Details of the Target

General Information of Target

Target ID LDTP13375
Target Name 2-hydroxyacyl-CoA lyase 1 (HACL1)
Gene Name HACL1
Gene ID 26061
Synonyms
HPCL; HPCL2; PHYH2; 2-hydroxyacyl-CoA lyase 1; EC 4.1.2.63; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKCSVGGLELTEQTPALLGNMAMATSLMDIGDSFGHPACPLVSRSRNSPVEDDDDDDDV
VFIESIQPPSISAPAIADQRNFIFASSKNEKPQGNYSVIPPSSRDLASQKGNISETIVID
DEEDIETNGGAEKKSSCFIEWGLPGTKNKTNDLDFSTSSLSRSKTKTGVRPFNPGRMNVA
GDLFQNGEFATHHSPDSWISQSASFPSNQKQPGVDSLSPVALLRKQNFQPTAQQQLTKPA
KITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTQNTRSIICKKDASTKKANV
ILPVESSKSFQEFYSTSCLSPCENNWNLKKGVFNKSRCTICSKLAEIRHEVSVNNVTHKL
CSNHCFNKYRLANGLIMNCCEHCGEYMPSKSTGNNILVIGGQQKRFCCQSCINEYKQMME
TKSKKLTASENRKRNAFREENEKQLYGSSNTLLKKIEGIPEKKEKTSQLQLSVECGTDTL
LIQENVNLPPSSTSTIADTFQEQLEEKNFEDSIVPVVLSADPGTWPRILNIKQRDTLVEN
VPPQVRNFNFPKDNTGRKFSETYYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLFGEGK
NQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKLKSDLKKNKAIDAAEHRLYENEK
NDGVLLLYT
Target Bioclass
Enzyme
Family
TPP enzyme family
Subcellular location
Peroxisome
Function
Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids. Plays a significant role in the biosynthesis of heptadecanal in the liver.
Uniprot ID
Q9UJ83
Ensemble ID
ENST00000321169.10
HGNC ID
HGNC:17856

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G415 SNV: p.G223V .
KMCH1 SNV: p.E230A .
LS180 Deletion: p.M357Ter .
LU65 SNV: p.P474S .
MFE319 SNV: p.K153R DBIA    Probe Info 
SKN SNV: p.A368P .
SW620 SNV: p.W494C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.47  LDD0402  [1]
STPyne
 Probe Info  		K566(5.05)  LDD0277  [2]
BTD
 Probe Info  		C392(1.72)  LDD1699  [3]
IPM
 Probe Info  		N.A.  LDD0241  [4]
P11
 Probe Info  		20.00  LDD0201  [5]
DBIA
 Probe Info  		C261(1.22)  LDD3310  [6]
AHL-Pu-1
 Probe Info  		C307(2.79)  LDD0168  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C261(0.00); C511(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C511(0.00); C166(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C511(0.00); C261(0.00); C166(0.00); C131(0.00)  LDD0037  [10]
Phosphinate-6
 Probe Info  		C511(0.00); C307(0.00)  LDD0018  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Crotonaldehyde
 Probe Info  		C261(0.00); C131(0.00)  LDD0219  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		12.40  LDD0443  [14]
NAIA_5
 Probe Info  		C392(0.00); C261(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C252
 Probe Info  		9.13  LDD1925  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C261(0.93)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C261(1.14)  LDD2095  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C261(0.98)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C261(1.12)  LDD2152  [3]
 LDCM0025  4SU-RNA HEK-293T C307(2.79)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C307(3.15)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C190(1.22); C204(1.22)  LDD0812  [17]
 LDCM0215  AC10 HEK-293T C190(1.05); C204(1.05)  LDD0813  [17]
 LDCM0216  AC100 HEK-293T C131(1.00); C190(0.92); C204(0.92)  LDD0814  [17]
 LDCM0217  AC101 HEK-293T C131(1.11); C190(1.00); C204(1.00)  LDD0815  [17]
 LDCM0218  AC102 HEK-293T C131(1.12); C190(1.24); C204(1.24)  LDD0816  [17]
 LDCM0219  AC103 HEK-293T C131(0.82); C190(1.01); C204(1.01)  LDD0817  [17]
 LDCM0220  AC104 HEK-293T C131(0.96); C190(1.26); C204(1.26)  LDD0818  [17]
 LDCM0221  AC105 HEK-293T C131(1.12); C190(0.97); C204(0.97)  LDD0819  [17]
 LDCM0222  AC106 HEK-293T C131(1.41); C190(0.97); C204(0.97)  LDD0820  [17]
 LDCM0223  AC107 HEK-293T C131(1.23); C190(1.04); C204(1.04)  LDD0821  [17]
 LDCM0224  AC108 HEK-293T C131(1.01); C190(0.91); C204(0.91)  LDD0822  [17]
 LDCM0225  AC109 HEK-293T C131(1.15); C190(0.96); C204(0.96)  LDD0823  [17]
 LDCM0226  AC11 HEK-293T C190(1.10); C204(1.10)  LDD0824  [17]
 LDCM0227  AC110 HEK-293T C131(1.41); C190(1.37); C204(1.37)  LDD0825  [17]
 LDCM0228  AC111 HEK-293T C131(1.02); C190(1.22); C204(1.22)  LDD0826  [17]
 LDCM0229  AC112 HEK-293T C131(1.11); C190(1.26); C204(1.26)  LDD0827  [17]
 LDCM0230  AC113 HEK-293T C131(1.40)  LDD0828  [17]
 LDCM0231  AC114 HEK-293T C131(1.29)  LDD0829  [17]
 LDCM0232  AC115 HEK-293T C131(1.31)  LDD0830  [17]
 LDCM0233  AC116 HEK-293T C131(0.91)  LDD0831  [17]
 LDCM0234  AC117 HEK-293T C131(1.22)  LDD0832  [17]
 LDCM0235  AC118 HEK-293T C131(0.73)  LDD0833  [17]
 LDCM0236  AC119 HEK-293T C131(1.00)  LDD0834  [17]
 LDCM0237  AC12 HEK-293T C190(1.02); C204(1.02)  LDD0835  [17]
 LDCM0238  AC120 HEK-293T C131(0.94)  LDD0836  [17]
 LDCM0239  AC121 HEK-293T C131(1.00)  LDD0837  [17]
 LDCM0240  AC122 HEK-293T C131(0.90)  LDD0838  [17]
 LDCM0241  AC123 HEK-293T C131(1.00)  LDD0839  [17]
 LDCM0242  AC124 HEK-293T C131(1.14)  LDD0840  [17]
 LDCM0243  AC125 HEK-293T C131(1.11)  LDD0841  [17]
 LDCM0244  AC126 HEK-293T C131(1.38)  LDD0842  [17]
 LDCM0245  AC127 HEK-293T C131(1.09)  LDD0843  [17]
 LDCM0246  AC128 PaTu 8988t C190(1.19); C204(1.19)  LDD1125  [17]
 LDCM0247  AC129 PaTu 8988t C190(1.28); C204(1.28)  LDD1126  [17]
 LDCM0249  AC130 PaTu 8988t C190(1.29); C204(1.29)  LDD1128  [17]
 LDCM0250  AC131 PaTu 8988t C190(1.43); C204(1.43)  LDD1129  [17]
 LDCM0251  AC132 PaTu 8988t C190(1.07); C204(1.07)  LDD1130  [17]
 LDCM0252  AC133 PaTu 8988t C190(0.87); C204(0.87)  LDD1131  [17]
 LDCM0253  AC134 PaTu 8988t C190(0.97); C204(0.97)  LDD1132  [17]
 LDCM0254  AC135 PaTu 8988t C190(1.21); C204(1.21)  LDD1133  [17]
 LDCM0255  AC136 PaTu 8988t C190(1.15); C204(1.15)  LDD1134  [17]
 LDCM0256  AC137 PaTu 8988t C190(1.17); C204(1.17)  LDD1135  [17]
 LDCM0257  AC138 PaTu 8988t C190(0.99); C204(0.99)  LDD1136  [17]
 LDCM0258  AC139 PaTu 8988t C190(0.99); C204(0.99)  LDD1137  [17]
 LDCM0259  AC14 HEK-293T C190(1.03); C204(1.03)  LDD0857  [17]
 LDCM0260  AC140 PaTu 8988t C190(1.08); C204(1.08)  LDD1139  [17]
 LDCM0261  AC141 PaTu 8988t C190(1.11); C204(1.11)  LDD1140  [17]
 LDCM0262  AC142 PaTu 8988t C190(1.16); C204(1.16)  LDD1141  [17]
 LDCM0263  AC143 HEK-293T C190(1.12); C204(1.12)  LDD0861  [17]
 LDCM0264  AC144 HEK-293T C190(0.93); C204(0.93)  LDD0862  [17]
 LDCM0265  AC145 HEK-293T C190(0.86); C204(0.86)  LDD0863  [17]
 LDCM0266  AC146 HEK-293T C190(1.00); C204(1.00)  LDD0864  [17]
 LDCM0267  AC147 HEK-293T C190(1.06); C204(1.06)  LDD0865  [17]
 LDCM0268  AC148 HEK-293T C190(0.99); C204(0.99)  LDD0866  [17]
 LDCM0269  AC149 HEK-293T C190(0.85); C204(0.85)  LDD0867  [17]
 LDCM0270  AC15 HEK-293T C190(1.19); C204(1.19)  LDD0868  [17]
 LDCM0271  AC150 HEK-293T C190(0.87); C204(0.87)  LDD0869  [17]
 LDCM0272  AC151 HEK-293T C190(1.03); C204(1.03)  LDD0870  [17]
 LDCM0273  AC152 HEK-293T C190(0.95); C204(0.95)  LDD0871  [17]
 LDCM0274  AC153 HEK-293T C190(0.85); C204(0.85)  LDD0872  [17]
 LDCM0621  AC154 HEK-293T C190(1.01); C204(1.01)  LDD2162  [17]
 LDCM0622  AC155 HEK-293T C190(0.87); C204(0.87)  LDD2163  [17]
 LDCM0623  AC156 HEK-293T C190(0.86); C204(0.86)  LDD2164  [17]
 LDCM0624  AC157 HEK-293T C190(0.99); C204(0.99)  LDD2165  [17]
 LDCM0276  AC17 HEK-293T C131(1.34)  LDD0874  [17]
 LDCM0277  AC18 HEK-293T C131(1.49)  LDD0875  [17]
 LDCM0278  AC19 HEK-293T C131(1.36)  LDD0876  [17]
 LDCM0279  AC2 HEK-293T C190(0.89); C204(0.89)  LDD0877  [17]
 LDCM0280  AC20 HEK-293T C131(1.66)  LDD0878  [17]
 LDCM0281  AC21 HEK-293T C131(1.25)  LDD0879  [17]
 LDCM0282  AC22 HEK-293T C131(1.10)  LDD0880  [17]
 LDCM0283  AC23 HEK-293T C131(1.19)  LDD0881  [17]
 LDCM0284  AC24 HEK-293T C131(1.17)  LDD0882  [17]
 LDCM0285  AC25 PaTu 8988t C131(0.71)  LDD1164  [17]
 LDCM0286  AC26 PaTu 8988t C131(0.89)  LDD1165  [17]
 LDCM0287  AC27 PaTu 8988t C131(1.00)  LDD1166  [17]
 LDCM0288  AC28 PaTu 8988t C131(0.85)  LDD1167  [17]
 LDCM0289  AC29 PaTu 8988t C131(0.93)  LDD1168  [17]
 LDCM0290  AC3 HEK-293T C190(0.87); C204(0.87)  LDD0888  [17]
 LDCM0291  AC30 PaTu 8988t C131(0.78)  LDD1170  [17]
 LDCM0292  AC31 PaTu 8988t C131(0.88)  LDD1171  [17]
 LDCM0293  AC32 PaTu 8988t C131(0.89)  LDD1172  [17]
 LDCM0294  AC33 PaTu 8988t C131(1.08)  LDD1173  [17]
 LDCM0295  AC34 PaTu 8988t C131(1.07)  LDD1174  [17]
 LDCM0296  AC35 HEK-293T C190(0.74); C204(0.74)  LDD0894  [17]
 LDCM0297  AC36 HEK-293T C190(0.66); C204(0.66)  LDD0895  [17]
 LDCM0298  AC37 HEK-293T C190(0.85); C204(0.85)  LDD0896  [17]
 LDCM0299  AC38 HEK-293T C190(0.91); C204(0.91)  LDD0897  [17]
 LDCM0300  AC39 HEK-293T C190(0.73); C204(0.73)  LDD0898  [17]
 LDCM0301  AC4 HEK-293T C190(0.98); C204(0.98)  LDD0899  [17]
 LDCM0302  AC40 HEK-293T C190(0.84); C204(0.84)  LDD0900  [17]
 LDCM0303  AC41 HEK-293T C190(0.78); C204(0.78)  LDD0901  [17]
 LDCM0304  AC42 HEK-293T C190(0.72); C204(0.72)  LDD0902  [17]
 LDCM0305  AC43 HEK-293T C190(0.81); C204(0.81)  LDD0903  [17]
 LDCM0306  AC44 HEK-293T C190(0.71); C204(0.71)  LDD0904  [17]
 LDCM0307  AC45 HEK-293T C190(0.85); C204(0.85)  LDD0905  [17]
 LDCM0308  AC46 HEK-293T C190(1.08); C204(1.08)  LDD0906  [17]
 LDCM0309  AC47 HEK-293T C190(0.88); C204(0.88)  LDD0907  [17]
 LDCM0310  AC48 HEK-293T C190(0.95); C204(0.95)  LDD0908  [17]
 LDCM0311  AC49 HEK-293T C190(1.00); C204(1.00)  LDD0909  [17]
 LDCM0312  AC5 HEK-293T C190(0.93); C204(0.93)  LDD0910  [17]
 LDCM0313  AC50 HEK-293T C190(0.95); C204(0.95)  LDD0911  [17]
 LDCM0314  AC51 HEK-293T C190(1.08); C204(1.08)  LDD0912  [17]
 LDCM0315  AC52 HEK-293T C190(0.89); C204(0.89)  LDD0913  [17]
 LDCM0316  AC53 HEK-293T C190(0.94); C204(0.94)  LDD0914  [17]
 LDCM0317  AC54 HEK-293T C190(1.01); C204(1.01)  LDD0915  [17]
 LDCM0318  AC55 HEK-293T C190(0.93); C204(0.93)  LDD0916  [17]
 LDCM0319  AC56 HEK-293T C190(0.78); C204(0.78)  LDD0917  [17]
 LDCM0320  AC57 HEK-293T C131(0.88)  LDD0918  [17]
 LDCM0321  AC58 HEK-293T C131(1.33)  LDD0919  [17]
 LDCM0322  AC59 HEK-293T C131(0.88)  LDD0920  [17]
 LDCM0323  AC6 HEK-293T C190(1.09); C204(1.09)  LDD0921  [17]
 LDCM0324  AC60 HEK-293T C131(0.68)  LDD0922  [17]
 LDCM0325  AC61 HEK-293T C131(1.45)  LDD0923  [17]
 LDCM0326  AC62 HEK-293T C131(1.09)  LDD0924  [17]
 LDCM0327  AC63 HEK-293T C131(1.43)  LDD0925  [17]
 LDCM0328  AC64 HEK-293T C131(1.14)  LDD0926  [17]
 LDCM0329  AC65 HEK-293T C131(1.27)  LDD0927  [17]
 LDCM0330  AC66 HEK-293T C131(1.63)  LDD0928  [17]
 LDCM0331  AC67 HEK-293T C131(1.60)  LDD0929  [17]
 LDCM0332  AC68 HEK-293T C190(0.88); C204(0.88)  LDD0930  [17]
 LDCM0333  AC69 HEK-293T C190(1.06); C204(1.06)  LDD0931  [17]
 LDCM0334  AC7 HEK-293T C190(1.00); C204(1.00)  LDD0932  [17]
 LDCM0335  AC70 HEK-293T C190(0.99); C204(0.99)  LDD0933  [17]
 LDCM0336  AC71 HEK-293T C190(0.98); C204(0.98)  LDD0934  [17]
 LDCM0337  AC72 HEK-293T C190(1.14); C204(1.14)  LDD0935  [17]
 LDCM0338  AC73 HEK-293T C190(1.21); C204(1.21)  LDD0936  [17]
 LDCM0339  AC74 HEK-293T C190(1.04); C204(1.04)  LDD0937  [17]
 LDCM0340  AC75 HEK-293T C190(0.91); C204(0.91)  LDD0938  [17]
 LDCM0341  AC76 HEK-293T C190(0.83); C204(0.83)  LDD0939  [17]
 LDCM0342  AC77 HEK-293T C190(1.00); C204(1.00)  LDD0940  [17]
 LDCM0343  AC78 HEK-293T C190(1.03); C204(1.03)  LDD0941  [17]
 LDCM0344  AC79 HEK-293T C190(1.17); C204(1.17)  LDD0942  [17]
 LDCM0345  AC8 HEK-293T C190(1.12); C204(1.12)  LDD0943  [17]
 LDCM0346  AC80 HEK-293T C190(0.94); C204(0.94)  LDD0944  [17]
 LDCM0347  AC81 HEK-293T C190(0.86); C204(0.86)  LDD0945  [17]
 LDCM0348  AC82 HEK-293T C190(0.99); C204(0.99)  LDD0946  [17]
 LDCM0349  AC83 HEK-293T C131(1.32); C190(0.93); C204(0.93)  LDD0947  [17]
 LDCM0350  AC84 HEK-293T C131(1.25); C190(0.99); C204(0.99)  LDD0948  [17]
 LDCM0351  AC85 HEK-293T C131(0.86); C190(0.89); C204(0.89)  LDD0949  [17]
 LDCM0352  AC86 HEK-293T C131(0.94); C190(1.18); C204(1.18)  LDD0950  [17]
 LDCM0353  AC87 HEK-293T C131(1.07); C190(0.96); C204(0.96)  LDD0951  [17]
 LDCM0354  AC88 HEK-293T C131(0.83); C190(1.13); C204(1.13)  LDD0952  [17]
 LDCM0355  AC89 HEK-293T C131(1.23); C190(1.11); C204(1.11)  LDD0953  [17]
 LDCM0357  AC90 HEK-293T C131(1.05); C190(1.06); C204(1.06)  LDD0955  [17]
 LDCM0358  AC91 HEK-293T C131(1.15); C190(1.04); C204(1.04)  LDD0956  [17]
 LDCM0359  AC92 HEK-293T C131(1.16); C190(1.13); C204(1.13)  LDD0957  [17]
 LDCM0360  AC93 HEK-293T C131(1.19); C190(1.27); C204(1.27)  LDD0958  [17]
 LDCM0361  AC94 HEK-293T C131(0.81); C190(0.93); C204(0.93)  LDD0959  [17]
 LDCM0362  AC95 HEK-293T C131(1.15); C190(0.98); C204(0.98)  LDD0960  [17]
 LDCM0363  AC96 HEK-293T C131(1.31); C190(1.10); C204(1.10)  LDD0961  [17]
 LDCM0364  AC97 HEK-293T C131(0.99); C190(1.15); C204(1.15)  LDD0962  [17]
 LDCM0365  AC98 HEK-293T C131(1.12); C190(0.95); C204(0.95)  LDD0963  [17]
 LDCM0366  AC99 HEK-293T C131(1.05); C190(1.03); C204(1.03)  LDD0964  [17]
 LDCM0520  AKOS000195272 MDA-MB-231 C261(1.36)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C190(1.12); C204(1.12)  LDD0846  [17]
 LDCM0356  AKOS034007680 HEK-293T C190(0.98); C204(0.98)  LDD0954  [17]
 LDCM0275  AKOS034007705 HEK-293T C190(1.42); C204(1.42)  LDD0873  [17]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [5]
 LDCM0367  CL1 PaTu 8988t C190(0.86); C204(0.86)  LDD1246  [17]
 LDCM0368  CL10 PaTu 8988t C190(0.99); C204(0.99)  LDD1247  [17]
 LDCM0369  CL100 HEK-293T C190(0.91); C204(0.91)  LDD0967  [17]
 LDCM0370  CL101 HEK-293T C190(1.25); C204(1.25)  LDD0968  [17]
 LDCM0371  CL102 HEK-293T C190(0.92); C204(0.92)  LDD0969  [17]
 LDCM0372  CL103 HEK-293T C190(1.23); C204(1.23)  LDD0970  [17]
 LDCM0373  CL104 HEK-293T C190(1.10); C204(1.10)  LDD0971  [17]
 LDCM0374  CL105 HEK-293T C131(1.04)  LDD0972  [17]
 LDCM0375  CL106 HEK-293T C131(1.02)  LDD0973  [17]
 LDCM0376  CL107 HEK-293T C131(1.46)  LDD0974  [17]
 LDCM0377  CL108 HEK-293T C131(1.05)  LDD0975  [17]
 LDCM0378  CL109 HEK-293T C131(0.96)  LDD0976  [17]
 LDCM0379  CL11 PaTu 8988t C190(0.63); C204(0.63)  LDD1258  [17]
 LDCM0380  CL110 HEK-293T C131(1.20)  LDD0978  [17]
 LDCM0381  CL111 HEK-293T C131(1.23)  LDD0979  [17]
 LDCM0382  CL112 PaTu 8988t C131(0.65)  LDD1261  [17]
 LDCM0383  CL113 PaTu 8988t C131(0.80)  LDD1262  [17]
 LDCM0384  CL114 PaTu 8988t C131(0.77)  LDD1263  [17]
 LDCM0385  CL115 PaTu 8988t C131(0.93)  LDD1264  [17]
 LDCM0386  CL116 PaTu 8988t C131(0.87)  LDD1265  [17]
 LDCM0387  CL117 HEK-293T C190(0.55); C204(0.55)  LDD0985  [17]
 LDCM0388  CL118 HEK-293T C190(0.77); C204(0.77)  LDD0986  [17]
 LDCM0389  CL119 HEK-293T C190(0.84); C204(0.84)  LDD0987  [17]
 LDCM0390  CL12 PaTu 8988t C190(0.74); C204(0.74)  LDD1269  [17]
 LDCM0391  CL120 HEK-293T C190(0.79); C204(0.79)  LDD0989  [17]
 LDCM0392  CL121 HEK-293T C190(0.89); C204(0.89)  LDD0990  [17]
 LDCM0393  CL122 HEK-293T C190(0.91); C204(0.91)  LDD0991  [17]
 LDCM0394  CL123 HEK-293T C190(0.87); C204(0.87)  LDD0992  [17]
 LDCM0395  CL124 HEK-293T C190(0.90); C204(0.90)  LDD0993  [17]
 LDCM0396  CL125 HEK-293T C131(1.29)  LDD0994  [17]
 LDCM0397  CL126 HEK-293T C131(0.83)  LDD0995  [17]
 LDCM0398  CL127 HEK-293T C131(1.29)  LDD0996  [17]
 LDCM0399  CL128 HEK-293T C131(0.90)  LDD0997  [17]
 LDCM0400  CL13 PaTu 8988t C190(0.81); C204(0.81)  LDD1279  [17]
 LDCM0401  CL14 PaTu 8988t C190(0.78); C204(0.78)  LDD1280  [17]
 LDCM0402  CL15 PaTu 8988t C190(0.74); C204(0.74)  LDD1281  [17]
 LDCM0403  CL16 PaTu 8988t C131(1.11); C190(1.32); C204(1.32)  LDD1282  [17]
 LDCM0404  CL17 PaTu 8988t C131(0.93); C190(1.29); C204(1.29)  LDD1283  [17]
 LDCM0405  CL18 PaTu 8988t C131(1.25); C190(1.06); C204(1.06)  LDD1284  [17]
 LDCM0406  CL19 PaTu 8988t C131(1.09); C190(1.24); C204(1.24)  LDD1285  [17]
 LDCM0407  CL2 PaTu 8988t C190(0.81); C204(0.81)  LDD1286  [17]
 LDCM0408  CL20 PaTu 8988t C131(1.09); C190(1.03); C204(1.03)  LDD1287  [17]
 LDCM0409  CL21 PaTu 8988t C131(1.16); C190(1.05); C204(1.05)  LDD1288  [17]
 LDCM0410  CL22 PaTu 8988t C131(1.17); C190(0.98); C204(0.98)  LDD1289  [17]
 LDCM0411  CL23 PaTu 8988t C131(1.37); C190(1.18); C204(1.18)  LDD1290  [17]
 LDCM0412  CL24 PaTu 8988t C131(1.34); C190(2.07); C204(2.07)  LDD1291  [17]
 LDCM0413  CL25 PaTu 8988t C131(1.36); C190(1.04); C204(1.04)  LDD1292  [17]
 LDCM0414  CL26 PaTu 8988t C131(1.10); C190(0.80); C204(0.80)  LDD1293  [17]
 LDCM0415  CL27 PaTu 8988t C131(1.30); C190(1.60); C204(1.60)  LDD1294  [17]
 LDCM0416  CL28 PaTu 8988t C131(1.32); C190(1.12); C204(1.12)  LDD1295  [17]
 LDCM0417  CL29 PaTu 8988t C131(1.33); C190(0.78); C204(0.78)  LDD1296  [17]
 LDCM0418  CL3 PaTu 8988t C190(0.98); C204(0.98)  LDD1297  [17]
 LDCM0419  CL30 PaTu 8988t C131(1.18); C190(1.13); C204(1.13)  LDD1298  [17]
 LDCM0420  CL31 PaTu 8988t C131(1.03)  LDD1299  [17]
 LDCM0421  CL32 PaTu 8988t C131(1.13)  LDD1300  [17]
 LDCM0422  CL33 PaTu 8988t C131(1.80)  LDD1301  [17]
 LDCM0423  CL34 PaTu 8988t C131(1.38)  LDD1302  [17]
 LDCM0424  CL35 PaTu 8988t C131(1.43)  LDD1303  [17]
 LDCM0425  CL36 PaTu 8988t C131(0.71)  LDD1304  [17]
 LDCM0426  CL37 PaTu 8988t C131(1.35)  LDD1305  [17]
 LDCM0428  CL39 PaTu 8988t C131(1.32)  LDD1307  [17]
 LDCM0429  CL4 PaTu 8988t C190(0.93); C204(0.93)  LDD1308  [17]
 LDCM0430  CL40 PaTu 8988t C131(1.36)  LDD1309  [17]
 LDCM0431  CL41 PaTu 8988t C131(1.41)  LDD1310  [17]
 LDCM0432  CL42 PaTu 8988t C131(1.22)  LDD1311  [17]
 LDCM0433  CL43 PaTu 8988t C131(1.33)  LDD1312  [17]
 LDCM0434  CL44 PaTu 8988t C131(1.61)  LDD1313  [17]
 LDCM0435  CL45 PaTu 8988t C131(1.49)  LDD1314  [17]
 LDCM0436  CL46 HEK-293T C261(1.01); C131(1.09); C511(0.95); C307(0.83)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C131(0.95); C511(0.97); C307(1.30); C166(1.03)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C261(0.90); C131(0.94); C511(1.01); C307(0.44)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C131(0.96); C511(1.04); C307(0.91); C204(0.98)  LDD1643  [18]
 LDCM0440  CL5 PaTu 8988t C190(0.89); C204(0.89)  LDD1319  [17]
 LDCM0441  CL50 HEK-293T C131(1.02); C511(0.96); C307(1.05); C204(0.94)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C261(1.50); C131(0.98); C511(0.99); C307(0.86)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C131(1.02); C511(1.01); C307(1.07); C204(1.16)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C261(0.87); C131(1.04); C511(0.84); C307(0.92)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C131(0.92); C511(1.05); C307(0.77); C204(0.91)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C261(0.97); C131(0.82); C511(0.97); C307(0.76)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C131(0.86); C511(0.97); C307(0.83); C204(1.23)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C261(0.96); C131(1.10); C511(0.97); C307(0.83)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C131(1.19); C511(1.02); C307(1.32); C166(1.51)  LDD1653  [18]
 LDCM0451  CL6 PaTu 8988t C190(0.69); C204(0.69)  LDD1330  [17]
 LDCM0452  CL60 HEK-293T C261(1.03); C131(0.99); C511(1.06); C307(0.64)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C131(0.94); C511(1.00); C307(0.95); C204(0.93)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C131(1.11); C511(1.00); C307(0.99); C204(0.89)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C131(1.14); C511(0.99); C307(1.05); C204(0.70)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C261(0.88); C131(0.83); C511(0.98); C307(0.88)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C131(1.18); C511(1.09); C307(0.94); C204(1.07)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C261(1.14); C131(1.03); C511(1.08); C307(1.04)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C131(1.10); C511(1.02); C307(0.97); C204(1.09)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C261(1.02); C131(0.85); C511(0.95); C307(0.67)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C131(0.96); C511(1.03); C307(0.74); C204(1.15)  LDD1664  [18]
 LDCM0462  CL7 PaTu 8988t C190(0.76); C204(0.76)  LDD1341  [17]
 LDCM0463  CL70 HEK-293T C261(1.20); C131(1.10); C511(1.00); C307(0.83)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C131(1.41); C511(1.06); C307(1.46); C166(0.83)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C261(0.99); C131(1.14); C511(0.95); C307(0.72)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C131(0.96); C511(1.03); C307(0.97); C204(1.01)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C131(1.03); C511(0.95); C307(1.04); C204(1.03)  LDD1670  [18]
 LDCM0469  CL76 PaTu 8988t C190(0.93); C204(0.93)  LDD1348  [17]
 LDCM0470  CL77 PaTu 8988t C190(0.88); C204(0.88)  LDD1349  [17]
 LDCM0471  CL78 PaTu 8988t C190(1.18); C204(1.18)  LDD1350  [17]
 LDCM0472  CL79 PaTu 8988t C190(1.03); C204(1.03)  LDD1351  [17]
 LDCM0473  CL8 PaTu 8988t C190(0.84); C204(0.84)  LDD1352  [17]
 LDCM0474  CL80 PaTu 8988t C190(0.92); C204(0.92)  LDD1353  [17]
 LDCM0475  CL81 PaTu 8988t C190(0.90); C204(0.90)  LDD1354  [17]
 LDCM0476  CL82 PaTu 8988t C190(1.04); C204(1.04)  LDD1355  [17]
 LDCM0477  CL83 PaTu 8988t C190(1.01); C204(1.01)  LDD1356  [17]
 LDCM0478  CL84 PaTu 8988t C190(0.86); C204(0.86)  LDD1357  [17]
 LDCM0479  CL85 PaTu 8988t C190(1.22); C204(1.22)  LDD1358  [17]
 LDCM0480  CL86 PaTu 8988t C190(0.99); C204(0.99)  LDD1359  [17]
 LDCM0481  CL87 PaTu 8988t C190(0.75); C204(0.75)  LDD1360  [17]
 LDCM0482  CL88 PaTu 8988t C190(0.91); C204(0.91)  LDD1361  [17]
 LDCM0483  CL89 PaTu 8988t C190(0.94); C204(0.94)  LDD1362  [17]
 LDCM0484  CL9 PaTu 8988t C190(0.72); C204(0.72)  LDD1363  [17]
 LDCM0485  CL90 PaTu 8988t C190(0.91); C204(0.91)  LDD1364  [17]
 LDCM0486  CL91 HEK-293T C190(1.00); C204(1.00)  LDD1084  [17]
 LDCM0487  CL92 HEK-293T C190(0.87); C204(0.87)  LDD1085  [17]
 LDCM0488  CL93 HEK-293T C190(0.81); C204(0.81)  LDD1086  [17]
 LDCM0489  CL94 HEK-293T C190(0.93); C204(0.93)  LDD1087  [17]
 LDCM0490  CL95 HEK-293T C190(0.91); C204(0.91)  LDD1088  [17]
 LDCM0491  CL96 HEK-293T C190(0.82); C204(0.82)  LDD1089  [17]
 LDCM0492  CL97 HEK-293T C190(0.91); C204(0.91)  LDD1090  [17]
 LDCM0493  CL98 HEK-293T C190(0.88); C204(0.88)  LDD1091  [17]
 LDCM0494  CL99 HEK-293T C190(0.89); C204(0.89)  LDD1092  [17]
 LDCM0495  E2913 HEK-293T C131(1.00); C511(1.04); C307(1.05); C204(0.94)  LDD1698  [18]
 LDCM0468  Fragment33 HEK-293T C131(1.15); C511(1.10); C307(0.97); C204(0.91)  LDD1671  [18]
 LDCM0427  Fragment51 PaTu 8988t C131(1.46)  LDD1306  [17]
 LDCM0022  KB02 HEK-293T C131(0.97); C307(0.96); C511(0.97); C190(0.97)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C131(1.07); C307(1.11); C511(1.08); C190(1.08)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C261(1.22)  LDD3310  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C261(1.33)  LDD2093  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C261(1.07)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C261(1.09)  LDD2104  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C261(1.13)  LDD2108  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C261(0.68)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C261(1.16)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C261(0.99)  LDD2114  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C261(0.97)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C261(1.17)  LDD2129  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C261(0.83)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C261(0.81)  LDD2140  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C261(0.63)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C261(1.07)  LDD2146  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2-hydroxyacyl-CoA lyase 1 (HACL1) TPP enzyme family Q9UJ83
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Melanoma-associated antigen B6 (MAGEB6) . Q8N7X4
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402