Details of the Target

General Information of Target

Target ID LDTP07602
Target Name Zinc finger CCCH domain-containing protein 14 (ZC3H14)
Gene Name ZC3H14
Gene ID 79882
Synonyms
Zinc finger CCCH domain-containing protein 14; Mammalian suppressor of tau pathology-2; MSUT-2; Renal carcinoma antigen NY-REN-37
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTI
RFTVWLHGVLDKLRSVTTEPSSLKSSDTNIFDSNVPSNKSNFSRGDERRHEAAVPPLAIP
SARPEKRDSRVSTSSQESKTTNVRQTYDDGAATRLMSTVKPLREPAPSEDVIDIKPEPDD
LIDEDLNFVQENPLSQKKPTVTLTYGSSRPSIEIYRPPASRNADSGVHLNRLQFQQQQNS
IHAAKQLDMQSSWVYETGRLCEPEVLNSLEETYSPFFRNNSEKMSMEDENFRKRKLPVVS
SVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAIS
EAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGD
SVEKNQGTQQRQLLSRLQIDPVMAETLQMSQDYYDMESMVHADTRSFILKKPKLSEEVVV
APNQESGMKTADSLRVLSGHLMQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMC
FEGMKPVNQTAASNKGLRGLLHPQQLHLLSRQLEDPNGSFSNAEMSELSVAQKPEKLLER
CKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRR
IPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTIN
VPPRHALKWIRPQTSE
Target Bioclass
Other
Family
ZC3H14 family
Subcellular location
Cytoplasm; Nucleus speckle
Function Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
Uniprot ID
Q6PJT7
Ensemble ID
ENST00000251038.10
HGNC ID
HGNC:20509

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.R104Q .
HCC1419 SNV: p.L635S DBIA    Probe Info 
HCT15 SNV: p.L507F .
HT115 SNV: p.R388Q .
HUH28 SNV: p.I619M .
LS180 SNV: p.D319N DBIA    Probe Info 
MDST8 SNV: p.Q46Ter DBIA    Probe Info 
NUGC3 SNV: p.E692K .
PF382 SNV: p.R436Ter DBIA    Probe Info 
SKOV3 SNV: p.T521M DBIA    Probe Info 
SUPT1 SNV: p.Y273H DBIA    Probe Info 
SW480 SNV: p.S97Ter .
WM793 SNV: p.P376S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
STPyne
 Probe Info  		K633(0.22); K728(5.56)  LDD0277  [2]
Probe 1
 Probe Info  		Y147(44.00)  LDD3495  [3]
P11
 Probe Info  		14.36  LDD0201  [4]
BTD
 Probe Info  		C682(0.49)  LDD2091  [5]
AHL-Pu-1
 Probe Info  		C261(3.94)  LDD0168  [6]
Acrolein
 Probe Info  		N.A.  LDD0227  [7]
DBIA
 Probe Info  		C634(0.89); C641(0.89)  LDD0078  [8]
ATP probe
 Probe Info  		K649(0.00); K307(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C261(0.00); C682(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C693(0.00); C261(0.00); C682(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C693(0.00); C261(0.00); C682(0.00)  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0147  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
TFBX
 Probe Info  		C688(0.00); C628(0.00); C682(0.00)  LDD0148  [11]
Phosphinate-6
 Probe Info  		C628(0.00); C634(0.00); C701(0.00); C707(0.00)  LDD0018  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
m-APA
 Probe Info  		N.A.  LDD0405  [15]
AOyne
 Probe Info  		7.50  LDD0443  [16]
NAIA_5
 Probe Info  		C682(0.00); C688(0.00)  LDD2223  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C693(1.48)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C693(0.87)  LDD2112  [5]
 LDCM0025  4SU-RNA HEK-293T C261(3.94)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C261(2.54); C540(20.00)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C634(0.64); C682(1.15)  LDD0531  [8]
 LDCM0215  AC10 HEK-293T C622(0.77)  LDD0813  [8]
 LDCM0216  AC100 HCT 116 C634(0.74); C641(0.67)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C634(0.94); C641(0.88)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C634(1.08); C641(1.01)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C634(1.00); C641(0.91)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C634(1.03); C641(1.03)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C634(0.96); C641(0.88)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C634(0.86); C641(0.79)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C634(0.96); C641(0.89)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C634(0.75); C641(0.73)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C634(0.95); C641(0.93)  LDD0542  [8]
 LDCM0226  AC11 HEK-293T C622(0.70)  LDD0824  [8]
 LDCM0227  AC110 HCT 116 C634(0.98); C641(0.93)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C634(1.13); C641(1.09)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C634(1.01); C641(0.94)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C613(1.12); C622(1.12)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C613(1.30); C622(1.30)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C613(1.38); C622(1.38)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C613(1.44); C622(1.44)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C613(1.20); C622(1.20)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C613(1.24); C622(1.24)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C613(1.01); C622(1.01)  LDD0553  [8]
 LDCM0237  AC12 HEK-293T C622(0.98)  LDD0835  [8]
 LDCM0238  AC120 HCT 116 C613(0.93); C622(0.93)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C613(1.14); C622(1.14)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C613(1.15); C622(1.15)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C613(1.00); C622(1.00)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C613(1.30); C622(1.30)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C613(1.00); C622(1.00)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C613(1.42); C622(1.42)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C613(1.35); C622(1.35)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C634(0.31); C613(1.35); C622(1.35)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C634(0.30); C613(0.97); C622(0.97)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C634(0.24); C613(1.27); C622(1.27)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C634(0.35); C613(1.06); C622(1.06)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C634(0.20); C613(1.04); C622(1.04)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C634(0.26); C613(1.11); C622(1.11)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C634(0.35); C613(1.12); C622(1.12)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C634(0.28); C613(1.33); C622(1.33)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C634(0.28); C613(1.13); C622(1.13)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C634(0.28); C613(0.91); C622(0.91)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C634(0.35); C613(1.16); C622(1.16)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C634(0.31); C613(1.00); C622(1.00)  LDD0575  [8]
 LDCM0259  AC14 HEK-293T C622(1.31)  LDD0857  [8]
 LDCM0260  AC140 HCT 116 C634(0.38); C613(1.09); C622(1.09)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C634(0.39); C613(1.06); C622(1.06)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C634(0.27); C613(0.89); C622(0.89)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C634(0.94); C641(0.94); C613(1.09); C622(1.09)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C634(0.84); C641(0.84); C682(0.94); C613(1.82)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C634(0.88); C641(0.88); C682(0.94); C613(1.40)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C682(0.74); C634(1.18); C641(1.18); C613(1.30)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C682(1.15); C634(1.57); C641(1.57); C613(1.62)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C682(0.90); C634(1.89); C641(1.89); C613(2.15)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C682(0.81); C634(1.48); C641(1.48); C613(1.70)  LDD0586  [8]
 LDCM0270  AC15 HEK-293T C622(1.00)  LDD0868  [8]
 LDCM0271  AC150 HCT 116 C634(0.97); C641(0.97); C682(0.98); C613(1.35)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C634(0.84); C641(0.84); C682(1.00); C613(1.66)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C682(0.90); C613(1.44); C622(1.44); C634(3.04)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C682(0.75); C634(1.16); C641(1.16); C613(2.44)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C634(1.10); C613(2.23); C622(2.23); C641(1.10)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C634(0.85); C613(1.47); C622(1.47); C641(0.85)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C634(1.21); C613(1.65); C622(1.65); C641(1.21)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C634(1.60); C613(1.47); C622(1.47); C641(1.60)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C641(0.34); C634(0.43); C682(0.55)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C641(0.55); C682(0.60); C634(0.64)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C641(0.46); C682(0.52); C634(0.54)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C634(0.58); C682(1.23)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C641(0.40); C682(0.47); C634(0.53)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C641(0.42); C682(0.47); C634(0.53)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C641(0.24); C634(0.34); C682(0.50)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C641(0.24); C634(0.32); C682(0.39)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C682(0.42); C641(0.55); C634(0.57)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C613(1.02); C622(1.02)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C613(0.87); C622(0.87)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C613(1.06); C622(1.06)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C613(1.02); C622(1.02)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C613(1.12); C622(1.12)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C634(0.47); C682(1.22)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C613(1.06); C622(1.06)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C613(1.11); C622(1.11)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C613(1.27); C622(1.27)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C613(1.18); C622(1.18)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C613(1.27); C622(1.27)  LDD0612  [8]
 LDCM0296  AC35 HEK-293T C634(1.10); C641(1.10)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C634(0.64); C641(0.64)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C634(1.63); C641(1.63)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C634(0.62); C641(0.62)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C634(0.61); C641(0.61)  LDD0898  [8]
 LDCM0301  AC4 HCT 116 C634(0.48); C682(1.40)  LDD0618  [8]
 LDCM0302  AC40 HEK-293T C634(0.76); C641(0.76)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C634(0.65); C641(0.65)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C634(1.14); C641(1.14)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C634(1.50); C641(1.50)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C634(0.88); C641(0.88)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C634(0.72); C641(0.72)  LDD0905  [8]
 LDCM0308  AC46 HCT 116 C682(0.95)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C682(1.03)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C682(1.27)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C682(1.12)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C634(0.53); C682(1.31)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C682(1.12)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C682(1.07)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C682(0.86)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C682(0.91)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C682(1.54)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C682(1.21)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C682(1.46)  LDD0636  [8]
 LDCM0320  AC57 HEK-293T C634(1.20); C641(1.20)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C634(1.72); C641(1.72)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C634(1.38); C641(1.38)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C622(0.82)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C634(1.07); C641(1.07)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C634(1.49); C641(1.49)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C634(1.07); C641(1.07)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C634(1.25); C641(1.25)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C634(1.19); C641(1.19)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C634(1.10); C641(1.10)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C634(1.02); C641(1.02)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C634(1.23); C641(1.23)  LDD0929  [8]
 LDCM0332  AC68 HCT 116 C682(1.15); C613(1.18); C622(1.18); C634(3.35)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C613(1.11); C622(1.11); C682(1.34); C634(3.27)  LDD0650  [8]
 LDCM0334  AC7 HEK-293T C622(1.19)  LDD0932  [8]
 LDCM0335  AC70 HCT 116 C613(0.99); C622(0.99); C682(1.28); C634(3.44)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C613(0.73); C622(0.73); C682(1.23); C634(3.69)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C682(1.16); C613(1.22); C622(1.22); C634(3.78)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C634(3.33); C613(1.19); C622(1.19); C682(1.68)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C682(1.25); C613(1.39); C622(1.39); C634(2.57)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C682(1.79); C613(2.12); C622(2.12); C634(3.01)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C613(1.04); C622(1.04); C682(1.20); C634(2.83)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C682(1.16); C613(1.39); C622(1.39); C634(3.15)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C613(0.83); C622(0.83); C682(1.24); C634(2.65)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C613(0.81); C622(0.81); C682(1.20); C634(3.85)  LDD0661  [8]
 LDCM0345  AC8 HEK-293T C622(0.99)  LDD0943  [8]
 LDCM0346  AC80 HCT 116 C613(0.87); C622(0.87); C682(1.15); C634(2.60)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C613(0.81); C622(0.81); C682(1.38); C634(4.17)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C613(1.32); C622(1.32); C682(1.63); C634(3.40)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C634(1.00)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C634(1.10)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C634(0.96)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C634(0.90)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C634(0.89)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C634(0.91)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C634(0.86)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C634(0.79)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C634(0.94)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C634(0.71)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C634(0.86)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C634(0.88)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C634(0.86)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C634(0.80)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C634(0.85)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C641(0.91); C634(0.97)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C641(0.76); C634(0.85)  LDD0683  [8]
 LDCM0248  AKOS034007472 HEK-293T C622(0.74)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C622(1.75)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C622(0.90)  LDD0873  [8]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [15]
 LDCM0020  ARS-1620 HCC44 C634(0.89); C641(0.89)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C682(0.49)  LDD2091  [5]
 LDCM0088  C45 HEK-293T 14.36  LDD0201  [4]
 LDCM0632  CL-Sc Hep-G2 C682(1.23)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C634(0.90); C641(0.90); C682(1.13)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C682(1.33); C634(1.37); C641(1.37)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C634(0.60); C682(1.58)  LDD0686  [8]
 LDCM0370  CL101 HEK-293T C622(1.03)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C622(1.15)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C622(1.37)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C622(0.93)  LDD0971  [8]
 LDCM0374  CL105 HCT 116 C641(0.25); C634(0.38); C682(0.48)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C641(0.25); C634(0.36); C682(0.54)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C641(0.25); C634(0.37); C682(0.55)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C641(0.21); C634(0.31); C682(0.50)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C641(0.24); C634(0.31); C682(0.51)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C682(0.73); C634(0.93); C641(0.93)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C641(0.27); C634(0.32); C682(0.55)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C641(0.45); C634(0.50); C682(0.52)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C613(0.91); C622(0.91)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C613(0.89); C622(0.89)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C613(0.79); C622(0.79)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C613(1.02); C622(1.02)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C613(1.00); C622(1.00)  LDD0703  [8]
 LDCM0387  CL117 HEK-293T C634(0.67); C641(0.67)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C634(0.56); C641(0.56)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C634(0.81); C641(0.81)  LDD0987  [8]
 LDCM0390  CL12 HCT 116 C682(1.72); C634(1.87); C641(1.87)  LDD0707  [8]
 LDCM0391  CL120 HEK-293T C634(0.62); C641(0.62)  LDD0989  [8]
 LDCM0392  CL121 HCT 116 C682(1.07)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C682(0.99)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C682(0.99)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C682(1.07)  LDD0712  [8]
 LDCM0396  CL125 HEK-293T C634(1.57); C641(1.57)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C634(1.11); C641(1.11)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C634(1.46); C641(1.46)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C634(1.39); C641(1.39)  LDD0997  [8]
 LDCM0400  CL13 HCT 116 C682(1.24); C634(1.53); C641(1.53)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C682(1.24); C634(1.40); C641(1.40)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C682(0.77); C634(1.30); C641(1.30)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C652(1.06); C693(0.98); C682(1.11); C540(1.12)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C647(1.05); C693(0.81); C682(0.96); C540(0.94)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C652(1.02); C693(0.98); C682(1.14); C540(1.03)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C652(1.03); C693(1.07); C682(1.15); C540(1.08)  LDD1610  [18]
 LDCM0407  CL2 HCT 116 C634(0.79); C641(0.79); C682(1.21)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C652(0.98); C693(0.96); C682(1.12); C540(1.39)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C652(0.92); C693(0.79); C682(1.46); C540(1.17)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C652(1.00); C693(0.95); C682(1.15); C540(1.34)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C652(1.14); C693(0.93); C682(1.08); C540(1.13)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C652(1.07); C693(0.93); C682(1.14); C540(1.31)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C652(0.85); C693(0.97); C682(0.84); C540(0.87)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C652(0.99); C693(1.11); C682(1.05); C540(0.76)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C652(1.00); C693(1.02); C682(0.87); C540(0.89)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C652(1.11); C693(1.02); C682(0.87); C540(1.04)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C647(1.07); C693(0.96); C682(0.93); C540(1.02)  LDD1621  [18]
 LDCM0418  CL3 HCT 116 C634(0.84); C641(0.84); C682(0.99)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C652(1.06); C693(1.01); C682(0.98); C540(1.11)  LDD1623  [18]
 LDCM0420  CL31 HCT 116 C634(0.77); C682(0.78)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C634(0.79); C682(1.10)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C634(0.74); C682(1.02)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C634(0.68); C682(1.14)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C634(1.02); C682(1.03)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C634(0.94); C682(0.89)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C634(1.29); C682(1.07)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C634(0.89); C682(1.00)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C634(0.76); C641(0.76); C682(1.18)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C634(0.85); C682(0.53)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C634(1.15); C682(1.24)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C634(0.90); C682(1.15)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C634(0.62); C682(1.06)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C634(0.85); C682(1.08)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C634(0.64); C682(0.76)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C634(0.67)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C634(0.93)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C634(1.08)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C634(0.65)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C634(1.01); C641(1.01); C682(1.17)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C634(1.21)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C634(0.74)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C634(1.18)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C634(1.79)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C634(1.11)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C634(0.92)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C634(1.01)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C634(0.92)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C634(0.85)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C634(0.74)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C634(1.23); C641(1.23); C682(1.15)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C634(0.97)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C622(0.96); C634(0.97); C641(0.97)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C622(1.30); C634(0.87); C641(0.87)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C622(1.34); C634(0.69); C641(0.69)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C622(1.36); C634(0.65); C641(0.65)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C622(1.24); C634(0.88); C641(0.88)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C622(1.22); C634(0.53); C641(0.53)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C622(1.95); C634(0.93); C641(0.93)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C622(1.28); C634(0.39); C641(0.39)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C622(1.84); C634(0.50); C641(0.50)  LDD1059  [8]
 LDCM0462  CL7 HCT 116 C634(2.41); C641(2.41); C682(1.14)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C622(1.23); C634(0.49); C641(0.49)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C622(1.99); C634(0.43); C641(0.43)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C622(1.22); C634(0.88); C641(0.88)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C622(1.83); C634(0.53); C641(0.53)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C622(2.62); C634(0.49); C641(0.49)  LDD1065  [8]
 LDCM0469  CL76 HCT 116 C682(0.78)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C682(0.95)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C682(0.85)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C682(0.96)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C634(0.97); C641(0.97); C682(0.66)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C682(0.99)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C682(1.01)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C682(0.97)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C682(0.85)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C682(0.88)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C682(0.83)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C682(0.87)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C682(0.84)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C682(0.90)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C682(0.91)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C634(1.09); C641(1.09); C682(1.31)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C682(0.70)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C634(0.85); C682(0.84)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C634(0.88); C682(1.03)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C634(0.55); C682(0.97)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C634(0.74); C682(1.17)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C634(0.59); C682(0.89)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C634(0.72); C682(1.34)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C634(0.67); C682(1.26)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C634(0.68); C682(0.82)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C634(0.79); C682(1.11)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C652(1.07); C693(0.92); C682(0.80); C540(0.98)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C693(1.00); C707(0.99); C682(0.86)  LDD1702  [5]
 LDCM0625  F8 Ramos C682(1.75)  LDD2187  [19]
 LDCM0573  Fragment11 Ramos C261(0.24); C682(0.81)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C682(0.83)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C682(1.05)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C682(0.88)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C261(2.12); C682(2.27)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C682(0.83)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C261(2.29); C682(1.50)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C682(1.00)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C682(0.97)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C261(4.18); C682(1.02)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C682(1.09)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C261(3.65); C682(0.37)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C622(3.06); C634(1.09); C641(1.09)  LDD1066  [8]
 LDCM0596  Fragment38 Ramos C682(1.29)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C682(1.23)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C634(0.89); C682(0.56)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C682(1.14)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C682(1.62)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C682(0.34)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C261(3.21); C682(1.04)  LDD2188  [19]
 LDCM0022  KB02 HCT 116 C613(1.72); C622(1.69); C707(1.73); C712(1.73)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C613(2.13); C622(1.30); C707(1.10); C712(1.10)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C613(1.92); C622(1.32); C707(1.18); C712(1.18)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0227  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C693(0.27)  LDD2096  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C682(0.95)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C682(0.96)  LDD2127  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C682(0.85)  LDD2136  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C682(0.57)  LDD2140  [5]
 LDCM0131  RA190 MM1.R C261(0.78)  LDD0304  [20]
 LDCM0021  THZ1 HCT 116 C707(1.61); C712(1.61); C634(1.57); C641(1.57)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain Tctex-type 3 (DYNLT3) Dynein light chain Tctex-type family P51808
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.