1.08)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C1485(1.08); C1125(0.96); C580(1.01); C1339(1.15)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C1485(1.04); C1125(1.08); C1339(0.97); C1191(1.05)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C1485(1.02); C1125(1.02); C1148(0.76); C1339(1.11)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C1485(1.06); C1125(0.79); C580(1.15); C1339(1.11)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C1125(1.05); C580(1.10); C1339(1.10); C751(1.02)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C1125(1.04); C580(1.05); C691(0.99); C1339(0.97)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C1485(0.93); C1125(0.90); C1148(0.97); C1339(1.06)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C1485(1.03); C1125(1.04); C1339(1.13); C1255(0.94)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C1485(1.01); C1125(1.02); C580(0.96); C1339(1.03)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C1485(1.04); C1125(0.98); C580(1.03); C1339(1.10)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C1485(1.07); C1125(1.06); C1339(0.92); C1191(0.97)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C1485(1.08); C1125(0.88); C580(1.24); C1339(0.99)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C1125(1.00); C580(1.03); C1339(1.11); C751(0.96)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C1485(0.99); C1125(0.93); C1339(1.12); C1255(0.92)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C1125(1.02); C580(1.08); C691(0.95); C1339(0.95)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C1485(1.02); C1125(1.01); C1148(0.85); C1339(1.06)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C1485(1.02); C1125(0.96); C1339(1.14); C1255(0.89)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C1485(1.02); C1125(1.02); C580(0.97); C1339(0.99)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C1485(1.05); C1125(0.95); C580(0.96); C1339(1.09)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C1485(1.03); C1125(1.03); C580(0.99); C1339(1.07)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C1485(1.12); C1125(0.98); C580(1.08); C1339(1.11)  LDD1569  [25]
 LDCM0520  AKOS000195272 MDA-MB-231 C1485(0.82); C1339(0.67); C41(0.80)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C1485(0.96); C1125(1.01); C1148(0.99); C1339(1.06)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C1485(1.05); C1125(1.14); C1339(0.99); C1191(1.07)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C1485(1.02); C1125(0.96); C580(1.11); C1339(1.08)  LDD1514  [25]
 LDCM0156  Aniline NCI-H1299 11.40  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C62(0.80); C41(0.35)  LDD2091  [6]
 LDCM0088  C45 HEK-293T 10.81  LDD0201  [5]
 LDCM0630  CCW28-3 231MFP C62(1.22)  LDD2214  [26]
 LDCM0108  Chloroacetamide HeLa C1191(0.00); C1125(0.00); H1332(0.00); H50(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C41(0.82); C62(0.10)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C1485(1.01); C1125(0.90); C580(0.98); C691(0.91)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C1485(0.88); C1125(0.81); C1339(0.95); C1255(0.91)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C1485(0.92); C1125(0.98); C580(0.93); C691(0.91)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C1485(0.94); C1125(1.06); C580(0.99); C691(1.01)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C1485(0.95); C1125(0.98); C580(1.00); C1339(0.94)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C1485(1.00); C1125(1.04); C580(0.93); C1339(0.98)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C1485(0.98); C1125(0.92); C580(1.19); C691(1.04)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C1485(0.94); C1125(0.93); C580(0.95); C691(1.03)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C1485(0.86); C1125(0.95); C580(1.12); C1339(0.92)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C1485(0.93); C1125(1.01); C580(0.97); C1339(0.96)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C1485(0.97); C1125(1.04); C580(0.88); C691(1.01)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C1485(0.95); C1125(0.97); C580(1.05); C691(1.06)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C1485(0.90); C1125(1.00); C580(0.87); C1339(1.13)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C1485(0.89); C1125(0.91); C580(0.84); C1339(0.95)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C1485(0.88); C1125(0.90); C580(0.89); C1339(0.92)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C1485(0.92); C1125(1.16); C580(0.90); C691(1.06)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C1485(1.00); C1125(1.00); C580(0.89); C691(1.13)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C1485(0.70); C1125(0.91); C580(0.99); C1339(0.87)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C1485(0.78); C1125(1.01); C580(0.90); C1339(1.04)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C1485(1.04); C1125(0.92); C580(0.96); C691(0.92)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C1485(1.00); C1125(0.95); C580(1.14); C691(1.07)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C1485(1.01); C1125(1.09); C580(0.96); C1339(1.10)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C1485(0.96); C1125(0.97); C580(0.95); C1339(1.06)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C1485(0.91); C1125(0.96); C580(1.12); C1339(0.94)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C1485(1.02); C1125(0.92); C580(0.99); C691(0.85)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C1485(0.88); C1125(0.96); C580(1.38); C691(1.06)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C1485(0.94); C1125(0.94); C580(1.05); C1339(0.95)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C1485(0.80); C1125(0.89); C580(0.88); C1339(0.87)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C1485(0.90); C1125(0.99); C580(1.01); C691(1.04)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C1485(0.98); C1125(0.98); C580(1.20); C691(1.03)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C1485(0.95); C1125(0.98); C580(1.45); C1339(1.01)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C1485(1.03); C1125(0.97); C580(0.84); C1339(0.93)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C1485(1.00); C1125(0.94); C580(1.11); C691(0.92)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C1485(1.04); C1125(0.85); C580(1.04); C691(0.91)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C1485(0.79); C1125(0.95); C580(0.98); C1339(1.13)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C1485(0.74); C1125(0.91); C580(0.78); C1339(0.87)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C1485(1.09); C1125(0.99); C580(0.98); C691(1.03)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C1485(0.73); C1125(0.99); C1339(0.92); C1191(0.85)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C1485(1.02); C1125(0.98); C580(1.36); C1339(1.16)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C1125(1.12); C580(1.19); C1339(0.98); C751(1.04)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C1485(0.81); C1125(1.01); C580(1.03); C1339(1.05)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C1125(1.19); C580(0.99); C691(1.38); C1339(0.94)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C1485(0.81); C1125(0.97); C1148(0.63); C1339(0.92)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C1485(0.97); C1125(1.02); C1339(1.08); C1255(0.91)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C1485(1.00); C1125(1.15); C580(0.86); C1339(1.22)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C1485(0.90); C1125(1.02); C580(1.09); C1339(1.05)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C1485(0.95); C1125(0.92); C580(1.21); C691(1.00)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C1485(1.03); C1125(1.00); C580(0.80); C1339(1.10)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C1485(1.11); C1125(0.96); C580(0.98); C1339(1.14)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C1485(1.02); C1125(0.97); C580(0.91); C691(1.08)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C1485(0.94); C1125(0.96); C1339(1.05); C1191(1.03)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C1485(0.90); C1125(0.93); C580(0.96); C1339(1.00)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C1485(1.18); C1125(0.97); C580(1.10); C1339(1.20)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C1125(1.05); C580(1.09); C1339(0.95); C751(1.07)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C1125(0.99); C580(1.11); C691(1.37); C1339(0.95)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C1485(0.85); C1125(0.93); C1148(0.62); C1339(0.83)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C1485(1.01); C1125(0.92); C1339(1.02); C1255(0.88)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C1485(0.94); C1125(1.05); C580(1.00); C1339(1.19)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C1485(1.01); C1125(0.90); C580(1.10); C1339(0.96)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C1485(0.90); C1125(0.91); C580(1.12); C691(1.01)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C1485(0.80); C1125(0.91); C580(1.00); C1339(1.06)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C1485(0.90); C1125(0.95); C580(0.96); C691(0.99)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C1485(1.01); C1125(0.88); C580(1.00); C691(1.02)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C1485(1.01); C1125(0.95); C1339(1.00); C1191(1.02)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C1485(1.07); C1125(0.96); C580(1.22); C1339(1.18)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C1125(1.03); C580(1.20); C1339(0.95); C751(1.25)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C1125(1.02); C580(1.07); C691(1.25); C1339(1.02)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C1485(0.78); C1125(0.85); C1148(0.64); C1339(0.85)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C1485(1.03); C1125(0.95); C1339(1.06); C1255(1.06)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C1485(1.00); C1125(1.10); C580(1.00); C1339(1.09)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C1485(0.99); C1125(1.05); C580(1.04); C1339(0.97)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C1485(0.99); C1125(1.00); C580(1.42); C691(0.98)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C1485(0.93); C1125(1.06); C1339(0.95); C1191(1.01)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C1485(0.90); C1125(0.92); C580(1.02); C1339(1.07)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C1485(1.01); C1125(1.05); C580(0.92); C691(1.16)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C1485(1.05); C1125(0.98); C1339(0.99); C1191(0.97)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C1485(1.16); C1125(0.92); C580(1.38); C1339(1.00)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C1125(1.06); C580(1.24); C1339(0.97); C751(1.09)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C1125(1.00); C580(1.35); C691(1.36); C1339(1.02)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C1485(0.86); C1125(0.84); C1148(0.90); C1339(0.88)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C1485(1.05); C1125(1.02); C1339(1.14); C1255(1.11)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C1485(0.99); C1125(1.15); C580(1.24); C1339(1.20)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C1485(0.71); C1125(0.99); C580(1.21); C1339(0.84)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C1485(1.06); C1125(1.10); C580(1.17); C1339(1.04)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C1485(1.02); C1125(0.97); C580(1.10); C691(1.10)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C1485(0.93); C1125(1.00); C580(1.04); C1339(1.16)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C1485(0.89); C1125(0.97); C580(0.99); C1339(1.04)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C1485(0.93); C1125(0.97); C580(0.99); C691(1.10)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C1485(1.03); C1125(1.02); C1339(1.06); C1191(1.11)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C1485(1.03); C1125(0.94); C580(1.15); C1339(1.10)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C1125(1.17); C580(1.07); C1339(1.07); C751(1.13)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C1125(0.98); C580(1.38); C691(1.22); C1339(1.07)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C1485(0.87); C1125(0.95); C1148(0.87); C1339(1.03)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C1125(1.05); C580(1.05); C1339(1.00); C751(1.08)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C1485(1.04); C1125(0.98); C1339(1.08); C1255(1.11)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C1485(1.02); C1125(1.11); C580(1.16); C1339(1.15)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C1485(1.06); C1125(1.00); C580(1.34); C1339(1.04)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C1485(0.99); C1125(0.90); C580(1.18); C691(0.98)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C1485(0.85); C1125(0.99); C580(1.48); C1339(1.14)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C1485(1.01); C1125(0.94); C580(0.97); C691(0.93)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C1485(0.76); C1125(0.90); C1339(0.86); C1191(1.01)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C1485(1.14); C1125(0.90); C580(1.31); C1339(1.13)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C1125(1.08); C580(1.03); C1339(1.06); C751(0.94)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C1125(0.79); C580(0.86); C691(1.28); C1339(0.80)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C1125(1.06); C580(1.01); C691(1.27); C1339(1.30)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C1485(0.89); C1125(1.05); C1148(0.66); C1339(1.04)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C1485(1.06); C1125(0.94); C1339(1.07); C1255(0.99)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C1485(0.96); C1125(1.05); C580(0.81); C1339(1.08)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C1485(0.88); C1125(0.92); C580(0.92); C1339(0.99)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C1485(0.99); C1125(0.91); C580(1.45); C691(1.09)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C1485(0.78); C1125(0.99); C580(0.99); C1339(1.18)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C1485(1.03); C1125(0.95); C580(0.93); C1339(0.96)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C1485(0.96); C1125(0.94); C580(1.04); C691(1.02)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C1485(0.97); C1125(1.14); C1339(1.01); C1191(1.05)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C1485(0.78); C1125(0.93); C1148(0.99); C1339(1.00)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C1485(0.88); C1125(0.63); C580(1.35); C1339(0.83)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C1125(1.03); C580(1.12); C1339(1.12); C751(1.04)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C1125(0.94); C580(1.22); C691(1.21); C1339(0.99)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C1485(0.87); C1125(0.93); C1148(0.74); C1339(0.97)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C1485(0.91); C1125(0.96); C1339(1.04); C1255(1.08)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C1485(0.83); C1125(1.03); C580(0.90); C1339(0.93)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C1485(0.89); C1125(0.97); C580(1.03); C1339(1.02)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C1485(0.76); C1125(0.90); C580(1.22); C691(0.95)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C1485(0.86); C1125(0.91); C580(0.87); C1339(1.01)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C1485(0.57); C1125(0.95); C580(0.83); C1339(0.92)  LDD1697  [25]
 LDCM0634  CY-0357 Hep-G2 C62(1.39); C1125(0.98)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C1485(0.70); C1125(0.93); C580(0.79); C1339(1.09)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C420(1.44); C62(1.32); C893(1.19); C1485(1.16)  LDD1702  [6]
 LDCM0625  F8 Ramos C1485(1.02); C41(1.32); C1125(1.20); C62(1.05)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C1485(0.29); C41(1.27); C1125(0.60); C1339(0.52)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C1485(0.68); C41(5.59); C1125(1.16); 0.50  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C1485(0.24); C41(1.19); C1125(0.53); C62(1.47)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C1485(0.93); C41(1.17); C1125(1.89); C62(0.89)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C1485(1.06); C41(1.73); C1125(0.97); C62(0.72)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C1485(0.28); C41(0.96); C1125(0.43); C62(1.34)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C1485(0.93); C41(0.88); C1125(1.13); C62(1.04)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C1485(1.01); C41(1.38); C1125(1.41); C62(1.50)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C1485(1.25); C41(1.14); C1125(2.11); C62(0.92)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C1485(0.53); C41(0.46); C1125(0.55); C62(0.58)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C1485(1.08); C41(1.45); C1125(1.13); C62(1.08)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C1485(1.28); C41(0.98); C1125(1.48); C62(1.01)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C1485(0.23); C41(2.36); C1125(0.62); C62(1.21)  LDD2201  [27]
 LDCM0468  Fragment33 HEK-293T C1485(0.90); C1125(0.92); C580(1.02); C1339(1.05)  LDD1671  [25]
 LDCM0596  Fragment38 Ramos C1485(1.05); C41(1.59); C1125(0.95); C62(0.89)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C1485(0.81); C41(0.87); C1125(0.78); C62(0.76)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C1485(1.06); C1125(0.96); C580(1.05); C1339(1.07)  LDD1631  [25]
 LDCM0610  Fragment52 Ramos C1485(1.54); C41(1.25); C1125(1.24); C62(1.13)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C1485(1.38); C41(1.33); C1125(1.43); C62(1.11)  LDD2205  [27]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [7]
 LDCM0569  Fragment7 Ramos C1485(0.21); C41(1.04); C1125(0.73); C62(1.04)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C1485(0.36); C41(1.01); C1125(0.58); C62(2.44)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y976(0.99); Y99(0.99); Y979(1.11); Y367(1.62)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y979(0.59); Y976(0.71); Y99(1.52)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y99(0.62); Y976(0.64); Y979(0.68); Y367(0.81)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y979(0.85); Y99(0.85); Y976(0.87); Y367(20.00)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y979(0.90); Y976(1.09); Y99(1.23)  LDD0268  [10]
 LDCM0107  IAA HeLa H1332(0.00); H1541(0.00); H50(0.00); C1191(0.00)  LDD0221  [23]
 LDCM0022  KB02 Ramos 4.67  LDD0431  [28]
 LDCM0023  KB03 Jurkat C1071(52.30)  LDD0209  [9]
 LDCM0024  KB05 G361 C1501(1.66); C665(3.65); C1515(2.66)  LDD3311  [29]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C41(1.07)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C62(0.76); C1339(0.51); C41(0.44)  LDD2121  [6]
 LDCM0109  NEM HeLa H50(0.00); H972(0.00); H1332(0.00); H170(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C62(0.79); C1485(1.19); C41(0.38); C1191(1.23)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C41(1.13)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C62(1.00); C41(0.93)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C62(1.19); C893(1.11); C41(0.96); C686(0.68)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C62(1.41); C41(1.18)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C41(1.16)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C41(0.99)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C62(1.22); C1485(0.79); C1339(0.71); C41(0.97)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C62(0.79); C1485(1.00); C41(0.82); C896(1.50)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C62(1.06); C41(0.91)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C62(0.44); C1485(1.11); C41(1.41); C686(1.10)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C62(0.86); C41(0.84)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1485(0.79); C41(1.18)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C62(0.80); C41(0.70)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1485(0.94); C1339(1.37); C41(0.83); C686(0.78)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C62(0.71); C41(0.78)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C62(0.73); C1485(0.49); C41(0.70); C686(0.67)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C62(2.31); C41(2.35)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C62(0.91); C1485(0.88); C1339(0.85); C41(0.87)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C62(0.58); C1339(0.63); C41(0.75)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1485(0.52); C41(0.61); C686(0.56)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C41(3.23); C1001(0.75)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C62(2.26); C1339(1.06)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C41(0.94); C1001(1.14)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C62(0.86); C41(2.53)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C62(0.92); C1339(0.87); C41(0.71); C686(0.57)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C62(0.78); C41(1.91)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1485(0.78); C41(0.68); C686(0.90); C896(0.71)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C41(3.53)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C62(0.80); C1339(1.55); C41(0.92); C686(0.72)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1339(0.92); C41(1.12)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C893(0.98); C41(0.91)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C41(0.55)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1485(0.52); C41(0.61); C686(0.67)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1485(1.10); C41(1.06); C686(0.59)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C62(1.18); C1485(0.94); C1339(1.09); C893(1.04)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C62(0.82); C1485(1.17); C1339(0.99); C893(0.68)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C62(2.01); C41(1.45)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C62(0.76); C1485(0.64); C41(0.65); C686(0.70)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C41(0.99)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C62(1.15); C1339(0.88); C41(1.28)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C62(2.67); C896(1.05)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C62(6.60)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1485(0.80); C41(0.84); C1476(1.52)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C893(0.52); C41(0.64); C686(0.63)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C41(3.46)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C41(0.25)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C41(1.35); C1001(0.46)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C62(1.45); C41(1.36)  LDD2153  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C1478(0.35)  LDD2207  [30]
 LDCM0131  RA190 MM1.R C62(1.44)  LDD0304  [31]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase 1 (PARP1) ARTD/PARP family P09874
Histone-lysine N-methyltransferase EZH2 (EZH2) Histone-lysine methyltransferase family Q15910
Histone-lysine N-methyltransferase SETD7 (SETD7) Histone-lysine methyltransferase family Q8WTS6
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
DDB1- and CUL4-associated factor 5 (DCAF5) . Q96JK2
E3 ubiquitin-protein ligase UHRF1 (UHRF1) . Q96T88
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Polycomb protein EED (EED) WD repeat ESC family O75530
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) . Q96JM7
Nuclear receptor-interacting protein 1 (NRIP1) . P48552
PRKCA-binding protein (PICK1) . Q9NRD5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azacitidine Small molecular drug DB00928
Decitabine Small molecular drug DB01262
Flucytosine Small molecular drug DB01099
Procainamide Small molecular drug DB01035
Procaine Small molecular drug DB00721
Phase 3
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cc-486 Small molecular drug D09NTC
Guadecitabine . D0VZ4N
S-110 . D0A2BO
Sgi110 . D0Q5KZ
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Palifosfamide Small molecular drug D04FDN
Antroquinonol . D0T3AW
Rx-3117 . D0L7WS
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Epigallocatechin Gallate Small molecular drug DB12116
Cp-4200 . D0OT1S
Pmx-700 . D03DTQ
Xb-05 . D0JV8Q
Patented
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid27376512-compound-ascebp-1 Nucleotide D0G6ON
Pmid27376512-compound-ascebp-1hpe Nucleotide D0LK4R
Pmid27376512-compound-ascebp-2 Nucleotide D0KE4E
Pmid27376512-compound-ascebp-2hpe Nucleotide D0E7OA
Pmid27376512-compound-mir-155-5p Nucleotide D01CGQ
Pmid27376512-compound-mtc-422 Nucleotide D0QY0N
Pmid27376512-compound-mtc-423 Nucleotide D0W9VZ
Pmid27376512-compound-mtc-424 Nucleotide D02WRM
Pmid27376512-compound-mtc-427 Nucleotide D0HA0J
Pmid27376512-compound-mtc-433 Nucleotide D0U5CK
Pmid27376512-compound-table1example11 Small molecular drug D04JIH
Pmid27376512-compound-table1example16 Small molecular drug D05DSL
Pmid27376512-compound-table1example30 Small molecular drug D0YK6K
Pmid27376512-compound-table1example4 Small molecular drug D0K4YF
Pmid27376512-compound-table1example5 Small molecular drug D09FMS
Pmid27376512-compound-table1example8 Small molecular drug D0RT6C

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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Mass spectrometry data entry: PXD044402
26 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.