Details of the Target

General Information of Target

Target ID LDTP09186
Target Name Histone-lysine N-methyltransferase 2C (KMT2C)
Gene Name KMT2C
Gene ID 58508
Synonyms
HALR; KIAA1506; MLL3; Histone-lysine N-methyltransferase 2C; Lysine N-methyltransferase 2C; EC 2.1.1.364; Homologous to ALR protein; Myeloid/lymphoid or mixed-lineage leukemia protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGK
TAVEDEDSMDGLETTETETIVETEIKEQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSL
VSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQ
ALFDSTGTCWAHHRCVEWSLGVCQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEE
KCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQP
VMKSVPTNGWKCKNCRICIECGTRSSSQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQK
DMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDS
LLIAVSSQHTVNTELEKQISNEVDSEDLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQI
TVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKAD
VSSSPTPSSDLPSHDMLHNYPSALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRP
RSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMC
VVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPG
RLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYM
PASNVPSSDCCESSLVAQIVTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRS
KPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDD
GWSEQLPDTLVDESVSVTESTEKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQSK
ISLDNLSEDGAQLLYKTNMNTGFLDPSLDPLLSSSSAPTKSGTHGPADDPLADISEVLNT
DDDILGIISDDLAKSVDHSDIGPVTDDPSSLPQPNVNQSSRPLSEEQLDGILSPELDKMV
TDGAILGKLYKIPELGGKDVEDLFTAVLSPANTQPTPLPQPPPPTQLLPIHNQDAFSRMP
LMNGLIGSSPHLPHNSLPPGSGLGTFSAIAQSSYPDARDKNSAFNPMASDPNNSWTSSAP
TVEGENDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAK
LWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSELFKDPL
KQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQFGSQHLLVQSGSD
TPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPPPPAPS
RIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFSRRNSA
APVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPRPVMTDQFPK
SLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSGP
GPFKTPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPIDNFSHNQSNDPYSQPPLT
PHPAVNESFAHPSRAFSQPGTISRPTSQDPYSQPPGTPRPVVDSYSQSSGTARSNTDPYS
QPPGTPRPTTVDPYSQQPQTPRPSTQTDLFVTPVTNQRHSDPYAHPPGTPRPGISVPYSQ
PPATPRPRISEGFTRSSMTRPVLMPNQDPFLQAAQNRGPALPGPLVRPPDTCSQTPRPPG
PGLSDTFSRVSPSAARDPYDQSPMTPRSQSDSFGTSQTAHDVADQPRPGSEGSFCASSNS
PMHSQGQQFSGVSQLPGPVPTSGVTDTQNTVNMAQADTEKLRQRQKLREIILQQQQQKKI
AGRQEKGSQDSPAVPHPGPLQHWQPENVNQAFTRPPPPYPGNIRSPVAPPLGPRYAVFPK
DQRGPYPPDVASMGMRPHGFRFGFPGGSHGTMPSQERFLVPPQQIQGSGVSPQLRRSVSV
DMPRPLNNSQMNNPVGLPQHFSPQSLPVQQHNILGQAYIELRHRAPDGRQRLPFSAPPGS
VVEASSNLRHGNFIPRPDFPGPRHTDPMRRPPQGLPNQLPVHPDLEQVPPSQQEQGHSVH
SSSMVMRTLNHPLGGEFSEAPLSTSVPSETTSDNLQITTQPSDGLEEKLDSDDPSVKELD
VKDLEGVEVKDLDDEDLENLNLDTEDGKVVELDTLDNLETNDPNLDDLLRSGEFDIIAYT
DPELDMGDKKSMFNEELDLPIDDKLDNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTN
EVKTEVLSPNSKVESKCETEKNDENKDNVDTPCSQASAHSDLNDGEKTSLHPCDPDLFEK
RTNRETAGPSANVIQASTQLPAQDVINSCGITGSTPVLSSLLANEKSDNSDIRPSGSPPP
PTLPASPSNHVSSLPPFIAPPGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIPGQSTV
NHSLGTGKPATQTGPQTSQSGTSSMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLD
QERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGMPP
MVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITHQISRPNPPNFGPGFVNDSQRKQY
EEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQ
QSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMS
QPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPI
KTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVD
RQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMG
QVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLS
GTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEE
KGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQES
VEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKL
EKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHL
LKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKT
DGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTP
PASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLAR
ALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPD
LSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLI
SVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQ
HLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCH
CKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKES
IPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEA
KPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEID
EFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVY
ETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKT
MLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQ
LLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGH
EDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPG
VEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQS
TVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEY
IGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVV
TFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements.
Uniprot ID
Q8NEZ4
Ensemble ID
ENST00000262189.11
HGNC ID
HGNC:13726
ChEMBL ID
CHEMBL2189113

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.M546T; p.R1092Ter; p.T3156A; p.R4763Q .
786O SNV: p.A3902G .
A2058 SNV: p.L998F DBIA    Probe Info 
A549 SNV: p.R3350I DBIA    Probe Info 
ABC1 SNV: p.A878V DBIA    Probe Info 
AU565 SNV: p.Q2054E DBIA    Probe Info 
CAL72 SNV: p.Q2635R; p.Q3450H .
CCK81 SNV: p.T693A DBIA    Probe Info 
CCSW1 SNV: p.R3995P DBIA    Probe Info 
CHL1 SNV: p.Q3792Ter DBIA    Probe Info 
DU145 Deletion: p.F4496LfsTer21 DBIA    Probe Info 
DU4475 SNV: p.D553N .
ECC2 SNV: p.G722R DBIA    Probe Info 
HCC1937 SNV: p.A4709V .
HCT116 Deletion: p.I1344Ter
SNV: p.Q419R		 .
HCT15 SNV: p.G3438D; p.S3543N .
HEC1 SNV: p.K4222N .
HEC1B Insertion: p.S4648VfsTer2
SNV: p.P4504L		 .
HKGZCC SNV: p.E545Ter .
HS936T SNV: p.K2009Ter DBIA    Probe Info 
HSC4 SNV: p.E510Q DBIA    Probe Info 
HT115 SNV: p.S1630L; p.M2522I; p.R3995Ter .
HT29 SNV: p.P2415S .
HUH7 SNV: p.L3234F DBIA    Probe Info 
IGROV1 Deletion: p.K2797GfsTer11 .
IM95 Deletion: p.F4496LfsTer21 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.R4725M DBIA    Probe Info 
J82 SNV: p.G1517R DBIA    Probe Info 
JHH7 SNV: p.Y4246C .
JURKAT SNV: p.S111Y; p.S4174R .
KMCH1 SNV: p.W449C; p.S2663L DBIA    Probe Info 
KYSE150 SNV: p.P2485S DBIA    Probe Info 
KYSE410 SNV: p.D1405Y .
LN18 Deletion: p.E864del .
LNCaP clone FGC Deletion: p.F4496LfsTer21
SNV: p.S1790F;p.L4142S		 DBIA    Probe Info 
MCC26 SNV: p.E531K; p.L2499F .
MDAMB453 SNV: p.C385Y .
MDST8 SNV: p.F3385L DBIA    Probe Info 
MEWO SNV: p.S1883P; p.P2485S .
MFE319 SNV: p.E4531D; p.S4872F .
NCIH2172 Substitution: p.P1543L .
NCIH446 SNV: p.K7N DBIA    Probe Info 
OVCAR4 SNV: p.L1794V DBIA    Probe Info 
OVK18 Deletion: p.F4496LfsTer21 DBIA    Probe Info 
PANC0403 Deletion: p.D372YfsTer15 .
REH Deletion: p.S2117PfsTer26 .
RKO SNV: p.G2636C; p.R3853W .
RL Deletion: p.V692HfsTer12
SNV: p.Q4140Ter		 DBIA    Probe Info 
RL952 SNV: p.R2610Ter .
SG231 SNV: p.T734I DBIA    Probe Info 
SHSY5Y SNV: p.P2467R .
SKMEL2 SNV: p.G4186C .
SKNSH SNV: p.P2467R .
SNU1 Deletion: p.K2797GfsTer11 DBIA    Probe Info 
TE1 SNV: p.I3096V .
TE8 SNV: p.D2843Y .
TOV21G SNV: p.L4126Ter DBIA    Probe Info 
TYKNU SNV: p.L4575F DBIA    Probe Info 
WM1552C SNV: p.Q1775H .
WM793 SNV: p.I776K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P11
 Probe Info  		20.00  LDD0201  [1]
m-APA
 Probe Info  		12.90  LDD0403  [2]
DBIA
 Probe Info  		C473(1.39)  LDD3310  [3]
AHL-Pu-1
 Probe Info  		C4345(3.87)  LDD0168  [4]
IA-alkyne
 Probe Info  		C1103(0.00); C1060(0.00)  LDD0165  [5]
NAIA_5
 Probe Info  		C4643(0.00); C2873(0.00)  LDD2224  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C4345(3.87)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C4345(4.34)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C473(0.99); C4345(1.02); C4883(0.93); C2873(0.98)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C473(0.93); C4345(1.11); C4883(1.00); C2789(0.92)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C473(1.02); C4345(0.98); C2873(1.10); C4643(1.04)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C638(1.13); C473(0.90); C4345(1.04); C4883(1.05)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C473(1.00); C2789(1.01); C4643(1.06); C4684(1.22)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C473(1.15); C4345(1.01); C2873(1.07); C4643(1.04)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C473(1.03); C4345(0.98); C4883(0.86); C2873(1.08)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C473(0.99); C4345(0.99); C4883(1.02); C2789(0.89)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C473(1.83); C4345(1.27); C2873(1.22); C4643(0.95)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C473(0.98); C4345(1.05); C4883(0.90); C2789(0.98)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C638(1.13); C473(0.96); C4345(0.99); C4883(0.89)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C638(0.97); C473(0.99); C4345(1.01); C4643(1.01)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C473(0.93); C2789(0.96); C4643(1.01); C4684(1.09)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C473(0.97); C4345(0.99); C2873(1.23); C4643(1.11)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C473(0.99); C4883(0.79); C2789(0.91); C2873(1.04)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C473(1.04); C4345(1.03); C4883(0.91); C2873(1.11)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C473(0.97); C4345(0.99); C4883(1.07); C2789(0.81)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C473(0.92); C4345(1.00); C2873(1.02); C4643(1.02)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C638(1.11); C473(0.90); C4345(0.91); C4883(0.98)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C638(1.02); C473(0.97); C4345(0.99); C4643(0.93)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C473(0.91); C4345(1.04); C2873(1.25); C4643(1.04)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C473(0.88); C2789(0.89); C4643(0.97); C4684(1.00)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C473(1.02); C4345(1.06); C2873(1.05); C4643(0.95)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C473(0.99); C4883(0.86); C2789(0.99); C2873(1.13)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C473(1.05); C4345(1.04); C4883(0.96); C2873(1.11)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C473(0.99); C4345(1.12); C4883(1.03); C2789(0.88)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C473(0.92); C4345(1.01); C2873(1.26); C4643(1.14)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C638(1.02); C473(0.92); C4345(0.98); C4883(0.93)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C638(1.03); C473(0.98); C4345(0.97); C4643(1.08)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C473(0.93); C2789(0.97); C4643(1.07); C4684(1.46)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C473(1.09); C4345(1.01); C2873(1.23); C4643(1.07)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C638(1.08); C473(0.94); C4345(0.92); C4883(1.03)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C473(0.98); C4883(0.94); C2789(0.94); C2873(1.03)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C473(1.04); C4345(1.04); C4883(0.86); C2873(1.23)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C473(1.19); C4345(1.11); C4883(1.28); C2789(0.94)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C473(1.04); C4345(0.97); C2873(1.23); C4643(1.08)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C638(1.01); C473(0.94); C4345(1.03); C4883(0.96)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C638(1.13); C473(0.99); C4345(0.99); C4643(1.01)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C473(0.93); C2789(0.95); C4643(1.18); C4684(1.14)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C473(1.05); C4345(0.96); C2873(1.09); C4643(1.01)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C473(1.04); C4883(0.99); C2789(0.93); C2873(1.05)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C473(1.09); C4345(1.02); C4883(0.85); C2873(1.16)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C638(1.06); C473(0.99); C4345(1.00); C4643(1.03)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C473(0.99); C4345(1.04); C4883(1.16); C2789(0.88)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C473(0.97); C4345(1.05); C2873(1.06); C4643(1.01)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C638(1.18); C473(0.99); C4345(1.01); C4883(0.97)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C638(1.01); C473(1.04); C4345(0.99); C4643(1.04)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C473(0.89); C2789(1.06); C4643(1.12); C4684(1.05)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C473(1.05); C4345(1.05); C2873(1.33); C4643(1.16)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C473(1.03); C4883(0.99); C2789(0.97); C2873(1.10)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C473(1.05); C4345(0.98); C4883(0.72); C2873(1.17)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C473(0.92); C4345(1.15); C4883(0.96); C2789(0.91)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C473(0.87); C4345(0.99); C2873(0.96); C4643(1.03)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C473(0.95); C2789(0.96); C4643(1.06); C4684(1.15)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C638(1.06); C473(0.92); C4345(1.01); C4883(0.92)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C638(1.04); C473(0.97); C4345(1.00); C4643(1.03)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C473(0.89); C2789(0.96); C4643(1.07); C4684(1.05)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C473(1.03); C4345(0.93); C2873(1.02); C4643(1.06)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C473(0.98); C4883(0.89); C2789(0.84); C2873(0.99)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C473(1.01); C4345(1.01); C2873(0.99); C4643(1.04)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C473(0.93); C4883(0.72); C2789(0.85); C2873(0.95)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C638(1.00); C473(1.00); C4345(0.95); C4643(1.00)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C473(1.05); C4345(1.02); C4883(0.80); C2873(1.24)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C473(0.97); C4883(0.89); C2789(0.96); C2873(1.02)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 12.90  LDD0403  [2]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [1]
 LDCM0367  CL1 HEK-293T C2853(1.49); C638(1.01); C473(0.87); C4345(1.08)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C473(0.89); C2789(1.29); C4643(1.28); C4684(1.19)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C473(0.99); C4643(1.06); C4684(1.00); C4375(1.02)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C2853(1.03); C638(1.04); C473(0.97); C4345(1.01)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C473(0.92); C4684(0.89); C4375(1.02); C710(0.98)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C473(0.98); C4345(0.98); C2789(1.16); C4643(1.12)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C473(1.03); C4643(1.07); C4684(0.96); C4375(1.06)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C2853(1.34); C638(0.94); C473(0.97); C4345(1.02)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C473(1.03); C4684(0.99); C4375(0.84); C710(1.11)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C473(0.96); C4345(0.95); C2789(1.07); C4643(1.08)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C473(1.01); C4643(0.91); C4684(0.95); C4375(1.10)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C2853(0.98); C638(1.03); C473(0.98); C4345(0.93)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C473(1.10); C4345(1.02); C2873(1.06); C4643(1.06)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C473(1.00); C4684(0.98); C4375(0.96); C710(0.91)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C473(1.00); C4345(1.00); C2789(0.94); C4643(1.06)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C473(1.04); C4643(1.00); C4684(1.00); C4375(1.03)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C2853(0.96); C638(1.09); C473(0.98); C4345(1.11)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C473(0.99); C4684(0.88); C4375(1.51); C710(1.08)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C473(0.96); C4345(0.96); C2789(0.99); C4643(1.20)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C473(1.11); C4643(1.06); C4684(1.04); C4375(1.10)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C2853(1.44); C638(1.21); C473(0.99); C4345(1.05)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C473(1.06); C4684(1.06); C4375(0.87); C710(0.74)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C473(1.02); C4345(1.00); C2789(1.27); C4643(1.17)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C473(1.04); C4883(1.21); C2789(1.38); C2873(1.07)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C473(1.00); C4643(1.05); C4684(1.13); C4375(1.01)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C2853(1.03); C638(1.06); C473(1.01); C4345(1.04)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C473(1.02); C4684(1.06); C4375(0.87); C710(0.84)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C473(0.87); C4345(1.05); C2789(0.77); C4643(1.06)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C473(1.00); C4643(1.07); C4684(1.03); C4375(1.08)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C2853(0.89); C638(1.02); C473(0.97); C4345(0.99)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C473(0.98); C4684(0.98); C4375(0.99); C710(1.17)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C473(0.97); C4345(1.04); C2789(1.15); C4643(1.11)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C473(1.02); C4643(1.00); C4684(1.09); C4375(1.02)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C2853(1.16); C638(1.08); C473(0.92); C4345(1.10)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C473(1.04); C4684(1.06); C4375(0.85); C710(0.84)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C473(0.93); C4345(1.07); C2789(1.29); C4643(1.09)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C473(1.11); C4643(1.01); C4684(1.12); C4375(0.98)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C473(0.96); C4345(1.01); C4883(0.80); C2873(1.07)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C473(1.06); C4345(1.12); C4883(1.01); C2789(0.99)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C473(1.05); C4345(0.97); C2873(1.08); C4643(1.03)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C473(0.98); C4684(1.03); C4375(0.83); C710(0.99)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C638(1.38); C473(0.97); C4345(1.04); C4883(1.21)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C638(1.09); C473(0.91); C4345(0.94); C4643(1.33)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C473(0.97); C2789(1.79); C4643(1.15); C4684(1.32)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C473(1.11); C4345(1.10); C2873(1.02); C4643(1.07)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C473(1.07); C4883(1.06); C2789(1.47); C2873(1.01)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C2853(0.99); C638(0.98); C473(0.86); C4345(0.99)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C473(1.01); C4684(0.83); C4375(0.78); C710(0.97)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C473(1.02); C4345(0.97); C2789(1.03); C4643(1.06)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C473(1.02); C4643(1.09); C4684(1.06); C4375(1.17)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C473(1.03); C4345(1.01); C4883(0.93); C2873(1.04)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C473(1.07); C4345(1.01); C2789(0.87); C4643(1.20)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C473(1.03); C4345(0.97); C4883(1.00); C2789(1.04)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C473(1.08); C4345(1.06); C2873(1.12); C4643(1.08)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C638(1.15); C473(0.94); C4345(1.03); C4883(1.17)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C638(1.19); C473(0.84); C4345(1.01); C4643(1.37)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C473(0.90); C2789(1.54); C4643(1.06); C4684(1.36)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C473(1.21); C4345(1.06); C2873(1.16); C4643(0.98)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C473(1.04); C4883(1.29); C2789(1.04); C2873(1.01)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C2853(1.22); C638(1.07); C473(0.86); C4345(0.99)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C473(1.07); C4345(0.97); C2789(1.02); C4643(0.97)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C473(0.98); C4643(1.11); C4684(1.05); C4375(1.05)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C473(1.03); C4643(1.02); C4684(0.99); C4375(1.16)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C473(0.98); C4345(0.97); C4883(0.87); C2873(1.03)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C473(0.98); C4345(1.06); C4883(0.94); C2789(1.09)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C473(1.03); C4345(0.98); C2873(0.90); C4643(1.01)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C638(1.19); C473(0.96); C4345(0.99); C4883(1.24)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C638(1.23); C473(0.97); C4345(1.05); C4643(1.14)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C473(0.97); C2789(1.66); C4643(1.06); C4684(1.09)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C473(1.18); C4345(1.02); C2873(1.37); C4643(1.01)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C473(1.02); C4883(1.18); C2789(1.36); C2873(1.11)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C2853(0.85); C638(1.04); C473(0.89); C4345(1.06)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C473(1.02); C4345(1.03); C4883(0.93); C2873(0.92)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C473(0.95); C4684(0.95); C4375(0.86); C710(0.87)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C473(1.11); C4643(1.14); C4684(1.04); C4375(1.21)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C473(0.95); C4345(1.05); C4883(0.94); C2873(1.15)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C473(0.92); C4345(1.14); C4883(1.09); C2789(1.09)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C473(0.94); C4345(0.96); C2873(1.22); C4643(1.21)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C638(1.37); C473(0.95); C4345(0.97); C4883(1.15)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C638(1.25); C473(1.03); C4345(1.04); C4643(1.17)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C473(0.89); C2789(1.53); C4643(1.22); C4684(1.14)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C473(1.20); C4345(1.07); C2873(1.26); C4643(1.16)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C473(0.95); C4345(1.11); C4883(0.86); C2789(0.94)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C473(1.04); C4883(1.17); C2789(1.21); C2873(1.30)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C2853(0.90); C638(0.96); C473(0.93); C4345(1.00)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C473(1.03); C4684(0.93); C4375(0.83); C710(1.13)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C473(1.02); C4345(1.02); C2789(0.95); C4643(1.14)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C473(0.98); C4643(1.13); C4684(1.10); C4375(1.08)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C473(1.08); C4345(1.04); C4883(1.20); C2873(1.12)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C473(0.97); C4345(1.09); C4883(1.27); C2789(1.01)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C473(0.95); C4345(1.04); C2873(1.09); C4643(1.15)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C638(1.26); C473(0.87); C4345(1.00); C4883(0.89)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C638(1.19); C473(1.00); C4345(0.99); C4643(1.13)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C473(0.91); C4345(1.03); C2873(1.07); C4643(1.05)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C473(0.91); C2789(1.80); C4643(1.12); C4684(1.07)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C473(1.20); C4345(0.98); C2873(1.21); C4643(1.13)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C473(1.02); C4883(1.40); C2789(1.39); C2873(1.19)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C2853(0.89); C638(1.12); C473(0.90); C4345(1.01)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C473(1.10); C4684(1.08); C4375(0.74); C710(0.83)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C473(1.03); C4643(0.99); C4684(0.98); C4375(1.14)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C473(1.01); C4345(1.08); C4883(0.97); C2873(1.11)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C473(1.04); C4345(1.04); C4883(0.98); C2789(0.88)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C473(0.93); C4345(1.00); C2873(1.03); C4643(1.03)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C638(0.91); C473(0.82); C4345(1.17); C4883(1.01)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C638(1.23); C473(1.00); C4345(1.02); C4883(1.05)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C638(1.32); C473(1.06); C4345(1.05); C4643(1.08)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C473(0.95); C2789(1.41); C4643(1.03); C4684(1.14)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C473(1.18); C4345(1.08); C2873(1.11); C4643(1.12)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C473(0.98); C4883(1.10); C2789(0.97); C2873(1.00)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C2853(0.91); C638(1.01); C473(0.89); C4345(1.00)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C473(0.93); C4684(0.98); C4375(0.70); C710(1.03)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C473(0.97); C4345(1.08); C2789(0.85); C4643(1.15)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C473(1.06); C4643(1.04); C4684(1.03); C4375(1.03)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C473(1.04); C4345(1.00); C4883(0.73); C2873(1.05)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C638(1.18); C473(1.01); C4345(1.03); C4643(1.17)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C473(0.83); C4345(1.27); C4883(0.87); C2789(0.92)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C473(0.93); C4345(0.98); C2873(1.07); C4643(1.10)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C638(1.12); C473(0.90); C4345(1.05); C4883(0.87)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C638(1.16); C473(0.93); C4345(0.90); C4643(1.19)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C473(0.95); C2789(1.58); C4643(1.18); C4684(1.10)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C473(1.04); C4345(1.18); C2873(1.00); C4643(1.33)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C473(0.90); C4883(0.81); C2789(0.86); C2873(0.92)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C2853(1.04); C638(1.03); C473(0.86); C4345(1.01)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C473(0.92); C4684(0.87); C4375(0.85); C710(0.82)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C473(0.99); C4345(1.00); C2789(1.51); C4643(1.04)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C473(0.96); C4345(1.03); C2789(1.24); C4643(1.26)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C473(0.95); C4345(0.94); C2789(0.89); C4643(1.15)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C473(0.96); C4684(0.99); C4375(0.91); C710(0.88)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C1317(0.92); C2789(0.92); C4643(0.93); C4684(1.04)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C1317(0.97); C2789(0.97); C4643(0.97); C4684(1.07)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C473(1.39)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Nuclear receptor coactivator 6 (NCOA6) . Q14686

References

1 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402