Details of the Target

General Information of Target

Target ID LDTP14787
Target Name Small ribosomal subunit protein mS25 (MRPS25)
Gene Name MRPS25
Gene ID 64432
Synonyms
RPMS25; Small ribosomal subunit protein mS25; 28S ribosomal protein S25, mitochondrial; MRP-S25; S25mt
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGF
LHSWWCVFWDLYCAAPERRETCEHSSEAKAFHDYSAAAAPSPVLGNIPPGDGMPVGPVPP
GFFQPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTP
PRGMVPLGPQNYGGAMRPPLNALGGPGMPGMNMGPGGGRPWPNPTNANSIPYSSASPGNY
VGPPGGGGPPGTPIMPSPADSTNSGDNMYTLMNAVPPGPNRPNFPMGPGSDGPMGGLGGM
ESHHMNGSLGSGDMDSISKNSPNNMSLSNQPGTPRDDGEMGGNFLNPFQSESYSPSMTMS
V
Target Bioclass
Other
Family
Mitochondrion-specific ribosomal protein mS25 family
Subcellular location
Mitochondrion
Uniprot ID
P82663
Ensemble ID
ENST00000253686.7
HGNC ID
HGNC:14511

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P60H .
MOLT4 SNV: p.Q122R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.28  LDD0402  [1]
TH211
 Probe Info  		Y34(13.85)  LDD0257  [2]
TH216
 Probe Info  		Y34(11.53)  LDD0259  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
P11
 Probe Info  		20.00  LDD0201  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C139(4.39); C149(4.39); C141(4.39)  LDD0080  [6]
5E-2FA
 Probe Info  		H125(0.00); H37(0.00)  LDD2235  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
AOyne
 Probe Info  		10.40  LDD0443  [9]
TER-AC
 Probe Info  		N.A.  LDD0426  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C251
 Probe Info  		27.67  LDD1924  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C139(1.02); C141(1.03); C149(0.98)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C139(0.90); C141(0.93); C149(0.93)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C141(0.78); C149(0.78)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C141(1.12); C149(1.12)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C141(0.91); C149(0.91)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C141(1.17); C149(1.17)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C141(1.03); C149(1.03)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C141(0.88); C149(0.88)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C141(0.94); C149(0.94)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C141(0.95); C149(0.95)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C141(0.92); C149(0.92)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C141(0.95); C149(0.95)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C139(0.88); C141(0.91); C149(0.91)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C141(1.13); C149(1.13)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C141(1.12); C149(1.12)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C141(1.24); C149(1.24)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C139(1.07); C149(1.07)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C139(1.07); C149(1.07)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C139(0.97); C149(0.97)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C139(0.84); C149(0.84)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C139(1.06); C149(1.06)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C139(1.22); C149(1.22)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C139(0.81); C149(0.81)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C139(1.00); C141(1.00); C149(1.00)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C139(0.93); C149(0.93)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C139(0.96); C149(0.96)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C139(0.93); C149(0.93)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C139(1.03); C149(1.03)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C139(1.00); C149(1.00)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C139(0.99); C149(0.99)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C139(1.00); C149(1.00)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C139(0.99); C149(0.99)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C139(0.65); C141(0.67); C149(0.66)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C139(1.20); C141(1.21); C149(1.21)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C139(0.81); C141(0.79); C149(0.80)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C139(1.24); C141(1.05); C149(1.15)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C139(1.15); C141(1.01); C149(1.08)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C139(1.00); C141(0.87); C149(0.93)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C139(0.74); C141(0.80); C149(0.77)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C139(0.72); C141(0.67); C149(0.69)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C139(0.78); C141(0.85); C149(0.82)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C139(0.95); C141(0.88); C149(0.91)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C139(0.81); C141(0.76); C149(0.78)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C139(0.79); C141(0.82); C149(0.81)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C139(0.96); C141(0.97); C149(0.97)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C139(0.77); C141(0.74); C149(0.75)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C139(0.85); C141(0.77); C149(0.81)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C139(1.45); C141(1.30); C149(1.37)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C141(0.79); C139(0.95); C149(0.95)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C141(0.41); C139(0.65); C149(0.65)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C141(0.55); C139(0.76); C149(0.76)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C141(0.42); C139(0.70); C149(0.70)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C141(0.41); C139(0.65); C149(0.65)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C141(0.31); C139(0.48); C149(0.48)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C141(0.43); C139(0.63); C149(0.63)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C139(0.89); C141(1.00); C149(1.00)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C141(0.66); C139(0.88); C149(0.88)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C141(1.03); C139(1.04); C149(1.04)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C141(0.51); C139(0.64); C149(0.64)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C141(0.30); C139(0.46); C149(0.46)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C139(0.72); C141(0.55); C149(0.72)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C139(0.82); C141(0.56); C149(0.82)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C139(0.89); C141(0.75); C149(0.89)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C139(0.98); C141(0.91); C149(0.98)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C139(0.91); C149(1.05); C141(1.19)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C139(1.05); C149(1.09); C141(1.12)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C139(0.97); C149(0.98); C141(0.98)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C149(0.88); C141(0.93); C139(0.95)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C141(0.97); C149(0.98); C139(0.99)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C141(0.86); C149(0.88); C139(0.90)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C139(0.99); C149(1.04); C141(1.10)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C139(0.81); C149(0.83); C141(0.85)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C139(0.88); C149(1.01); C141(1.14)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C139(0.79); C141(0.89)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C139(1.02); C141(0.85)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C139(1.39); C141(0.84)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C139(1.56); C141(0.86)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C139(0.97); C141(0.84)  LDD0887  [6]
 LDCM0290  AC3 HCT 116 C139(0.86); C149(0.87); C141(0.92)  LDD0607  [6]
 LDCM0291  AC30 HEK-293T C139(1.10); C141(0.80)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C139(0.79); C141(0.92)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C139(1.04); C141(0.82)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C139(1.12); C141(0.81)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C139(1.02); C141(0.79)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C139(1.11); C141(1.18)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C139(0.94); C141(1.02)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C139(1.22); C141(0.98)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C139(1.12); C141(1.07)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C139(1.10); C141(1.02)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C139(0.84); C149(0.89); C141(0.97)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C139(1.13); C141(0.93)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C139(1.08); C141(0.99)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C139(1.15); C141(0.89)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C139(1.57); C141(0.99)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C139(1.21); C141(0.97)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C139(1.10); C141(0.92)  LDD0905  [6]
 LDCM0308  AC46 HCT 116 C139(0.98); C141(1.05); C149(1.05)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C141(1.03); C149(1.03); C139(1.04)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C139(1.23); C141(1.37); C149(1.37)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C139(0.71); C141(0.77); C149(0.77)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C139(0.80); C149(0.83); C141(0.90)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C139(0.91); C141(0.93); C149(0.93)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C139(1.17); C141(1.31); C149(1.31)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C139(0.91); C141(0.95); C149(0.95)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C139(0.85); C141(0.88); C149(0.88)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C141(0.99); C149(0.99); C139(1.04)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C141(1.00); C149(1.00); C139(1.08)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C139(0.78); C141(0.79); C149(0.79)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C141(1.07); C149(1.07)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C141(0.91); C149(0.91)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C141(0.85); C149(0.85)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C139(0.86); C141(0.95); C149(0.95)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C141(1.12); C149(1.12)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C141(1.27); C149(1.27)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C141(0.82); C149(0.82)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C141(1.11); C149(1.11)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C141(0.89); C149(0.89)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C141(0.69); C149(0.69)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C141(0.83); C149(0.83)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C141(0.45); C149(0.45)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C141(0.77); C139(0.95); C149(0.97)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C141(0.69); C149(0.85); C139(0.86)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C141(0.98); C149(0.98); C139(1.05)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C141(0.34); C149(0.70); C139(0.71)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C141(0.77); C139(0.87); C149(0.90)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C141(0.67); C139(0.93); C149(0.96)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C141(0.47); C149(0.82); C139(0.82)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C141(0.46); C139(0.77); C149(0.77)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C141(0.45); C139(0.76); C149(0.76)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C141(0.57); C139(0.80); C149(0.81)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C141(0.51); C139(0.76); C149(0.78)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C139(1.15); C149(1.21); C141(1.42)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C141(0.73); C139(0.93); C149(0.94)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C139(0.86); C141(0.98); C149(0.98)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C141(0.70); C139(0.79); C149(0.82)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C141(0.82); C139(0.91); C149(0.92)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C141(0.28); C139(0.57); C149(0.58)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C139(0.66); C149(0.66)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C139(0.69); C149(0.69)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C139(1.05); C149(1.05)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C139(1.23); C149(1.23)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C139(1.08); C149(1.08)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C139(1.14); C149(1.14)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C139(0.86); C149(0.86)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C139(1.03); C149(1.03)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C139(0.72); C149(0.72)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C139(0.72); C149(0.72)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C139(1.10); C149(1.10)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C139(1.06); C149(1.06)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C139(1.65); C149(1.65)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C139(0.99); C149(0.99)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C139(0.88); C149(0.88)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C141(1.06); C149(1.06)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C141(0.88); C149(0.88)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C139(1.00); C141(1.03); C149(1.03)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C141(0.94); C149(0.94); C139(1.00)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C139(0.82); C141(0.95); C149(0.95)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.24  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HCT 116 C139(1.09); C149(1.15); C141(1.16)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C139(0.76); C141(0.87); C149(0.88)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C149(0.86); C141(0.88); C139(1.07)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C139(0.92); C141(0.96); C149(0.96)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C139(1.05); C141(1.09); C149(1.09)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C139(1.03); C141(1.06); C149(1.06)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C141(0.97); C149(0.97); C139(1.02)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C139(1.02); C149(1.23); C141(1.43)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C139(0.84); C149(1.01); C141(1.18)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C139(0.84); C149(0.98); C141(1.13)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C139(0.81); C149(0.98); C141(1.15)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C139(0.93); C149(1.06); C141(1.20)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C139(0.96); C141(1.02); C149(1.02)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C139(0.77); C149(0.88); C141(0.99)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C139(0.82); C149(0.87); C141(0.92)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C139(0.77); C141(0.79)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C139(0.96); C141(0.86)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C139(1.04); C141(0.88)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C139(0.99); C141(0.82)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C139(1.14); C141(0.85)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C139(1.19); C141(1.00)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C139(1.14); C141(1.21)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C139(1.15); C141(0.86)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C139(0.87); C141(0.95); C149(0.96)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C139(1.21); C141(0.95)  LDD0989  [6]
 LDCM0392  CL121 HCT 116 C141(1.45); C149(1.45); C139(1.73)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C139(0.76); C141(0.85); C149(0.85)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C141(0.93); C149(0.93); C139(1.02)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C141(0.89); C149(0.89); C139(0.98)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C141(1.09); C149(1.09)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C141(1.00); C149(1.00)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C141(1.03); C149(1.03)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C141(0.99); C149(0.99)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C139(1.01); C141(1.04); C149(1.07)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C139(0.94); C141(0.95); C149(0.95)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C141(1.21); C149(1.22); C139(1.29)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C139(1.16); C149(1.16); C141(1.24)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C139(0.92); C149(0.92); C141(0.97)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C139(1.44); C149(1.44); C141(1.52)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C141(0.96); C139(1.08); C149(1.08)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C149(1.15); C139(1.16); C141(1.17)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C141(0.88); C139(0.96); C149(0.96)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C141(0.74); C139(0.78); C149(0.78)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C141(0.76); C139(0.77); C149(0.77)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C141(0.89); C139(1.02); C149(1.02)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C141(0.86); C139(0.90); C149(0.90)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C139(0.97); C141(0.81); C149(0.97)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C139(0.98); C141(0.96); C149(0.98)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C139(0.97); C141(0.96); C149(0.97)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C139(0.97); C141(0.89); C149(0.97)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C139(0.88); C141(0.85); C149(0.88)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C139(1.10); C141(1.11); C149(1.10)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C139(1.04); C141(1.01); C149(1.04)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C139(0.70); C141(0.69); C149(0.69)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C139(0.87); C141(1.39); C149(1.13)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C139(1.08); C141(0.82); C149(0.95)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C139(1.05); C141(0.52); C149(0.78)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C139(1.25); C141(0.60); C149(0.92)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C139(0.98); C141(0.61); C149(0.80)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C139(1.07); C141(0.57); C149(0.82)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C139(0.97); C141(0.58); C149(0.77)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C139(1.11); C141(1.06); C149(1.05)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C139(0.82); C141(0.62); C149(0.72)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C139(0.96); C141(0.64); C149(0.80)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C139(0.95); C141(0.55); C149(0.75)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C139(0.92); C141(0.64); C149(0.78)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C139(0.96); C141(0.73); C149(0.85)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C139(0.78); C141(0.59); C149(0.69)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C141(1.22); C149(1.22)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C141(1.08); C149(1.08)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C141(1.03); C149(1.03)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C141(0.86); C149(0.86)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C139(1.01); C141(0.99); C149(1.00)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C141(1.08); C149(1.08)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C141(0.96); C149(0.96)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C141(1.05); C149(1.05)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C141(1.27); C149(1.27)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C141(0.96); C149(0.96)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C141(0.98); C149(0.98)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C141(1.11); C149(1.11)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C141(0.98); C149(0.98)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C141(0.98); C149(0.98)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C141(0.97); C149(0.97)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C139(1.03); C141(1.01); C149(1.00)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C141(1.08); C149(1.08)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C139(0.72); C141(0.72); C149(0.72)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C139(0.66); C141(0.66); C149(0.66)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C139(0.69); C141(0.69); C149(0.69)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C139(0.60); C141(0.60); C149(0.60)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C139(0.69); C141(0.69); C149(0.69)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C139(0.59); C141(0.59); C149(0.59)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C139(0.60); C141(0.60); C149(0.60)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C139(0.65); C141(0.65); C149(0.65)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C139(0.92); C141(0.92); C149(0.92)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C139(0.88); C141(0.96); C149(0.97)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C139(0.79); C141(0.79); C149(0.79)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C139(0.63); C141(0.63); C149(0.63)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C139(0.66); C141(0.66); C149(0.66)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C139(0.53); C141(0.53); C149(0.53)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C139(0.73); C141(0.73); C149(0.73)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C139(0.81); C141(0.85); C149(0.85)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C139(0.77); C141(0.77); C149(0.78)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C139(0.85); C141(0.79); C149(0.83)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C139(0.85); C141(0.87); C149(0.90)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C139(0.77); C141(0.88); C149(0.89)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C139(1.02); C141(0.97); C149(1.02)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C139(0.84); C141(0.88); C149(0.88)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C139(0.87); C141(0.80); C149(0.89)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C139(0.92); C141(0.74); C149(0.85)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C139(0.85); C141(0.73); C149(0.82)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C139(0.82); C141(0.84); C149(0.85)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C139(0.88); C141(0.89); C149(0.90)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C139(0.87); C141(0.98); C149(0.95)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C139(0.82); C141(0.81); C149(0.85)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C139(0.79); C141(0.71); C149(0.79)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C139(0.97); C141(1.09); C149(1.09)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C139(0.78); C141(0.74); C149(0.78)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C139(1.24); C141(0.96); C149(0.95)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C139(1.21); C141(0.94); C149(0.93)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C139(0.88); C141(0.90); C149(0.85)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C139(1.17); C141(0.92); C149(0.92)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C139(1.69); C141(1.08); C149(1.04)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C139(0.92); C141(0.90); C149(0.84)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C139(1.02); C141(0.92); C149(0.88)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C139(1.00); C141(0.86); C149(0.86)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C139(0.97); C141(0.89); C149(0.86)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C149(0.83); C141(0.98)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C139(0.65); C141(0.65); C149(0.65)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C139(0.99); C141(0.60); C149(0.79)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C139(4.39); C149(4.39); C141(4.39)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C139(4.85); C149(4.85); C141(4.85)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C139(2.99); C149(2.99); C141(2.99)  LDD0082  [6]
 LDCM0109  NEM HeLa H37(0.00); H101(0.00)  LDD0223  [5]
 LDCM0131  RA190 MM1.R C139(1.24); C141(1.24)  LDD0304  [13]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.