Details of the Target

General Information of Target

Target ID LDTP03433
Target Name NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1)
Gene Name NDUFS1
Gene ID 4719
Synonyms
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; EC 7.1.1.2; Complex I-75kD; CI-75kD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRIPVRKALVGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQI
PRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFL
LANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCT
RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTA
RPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQ
RLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNR
VDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRK
SWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSA
LQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKN
PPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTE
GRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIE
GANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQA
VEEPSIC
Target Bioclass
Enzyme
Family
Complex I 75 kDa subunit family
Subcellular location
Mitochondrion inner membrane
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.
Uniprot ID
P28331
Ensemble ID
ENST00000233190.11
HGNC ID
HGNC:7707
ChEMBL ID
CHEMBL2363065

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 Deletion: p.K234AfsTer18 DBIA    Probe Info 
HCT15 SNV: p.D194E; p.A580S DBIA    Probe Info 
KMRC3 SNV: p.V43L DBIA    Probe Info 
MOLT4 SNV: p.V34A IA-alkyne    Probe Info 
NCIH1155 SNV: p.C226Y DBIA    Probe Info 
NCIH1299 SNV: p.C128F .
OVK18 SNV: p.A322V DBIA    Probe Info 
RBE SNV: p.M204V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.18  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y294(18.66)  LDD0257  [3]
STPyne
 Probe Info  		K298(8.33); K467(9.31)  LDD0277  [4]
Probe 1
 Probe Info  		Y596(10.45)  LDD3495  [5]
P11
 Probe Info  		7.16  LDD0201  [6]
BTD
 Probe Info  		C75(1.65)  LDD1700  [7]
DBIA
 Probe Info  		C554(32.90)  LDD0209  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
CY4
 Probe Info  		D637(0.00); D640(0.00); T633(0.00); T638(0.00)  LDD0247  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C367(0.00); C78(0.00); C554(0.00); C92(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C75(0.00); C78(0.00); C367(0.00)  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
Lodoacetamide azide
 Probe Info  		C564(0.00); C367(0.00); C78(0.00); C226(0.00)  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0025  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		C727(0.00); C75(0.00); C78(0.00); C176(0.00)  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		C554(0.00); C710(0.00); C226(0.00); C64(0.00)  LDD0018  [16]
Ox-W18
 Probe Info  		N.A.  LDD2175  [17]
1c-yne
 Probe Info  		K531(0.00); K692(0.00); K499(0.00); K607(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		C367(0.00); C554(0.00); C727(0.00); C92(0.00)  LDD0217  [19]
Crotonaldehyde
 Probe Info  		C92(0.00); C367(0.00); C64(0.00); C727(0.00)  LDD0219  [19]
Methacrolein
 Probe Info  		C367(0.00); C92(0.00); C75(0.00); C727(0.00)  LDD0218  [19]
W1
 Probe Info  		C727(0.00); C554(0.00)  LDD0236  [20]
AOyne
 Probe Info  		4.40  LDD0443  [21]
NAIA_5
 Probe Info  		C727(0.00); C367(0.00); C78(0.00); C554(0.00)  LDD2223  [22]
TER-AC
 Probe Info  		N.A.  LDD0426  [23]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		18.55  LDD0471  [24]
FFF probe13
 Probe Info  		13.04  LDD0475  [24]
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
FFF probe15
 Probe Info  		12.38  LDD0478  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]
JN0003
 Probe Info  		12.60  LDD0469  [24]
STS-1
 Probe Info  		1.26  LDD0136  [25]
STS-2
 Probe Info  		1.48  LDD0138  [25]
OEA-DA
 Probe Info  		3.04  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C75(0.78); C92(0.97); C78(1.68)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C64(1.41); C75(1.15)  LDD2152  [7]
 LDCM0214  AC1 HEK-293T C92(0.93); C78(0.94); C367(0.88); C554(0.96)  LDD1507  [27]
 LDCM0215  AC10 HEK-293T C92(0.96); C78(0.95); C367(1.12); C554(0.88)  LDD1508  [27]
 LDCM0226  AC11 HEK-293T C92(0.99); C78(1.03); C367(1.01); C554(0.92)  LDD1509  [27]
 LDCM0237  AC12 HEK-293T C92(0.97); C78(0.99); C367(0.99); C554(0.94)  LDD1510  [27]
 LDCM0259  AC14 HEK-293T C92(0.91); C78(0.94); C367(0.99); C554(0.99)  LDD1512  [27]
 LDCM0270  AC15 HEK-293T C92(0.90); C78(0.93); C367(1.10); C554(0.96)  LDD1513  [27]
 LDCM0276  AC17 HEK-293T C92(0.93); C78(0.92); C367(0.83); C554(1.04)  LDD1515  [27]
 LDCM0277  AC18 HEK-293T C92(0.95); C78(1.05); C367(1.07); C554(0.94)  LDD1516  [27]
 LDCM0278  AC19 HEK-293T C92(0.99); C78(0.75); C367(0.84); C554(0.91)  LDD1517  [27]
 LDCM0279  AC2 HEK-293T C92(0.93); C78(1.03); C367(0.94); C554(0.89)  LDD1518  [27]
 LDCM0280  AC20 HEK-293T C92(1.02); C78(0.96); C367(0.96); C554(0.87)  LDD1519  [27]
 LDCM0281  AC21 HEK-293T C92(0.93); C78(1.01); C367(1.14); C554(0.88)  LDD1520  [27]
 LDCM0282  AC22 HEK-293T C92(0.99); C78(0.99); C367(1.06); C554(0.97)  LDD1521  [27]
 LDCM0283  AC23 HEK-293T C92(0.95); C78(0.92); C367(1.08); C554(0.93)  LDD1522  [27]
 LDCM0284  AC24 HEK-293T C92(0.98); C78(1.03); C367(1.12); C554(0.90)  LDD1523  [27]
 LDCM0285  AC25 HEK-293T C92(0.93); C78(1.04); C367(1.40); C554(1.03)  LDD1524  [27]
 LDCM0286  AC26 HEK-293T C92(0.99); C78(1.02); C367(1.13); C554(0.92)  LDD1525  [27]
 LDCM0287  AC27 HEK-293T C92(0.85); C78(1.03); C367(0.90); C554(0.94)  LDD1526  [27]
 LDCM0288  AC28 HEK-293T C92(1.03); C78(0.97); C367(1.12); C554(0.93)  LDD1527  [27]
 LDCM0289  AC29 HEK-293T C92(0.94); C78(1.00); C367(1.09); C554(0.90)  LDD1528  [27]
 LDCM0290  AC3 HEK-293T C92(0.88); C78(1.01); C367(0.90); C554(0.94)  LDD1529  [27]
 LDCM0291  AC30 HEK-293T C92(0.98); C78(1.01); C367(0.92); C554(1.07)  LDD1530  [27]
 LDCM0292  AC31 HEK-293T C92(0.97); C78(0.98); C367(1.20); C554(0.97)  LDD1531  [27]
 LDCM0293  AC32 HEK-293T C92(0.97); C78(1.01); C367(1.22); C554(0.97)  LDD1532  [27]
 LDCM0294  AC33 HEK-293T C92(0.91); C78(0.97); C367(0.84); C554(0.95)  LDD1533  [27]
 LDCM0295  AC34 HEK-293T C92(0.93); C78(0.91); C367(1.16); C554(0.98)  LDD1534  [27]
 LDCM0296  AC35 HEK-293T C92(0.91); C78(0.94); C367(1.06); C554(0.96)  LDD1535  [27]
 LDCM0297  AC36 HEK-293T C92(0.96); C78(0.96); C367(1.11); C554(1.01)  LDD1536  [27]
 LDCM0298  AC37 HEK-293T C92(1.01); C78(1.11); C367(1.10); C554(0.94)  LDD1537  [27]
 LDCM0299  AC38 HEK-293T C92(0.96); C78(0.95); C367(1.06); C554(1.15)  LDD1538  [27]
 LDCM0300  AC39 HEK-293T C92(0.90); C78(0.90); C367(1.03); C554(0.98)  LDD1539  [27]
 LDCM0301  AC4 HEK-293T C92(0.97); C78(1.00); C367(1.02); C554(1.04)  LDD1540  [27]
 LDCM0302  AC40 HEK-293T C92(0.93); C78(0.91); C367(1.09); C554(0.90)  LDD1541  [27]
 LDCM0303  AC41 HEK-293T C92(0.93); C78(0.93); C367(0.93); C554(0.89)  LDD1542  [27]
 LDCM0304  AC42 HEK-293T C92(0.88); C78(0.94); C367(0.95); C554(0.85)  LDD1543  [27]
 LDCM0305  AC43 HEK-293T C92(0.95); C78(0.97); C367(0.93); C554(0.83)  LDD1544  [27]
 LDCM0306  AC44 HEK-293T C92(1.03); C78(0.97); C367(1.12); C554(0.92)  LDD1545  [27]
 LDCM0307  AC45 HEK-293T C92(1.03); C78(1.02); C367(1.21); C554(0.94)  LDD1546  [27]
 LDCM0308  AC46 HEK-293T C92(0.97); C78(0.91); C367(1.06); C554(0.98)  LDD1547  [27]
 LDCM0309  AC47 HEK-293T C92(1.00); C78(0.97); C367(1.09); C554(0.92)  LDD1548  [27]
 LDCM0310  AC48 HEK-293T C92(0.98); C78(0.95); C367(1.07); C554(0.87)  LDD1549  [27]
 LDCM0311  AC49 HEK-293T C92(0.94); C78(0.92); C367(0.82); C554(0.89)  LDD1550  [27]
 LDCM0312  AC5 HEK-293T C92(1.08); C78(1.10); C367(0.97); C554(0.90)  LDD1551  [27]
 LDCM0313  AC50 HEK-293T C92(0.93); C78(0.99); C367(1.08); C554(0.99)  LDD1552  [27]
 LDCM0314  AC51 HEK-293T C92(0.93); C78(1.02); C367(0.92); C554(1.10)  LDD1553  [27]
 LDCM0315  AC52 HEK-293T C92(1.01); C78(0.99); C367(0.94); C554(0.95)  LDD1554  [27]
 LDCM0316  AC53 HEK-293T C92(0.99); C78(1.07); C367(1.07); C554(0.89)  LDD1555  [27]
 LDCM0317  AC54 HEK-293T C92(0.97); C78(0.95); C367(0.91); C554(0.93)  LDD1556  [27]
 LDCM0318  AC55 HEK-293T C92(0.94); C78(0.95); C367(1.07); C554(0.94)  LDD1557  [27]
 LDCM0319  AC56 HEK-293T C92(0.94); C78(0.96); C367(1.00); C554(1.04)  LDD1558  [27]
 LDCM0320  AC57 HEK-293T C92(0.89); C78(0.89); C367(1.02); C554(0.90)  LDD1559  [27]
 LDCM0321  AC58 HEK-293T C92(0.96); C78(0.99); C367(1.12); C554(0.93)  LDD1560  [27]
 LDCM0322  AC59 HEK-293T C92(0.96); C78(1.00); C367(1.04); C554(1.05)  LDD1561  [27]
 LDCM0323  AC6 HEK-293T C92(0.94); C78(0.90); C367(0.91); C554(0.97)  LDD1562  [27]
 LDCM0324  AC60 HEK-293T C92(0.92); C78(0.94); C367(0.93); C554(0.88)  LDD1563  [27]
 LDCM0325  AC61 HEK-293T C92(0.95); C78(0.95); C367(1.18); C554(0.90)  LDD1564  [27]
 LDCM0326  AC62 HEK-293T C92(0.96); C78(0.95); C367(1.00); C554(1.07)  LDD1565  [27]
 LDCM0327  AC63 HEK-293T C92(0.93); C78(0.91); C367(1.34); C554(0.86)  LDD1566  [27]
 LDCM0328  AC64 HEK-293T C92(0.97); C78(0.94); C367(0.99); C554(0.89)  LDD1567  [27]
 LDCM0334  AC7 HEK-293T C92(0.95); C78(0.94); C367(1.08); C554(0.92)  LDD1568  [27]
 LDCM0345  AC8 HEK-293T C92(0.96); C78(0.96); C367(0.94); C554(0.91)  LDD1569  [27]
 LDCM0545  Acetamide MDA-MB-231 C64(0.92)  LDD2138  [7]
 LDCM0248  AKOS034007472 HEK-293T C92(1.01); C78(0.99); C367(1.09); C554(0.86)  LDD1511  [27]
 LDCM0356  AKOS034007680 HEK-293T C92(0.94); C78(0.95); C367(0.85); C554(0.93)  LDD1570  [27]
 LDCM0275  AKOS034007705 HEK-293T C92(0.91); C78(0.93); C367(0.98); C554(0.86)  LDD1514  [27]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0088  C45 HEK-293T 7.16  LDD0201  [6]
 LDCM0108  Chloroacetamide HeLa C367(0.00); C554(0.00); C92(0.00); C727(0.00)  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C554(20.00); C92(1.29)  LDD2227  [22]
 LDCM0367  CL1 HEK-293T C92(0.95); C78(1.04); C367(1.24); C554(0.99)  LDD1571  [27]
 LDCM0368  CL10 HEK-293T C92(0.86); C78(0.83); C367(1.12); C554(0.87)  LDD1572  [27]
 LDCM0369  CL100 HEK-293T C92(0.96); C78(1.03); C367(0.90); C554(1.06)  LDD1573  [27]
 LDCM0370  CL101 HEK-293T C92(0.89); C78(1.00); C367(1.06); C554(0.90)  LDD1574  [27]
 LDCM0371  CL102 HEK-293T C92(0.99); C78(0.94); C367(1.02); C554(1.06)  LDD1575  [27]
 LDCM0372  CL103 HEK-293T C92(1.06); C78(1.02); C367(0.75); C554(1.08)  LDD1576  [27]
 LDCM0373  CL104 HEK-293T C92(0.90); C78(1.00); C367(0.89); C554(0.96)  LDD1577  [27]
 LDCM0374  CL105 HEK-293T C92(0.91); C78(0.96); C367(0.75); C554(0.96)  LDD1578  [27]
 LDCM0375  CL106 HEK-293T C92(1.05); C78(0.93); C367(1.17); C554(0.93)  LDD1579  [27]
 LDCM0376  CL107 HEK-293T C92(1.04); C78(1.01); C367(0.99); C554(0.99)  LDD1580  [27]
 LDCM0377  CL108 HEK-293T C92(0.92); C78(1.02); C367(1.01); C554(1.03)  LDD1581  [27]
 LDCM0378  CL109 HEK-293T C92(0.94); C78(0.96); C367(1.05); C554(0.91)  LDD1582  [27]
 LDCM0379  CL11 HEK-293T C92(0.89); C78(0.95); C367(1.26); C554(0.94)  LDD1583  [27]
 LDCM0380  CL110 HEK-293T C92(1.01); C78(0.93); C367(0.74); C554(0.92)  LDD1584  [27]
 LDCM0381  CL111 HEK-293T C92(0.97); C78(0.94); C367(0.85); C554(0.96)  LDD1585  [27]
 LDCM0382  CL112 HEK-293T C92(0.93); C78(0.92); C367(1.22); C554(0.98)  LDD1586  [27]
 LDCM0383  CL113 HEK-293T C92(1.00); C78(1.01); C367(1.15); C554(0.92)  LDD1587  [27]
 LDCM0384  CL114 HEK-293T C92(1.02); C78(0.85); C367(0.76); C554(1.00)  LDD1588  [27]
 LDCM0385  CL115 HEK-293T C92(1.01); C78(0.99); C367(0.94); C554(0.98)  LDD1589  [27]
 LDCM0386  CL116 HEK-293T C92(0.95); C78(0.94); C367(0.93); C554(1.00)  LDD1590  [27]
 LDCM0387  CL117 HEK-293T C92(0.97); C78(1.03); C367(0.94); C554(0.88)  LDD1591  [27]
 LDCM0388  CL118 HEK-293T C92(1.04); C78(1.00); C367(1.07); C554(0.92)  LDD1592  [27]
 LDCM0389  CL119 HEK-293T C92(1.01); C78(1.01); C367(0.88); C554(1.00)  LDD1593  [27]
 LDCM0390  CL12 HEK-293T C92(0.89); C78(0.93); C367(1.07); C554(0.86)  LDD1594  [27]
 LDCM0391  CL120 HEK-293T C92(0.90); C78(0.93); C367(1.08); C554(0.99)  LDD1595  [27]
 LDCM0392  CL121 HEK-293T C92(0.90); C78(1.02); C367(1.18); C554(0.93)  LDD1596  [27]
 LDCM0393  CL122 HEK-293T C92(1.03); C78(1.00); C367(1.04); C554(1.01)  LDD1597  [27]
 LDCM0394  CL123 HEK-293T C92(0.87); C78(0.97); C367(0.83); C554(1.08)  LDD1598  [27]
 LDCM0395  CL124 HEK-293T C92(0.89); C78(1.02); C367(0.87); C554(0.94)  LDD1599  [27]
 LDCM0396  CL125 HEK-293T C92(0.99); C78(1.00); C367(0.83); C554(0.84)  LDD1600  [27]
 LDCM0397  CL126 HEK-293T C92(1.05); C78(0.92); C367(1.15); C554(1.03)  LDD1601  [27]
 LDCM0398  CL127 HEK-293T C92(1.06); C78(1.00); C367(0.81); C554(0.93)  LDD1602  [27]
 LDCM0399  CL128 HEK-293T C92(0.90); C78(0.95); C367(1.11); C554(0.97)  LDD1603  [27]
 LDCM0400  CL13 HEK-293T C92(0.87); C78(0.98); C367(0.92); C554(1.01)  LDD1604  [27]
 LDCM0401  CL14 HEK-293T C92(1.10); C78(0.95); C367(0.99); C554(1.09)  LDD1605  [27]
 LDCM0402  CL15 HEK-293T C92(0.96); C78(0.91); C367(0.69); C554(0.96)  LDD1606  [27]
 LDCM0403  CL16 HEK-293T C92(0.90); C78(1.02); C367(1.14); C554(1.02)  LDD1607  [27]
 LDCM0404  CL17 HEK-293T C92(0.84); C78(0.79); C367(0.75); C554(0.88)  LDD1608  [27]
 LDCM0405  CL18 HEK-293T C92(0.94); C78(0.96); C367(1.09); C554(0.97)  LDD1609  [27]
 LDCM0406  CL19 HEK-293T C92(1.00); C78(1.02); C367(0.91); C554(1.16)  LDD1610  [27]
 LDCM0407  CL2 HEK-293T C92(1.04); C78(1.02); C367(1.08); C554(1.02)  LDD1611  [27]
 LDCM0408  CL20 HEK-293T C92(1.03); C78(1.01); C367(1.08); C554(0.80)  LDD1612  [27]
 LDCM0409  CL21 HEK-293T C92(0.93); C78(1.06); C367(1.12); C554(0.83)  LDD1613  [27]
 LDCM0410  CL22 HEK-293T C92(0.96); C78(0.97); C367(1.21); C554(0.99)  LDD1614  [27]
 LDCM0411  CL23 HEK-293T C92(0.88); C78(0.99); C367(1.40); C554(0.95)  LDD1615  [27]
 LDCM0412  CL24 HEK-293T C92(0.94); C78(1.02); C367(1.05); C554(0.84)  LDD1616  [27]
 LDCM0413  CL25 HEK-293T C92(0.83); C78(0.95); C367(0.76); C554(0.94)  LDD1617  [27]
 LDCM0414  CL26 HEK-293T C92(1.01); C78(1.06); C367(0.93); C554(0.97)  LDD1618  [27]
 LDCM0415  CL27 HEK-293T C92(1.03); C78(0.95); C367(1.04); C554(0.99)  LDD1619  [27]
 LDCM0416  CL28 HEK-293T C92(0.95); C78(0.93); C367(0.91); C554(0.98)  LDD1620  [27]
 LDCM0417  CL29 HEK-293T C92(0.94); C78(0.96); C367(1.00); C554(1.00)  LDD1621  [27]
 LDCM0418  CL3 HEK-293T C92(1.03); C78(1.02); C367(0.80); C554(1.02)  LDD1622  [27]
 LDCM0419  CL30 HEK-293T C92(1.00); C78(1.07); C367(1.08); C554(0.98)  LDD1623  [27]
 LDCM0420  CL31 HEK-293T C92(1.11); C78(1.02); C367(1.13); C554(0.88)  LDD1624  [27]
 LDCM0421  CL32 HEK-293T C92(0.98); C78(1.03); C367(1.13); C554(0.92)  LDD1625  [27]
 LDCM0422  CL33 HEK-293T C92(0.80); C78(0.96); C367(1.01); C554(0.74)  LDD1626  [27]
 LDCM0423  CL34 HEK-293T C92(0.97); C78(1.02); C367(0.97); C554(1.02)  LDD1627  [27]
 LDCM0424  CL35 HEK-293T C92(0.97); C78(1.02); C367(1.18); C554(0.94)  LDD1628  [27]
 LDCM0425  CL36 HEK-293T C92(0.94); C78(1.01); C367(1.05); C554(0.87)  LDD1629  [27]
 LDCM0426  CL37 HEK-293T C92(0.95); C78(0.95); C367(0.90); C554(0.89)  LDD1630  [27]
 LDCM0428  CL39 HEK-293T C92(1.01); C78(0.96); C367(0.72); C554(1.09)  LDD1632  [27]
 LDCM0429  CL4 HEK-293T C92(0.92); C78(1.02); C367(0.80); C554(0.96)  LDD1633  [27]
 LDCM0430  CL40 HEK-293T C92(0.88); C78(1.01); C367(0.79); C554(1.02)  LDD1634  [27]
 LDCM0431  CL41 HEK-293T C92(0.91); C78(0.92); C367(0.87); C554(0.92)  LDD1635  [27]
 LDCM0432  CL42 HEK-293T C92(0.95); C78(0.99); C367(1.06); C554(0.90)  LDD1636  [27]
 LDCM0433  CL43 HEK-293T C92(1.14); C78(1.13); C367(1.10); C554(0.95)  LDD1637  [27]
 LDCM0434  CL44 HEK-293T C92(0.94); C78(1.00); C367(1.18); C554(0.83)  LDD1638  [27]
 LDCM0435  CL45 HEK-293T C92(0.92); C78(0.98); C367(0.72); C554(0.91)  LDD1639  [27]
 LDCM0436  CL46 HEK-293T C92(0.89); C78(1.02); C367(1.33); C554(1.13)  LDD1640  [27]
 LDCM0437  CL47 HEK-293T C92(0.95); C78(1.00); C367(1.30); C554(0.89)  LDD1641  [27]
 LDCM0438  CL48 HEK-293T C92(0.91); C78(0.99); C367(1.13); C554(0.93)  LDD1642  [27]
 LDCM0439  CL49 HEK-293T C92(0.91); C78(0.96); C367(1.33); C554(0.89)  LDD1643  [27]
 LDCM0440  CL5 HEK-293T C92(0.89); C78(0.89); C367(0.96); C554(0.96)  LDD1644  [27]
 LDCM0441  CL50 HEK-293T C92(0.99); C78(0.91); C367(1.16); C554(0.99)  LDD1645  [27]
 LDCM0443  CL52 HEK-293T C92(0.91); C78(0.93); C367(0.96); C554(0.94)  LDD1646  [27]
 LDCM0444  CL53 HEK-293T C92(0.81); C78(0.87); C367(1.10); C554(0.89)  LDD1647  [27]
 LDCM0445  CL54 HEK-293T C92(0.80); C78(0.83); C367(0.90); C554(0.92)  LDD1648  [27]
 LDCM0446  CL55 HEK-293T C92(1.03); C78(1.04); C367(0.93); C554(0.91)  LDD1649  [27]
 LDCM0447  CL56 HEK-293T C92(0.92); C78(1.04); C367(1.03); C554(0.82)  LDD1650  [27]
 LDCM0448  CL57 HEK-293T C92(0.96); C78(1.05); C367(1.04); C554(0.78)  LDD1651  [27]
 LDCM0449  CL58 HEK-293T C92(0.88); C78(1.00); C367(1.24); C554(1.21)  LDD1652  [27]
 LDCM0450  CL59 HEK-293T C92(0.89); C78(0.95); C367(1.17); C554(0.91)  LDD1653  [27]
 LDCM0451  CL6 HEK-293T C92(0.79); C78(0.88); C367(1.03); C554(0.90)  LDD1654  [27]
 LDCM0452  CL60 HEK-293T C92(0.94); C78(0.96); C367(1.15); C554(0.90)  LDD1655  [27]
 LDCM0453  CL61 HEK-293T C92(0.94); C78(1.02); C367(0.99); C554(0.94)  LDD1656  [27]
 LDCM0454  CL62 HEK-293T C92(0.98); C78(0.97); C367(1.08); C554(1.03)  LDD1657  [27]
 LDCM0455  CL63 HEK-293T C92(1.07); C78(0.99); C367(0.83); C554(0.96)  LDD1658  [27]
 LDCM0456  CL64 HEK-293T C92(0.86); C78(0.93); C367(1.02); C554(0.93)  LDD1659  [27]
 LDCM0457  CL65 HEK-293T C92(0.89); C78(0.90); C367(1.14); C554(0.89)  LDD1660  [27]
 LDCM0458  CL66 HEK-293T C92(0.88); C78(0.91); C367(0.99); C554(0.81)  LDD1661  [27]
 LDCM0459  CL67 HEK-293T C92(0.99); C78(1.08); C367(1.04); C554(0.94)  LDD1662  [27]
 LDCM0460  CL68 HEK-293T C92(1.00); C78(1.00); C367(1.23); C554(0.85)  LDD1663  [27]
 LDCM0461  CL69 HEK-293T C92(1.03); C78(1.07); C367(1.17); C554(0.86)  LDD1664  [27]
 LDCM0462  CL7 HEK-293T C92(0.88); C78(1.01); C367(0.86); C554(1.17)  LDD1665  [27]
 LDCM0463  CL70 HEK-293T C92(0.89); C78(0.94); C367(1.32); C554(0.95)  LDD1666  [27]
 LDCM0464  CL71 HEK-293T C92(0.90); C78(0.97); C367(1.52); C554(0.94)  LDD1667  [27]
 LDCM0465  CL72 HEK-293T C92(0.92); C78(0.97); C367(1.01); C554(0.87)  LDD1668  [27]
 LDCM0466  CL73 HEK-293T C92(0.90); C78(1.00); C367(0.83); C554(0.99)  LDD1669  [27]
 LDCM0467  CL74 HEK-293T C92(0.97); C78(1.04); C367(1.05); C554(0.99)  LDD1670  [27]
 LDCM0469  CL76 HEK-293T C92(0.92); C78(0.99); C367(0.90); C554(1.06)  LDD1672  [27]
 LDCM0470  CL77 HEK-293T C92(0.89); C78(0.85); C367(0.69); C554(0.82)  LDD1673  [27]
 LDCM0471  CL78 HEK-293T C92(0.92); C78(0.97); C367(1.04); C554(0.99)  LDD1674  [27]
 LDCM0472  CL79 HEK-293T C92(0.88); C78(1.09); C367(1.04); C554(1.06)  LDD1675  [27]
 LDCM0473  CL8 HEK-293T C92(0.75); C78(0.78); C367(0.87); C554(0.64)  LDD1676  [27]
 LDCM0474  CL80 HEK-293T C92(0.98); C78(1.03); C367(1.05); C554(0.94)  LDD1677  [27]
 LDCM0475  CL81 HEK-293T C92(1.02); C78(1.08); C367(1.31); C554(0.95)  LDD1678  [27]
 LDCM0476  CL82 HEK-293T C92(0.99); C78(0.99); C367(0.97); C554(1.05)  LDD1679  [27]
 LDCM0477  CL83 HEK-293T C92(0.92); C78(0.93); C367(1.18); C554(0.88)  LDD1680  [27]
 LDCM0478  CL84 HEK-293T C92(0.96); C78(1.02); C367(0.99); C554(0.81)  LDD1681  [27]
 LDCM0479  CL85 HEK-293T C92(0.89); C78(0.99); C367(0.99); C554(0.91)  LDD1682  [27]
 LDCM0480  CL86 HEK-293T C92(1.03); C78(0.96); C367(0.73); C554(1.02)  LDD1683  [27]
 LDCM0481  CL87 HEK-293T C92(1.01); C78(0.99); C367(0.88); C554(1.04)  LDD1684  [27]
 LDCM0482  CL88 HEK-293T C92(0.89); C78(1.00); C367(1.18); C554(1.04)  LDD1685  [27]
 LDCM0483  CL89 HEK-293T C92(0.90); C78(0.96); C367(0.78); C554(0.98)  LDD1686  [27]
 LDCM0484  CL9 HEK-293T C92(0.95); C78(1.14); C367(0.99); C554(0.88)  LDD1687  [27]
 LDCM0485  CL90 HEK-293T C92(0.72); C78(0.80); C367(0.78); C554(0.81)  LDD1688  [27]
 LDCM0486  CL91 HEK-293T C92(0.96); C78(1.07); C367(1.02); C554(0.88)  LDD1689  [27]
 LDCM0487  CL92 HEK-293T C92(0.91); C78(0.96); C367(0.81); C554(0.87)  LDD1690  [27]
 LDCM0488  CL93 HEK-293T C92(1.00); C78(1.02); C367(1.23); C554(0.87)  LDD1691  [27]
 LDCM0489  CL94 HEK-293T C92(0.89); C78(0.93); C367(0.99); C554(1.07)  LDD1692  [27]
 LDCM0490  CL95 HEK-293T C92(0.77); C78(0.81); C367(1.07); C554(0.86)  LDD1693  [27]
 LDCM0491  CL96 HEK-293T C92(0.91); C78(0.91); C367(0.78); C554(0.81)  LDD1694  [27]
 LDCM0492  CL97 HEK-293T C92(0.90); C78(0.94); C367(1.02); C554(0.87)  LDD1695  [27]
 LDCM0493  CL98 HEK-293T C92(1.04); C78(1.03); C367(1.13); C554(1.21)  LDD1696  [27]
 LDCM0494  CL99 HEK-293T C92(1.01); C78(1.07); C367(0.82); C554(1.05)  LDD1697  [27]
 LDCM0495  E2913 HEK-293T C92(1.03); C78(0.98); C367(0.69); C554(0.89)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C75(0.73)  LDD1702  [7]
 LDCM0625  F8 Ramos C92(1.19)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C92(1.07)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C92(0.52)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C92(1.00)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C92(1.34)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C92(0.62)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C92(0.75)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C92(1.01)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C92(1.34)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C92(1.08)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C92(0.67)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C92(1.43)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C92(1.23)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C92(1.00)  LDD2201  [28]
 LDCM0468  Fragment33 HEK-293T C92(1.00); C78(0.97); C367(0.86); C554(0.97)  LDD1671  [27]
 LDCM0596  Fragment38 Ramos C92(0.91)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C92(0.98)  LDD2184  [28]
 LDCM0427  Fragment51 HEK-293T C92(1.00); C78(0.99); C367(0.92); C554(1.03)  LDD1631  [27]
 LDCM0610  Fragment52 Ramos C92(1.33)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C92(1.25)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C92(0.72)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C92(0.97)  LDD2188  [28]
 LDCM0107  IAA HeLa C367(0.00); H444(0.00); C554(0.00); C727(0.00)  LDD0221  [19]
 LDCM0022  KB02 HEK-293T C75(0.99); C727(0.96); C92(1.01); C78(0.96)  LDD1492  [27]
 LDCM0023  KB03 Jurkat C554(32.90)  LDD0209  [8]
 LDCM0024  KB05 COLO792 C89(1.57); C92(1.17); C568(1.35)  LDD3310  [29]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C75(0.65)  LDD2121  [7]
 LDCM0109  NEM HeLa H444(0.00); C367(0.00)  LDD0223  [19]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C64(1.20); C75(0.72); C92(0.73)  LDD2089  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C75(1.02); C92(1.07)  LDD2093  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C92(1.09)  LDD2097  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C64(1.95); C92(1.51)  LDD2099  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C75(1.00); C92(1.09)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C64(0.97); C75(0.60); C92(0.65)  LDD2109  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C75(0.78)  LDD2115  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C64(0.96); C75(1.84)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C92(0.77)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C64(1.55); C92(0.92)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C75(0.50)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C75(0.63); C92(0.79)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C64(1.40); C75(0.90); C92(1.03); C78(0.69)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C64(1.34); C75(1.24)  LDD2129  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C75(1.33); C92(1.33); C78(1.52)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C64(1.69); C75(1.03); C92(1.25); C78(1.40)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C64(1.29); C75(0.77); C92(1.06); C78(0.82)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C75(1.65)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C75(0.67); C92(0.85); C78(1.56)  LDD2140  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C64(0.72); C75(2.12)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C75(0.83)  LDD2146  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C64(0.57); C75(0.77)  LDD2148  [7]
 LDCM0131  RA190 MM1.R C727(1.32)  LDD0304  [30]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydropyrimidinase-related protein 5 (DPYSL5) Hydantoinase/dihydropyrimidinase family Q9BPU6
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 7A1, mitochondrial (COX7A1) Cytochrome c oxidase VIIa family P24310
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 5 (KLF5) Krueppel C2H2-type zinc-finger protein family Q13887
Neurogenic differentiation factor 1 (NEUROD1) . Q13562
THAP domain-containing protein 3 (THAP3) . Q8WTV1
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oncostatin-M-specific receptor subunit beta (OSMR) Type I cytokine receptor family Q99650
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Conserved oligomeric Golgi complex subunit 8 (COG8) COG8 family Q96MW5
DAP3-binding cell death enhancer 1 (DELE1) DELE1 family Q14154
HAUS augmin-like complex subunit 7 (HAUS7) HAUS7 family Q99871
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
La-related protein 4B (LARP4B) . Q92615
Leucine-rich repeat-containing protein 61 (LRRC61) . Q9BV99
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.