Details of the Target

General Information of Target

Target ID LDTP13007
Target Name Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)
Gene Name CALCOCO1
Gene ID 57658
Synonyms
KIAA1536; Calcium-binding and coiled-coil domain-containing protein 1; Calphoglin; Coiled-coil coactivator protein; Sarcoma antigen NY-SAR-3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPPPAEVTDPSHAPAVLRQLNEQRLRGLFCDVTLIAGDTKFPAHRSVLAASSPFFREALL
TSAPLPLPPATGGAAPNPATTTAASSSSSSSSSSSSSSSSASSSSSSSSSSPPPASPPAS
SPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGE
GGDAWVPPTPAPMATSQPEEDSFGPGPRPAGEWEGDRAEAQAPDLQCSLPRRPLPCPQCG
KSFIHPKRLQTHEAQCRRGASTRGSTGLGAGGAGPGGPAGVDASALPPPVGFRGGPEHVV
KVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHT
GERRYQCIFCWETFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPKLNTLKLYRLLPM
RAAKRPYKTYSQGAPEAPLSPTLNTPAPVAMPASPPPGPPPAPEPGPPPSVITFAHPAPS
VIVHGGSSSGGGGSGTASTGGSQAASVITYTAPPRPPKKREYPPPPPEPAATPTSPATAV
SPATAAGPAMATTTEEAKGRNPRAGRTLTYTAKPVGGIGGGGGPPTGAGRGPSQLQAPPP
LCQITVRIGEEAIVKRRISETDLRPGELSGEEMEESEEDEEEEDEEEEEEDEEESKAGGE
DQLWRPYYSYKPKRKAGAAGGASVGGSGLPRGRRPPRWRQKLERRSWEETPAAESPAGRA
RTERRHRCGDCAQTFTTLRKLRKHQEAHGGGSHSSRAGRRPSTRFTCPHCAKVCKTAAAL
SRHGQRHAAERPGGTPTPVIAYSKGSAGTRPGDVKEEAPQEMQVSSSSGEAGGGSTAAEE
ASETASLQDPIISGGEEPPVVASGGSYVYPPVQEFPLALIGGGREPGGGRGKSGSEGPVG
AGEGDRMEGIGAAKVTFYPEPYPLVYGPQLLAAYPYNFSNLAALPVALNMVLPDEKGAGA
LPFLPGVFGYAVNPQAAPPAPPTPPPPTLPPPIPPKGEGERAGVERTQKGDVG
Target Bioclass
Other
Family
CALCOCO family
Subcellular location
Cytoplasm
Function
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells.; Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {|Ref.1}.
Uniprot ID
Q9P1Z2
Ensemble ID
ENST00000262059.8
HGNC ID
HGNC:29306

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MEWO SNV: p.P114L DBIA    Probe Info 
MFE296 SNV: p.R480C .
MFE319 SNV: p.A527V .
SW756 SNV: p.E513D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K325(0.91)  LDD0277  [2]
Probe 1
 Probe Info  		Y24(13.07)  LDD3495  [3]
DA-P3
 Probe Info  		11.75  LDD0180  [4]
DBIA
 Probe Info  		C57(13.40)  LDD0209  [5]
IA-alkyne
 Probe Info  		C57(20.00)  LDD1703  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		7.52  LDD1850  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C110(0.89); C57(0.98)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C110(0.93); C32(0.95); C57(0.88)  LDD1508  [9]
 LDCM0216  AC100 HEK-293T C110(1.04); C57(0.95)  LDD0814  [10]
 LDCM0217  AC101 HEK-293T C110(0.83); C57(1.09)  LDD0815  [10]
 LDCM0218  AC102 HEK-293T C110(0.90); C57(0.92)  LDD0816  [10]
 LDCM0219  AC103 HEK-293T C110(0.95); C57(0.95)  LDD0817  [10]
 LDCM0220  AC104 HEK-293T C110(0.87); C57(1.03)  LDD0818  [10]
 LDCM0221  AC105 HEK-293T C110(1.15); C57(1.02)  LDD0819  [10]
 LDCM0222  AC106 HEK-293T C110(1.52); C57(0.89)  LDD0820  [10]
 LDCM0223  AC107 HEK-293T C110(0.95); C57(1.03)  LDD0821  [10]
 LDCM0224  AC108 HEK-293T C110(1.25); C57(0.96)  LDD0822  [10]
 LDCM0225  AC109 HEK-293T C110(0.95); C57(0.85)  LDD0823  [10]
 LDCM0226  AC11 HEK-293T C110(0.89)  LDD1509  [9]
 LDCM0227  AC110 HEK-293T C110(1.05); C57(0.58)  LDD0825  [10]
 LDCM0228  AC111 HEK-293T C110(1.16); C57(0.40)  LDD0826  [10]
 LDCM0229  AC112 HEK-293T C110(0.97); C57(0.47)  LDD0827  [10]
 LDCM0237  AC12 HEK-293T C110(1.04); C32(1.05)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C110(1.09); C555(1.03)  LDD1512  [9]
 LDCM0263  AC143 HEK-293T C110(1.17); C57(1.03)  LDD0861  [10]
 LDCM0264  AC144 HEK-293T C110(1.02); C57(0.85)  LDD0862  [10]
 LDCM0265  AC145 HEK-293T C110(1.24); C57(0.70)  LDD0863  [10]
 LDCM0266  AC146 HEK-293T C110(0.86); C57(0.70)  LDD0864  [10]
 LDCM0267  AC147 HEK-293T C110(1.02); C57(0.69)  LDD0865  [10]
 LDCM0268  AC148 HEK-293T C110(1.59); C57(1.01)  LDD0866  [10]
 LDCM0269  AC149 HEK-293T C110(1.70); C57(0.93)  LDD0867  [10]
 LDCM0270  AC15 HEK-293T C110(0.94); C32(1.09); C555(1.01)  LDD1513  [9]
 LDCM0271  AC150 HEK-293T C110(1.19); C57(1.02)  LDD0869  [10]
 LDCM0272  AC151 HEK-293T C110(0.93); C57(0.89)  LDD0870  [10]
 LDCM0273  AC152 HEK-293T C110(1.05); C57(0.79)  LDD0871  [10]
 LDCM0274  AC153 HEK-293T C110(1.09); C57(0.80)  LDD0872  [10]
 LDCM0621  AC154 HEK-293T C110(1.16); C57(0.90)  LDD2162  [10]
 LDCM0622  AC155 HEK-293T C110(0.94); C57(1.04)  LDD2163  [10]
 LDCM0623  AC156 HEK-293T C110(1.39); C57(0.63)  LDD2164  [10]
 LDCM0624  AC157 HEK-293T C110(1.32); C57(0.41)  LDD2165  [10]
 LDCM0276  AC17 HEK-293T C110(0.92); C57(1.04)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C110(0.95); C32(0.76); C57(1.04)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C110(0.91)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C110(0.94); C32(1.21); C57(0.84)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C110(1.11); C32(0.96)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C110(1.03); C555(1.04)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C110(0.91); C555(1.01)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C110(1.01); C32(1.18); C555(1.02)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C110(1.06); C32(0.82)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C110(0.91); C57(1.01)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C110(0.90); C32(0.89); C57(1.00)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C110(0.93)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C110(1.02); C32(0.93)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C110(0.97); C555(1.01)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C110(1.08)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C110(1.09); C555(1.03)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C110(0.94); C32(0.95); C555(1.02)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C110(0.94); C32(1.16)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C110(0.97); C57(0.98)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C110(1.03); C32(0.82); C57(0.83)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C110(0.99)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C110(1.07); C32(1.08)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C110(1.08); C555(1.07)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C110(1.07); C555(1.00)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C110(1.00); C32(1.15); C555(0.93)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C110(0.99); C32(0.99)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C110(1.03); C32(1.07)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C110(0.87); C57(0.98)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C110(0.99); C32(0.92); C57(0.95)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C110(0.98)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C110(1.06); C32(1.10)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C110(1.04); C555(1.05)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C110(0.91)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C110(0.68)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C110(0.91)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C110(0.81)  LDD0909  [10]
 LDCM0312  AC5 HEK-293T C110(1.05); C555(0.98)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C110(0.85)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C110(0.73)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C110(0.73)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C110(0.67)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C110(0.72)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C110(0.88)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C110(0.68)  LDD0917  [10]
 LDCM0320  AC57 HEK-293T C110(1.27)  LDD0918  [10]
 LDCM0321  AC58 HEK-293T C110(1.11)  LDD0919  [10]
 LDCM0322  AC59 HEK-293T C110(1.20)  LDD0920  [10]
 LDCM0323  AC6 HEK-293T C110(1.14); C555(0.96)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C110(1.33)  LDD0922  [10]
 LDCM0325  AC61 HEK-293T C110(0.80)  LDD0923  [10]
 LDCM0326  AC62 HEK-293T C110(0.87)  LDD0924  [10]
 LDCM0327  AC63 HEK-293T C110(0.75)  LDD0925  [10]
 LDCM0328  AC64 HEK-293T C110(0.99)  LDD0926  [10]
 LDCM0329  AC65 HEK-293T C110(0.67)  LDD0927  [10]
 LDCM0330  AC66 HEK-293T C110(0.94)  LDD0928  [10]
 LDCM0331  AC67 HEK-293T C110(0.76)  LDD0929  [10]
 LDCM0332  AC68 HEK-293T C110(1.33); C57(1.15)  LDD0930  [10]
 LDCM0333  AC69 HEK-293T C110(0.76); C57(0.92)  LDD0931  [10]
 LDCM0334  AC7 HEK-293T C110(0.95); C32(1.24); C555(0.91)  LDD1568  [9]
 LDCM0335  AC70 HEK-293T C110(0.72); C57(1.04)  LDD0933  [10]
 LDCM0336  AC71 HEK-293T C110(0.75); C57(1.17)  LDD0934  [10]
 LDCM0337  AC72 HEK-293T C110(0.70); C57(1.08)  LDD0935  [10]
 LDCM0338  AC73 HEK-293T C110(0.83); C57(1.11)  LDD0936  [10]
 LDCM0339  AC74 HEK-293T C110(0.96); C57(1.54)  LDD0937  [10]
 LDCM0340  AC75 HEK-293T C110(0.67); C57(1.45)  LDD0938  [10]
 LDCM0341  AC76 HEK-293T C110(0.87); C57(1.14)  LDD0939  [10]
 LDCM0342  AC77 HEK-293T C110(0.90); C57(0.85)  LDD0940  [10]
 LDCM0343  AC78 HEK-293T C110(0.72); C57(1.03)  LDD0941  [10]
 LDCM0344  AC79 HEK-293T C110(0.84); C57(1.09)  LDD0942  [10]
 LDCM0345  AC8 HEK-293T C110(0.99); C32(0.82)  LDD1569  [9]
 LDCM0346  AC80 HEK-293T C110(0.68); C57(0.97)  LDD0944  [10]
 LDCM0347  AC81 HEK-293T C110(0.67); C57(1.26)  LDD0945  [10]
 LDCM0348  AC82 HEK-293T C110(0.67); C57(1.73)  LDD0946  [10]
 LDCM0349  AC83 HEK-293T C57(1.14)  LDD0947  [10]
 LDCM0350  AC84 HEK-293T C57(1.13)  LDD0948  [10]
 LDCM0351  AC85 HEK-293T C57(0.87)  LDD0949  [10]
 LDCM0352  AC86 HEK-293T C57(1.23)  LDD0950  [10]
 LDCM0353  AC87 HEK-293T C57(1.30)  LDD0951  [10]
 LDCM0354  AC88 HEK-293T C57(1.43)  LDD0952  [10]
 LDCM0355  AC89 HEK-293T C57(1.10)  LDD0953  [10]
 LDCM0357  AC90 HEK-293T C57(1.32)  LDD0955  [10]
 LDCM0358  AC91 HEK-293T C57(1.11)  LDD0956  [10]
 LDCM0359  AC92 HEK-293T C57(1.19)  LDD0957  [10]
 LDCM0360  AC93 HEK-293T C57(1.63)  LDD0958  [10]
 LDCM0361  AC94 HEK-293T C57(1.15)  LDD0959  [10]
 LDCM0362  AC95 HEK-293T C57(1.20)  LDD0960  [10]
 LDCM0363  AC96 HEK-293T C57(1.34)  LDD0961  [10]
 LDCM0364  AC97 HEK-293T C57(0.53)  LDD0962  [10]
 LDCM0365  AC98 HEK-293T C110(1.24); C57(0.95)  LDD0963  [10]
 LDCM0366  AC99 HEK-293T C110(0.94); C57(0.86)  LDD0964  [10]
 LDCM0248  AKOS034007472 HEK-293T C110(0.92); C555(0.99)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C110(1.00); C57(1.05)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C110(0.93); C32(1.02)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 11.88  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C110(1.07); C32(0.88)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C110(1.37); C555(1.19)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C110(0.94); C32(1.07)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C110(1.02); C32(0.82)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C110(1.06)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C110(0.99)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C110(0.94); C32(0.87)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C110(1.08); C32(1.05)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C110(0.92)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C110(0.91)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C110(0.95); C32(0.81)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C110(0.99); C32(0.73)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C110(1.01); C32(1.46); C555(1.21)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C110(0.99)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C110(1.06)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C110(0.93); C32(0.82)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C110(1.06); C32(0.71)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C110(1.02)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C110(0.95)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C110(1.01); C32(1.07)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C110(1.17); C32(0.83)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C110(0.91)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C110(1.01)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C110(0.92); C32(1.27)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C110(1.00); C32(1.03)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C110(0.78)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C110(0.87)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C110(0.85)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C110(0.75)  LDD0993  [10]
 LDCM0396  CL125 HEK-293T C110(1.05)  LDD0994  [10]
 LDCM0397  CL126 HEK-293T C110(1.31)  LDD0995  [10]
 LDCM0398  CL127 HEK-293T C110(1.04)  LDD0996  [10]
 LDCM0399  CL128 HEK-293T C110(1.35)  LDD0997  [10]
 LDCM0400  CL13 HEK-293T C110(1.13); C32(0.88)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C110(1.03)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C110(1.09)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C110(0.94); C32(1.00)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C110(1.04); C57(1.10)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C110(0.94); C32(0.96); C57(0.92)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C110(1.09)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C110(1.04)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C110(1.09); C32(1.05)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C110(1.23); C555(1.30)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C110(1.33); C555(1.30)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C110(1.06); C32(1.75); C555(1.30)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C110(0.93); C32(1.33)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C110(1.12); C32(0.78)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C110(1.02)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C110(1.29)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C110(0.95); C32(1.00)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C110(1.02); C57(1.01)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C110(0.92)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C110(0.96); C32(0.93); C57(1.05)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C110(0.79); C57(1.22)  LDD1018  [10]
 LDCM0421  CL32 HEK-293T C110(1.00); C57(1.27)  LDD1019  [10]
 LDCM0422  CL33 HEK-293T C110(0.67); C57(1.02)  LDD1020  [10]
 LDCM0423  CL34 HEK-293T C110(0.96); C57(0.99)  LDD1021  [10]
 LDCM0424  CL35 HEK-293T C110(0.83); C57(1.02)  LDD1022  [10]
 LDCM0425  CL36 HEK-293T C110(0.74); C57(1.05)  LDD1023  [10]
 LDCM0426  CL37 HEK-293T C110(0.74); C57(1.25)  LDD1024  [10]
 LDCM0428  CL39 HEK-293T C110(0.64); C57(0.98)  LDD1026  [10]
 LDCM0429  CL4 HEK-293T C110(1.06); C32(0.83)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C110(0.62); C57(1.36)  LDD1028  [10]
 LDCM0431  CL41 HEK-293T C110(0.60); C57(0.90)  LDD1029  [10]
 LDCM0432  CL42 HEK-293T C110(0.58); C57(1.02)  LDD1030  [10]
 LDCM0433  CL43 HEK-293T C110(0.62); C57(1.04)  LDD1031  [10]
 LDCM0434  CL44 HEK-293T C110(0.69); C57(1.10)  LDD1032  [10]
 LDCM0435  CL45 HEK-293T C110(0.61); C57(1.14)  LDD1033  [10]
 LDCM0436  CL46 HEK-293T C57(0.87)  LDD1034  [10]
 LDCM0437  CL47 HEK-293T C57(0.88)  LDD1035  [10]
 LDCM0438  CL48 HEK-293T C57(0.86)  LDD1036  [10]
 LDCM0439  CL49 HEK-293T C57(0.89)  LDD1037  [10]
 LDCM0440  CL5 HEK-293T C110(0.95); C57(1.04)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C57(0.81)  LDD1039  [10]
 LDCM0442  CL51 HEK-293T C57(1.06)  LDD1040  [10]
 LDCM0443  CL52 HEK-293T C57(0.96)  LDD1041  [10]
 LDCM0444  CL53 HEK-293T C57(1.07)  LDD1042  [10]
 LDCM0445  CL54 HEK-293T C57(0.88)  LDD1043  [10]
 LDCM0446  CL55 HEK-293T C57(0.93)  LDD1044  [10]
 LDCM0447  CL56 HEK-293T C57(0.80)  LDD1045  [10]
 LDCM0448  CL57 HEK-293T C57(1.01)  LDD1046  [10]
 LDCM0449  CL58 HEK-293T C57(1.10)  LDD1047  [10]
 LDCM0450  CL59 HEK-293T C57(0.89)  LDD1048  [10]
 LDCM0451  CL6 HEK-293T C110(0.90); C32(1.03); C57(1.00)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C57(0.89)  LDD1050  [10]
 LDCM0453  CL61 HEK-293T C110(0.58); C57(0.68)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C110(0.77); C57(0.73)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C110(0.46); C57(0.76)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C110(0.61); C57(0.71)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C110(0.53); C57(0.77)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C110(0.67); C57(0.82)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C110(0.61); C57(0.91)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C110(0.54); C57(1.02)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C110(0.55); C57(1.01)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C110(1.13)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C110(0.64); C57(0.79)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C110(0.49); C57(1.05)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C110(0.57); C57(0.77)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C110(0.58); C57(1.01)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C110(0.47); C57(0.86)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C110(1.15); C32(1.00)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C110(1.00); C57(1.21)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C110(0.96); C32(0.75); C57(0.90)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C110(0.92)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C110(1.11); C32(1.15)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C110(1.00); C32(0.88)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C110(0.95); C555(1.13)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C110(0.89); C555(1.13)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C110(1.01); C32(1.21); C555(1.13)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C110(0.99); C32(1.45)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C110(1.28); C32(0.76)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C110(1.06)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C110(1.11)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C110(0.90); C32(0.99)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C110(0.89); C57(0.99)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C110(1.19); C555(1.06)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C110(0.88); C32(1.48); C57(1.02)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C110(0.97)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C110(1.07); C32(0.97)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C110(1.07); C555(1.12)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C110(0.88); C555(1.14)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C110(0.97); C32(1.43); C555(1.09)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C110(0.93); C32(0.77)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C110(1.16); C32(0.72)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C110(0.98)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C110(0.98)  LDD1697  [9]
 LDCM0028  Dobutamine HEK-293T 11.75  LDD0180  [4]
 LDCM0495  E2913 HEK-293T C110(1.02)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C57(1.52)  LDD1702  [11]
 LDCM0625  F8 Ramos C57(1.11)  LDD2187  [12]
 LDCM0575  Fragment13 Ramos C57(1.14)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C57(0.91)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C57(1.76)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C57(0.94)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C57(0.76)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C57(0.78)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C57(0.79)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C57(1.05)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C57(0.81)  LDD2200  [12]
 LDCM0468  Fragment33 HEK-293T C110(0.39); C57(1.02)  LDD1066  [10]
 LDCM0596  Fragment38 Ramos C57(0.78)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C57(1.12)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C110(0.58); C57(1.23)  LDD1025  [10]
 LDCM0610  Fragment52 Ramos C57(0.99)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C57(1.40)  LDD2205  [12]
 LDCM0571  Fragment9 Ramos C57(1.95)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C110(1.04); C32(1.02); C57(0.86); C555(1.00)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C57(13.40)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C57(2.73)  LDD3310  [13]
 LDCM0032  Oleacein HEK-293T 5.23  LDD0184  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Isochorismatase domain-containing protein 1 (ISOC1) Isochorismatase family Q96CN7
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Dual specificity protein phosphatase 13B (DUSP13B) Protein-tyrosine phosphatase family Q9UII6
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Protein FAM161A (FAM161A) FAM161 family Q3B820
Phakinin (BFSP2) Intermediate filament family Q13515
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
TBC1 domain family member 15 (TBC1D15) . Q8TC07
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840