Details of the Target

General Information of Target

Target ID LDTP09694
Target Name Paraspeckle component 1 (PSPC1)
Gene Name PSPC1
Gene ID 55269
Synonyms
PSP1; Paraspeckle component 1; Paraspeckle protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGEPAPPAPAPPEDHPDEE
MGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFG
FIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFG
PVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDD
EDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREA
KEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRRE
EEMIRHREQEELRRQQEGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGNQGPPP
MMGMNMNNRATIPGPPMGPGPAMGPEGAANMGTPMMPDNGAVHNDRFPQGPPSQMGSPMG
SRTGSETPQAPMSGVGPVSGGPGGFGRGSQGGNFEGPNKRRRY
Target Bioclass
Transcription factor
Family
PSPC family
Subcellular location
Nucleus, nucleolus
Function
Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Uniprot ID
Q8WXF1
Ensemble ID
ENST00000338910.9
HGNC ID
HGNC:20320

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.E305K .
CORL23 SNV: p.T159A .
GB1 SNV: p.V498L; p.P502H .
HCC1143 SNV: p.H313Y .
HCT15 SNV: p.G193S .
MFE319 SNV: p.A135T; p.M391T .
REH Deletion: p.N15TfsTer144 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y383(20.00); Y255(19.55)  LDD0260  [1]
STPyne
 Probe Info  		K14(10.00); K206(5.65); K257(4.51); K344(4.67)  LDD0277  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
Probe 1
 Probe Info  		Y105(106.73); Y255(29.39); Y275(11.07); Y383(28.38)  LDD3495  [4]
P11
 Probe Info  		20.00  LDD0201  [5]
BTD
 Probe Info  		C216(0.14)  LDD2096  [6]
Jackson_14
 Probe Info  		2.13  LDD0123  [7]
HHS-475
 Probe Info  		Y383(1.00)  LDD0264  [8]
DBIA
 Probe Info  		C216(1.17)  LDD0531  [9]
ATP probe
 Probe Info  		K206(0.00); K99(0.00)  LDD0199  [10]
m-APA
 Probe Info  		H154(0.00); H352(0.00)  LDD2231  [11]
1d-yne
 Probe Info  		N.A.  LDD0358  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
NHS
 Probe Info  		N.A.  LDD0010  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
1c-yne
 Probe Info  		K134(0.00); K161(0.00)  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
HHS-465
 Probe Info  		K257(0.00); K380(0.00); Y255(0.00); Y383(0.00)  LDD2240  [18]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		7.16  LDD1779  [19]
C201
 Probe Info  		28.64  LDD1877  [19]
C210
 Probe Info  		39.40  LDD1884  [19]
C231
 Probe Info  		11.88  LDD1904  [19]
C246
 Probe Info  		18.13  LDD1919  [19]
C313
 Probe Info  		13.93  LDD1980  [19]
C350
 Probe Info  		41.36  LDD2011  [19]
C391
 Probe Info  		25.11  LDD2050  [19]
C419
 Probe Info  		9.99  LDD2074  [19]
FFF probe13
 Probe Info  		14.04  LDD0475  [20]
FFF probe14
 Probe Info  		18.71  LDD0477  [20]
FFF probe2
 Probe Info  		16.43  LDD0463  [20]
FFF probe3
 Probe Info  		19.26  LDD0464  [20]
FFF probe6
 Probe Info  		13.86  LDD0467  [20]
JN0003
 Probe Info  		13.77  LDD0469  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C216(1.17)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C216(1.02)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C216(0.85)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C216(0.72)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C216(0.74)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C216(0.74)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C216(0.75)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C216(0.78)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C216(0.76)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C216(0.79)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C216(0.72)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C216(0.73)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C216(0.95)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C216(0.70)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C216(0.70)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C216(0.68)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C216(1.04)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C216(1.07)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C216(1.06)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C216(1.19)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C216(1.33)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C216(1.42)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C216(1.03)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C216(1.09)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C216(1.02)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C216(1.30)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C216(1.31)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C216(1.05)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C216(1.54)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C216(1.28)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C216(1.24)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C216(1.65)  LDD0562  [9]
 LDCM0259  AC14 HCT 116 C216(1.25)  LDD0576  [9]
 LDCM0263  AC143 HEK-293T C216(0.57)  LDD0861  [9]
 LDCM0264  AC144 HEK-293T C216(0.75)  LDD0862  [9]
 LDCM0265  AC145 HEK-293T C216(0.66)  LDD0863  [9]
 LDCM0266  AC146 HEK-293T C216(0.46)  LDD0864  [9]
 LDCM0267  AC147 HEK-293T C216(0.62)  LDD0865  [9]
 LDCM0268  AC148 HEK-293T C216(0.45)  LDD0866  [9]
 LDCM0269  AC149 HEK-293T C216(0.78)  LDD0867  [9]
 LDCM0270  AC15 HCT 116 C216(1.59)  LDD0587  [9]
 LDCM0271  AC150 HEK-293T C216(0.67)  LDD0869  [9]
 LDCM0272  AC151 HEK-293T C216(0.67)  LDD0870  [9]
 LDCM0273  AC152 HEK-293T C216(0.66)  LDD0871  [9]
 LDCM0274  AC153 HEK-293T C216(0.62)  LDD0872  [9]
 LDCM0621  AC154 HEK-293T C216(0.75)  LDD2162  [9]
 LDCM0622  AC155 HEK-293T C216(0.68)  LDD2163  [9]
 LDCM0623  AC156 HEK-293T C216(0.64)  LDD2164  [9]
 LDCM0624  AC157 HEK-293T C216(0.84)  LDD2165  [9]
 LDCM0276  AC17 HCT 116 C216(0.84)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C216(0.53)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C216(0.52)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C216(1.25)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C216(0.57)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C216(0.67)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C216(0.66)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C216(0.48)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C216(0.60)  LDD0601  [9]
 LDCM0285  AC25 HEK-293T C216(1.78)  LDD0883  [9]
 LDCM0286  AC26 HEK-293T C216(1.28)  LDD0884  [9]
 LDCM0287  AC27 HEK-293T C216(1.77)  LDD0885  [9]
 LDCM0288  AC28 HEK-293T C216(1.99)  LDD0886  [9]
 LDCM0289  AC29 HEK-293T C216(1.35)  LDD0887  [9]
 LDCM0290  AC3 HCT 116 C216(1.52)  LDD0607  [9]
 LDCM0291  AC30 HEK-293T C216(1.89)  LDD0889  [9]
 LDCM0292  AC31 HEK-293T C216(1.95)  LDD0890  [9]
 LDCM0293  AC32 HEK-293T C216(2.03)  LDD0891  [9]
 LDCM0294  AC33 HEK-293T C216(1.42)  LDD0892  [9]
 LDCM0295  AC34 HEK-293T C216(1.25)  LDD0893  [9]
 LDCM0296  AC35 HCT 116 C216(1.25)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C216(1.05)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C216(1.37)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C216(1.28)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C216(0.99)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C216(1.59)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C216(1.16)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C216(1.20)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C216(1.11)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C216(1.11)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C216(1.30)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C216(1.17)  LDD0624  [9]
 LDCM0309  AC47 HEK-293T C216(1.14)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C216(0.98)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C216(1.30)  LDD1550  [21]
 LDCM0312  AC5 HCT 116 C216(1.46)  LDD0629  [9]
 LDCM0313  AC50 HEK-293T C216(1.13)  LDD1552  [21]
 LDCM0316  AC53 HEK-293T C216(0.96)  LDD1555  [21]
 LDCM0318  AC55 HEK-293T C216(1.06)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C216(1.01)  LDD1558  [21]
 LDCM0320  AC57 HCT 116 C216(1.02)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C216(1.00)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C216(1.13)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C216(1.06)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C216(1.01)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C216(1.06)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C216(1.06)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C216(1.02)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C216(0.99)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C216(0.99)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C216(0.99)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C216(1.01)  LDD0648  [9]
 LDCM0332  AC68 HEK-293T C216(1.18)  LDD0930  [9]
 LDCM0333  AC69 HEK-293T C216(1.19)  LDD0931  [9]
 LDCM0334  AC7 HCT 116 C216(1.11)  LDD0651  [9]
 LDCM0335  AC70 HEK-293T C216(1.15)  LDD0933  [9]
 LDCM0336  AC71 HEK-293T C216(1.02)  LDD0934  [9]
 LDCM0337  AC72 HEK-293T C216(0.89)  LDD0935  [9]
 LDCM0338  AC73 HEK-293T C216(0.75)  LDD0936  [9]
 LDCM0339  AC74 HEK-293T C216(1.53)  LDD0937  [9]
 LDCM0340  AC75 HEK-293T C216(0.93)  LDD0938  [9]
 LDCM0341  AC76 HEK-293T C216(1.69)  LDD0939  [9]
 LDCM0342  AC77 HEK-293T C216(1.45)  LDD0940  [9]
 LDCM0343  AC78 HEK-293T C216(1.35)  LDD0941  [9]
 LDCM0344  AC79 HEK-293T C216(1.38)  LDD0942  [9]
 LDCM0345  AC8 HCT 116 C216(1.33)  LDD0662  [9]
 LDCM0346  AC80 HEK-293T C216(1.36)  LDD0944  [9]
 LDCM0347  AC81 HEK-293T C216(1.51)  LDD0945  [9]
 LDCM0348  AC82 HEK-293T C216(1.56)  LDD0946  [9]
 LDCM0349  AC83 HCT 116 C216(4.02)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C216(3.02)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C216(4.29)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C216(3.82)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C216(3.04)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C216(3.63)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C216(4.27)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C216(3.83)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C216(3.46)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C216(4.02)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C216(2.39)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C216(3.33)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C216(3.23)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C216(3.18)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C216(3.86)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C216(0.72)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C216(0.62)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C216(1.07)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C216(0.95)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C216(1.31)  LDD0592  [9]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [5]
 LDCM0367  CL1 HCT 116 C216(1.42)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C216(0.92)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C216(1.25)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C216(1.17)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C216(1.15)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C216(1.37)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C216(1.31)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C216(0.51)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C216(0.50)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C216(0.56)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C216(0.80)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C216(0.58)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C216(1.29)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C216(0.65)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C216(0.47)  LDD0698  [9]
 LDCM0382  CL112 HEK-293T C216(1.38)  LDD0980  [9]
 LDCM0383  CL113 HEK-293T C216(1.79)  LDD0981  [9]
 LDCM0384  CL114 HEK-293T C216(1.91)  LDD0982  [9]
 LDCM0385  CL115 HEK-293T C216(2.64)  LDD0983  [9]
 LDCM0386  CL116 HEK-293T C216(1.58)  LDD0984  [9]
 LDCM0387  CL117 HCT 116 C216(0.94)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C216(1.62)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C216(1.10)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C216(1.88)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C216(1.14)  LDD0708  [9]
 LDCM0392  CL121 HEK-293T C216(0.99)  LDD1596  [21]
 LDCM0395  CL124 HEK-293T C216(1.12)  LDD1599  [21]
 LDCM0396  CL125 HCT 116 C216(1.15)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C216(0.99)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C216(0.92)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C216(1.01)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C216(1.23)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C216(1.47)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C216(1.30)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C216(0.93)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C216(1.01)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C216(1.20)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C216(1.23)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C216(1.31)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C216(1.13)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C216(1.22)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C216(0.91)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C216(1.01)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C216(0.95)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C216(1.00)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C216(0.96)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C216(1.08)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C216(1.08)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C216(0.99)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C216(1.20)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C216(1.14)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C216(1.39)  LDD0737  [9]
 LDCM0421  CL32 HEK-293T C216(1.01)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C216(0.73)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C216(0.89)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C216(0.96)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C216(1.00)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C216(0.87)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C216(0.80)  LDD1026  [9]
 LDCM0429  CL4 HCT 116 C216(1.27)  LDD0746  [9]
 LDCM0430  CL40 HEK-293T C216(0.89)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C216(0.84)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C216(0.99)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C216(1.21)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C216(1.25)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C216(0.93)  LDD1033  [9]
 LDCM0436  CL46 HCT 116 C216(0.85)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C216(0.77)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C216(0.84)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C216(1.09)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C216(1.54)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C216(1.20)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C216(1.02)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C216(0.77)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C216(1.01)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C216(1.03)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C216(0.88)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C216(1.03)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C216(1.29)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C216(1.15)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C216(1.29)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C216(0.83)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C216(0.86)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C216(1.17)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C216(0.75)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C216(0.94)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C216(1.03)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C216(1.08)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C216(1.09)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C216(1.16)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C216(1.46)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C216(0.97)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C216(1.06)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C216(0.80)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C216(0.91)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C216(1.29)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C216(1.21)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C216(1.15)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C216(1.31)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C216(1.15)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C216(1.01)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C216(1.55)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C216(1.50)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C216(1.92)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C216(1.52)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C216(1.38)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C216(1.19)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C216(1.23)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C216(1.54)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C216(1.29)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C216(1.45)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C216(1.68)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C216(1.39)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C216(1.16)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C216(1.33)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C216(1.13)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C216(1.23)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C216(1.22)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C216(1.13)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C216(1.07)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C216(1.14)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C216(1.20)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C216(1.20)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C216(1.45)  LDD0811  [9]
 LDCM0468  Fragment33 HCT 116 C216(1.14)  LDD0785  [9]
 LDCM0427  Fragment51 HEK-293T C216(1.09)  LDD1025  [9]
 LDCM0116  HHS-0101 DM93 Y383(1.00)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y383(0.79)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y383(0.73)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y383(0.88)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y383(1.23)  LDD0268  [8]
 LDCM0109  NEM HeLa N.A.  LDD0224  [16]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C216(0.14)  LDD2096  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C216(0.26)  LDD2122  [6]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.13  LDD0123  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) Nudix hydrolase family O43809
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Non-POU domain-containing octamer-binding protein (NONO) . Q15233
Zinc finger and SCAN domain-containing protein 5B (ZSCAN5B) . A6NJL1
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402