Details of the Target

General Information of Target

Target ID LDTP12396
Target Name Suppressor of SWI4 1 homolog (PPAN)
Gene Name PPAN
Gene ID 56342
Synonyms
BXDC3; SSF1; Suppressor of SWI4 1 homolog; Ssf-1; Brix domain-containing protein 3; Peter Pan homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTASVLRSISLALRPTSGLLGTWQTQLRETHQRASLLSFWELIPMRSEPLRKKKKVDPKK
DQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKK
WSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTP
PIPNYQPPEGRYNDITKVYTQVEFKR
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function May have a role in cell growth.
Uniprot ID
Q9NQ55
Ensemble ID
ENST00000253107.12
HGNC ID
HGNC:9227

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.G466AfsTer47 .
CORL88 SNV: p.Q434H DBIA    Probe Info 
LS180 SNV: p.G150C DBIA    Probe Info 
MDAMB231 SNV: p.S189Y .
MDAMB453 SNV: p.R36P .
REH SNV: p.D384Y .
RH30 SNV: p.V53G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
P11
 Probe Info  		20.00  LDD0201  [3]
DBIA
 Probe Info  		C73(1.58)  LDD3310  [4]
BTD
 Probe Info  		C432(0.96)  LDD2096  [5]
AHL-Pu-1
 Probe Info  		C391(10.74)  LDD0168  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C180(0.00); C73(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C180(0.00); C73(0.00); C432(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe2
 Probe Info  		12.43  LDD0463  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C391(10.74)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C432(2.32)  LDD0169  [6]
 LDCM0215  AC10 HEK-293T C73(0.89)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C73(1.02)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C73(0.72)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C73(1.02)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C73(1.04)  LDD1513  [14]
 LDCM0277  AC18 HEK-293T C73(1.00)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C73(0.84)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C73(0.98)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C73(0.83)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C73(0.92)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C73(1.17)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C73(1.03)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C73(0.97)  LDD1523  [14]
 LDCM0286  AC26 HEK-293T C73(0.90)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C73(0.95)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C73(0.80)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C73(0.87)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C73(1.04)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C73(1.07)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C73(0.99)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C73(0.95)  LDD1532  [14]
 LDCM0295  AC34 HEK-293T C73(0.98)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C73(0.96)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C73(0.80)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C73(0.97)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C73(0.89)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C73(1.09)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C73(0.91)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C73(1.02)  LDD1541  [14]
 LDCM0304  AC42 HEK-293T C73(0.85)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C73(1.02)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C73(0.84)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C73(0.94)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C73(1.04)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C73(1.01)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C73(1.09)  LDD1549  [14]
 LDCM0312  AC5 HEK-293T C73(0.94)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C73(0.96)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C73(0.97)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C73(0.82)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C73(0.95)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C73(0.94)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C73(0.99)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C73(1.03)  LDD1558  [14]
 LDCM0321  AC58 HEK-293T C73(1.09)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C73(0.98)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C73(1.01)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C73(0.87)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C73(0.92)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C73(1.02)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C73(1.02)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C73(1.07)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C73(1.14)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C73(0.93)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C73(1.00)  LDD1511  [14]
 LDCM0275  AKOS034007705 HEK-293T C73(0.99)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 11.91  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [3]
 LDCM0632  CL-Sc Hep-G2 C73(0.46)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C73(1.02)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C73(1.26)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C73(0.88)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C73(0.99)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C73(0.91)  LDD1575  [14]
 LDCM0373  CL104 HEK-293T C73(0.88)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C73(0.91)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C73(0.92)  LDD1579  [14]
 LDCM0377  CL108 HEK-293T C73(0.88)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C73(0.94)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C73(1.34)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C73(0.87)  LDD1584  [14]
 LDCM0382  CL112 HEK-293T C73(0.90)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C73(0.99)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C73(0.88)  LDD1588  [14]
 LDCM0386  CL116 HEK-293T C73(1.02)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C73(0.94)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C73(0.89)  LDD1592  [14]
 LDCM0390  CL12 HEK-293T C73(1.58)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C73(0.85)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C73(1.00)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C73(0.94)  LDD1597  [14]
 LDCM0395  CL124 HEK-293T C73(0.88)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C73(1.00)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C73(0.96)  LDD1601  [14]
 LDCM0399  CL128 HEK-293T C73(0.89)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C73(0.99)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C73(0.88)  LDD1605  [14]
 LDCM0403  CL16 HEK-293T C73(0.89)  LDD1607  [14]
 LDCM0405  CL18 HEK-293T C73(0.92)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C73(1.08)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C73(0.92)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C73(0.99)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C73(1.14)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C73(1.54)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C73(1.57)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C73(1.41)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C73(0.98)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C73(1.03)  LDD1618  [14]
 LDCM0416  CL28 HEK-293T C73(0.96)  LDD1620  [14]
 LDCM0419  CL30 HEK-293T C73(1.12)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C73(1.05)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C73(1.31)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C73(0.99)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C73(1.50)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C73(1.33)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C73(1.33)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C73(1.00)  LDD1630  [14]
 LDCM0429  CL4 HEK-293T C73(0.99)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C73(1.05)  LDD1634  [14]
 LDCM0432  CL42 HEK-293T C73(1.20)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C73(1.12)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C73(1.12)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C73(1.14)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C73(1.42)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C73(1.40)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C73(1.33)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C73(1.02)  LDD1643  [14]
 LDCM0441  CL50 HEK-293T C73(0.91)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C73(0.86)  LDD1646  [14]
 LDCM0445  CL54 HEK-293T C73(0.99)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C73(1.12)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C73(0.93)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C73(1.06)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C73(1.32)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C73(1.26)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C73(0.77)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C73(1.42)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C73(1.03)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C73(1.06)  LDD1657  [14]
 LDCM0456  CL64 HEK-293T C73(0.77)  LDD1659  [14]
 LDCM0458  CL66 HEK-293T C73(1.14)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C73(0.98)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C73(1.07)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C73(0.90)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C73(1.13)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C73(1.30)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C73(1.24)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C73(1.39)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C73(0.89)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C73(0.91)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C73(0.89)  LDD1672  [14]
 LDCM0471  CL78 HEK-293T C73(0.89)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C73(0.96)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C73(0.91)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C73(0.94)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C73(1.07)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C73(1.26)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C73(1.18)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C73(0.97)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C73(1.05)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C73(1.10)  LDD1683  [14]
 LDCM0482  CL88 HEK-293T C73(1.08)  LDD1685  [14]
 LDCM0484  CL9 HEK-293T C73(1.21)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C73(0.84)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C73(1.10)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C73(0.82)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C73(0.91)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C73(1.27)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C73(1.00)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C73(1.22)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C73(0.90)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C73(0.99)  LDD1696  [14]
 LDCM0427  Fragment51 HEK-293T C73(0.92)  LDD1631  [14]
 LDCM0022  KB02 HEK-293T C73(1.03)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C73(1.12)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C73(1.58)  LDD3310  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C432(0.96)  LDD2096  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C432(1.21)  LDD2120  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C432(1.30)  LDD2128  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C432(1.07)  LDD2143  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C432(3.26)  LDD2147  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402