Details of the Target

General Information of Target

Target ID LDTP00408
Target Name Histone-lysine N-methyltransferase 2D (KMT2D)
Gene Name KMT2D
Gene ID 8085
Synonyms
ALR; MLL2; MLL4; Histone-lysine N-methyltransferase 2D; Lysine N-methyltransferase 2D; EC 2.1.1.364; ALL1-related protein; Myeloid/lymphoid or mixed-lineage leukemia protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSQKLAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGSPRLQETPQDCSG
GPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGSPGPNEAVLPSEDLSQIGF
PEGLTPAHLGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGA
SIPCRSPGCPRLYHFPCATASGSFLSMKTLQLLCPEHSEGAAYLEEARCAVCEGPGELCD
LFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCETCDKGYHT
FCLKPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCHKAQGGQTIRS
VAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLG
KAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLP
EALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPP
EASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLF
PPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS
RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPL
EESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLC
AVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP
CLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPAL
SEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYP
FGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPL
PPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSE
PECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQT
PGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLI
KSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLC
TDSLPETDDSLLCDAGTAISGGKAEGEKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHG
GRGRGRARLKSTASSIETLVVADIDSSPSKEEEEEDDDTMQNTVVLFSNTDKFVLMQDMC
VVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPS
RLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGP
CASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYV
VKPVAPVAPPELVPMKVKEPEPQYFRFEGVWLTETGMALLRNLTMSPLHKRRQRRGRLGL
PGEAGLEGSEPSDALGPDDKKDGDLDTDELLKGEGGVEHMECEIKLEGPVSPDVEPGKEE
TEESKKRKRKPYRPGIGGFMVRQRKSHTRTKKGPAAQAEVLSGDGQPDEVIPADLPAEGA
VEQSLAEGDEKKKQQRRGRKKSKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFG
LGTPKAKGDGGSERKELPTSQKGDDGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDP
EKPGTPGEGMLSSDLDRISTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGSRTP
LQRPFLQGGLPLGNLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTT
PSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWSS
RCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDRP
ALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELF
LKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGA
GQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGE
SRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEP
QSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPP
RSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSR
DPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVR
SPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNY
TVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITS
PVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTL
RQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPI
LGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQ
QQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIEL
RHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAP
ELNNSLHPTPHTKGPTLPTGLELVNRPPSSTELGRPNPLALEAGKLPCEDPELDDDFDAH
KALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTG
DKKDIFNEHLRLVESANEKAEREALLRGVEPGPLGPEERPPPAADASEPRLASVLPEVKP
KVEEGGRHPSPCQFTIATPKVEPAPAANSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTA
EKASFGATGGPPAHLLTPSPLSGPGGSSLLEKFELESGALTLPGGPAASGDELDKMESSL
VASELPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHE
GSSPSLAGSQQQLSLGLAGARQPGLPQPLMPTQPPAHALQQRLAPSMAMVSNQGHMLSGQ
HGGQAGLVPQQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDI
IDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPSSDLQNHVAAGSGQ
ERSAGDPSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRK
ALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQ
QQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPG
GMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQ
LQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPS
SHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQL
AQQGQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQL
QQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQ
QQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLL
LTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQP
QPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVS
LGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQ
LQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQ
PQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRP
SQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPP
DNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPI
GAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQ
KLQGTPSNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELS
LLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPP
TPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAAL
PTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALSPV
IPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVM
VAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQF
DAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSP
LAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLK
KWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGD
GATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGA
TSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERD
EVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLR
TNNRRCCYRCSIGENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADM
LRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCAR
SEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVY
LARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHV
IDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQ
HKIPCHCGAWNCRKWMN
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
Uniprot ID
O14686
Ensemble ID
ENST00000301067.12
HGNC ID
HGNC:7133
ChEMBL ID
CHEMBL2189114

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R1252Ter; p.E1847D; p.Q3158Ter DBIA    Probe Info 
AN3CA Deletion: p.P2210RfsTer54 .
CAL33 SNV: p.G2523V .
CAL51 SNV: p.R5214H DBIA    Probe Info 
CASKI SNV: p.Q4079Ter DBIA    Probe Info 
CCK81 Insertion: p.S2532LfsTer123
SNV: p.E749G;p.E2270K;p.P2841L		 DBIA    Probe Info 
COLO678 SNV: p.S3869A; p.A4826E DBIA    Probe Info 
CORL23 SNV: p.G4375R DBIA    Probe Info 
DU145 SNV: p.G4479R; p.K4843N DBIA    Probe Info 
EFO21 SNV: p.P235T DBIA    Probe Info 
EFO27 Deletion: p.A221LfsTer40
SNV: p.R5048H		 .
HCC1395 SNV: p.Q2885E DBIA    Probe Info 
HCC15 SNV: p.V3807L DBIA    Probe Info 
HCT116 Insertion: p.R2443SfsTer6
SNV: p.V160M		 .
HCT15 SNV: p.P1152H; p.E1517D; p.P1931H DBIA    Probe Info 
HEC1 SNV: p.P1860H; p.P2641H DBIA    Probe Info 
HEC1B SNV: p.P1162H; p.P2641H .
HG3 SNV: p.L5094V; p.C5095F DBIA    Probe Info 
HLF SNV: p.G4071E DBIA    Probe Info 
HSC3 SNV: p.L2929I .
HT3 SNV: p.H3746Q DBIA    Probe Info 
HUCCT1 Deletion: p.R845GfsTer85 DBIA    Probe Info 
HUH1 Deletion: p.Q3740_Q3745del
SNV: p.E767A		 DBIA    Probe Info 
HUH28 SNV: p.P4911S DBIA    Probe Info 
HUH7 SNV: p.D2037E DBIA    Probe Info 
HUPT4 Insertion: p.A3416CfsTer7 DBIA    Probe Info 
ICC3 Deletion: p.C294Ter DBIA    Probe Info 
IGR37 SNV: p.S4915P DBIA    Probe Info 
IGROV1 Deletion: p.P2354LfsTer30; p.P2931HfsTer12 DBIA    Probe Info 
IM95 Deletion: p.P647HfsTer283;p.Q809RfsTer121
SNV: p.R5323C		 DBIA    Probe Info 
IPC298 Deletion: p.L671_P679del
SNV: p.E4731Q		 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.V1670SfsTer52
Insertion: p.P648TfsTer2		 DBIA    Probe Info 
JEKO1 SNV: p.R5225C DBIA    Probe Info 
JM1 Insertion: p.L973GfsTer28
SNV: p.S717Y		 DBIA    Probe Info 
JURKAT Deletion: p.V3089WfsTer30
SNV: p.D90N;p.P282L		 Compound 10    Probe Info 
JURLMK1 SNV: p.Y1495Ter; p.T4368S DBIA    Probe Info 
KARPAS422 SNV: p.Q3278Ter DBIA    Probe Info 
KATOIII SNV: p.E1747Ter; p.A3242P DBIA    Probe Info 
KU1919 Deletion: p.T2441PfsTer44 DBIA    Probe Info 
KYSE410 SNV: p.Q3904H DBIA    Probe Info 
KYSE510 SNV: p.S3130F DBIA    Probe Info 
LUDLU1 Insertion: p.T2323DfsTer3 DBIA    Probe Info 
MCC13 SNV: p.P2533S; p.L5302F .
MCC26 Insertion: p.L4296FfsTer38
SNV: p.P1691S		 DBIA    Probe Info 
MDAMB436 SNV: p.R2072C DBIA    Probe Info 
MELHO SNV: p.G2279W DBIA    Probe Info 
MELJUSO SNV: p.Q170Ter; p.S2373F DBIA    Probe Info 
MEWO SNV: p.G78E
Substitution: p.P759L		 DBIA    Probe Info 
MFE296 Deletion: p.Q836SfsTer94;p.P2354LfsTer30
SNV: p.L4616P		 DBIA    Probe Info 
MFE319 Deletion: p.E922SfsTer8;p.Y2907TfsTer3
SNV: p.V3376M		 DBIA    Probe Info 
MOLT4 Deletion: p.P2354LfsTer30;p.P2475LfsTer10
SNV: p.A221D;p.T980I;p.D1825N;p.G1960D;p.Q2514Ter;p.R4484Q;p.P5309A		 IA-alkyne    Probe Info 
MSTO211H SNV: p.G220E DBIA    Probe Info 
NCIH1048 Deletion: p.P2354LfsTer30
Insertion: p.R755PfsTer3		 .
NCIH1155 SNV: p.V38M; p.A3561D DBIA    Probe Info 
NCIH146 SNV: p.E2911Ter; p.Q4588Ter DBIA    Probe Info 
NCIH1650 Deletion: p.E888_P889delinsA DBIA    Probe Info 
NCIH196 SNV: p.L662Q DBIA    Probe Info 
NCIH23 SNV: p.S4328T DBIA    Probe Info 
NCIH446 SNV: p.S1263Ter .
NCIN87 SNV: p.S537F DBIA    Probe Info 
OCUG1 SNV: p.P1097R DBIA    Probe Info 
OPM2 SNV: p.G1486D; p.Q3322Ter DBIA    Probe Info 
OVK18 SNV: p.R1528W DBIA    Probe Info 
REH SNV: p.S597F; p.T1164I; p.R2410Ter DBIA    Probe Info 
RKO Deletion: p.G1960AfsTer87;p.P2550LfsTer33
SNV: p.L1600P;p.G3465Ter;p.L5056P		 DBIA    Probe Info 
RL952 SNV: p.P530H; p.R1252Ter; p.S4371N DBIA    Probe Info 
RPMI8226 SNV: p.Q2811H DBIA    Probe Info 
SAOS2 SNV: p.Q1361L DBIA    Probe Info 
SBC5 Deletion: p.G2157VfsTer107 DBIA    Probe Info 
SJSA1 Deletion: p.Y2199IfsTer65
SNV: p.Y2196Ter		 DBIA    Probe Info 
SKMEL24 SNV: p.Q2800Ter DBIA    Probe Info 
SNU1 Deletion: p.P2363del
Insertion: p.A2119RfsTer36
SNV: p.R5030C		 DBIA    Probe Info 
SNU245 SNV: p.P88R DBIA    Probe Info 
SSP25 Substitution: p.S831P DBIA    Probe Info 
SUDHL6 SNV: p.Q211Ter; p.E4712Ter .
SUPT1 SNV: p.D4030E DBIA    Probe Info 
SW1783 SNV: p.P4242S DBIA    Probe Info 
SW948 SNV: p.N2030H; p.R5120C DBIA    Probe Info 
TC71 SNV: p.R5214C DBIA    Probe Info 
TE1 SNV: p.Q2473R DBIA    Probe Info 
TOV21G Deletion: p.K4432NfsTer52
SNV: p.P4209Q;p.G4397V		 DBIA    Probe Info 
U937 SNV: p.Q1139K DBIA    Probe Info 
UACC257 SNV: p.R1524L DBIA    Probe Info 
UMUC3 SNV: p.S2670C DBIA    Probe Info 
WM1552C SNV: p.R93Q DBIA    Probe Info 
WM793 SNV: p.S2451F; p.R2452S DBIA    Probe Info 
YSCCC SNV: p.E784Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P11
 Probe Info  		20.00  LDD0201  [2]
DBIA
 Probe Info  		C369(1.36); C5107(2.46)  LDD3310  [3]
AHL-Pu-1
 Probe Info  		C369(2.80); C1909(2.78)  LDD0170  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C58(0.00); C214(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C1424(0.00); C1430(0.00); C58(0.00); C369(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C58(0.00); C369(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		C369(0.00); C1909(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		C1909(0.00); C58(0.00); C369(0.00)  LDD2224  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		C369(0.00); C4424(0.00)  LDD0005  [8]
TFBX
 Probe Info  		C5525(0.00); C5314(0.00)  LDD0148  [9]
VSF
 Probe Info  		C4424(0.00); C2249(0.00)  LDD0007  [8]
Phosphinate-6
 Probe Info  		C3132(0.00); C2249(0.00); C3543(0.00); C4424(0.00)  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
AOyne
 Probe Info  		8.70  LDD0443  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C369(2.80); C1909(2.78)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C2988(2.82); C1909(3.15)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C369(0.97); C1909(1.02); C58(0.65); C4424(1.09)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C369(1.22); C1909(0.99); C58(1.01); C4424(1.10)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C369(1.01); C1909(0.93); C58(0.80); C4424(0.92)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C1909(1.00); C58(1.18); C4424(1.03); C2249(1.00)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C369(1.08); C1909(0.90); C58(0.87); C4424(0.99)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C1909(1.01); C58(1.14); C4424(0.97); C2249(1.01)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C369(1.12); C1909(1.04); C58(0.75); C4424(1.03)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C369(1.31); C1909(1.04); C58(1.02); C4424(1.06)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C369(1.58); C1909(1.18); C58(1.43); C4424(1.07)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C369(1.05); C1909(0.96); C58(0.90); C4424(0.94)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C1909(0.98); C58(1.19); C4424(0.99); C2249(1.09)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C369(0.78); C1909(0.95); C58(0.87); C4424(1.00)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C369(0.97); C1909(0.96); C58(0.86); C4424(1.04)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C1909(1.11); C58(1.17); C4424(1.09); C2249(1.05)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C1909(0.96); C58(1.00); C4424(0.96); C2249(0.99)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C369(1.05); C1909(1.08); C58(0.79); C4424(1.09)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C369(0.97); C1909(1.03); C58(1.15); C4424(0.90)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C369(1.06); C1909(0.95); C58(0.79); C4424(0.88)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C1909(0.99); C58(1.04); C4424(1.00); C2249(1.02)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C369(1.09); C1909(0.97); C58(0.87); C4424(0.97)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C369(0.97); C1909(0.93); C58(0.94); C4424(1.08)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C369(0.85); C1909(0.96); C58(0.96); C4424(1.04)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C1909(0.89); C58(1.00); C4424(1.05); C2249(0.97)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C1909(1.00); C58(1.11); C4424(0.90); C2249(1.06)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C369(1.10); C1909(1.03); C58(0.99); C4424(1.10)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C369(0.99); C1909(1.04); C58(1.32); C4424(0.93)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C369(1.08); C1909(0.97); C58(0.83); C4424(0.82)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C1909(1.02); C58(1.18); C4424(1.03); C2249(1.07)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C369(0.86); C1909(0.90); C58(1.00); C4424(0.93)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C369(1.00); C1909(1.09); C58(1.10); C4424(0.97)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C1909(0.98); C58(1.06); C4424(1.05); C2249(1.09)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C1909(0.98); C58(0.94); C4424(0.95); C2249(0.98)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C1909(1.06); C58(0.94); C4424(0.86); C2249(0.96)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C369(1.06); C1909(1.06); C58(1.04); C4424(1.09)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C369(1.11); C1909(1.09); C58(1.03); C4424(1.04)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C369(1.02); C1909(0.96); C58(0.81); C4424(0.85)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C1909(0.96); C58(1.40); C4424(1.05); C2249(1.09)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C369(1.02); C1909(0.98); C58(1.01); C4424(1.06)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C369(1.20); C1909(1.01); C58(0.95); C4424(0.99)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C1909(1.17); C58(0.99); C4424(1.01); C2249(1.07)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C1909(1.00); C58(0.99); C4424(0.87); C2249(1.06)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C369(0.95); C1909(0.99); C58(0.94); C4424(1.07)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C369(1.21); C1909(0.93); C58(0.92); C4424(0.96)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C369(1.01); C1909(1.06); C58(0.96); C4424(1.04)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C369(1.01); C1909(0.96); C58(1.17); C4424(0.99)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C1909(0.97); C58(1.09); C4424(1.08); C2249(1.06)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C369(1.33); C1909(0.93); C58(0.90); C4424(0.98)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C369(1.04); C1909(0.91); C58(1.08); C4424(1.01)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C1909(1.00); C58(1.23); C4424(0.97); C2249(1.06)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C1909(1.03); C58(1.06); C4424(0.87); C2249(0.98)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C369(1.04); C1909(1.06); C58(0.80); C4424(1.10)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C369(0.96); C1909(1.05); C58(1.43); C4424(0.94)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C369(0.90); C1909(0.96); C58(0.93); C4424(0.95)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C369(0.97); C1909(1.04); C58(1.05); C4424(1.02)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C1909(1.00); C58(1.11); C4424(1.08); C2249(1.07)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C369(0.99); C1909(0.97); C58(1.03); C4424(1.00)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C369(0.95); C1909(0.92); C58(1.10); C4424(1.05)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C1909(1.22); C58(1.10); C4424(1.07); C2249(1.07)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C1909(0.99); C58(0.95); C4424(0.90); C2249(1.01)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C1909(1.11); C58(0.97); C4424(1.03); C2249(0.93)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C1909(1.04); C58(0.97); C4424(0.88); C2249(0.98)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C369(1.08); C1909(1.00); C58(0.89); C4424(0.98)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C369(0.94); C1909(1.07); C58(1.00); C4424(1.07)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C1909(1.06); C58(1.09); C4424(0.88); C2249(1.11)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 12.13  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [2]
 LDCM0367  CL1 HEK-293T C369(0.91); C1909(0.86); C58(0.75); C4424(0.97)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C369(0.95); C1909(0.94); C58(0.68); C4424(1.01)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C369(0.91); C1909(1.08); C58(0.83); C4424(0.99)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C369(0.93); C1909(0.97); C58(0.84); C4424(1.07)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C369(1.15); C1909(0.92); C58(0.94); C4424(0.96)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C369(1.02); C1909(1.01); C58(1.20); C4424(0.94)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C369(0.91); C1909(1.02); C58(0.78); C4424(1.03)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C369(1.05); C1909(1.03); C58(0.69); C4424(0.96)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C369(1.25); C1909(0.97); C58(0.91); C4424(0.90)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C369(1.04); C1909(0.98); C58(0.98); C4424(0.89)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C369(0.90); C1909(0.94); C58(0.92); C4424(0.99)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C369(0.97); C1909(0.95); C58(1.02); C4424(1.04)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C1909(0.99); C58(1.57); C4424(1.16); C2249(0.93)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C369(1.14); C1909(0.99); C58(0.97); C4424(0.90)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C369(0.97); C1909(0.98); C58(1.10); C4424(1.09)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C369(0.93); C1909(0.98); C58(0.83); C4424(1.01)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C369(0.98); C1909(0.93); C58(1.03); C4424(1.03)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C369(1.55); C1909(1.04); C58(0.93); C4424(1.00)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C369(0.93); C1909(1.03); C58(1.12); C4424(0.99)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C369(0.78); C1909(0.99); C58(0.90); C4424(0.98)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C369(1.28); C1909(0.98); C58(1.01); C4424(0.98)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C369(1.49); C1909(1.08); C58(0.97); C4424(1.03)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C369(0.96); C1909(1.11); C58(1.17); C4424(0.91)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C1909(1.03); C58(1.17); C4424(0.86); C2249(0.98)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C369(0.86); C1909(1.02); C58(0.76); C4424(1.04)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C369(1.13); C1909(0.94); C58(0.88); C4424(0.94)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C369(1.59); C1909(0.98); C58(1.02); C4424(0.97)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C369(0.86); C1909(0.96); C58(1.35); C4424(0.79)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C369(0.86); C1909(1.04); C58(1.08); C4424(1.03)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C369(0.80); C1909(0.91); C58(0.72); C4424(0.98)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C369(1.30); C1909(0.97); C58(1.05); C4424(0.99)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C369(1.03); C1909(1.05); C58(1.32); C4424(0.97)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C369(0.80); C1909(1.01); C58(1.27); C4424(1.13)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C369(1.13); C1909(0.98); C58(0.65); C4424(0.99)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C369(1.14); C1909(1.06); C58(1.14); C4424(1.03)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C369(0.93); C1909(1.15); C58(1.53); C4424(0.91)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C369(0.81); C1909(0.96); C58(0.84); C4424(0.95)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C369(0.88); C1909(0.82); C58(1.00); C4424(1.02)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C369(0.98); C1909(1.10); C58(1.28); C4424(1.05)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C369(1.05); C1909(0.99); C58(1.13); C4424(0.93)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C369(1.61); C1909(1.08); C58(1.14); C4424(1.03)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C1909(1.09); C58(1.48); C4424(1.07); C2249(1.07)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C369(1.22); C1909(1.06); C58(0.79); C4424(0.97)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C369(1.18); C1909(1.14); C58(0.76); C4424(1.01)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C1909(0.73); C58(1.68); C4424(1.12); C2249(1.04)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C1909(1.01); C58(1.29); C4424(0.87); C2249(0.93)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C369(0.94); C1909(0.91); C58(0.83); C4424(0.80)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C369(1.19); C1909(1.04); C58(0.98); C4424(0.99)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C369(0.95); C1909(0.98); C58(1.07); C4424(1.02)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C369(0.95); C1909(0.98); C58(1.18); C4424(0.97)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C369(1.06); C1909(1.06); C58(0.86); C4424(0.96)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C369(0.92); C1909(1.02); C58(1.22); C4424(0.98)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C369(0.98); C1909(1.06); C58(1.18); C4424(0.92)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C369(1.04); C1909(0.93); C58(1.22); C4424(0.96)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C1909(1.02); C58(1.37); C4424(1.02); C2249(1.04)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C369(1.01); C1909(0.94); C58(0.68); C4424(0.95)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C369(1.21); C1909(1.02); C58(0.69); C4424(1.07)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C1909(1.01); C58(1.70); C4424(1.12); C2249(1.02)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C1909(1.09); C58(1.43); C4424(0.98); C2249(1.04)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C369(0.77); C1909(0.93); C58(0.82); C4424(0.94)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C369(1.02); C1909(1.07); C58(1.16); C4424(0.99)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C369(0.84); C1909(1.03); C58(0.72); C4424(1.01)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C369(1.01); C1909(1.01); C58(1.09); C4424(0.99)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C369(1.18); C1909(1.03); C58(0.86); C4424(0.99)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C369(1.30); C1909(1.09); C58(1.34); C4424(0.97)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C369(1.06); C1909(0.93); C58(0.97); C4424(0.91)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C1909(1.07); C58(1.33); C4424(1.06); C2249(1.08)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C369(1.12); C1909(0.94); C58(0.74); C4424(1.16)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C369(1.14); C1909(0.94); C58(0.67); C4424(1.08)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C1909(0.93); C58(1.51); C4424(1.12); C2249(1.01)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C1909(0.95); C58(1.26); C4424(0.95); C2249(0.92)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C369(0.82); C1909(0.97); C58(0.81); C4424(0.87)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C369(0.97); C1909(1.11); C58(0.89); C4424(1.11)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C369(1.11); C1909(1.06); C58(1.03); C4424(0.95)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C369(1.00); C1909(1.04); C58(1.03); C4424(1.14)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C369(1.04); C1909(1.00); C58(0.91); C4424(0.98)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C369(0.98); C1909(0.99); C58(1.00); C4424(0.91)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C369(1.01); C1909(0.96); C58(1.20); C4424(1.00)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C1909(0.98); C58(1.33); C4424(1.12); C2249(1.09)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C369(1.32); C1909(1.12); C58(0.77); C4424(1.04)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C369(1.16); C1909(0.93); C58(0.71); C4424(0.98)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C1909(1.16); C58(1.51); C4424(1.08); C2249(1.08)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C369(0.89); C1909(1.07); C58(0.97); C4424(1.11)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C1909(1.03); C58(1.41); C4424(0.90); C2249(0.87)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C369(1.02); C1909(0.88); C58(0.64); C4424(0.92)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C369(1.14); C1909(1.07); C58(0.94); C4424(0.99)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C369(0.99); C1909(1.05); C58(1.25); C4424(0.93)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C369(0.83); C1909(0.96); C58(0.79); C4424(1.01)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C369(0.99); C1909(1.06); C58(0.82); C4424(1.08)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C369(0.85); C1909(1.03); C58(1.19); C4424(0.95)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C369(1.14); C1909(0.98); C58(1.28); C4424(0.99)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C1909(0.97); C58(1.36); C4424(1.10); C2249(1.02)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C369(1.19); C1909(1.03); C58(0.82); C4424(0.97)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C369(1.05); C1909(1.12); C58(1.07); C4424(0.97)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C369(1.30); C1909(1.06); C58(0.72); C4424(1.01)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C1909(1.12); C58(1.43); C4424(0.93); C2249(1.10)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C1909(1.07); C58(1.62); C4424(0.95); C2249(0.95)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C369(0.97); C1909(0.87); C58(0.55); C4424(0.97)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C369(1.36); C1909(0.90); C58(1.05); C4424(1.02)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C369(0.94); C1909(1.10); C58(0.79); C4424(1.01)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C369(0.92); C1909(1.16); C58(0.74); C4424(1.05)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C369(0.84); C1909(1.04); C58(0.99); C4424(1.07)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C369(0.96); C1909(0.89); C58(1.22); C4424(1.04)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C1909(0.85); C58(0.88); C4424(0.85); C2249(0.78)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C1909(1.02); C58(1.26); C4424(1.07); C2249(0.99)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C369(1.14); C1909(1.01); C58(0.84); C4424(0.97)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C369(1.02); C1909(1.05); C58(0.71); C4424(0.96)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C1909(1.28); C58(1.12); C4424(1.05); C2249(0.97)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C1909(0.93); C58(1.18); C4424(0.87); C2249(0.88)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C369(0.96); C1909(0.94); C58(0.71); C4424(0.94)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C369(1.11); C1909(0.90); C58(1.01); C4424(1.03)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C369(0.89); C1909(0.99); C58(1.73); C4424(0.93)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C369(0.89); C1909(0.88); C58(1.13); C4424(0.98)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C369(0.94); C1909(0.94); C58(0.79); C4424(1.02)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C369(1.34); C1909(0.93); C58(0.76); C4424(0.90)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C369(0.74); C1909(0.90); C58(1.01); C4424(0.75)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C369(0.87); C1909(0.92); C58(1.00); C4424(0.88)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C1909(0.98); C58(1.13); C4424(1.00); C2249(1.07)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C369(0.85); C1909(0.94); C58(0.83); C4424(0.96)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C369(1.31); C1909(1.06); C58(0.82); C4424(1.03)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C1909(0.89); C58(1.17); C4424(1.09); C2249(1.00)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C1909(0.93); C58(1.00); C4424(0.79); C2249(0.98)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C369(0.84); C1909(0.89); C58(0.80); C4424(0.97)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C369(1.12); C1909(0.99); C58(0.97); C4424(1.01)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C369(0.94); C1909(1.07); C58(1.03); C4424(1.04)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C369(1.18); C1909(1.03); C58(1.08); C4424(1.04)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1909(1.14); C5104(1.02)  LDD1702  [14]
 LDCM0625  F8 Ramos C58(1.40)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C58(1.67); C369(1.26)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C58(2.55); C369(20.00)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C58(0.65); C369(0.90)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C58(0.90); C369(1.19)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C58(0.67)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C58(0.52); C369(0.81)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C58(1.15); C369(1.25)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C58(1.04)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C58(1.25); C369(0.78)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C58(1.03)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C58(1.32)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C58(1.05); C369(0.94)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C58(0.97)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C369(0.94); C1909(0.99); C58(1.09); C4424(0.94)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C58(1.17); C369(1.33)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C58(0.93); C369(0.87)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C369(1.56); C1909(1.00); C58(1.06); C4424(0.96)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C58(1.14)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C58(1.82)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C58(1.05)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C58(0.89); C369(1.15)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C5104(1.00); C369(0.98); C1909(0.96); C58(0.70)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C5104(0.99); C369(1.00); C1909(1.04); C58(1.06)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C369(1.36); C5107(2.46)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578