Details of the Target

General Information of Target

Target ID LDTP09397
Target Name Centrosome-associated protein ALMS1 (ALMS1)
Gene Name ALMS1
Gene ID 7840
Synonyms
KIAA0328; Centrosome-associated protein ALMS1; Alstrom syndrome protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEPEDLPWPGELEEEEEEEEEEEEEEEEAAAAAAANVDDVVVVEEVEEEAGRELDSDSHY
GPQHLESIDDEEDEEAKAWLQAHPGRILPPLSPPQHRYSEGERTSLEKIVPLTCHVWQQI
VYQGNSRTQISDTNVVCLETTAQRGSGDDQKTESWHCLPQEMDSSQTLDTSQTRFNVRTE
DTEVTDFPSLEEGILTQSENQVKEPNRDLFCSPLLVIQDSFASPDLPLLTCLTQDQEFAP
DSLFHQSELSFAPLRGIPDKSEDTEWSSRPSEVSEALFQATAEVASDLASSRFSVSQHPL
IGSTAVGSQCPFLPSEQGNNEETISSVDELKIPKDCDRYDDLCSYMSWKTRKDTQWPENN
LADKDQVSVATSFDITDENIATKRSDHFDAARSYGQYWTQEDSSKQAETYLTKGLQGKVE
SDVITLDGLNENAVVCSERVAELQRKPTRESEYHSSDLRMLRMSPDTVPKAPKHLKAGDT
SKGGIAKVTQSNLKSGITTTPVDSDIGSHLSLSLEDLSQLAVSSPLETTTGQHTDTLNQK
TLADTHLTEETLKVTAIPEPADQKTATPTVLSSSHSHRGKPSIFYQQGLPDSHLTEEALK
VSAAPGLADQTTGMSTLTSTSYSHREKPGTFYQQELPESNLTEEPLEVSAAPGPVEQKTG
IPTVSSTSHSHVEDLLFFYRQTLPDGHLTDQALKVSAVSGPADQKTGTATVLSTPHSHRE
KPGIFYQQEFADSHQTEETLTKVSATPGPADQKTEIPAVQSSSYSQREKPSILYPQDLAD
SHLPEEGLKVSAVAGPADQKTGLPTVPSSAYSHREKLLVFYQQALLDSHLPEEALKVSAV
SGPADGKTGTPAVTSTSSASSSLGEKPSAFYQQTLPNSHLTEEALKVSIVPGPGDQKTGI
PSAPSSFYSHREKPIIFSQQTLPDFLFPEEALKVSAVSVLAAQKTGTPTVSSNSHSHSEK
SSVFYQQELPDSDLPRESLKMSAIPGLTDQKTVPTPTVPSGSFSHREKPSIFYQQEWPDS
YATEKALKVSTGPGPADQKTEIPAVQSSSYPQREKPSVLYPQVLSDSHLPEESLKVSAFP
GPADQMTDTPAVPSTFYSQREKPGIFYQQTLPESHLPKEALKISVAPGLADQKTGTPTVT
STSYSQHREKPSIFHQQALPGTHIPEEAQKVSAVTGPGNQKTWIPRVLSTFYSQREKPGI
FYQQTLPGSHIPEEAQKVSPVLGPADQKTGTPTPTSASYSHTEKPGIFYQQVLPDNHPTE
EALKISVASEPVDQTTGTPAVTSTSYSQYREKPSIFYQQSLPSSHLTEEAKNVSAVPGPA
DQKTVIPILPSTFYSHTEKPGVFYQQVLPHSHPTEEALKISVASEPVDQTTGTPTVTSTS
YSQHTEKPSIFYQQSLPGSHLTEEAKNVSAVPGPGDRKTGIPTLPSTFYSHTEKPGSFYQ
QVLPHSHLPEEALEVSVAPGPVDQTIGTPTVTSPSSSFGEKPIVIYKQAFPEGHLPEESL
KVSVAPGPVGQTTGAPTITSPSYSQHRAKSGSFYQLALLGSQIPEEALRVSSAPGPADQT
TGIPTITSTSYSFGEKPIVNYKQAFPDGHLPEEALKVSIVSGPTEKKTDIPAGPLGSSAL
GEKPITFYRQALLDSPLNKEVVKVSAAPGPADQKTETLPVHSTSYSNRGKPVIFYQQTLS
DSHLPEEALKVPPVPGPDAQKTETPSVSSSLYSYREKPIVFYQQALPDSELTQEALKVSA
VPQPADQKTGLSTVTSSFYSHTEKPNISYQQELPDSHLTEEALKVSNVPGPADQKTGVST
VTSTSYSHREKPIVSYQRELPHFTEAGLKILRVPGPADQKTGINILPSNSYPQREHSVIS
YEQELPDLTEVTLKAIGVPGPADQKTGIQIASSSSYSNREKASIFHQQELPDVTEEALNV
FVVPGQGDRKTEIPTVPLSYYSRREKPSVISQQELPDSHLTEEALKVSPVSIPAEQKTGI
PIGLSSSYSHSHKEKLKISTVHIPDDQKTEFPAATLSSYSQIEKPKISTVIGPNDQKTPS
QTAFHSSYSQTVKPNILFQQQLPDRDQSKGILKISAVPELTDVNTGKPVSLSSSYFHREK
SNIFSPQELPGSHVTEDVLKVSTIPGPAGQKTVLPTALPSSFSHREKPDIFYQKDLPDRH
LTEDALKISSALGQADQITGLQTVPSGTYSHGENHKLVSEHVQRLIDNLNSSDSSVSSNN
VLLNSQADDRVVINKPESAGFRDVGSEEIQDAENSAKTLKEIRTLLMEAENMALKRCNFP
APLARFRDISDISFIQSKKVVCFKEPSSTGVSNGDLLHRQPFTEESPSSRCIQKDIGTQT
NLKCRRGIENWEFISSTTVRSPLQEAESKVSMALEETLRQYQAAKSVMRSEPEGCSGTIG
NKIIIPMMTVIKSDSSSDASDGNGSCSWDSNLPESLESVSDVLLNFFPYVSPKTSITDSR
EEEGVSESEDGGGSSVDSLAAHVKNLLQCESSLNHAKEILRNAEEEESRVRAHAWNMKFN
LAHDCGYSISELNEDDRRKVEEIKAELFGHGRTTDLSKGLQSPRGMGCKPEAVCSHIIIE
SHEKGCFRTLTSEHPQLDRHPCAFRSAGPSEMTRGRQNPSSCRAKHVNLSASLDQNNSHF
KVWNSLQLKSHSPFQNFIPDEFKISKGLRMPFDEKMDPWLSELVEPAFVPPKEVDFHSSS
QMPSPEPMKKFTTSITFSSHRHSKCISNSSVVKVGVTEGSQCTGASVGVFNSHFTEEQNP
PRDLKQKTSSPSSFKMHSNSQDKEVTILAEGRRQSQKLPVDFERSFQEEKPLERSDFTGS
HSEPSTRANCSNFKEIQISDNHTLISMGRPSSTLGVNRSSSRLGVKEKNVTITPDLPSCI
FLEQRELFEQSKAPRADDHVRKHHSPSPQHQDYVAPDLPSCIFLEQRELFEQCKAPYVDH
QMRENHSPLPQGQDSIASDLPSPISLEQCQSKAPGVDDQMNKHHFPLPQGQDCVVEKNNQ
HKPKSHISNINVEAKFNTVVSQSAPNHCTLAASASTPPSNRKALSCVHITLCPKTSSKLD
SGTLDERFHSLDAASKARMNSEFNFDLHTVSSRSLEPTSKLLTSKPVAQDQESLGFLGPK
SSLDFQVVQPSLPDSNTITQDLKTIPSQNSQIVTSRQIQVNISDFEGHSNPEGTPVFADR
LPEKMKTPLSAFSEKLSSDAVTQITTESPEKTLFSSEIFINAEDRGHEIIEPGNQKLRKA
PVKFASSSSVQQVTFSRGTDGQPLLLPYKPSGSTKMYYVPQLRQIPPSPDSKSDTTVESS
HSGSNDAIAPDFPAQVLGTRDDDLSATVNIKHKEGIYSKRVVTKASLPVGEKPLQNENAD
ASVQVLITGDENLSDKKQQEIHSTRAVTEAAQAKEKESLQKDTADSSAAAAAEHSAQVGD
PEMKNLPDTKAITQKEEIHRKKTVPEEAWPNNKESLQINIEESECHSEFENTTRSVFRSA
KFYIHHPVHLPSDQDICHESLGKSVFMRHSWKDFFQHHPDKHREHMCLPLPYQNMDKTKT
DYTRIKSLSINVNLGNKEVMDTTKSQVRDYPKHNGQISDPQRDQKVTPEQTTQHTVSLNE
LWNKYRERQRQQRQPELGDRKELSLVDRLDRLAKILQNPITHSLQVSESTHDDSRGERSV
KEWSGRQQQRNKLQKKKRFKSLEKSHKNTGELKKSKVLSHHRAGRSNQIKIEQIKFDKYI
LSKQPGFNYISNTSSDCRPSEESELLTDTTTNILSGTTSTVESDILTQTDREVALHERSS
SVSTIDTARLIQAFGHERVCLSPRRIKLYSSITNQQRRYLEKRSKHSKKVLNTGHPLVTS
EHTRRRHIQVANHVISSDSISSSASSFLSSNSTFCNKQNVHMLNKGIQAGNLEIVNGAKK
HTRDVGITFPTPSSSEAKLEENSDVTSWSEEKREEKMLFTGYPEDRKLKKNKKNSHEGVS
WFVPVENVESRSKKENVPNTCGPGISWFEPITKTRPWREPLREQNCQGQHLDGRGYLAGP
GREAGRDLLRPFVRATLQESLQFHRPDFISRSGERIKRLKLIVQERKLQSMLQTERDALF
NIDRERQGHQNRMCPLPKRVFLAIQKNKPISKKEMIQRSKRIYEQLPEVQKKREEEKRKS
EYKSYRLRAQLYKKRVTNQLLGRKVPWD
Target Bioclass
Other
Family
ALMS1 family
Subcellular location
Cytoplasm
Function
Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.
Uniprot ID
Q8TCU4
Ensemble ID
ENST00000613296.6
HGNC ID
HGNC:428

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.S3695AfsTer27 .
AGS SNV: p.P3725L .
AN3CA SNV: p.Y2152H .
CAOV3 SNV: p.L1059W; p.Q1156R DBIA    Probe Info 
CCFSTTG1 SNV: p.M4115I .
CMK SNV: p.I3230V .
COLO792 SNV: p.S511F;p.S2752F
Substitution: p.P715F		 DBIA    Probe Info 
DU145 SNV: p.V284L; p.V1936I; p.K3950Ter .
EFO21 SNV: p.Q634Ter .
HCT116 SNV: p.S286L .
HCT15 SNV: p.S2581R; p.W2679Ter; p.R3705M .
HEC1 SNV: p.A1026S .
HT SNV: p.C336W; p.K2810N .
HT115 SNV: p.K405N; p.E2270Ter .
IGR1 Insertion: p.R86QfsTer41 .
IPC298 Deletion: p.Q3126RfsTer10; p.V3127GfsTer9 .
JHH6 SNV: p.Y2381H .
JURKAT SNV: p.P357S .
KPNYN SNV: p.E1338Q .
LNCaP clone FGC SNV: p.R292H .
LU65 SNV: p.L818F .
MCC13 SNV: p.S3986F .
MELJUSO SNV: p.S2645F DBIA    Probe Info 
MEWO SNV: p.S3463F .
MFE319 Insertion: p.Q3378TfsTer12
SNV: .		 .
NCIH1155 SNV: p.V2914I .
NCIH1703 SNV: p.G4013C .
NCIH1993 SNV: p.S1635N .
NCIH23 SNV: p.K3292Ter .
OAW42 SNV: p.Q1203E .
OVK18 SNV: p.A3404V .
P31FUJ SNV: p.R52G .
PANC0403 SNV: p.V2077I .
PF382 SNV: p.A4078V .
RKN SNV: p.K4143N .
RL952 SNV: p.S3549G .
SH4 SNV: p.A1725D .
SHP77 SNV: p.E3371D .
SISO SNV: p.A78D .
SKMEL30 SNV: p.P258S .
SNGM SNV: p.V1045I .
SW1116 SNV: p.Q2561L .
SW1271 SNV: p.A1528T .
TE4 SNV: p.D3583N .
TGBC1TKB SNV: p.Y4145H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P3
 Probe Info  		4.00  LDD0180  [1]
IA-alkyne
 Probe Info  		C2878(8.47)  LDD1704  [2]
DBIA
 Probe Info  		C336(1.05); C343(1.05)  LDD0078  [3]
NAIA_4
 Probe Info  		C310(0.00); C2489(0.00)  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C2621(0.87)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C436(1.19)  LDD1508  [6]
 LDCM0216  AC100 HEK-293T C4005(1.26)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C4005(1.31)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C4005(1.00)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C4005(1.09)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C4005(1.21)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C4005(1.53)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C4005(1.38)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C4005(0.92)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C4005(1.20)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C4005(1.08)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C436(1.29)  LDD1509  [6]
 LDCM0227  AC110 HEK-293T C4005(1.47)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C4005(0.95)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C4005(1.68)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C2621(1.07)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C2621(0.98)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C2621(1.03)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C2621(0.85)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C2621(1.25)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C2621(0.94)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C2621(1.39)  LDD0553  [3]
 LDCM0238  AC120 HCT 116 C2621(1.06)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C2621(0.93)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C2621(1.09)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C2621(1.04)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C2621(1.17)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C2621(1.13)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C2621(0.89)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C2621(1.02)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C2621(0.68)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C2621(0.69)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C2621(0.78)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C2621(0.54)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C2621(0.94)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C2621(0.79)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C2621(1.06)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C2621(1.02)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C2621(0.82)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C2621(0.70)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C2621(0.91)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C2621(0.78)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C436(1.12)  LDD1512  [6]
 LDCM0260  AC140 HCT 116 C2621(1.19)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C2621(1.14)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C2621(0.72)  LDD0579  [3]
 LDCM0270  AC15 HEK-293T C436(0.76)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C436(1.30)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C436(1.82)  LDD1517  [6]
 LDCM0279  AC2 HCT 116 C2621(0.79)  LDD0596  [3]
 LDCM0281  AC21 HEK-293T C2933(1.17)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C436(0.99)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C436(0.79)  LDD1522  [6]
 LDCM0285  AC25 HCT 116 C2621(1.05)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C2621(1.10)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C2621(1.17)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C2621(1.30)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C2621(1.34)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C2621(0.81)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C2621(1.78)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C2621(1.08)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C2621(1.36)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C2621(1.20)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C2621(1.59)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C436(0.90)  LDD1535  [6]
 LDCM0298  AC37 HEK-293T C2933(0.88)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C436(0.99)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C436(0.79)  LDD1539  [6]
 LDCM0301  AC4 HCT 116 C2621(0.85)  LDD0618  [3]
 LDCM0304  AC42 HEK-293T C436(1.35)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C436(1.58)  LDD1544  [6]
 LDCM0307  AC45 HEK-293T C2933(1.01)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C436(1.25)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C436(0.79)  LDD1548  [6]
 LDCM0312  AC5 HCT 116 C2621(0.75)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C436(1.32)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C436(1.17)  LDD1553  [6]
 LDCM0316  AC53 HEK-293T C2933(1.00)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C436(0.92)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C436(0.76)  LDD1557  [6]
 LDCM0321  AC58 HEK-293T C436(0.78)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C436(1.40)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C436(1.18)  LDD1562  [6]
 LDCM0325  AC61 HEK-293T C2933(0.94)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C436(1.03)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C436(0.72)  LDD1566  [6]
 LDCM0332  AC68 HEK-293T C4005(1.08)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C4005(1.41)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C436(0.57)  LDD1568  [6]
 LDCM0335  AC70 HEK-293T C4005(0.99)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C4005(1.14)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C4005(1.15)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C4005(0.98)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C4005(1.00)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C4005(0.88)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C4005(1.22)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C4005(1.33)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C4005(1.30)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C4005(1.86)  LDD0942  [3]
 LDCM0346  AC80 HEK-293T C4005(0.90)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C4005(1.14)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C4005(1.81)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C2621(1.06)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C2621(1.17)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C2621(1.13)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C2621(1.72)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C2621(1.14)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C2621(0.96)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C2621(0.73)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C2621(1.17)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C2621(0.98)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C2621(0.97)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C2621(1.02)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C2621(0.81)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C2621(1.53)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C2621(0.92)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C2621(0.94)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C4005(0.97)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C4005(1.17)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C2933(1.02)  LDD1511  [6]
 LDCM0020  ARS-1620 HCC44 C336(1.05); C343(1.05)  LDD0078  [3]
 LDCM0368  CL10 HEK-293T C436(1.87)  LDD1572  [6]
 LDCM0369  CL100 HCT 116 C2621(1.05)  LDD0686  [3]
 LDCM0371  CL102 HEK-293T C436(1.01)  LDD1575  [6]
 LDCM0375  CL106 HEK-293T C436(0.93)  LDD1579  [6]
 LDCM0379  CL11 HEK-293T C436(0.68)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C436(0.98)  LDD1584  [6]
 LDCM0382  CL112 HCT 116 C2621(1.28)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C2621(1.58)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C2621(1.80)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C2621(1.23)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C2621(1.29)  LDD0703  [3]
 LDCM0388  CL118 HEK-293T C436(0.84)  LDD1592  [6]
 LDCM0393  CL122 HEK-293T C436(1.14)  LDD1597  [6]
 LDCM0397  CL126 HEK-293T C436(1.26)  LDD1601  [6]
 LDCM0401  CL14 HEK-293T C436(1.32)  LDD1605  [6]
 LDCM0403  CL16 HCT 116 C2621(1.31)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C2621(1.43)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C2621(1.18)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C2621(1.06)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C436(1.39)  LDD1611  [6]
 LDCM0408  CL20 HCT 116 C2621(1.21)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C2621(1.01)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C2621(1.05)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C2621(1.23)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C2621(1.18)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C2621(1.06)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C2621(1.13)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C2621(0.91)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C2621(1.20)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C2621(1.35)  LDD0734  [3]
 LDCM0419  CL30 HCT 116 C2621(0.99)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C2621(0.84)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C2621(1.07)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C2621(0.96)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C2621(1.00)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C2621(0.92)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C2621(0.76)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C2621(1.06)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C2621(0.50)  LDD0745  [3]
 LDCM0430  CL40 HCT 116 C2621(0.73)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C2621(1.21)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C2621(1.15)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C2621(0.96)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C2621(0.99)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C2621(0.99)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C2621(0.86)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C2621(0.96)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C2621(0.97)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C2621(1.05)  LDD0756  [3]
 LDCM0441  CL50 HCT 116 C2621(0.72)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C2621(0.71)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C2621(1.20)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C2621(0.77)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C2621(0.41)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C2621(1.21)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C2621(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C2621(0.92)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C2621(0.97)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C2621(0.88)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C436(1.01)  LDD1654  [6]
 LDCM0452  CL60 HCT 116 C2621(1.11)  LDD0769  [3]
 LDCM0454  CL62 HEK-293T C436(1.16)  LDD1657  [6]
 LDCM0458  CL66 HEK-293T C436(1.20)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C436(1.13)  LDD1662  [6]
 LDCM0461  CL69 HEK-293T C2933(1.03)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C436(0.86)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C436(1.53)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C436(0.90)  LDD1667  [6]
 LDCM0467  CL74 HEK-293T C436(1.32)  LDD1670  [6]
 LDCM0471  CL78 HEK-293T C436(1.05)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C436(1.09)  LDD1675  [6]
 LDCM0475  CL81 HEK-293T C2933(1.04)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C436(0.86)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C436(0.72)  LDD1680  [6]
 LDCM0480  CL86 HEK-293T C436(1.02)  LDD1683  [6]
 LDCM0484  CL9 HEK-293T C2933(1.12)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C436(0.91)  LDD1688  [6]
 LDCM0486  CL91 HCT 116 C2621(1.10)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C2621(1.08)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C2621(0.94)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C2621(1.07)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C2621(0.92)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C2621(0.92)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C2621(0.86)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C2621(0.82)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C2621(0.85)  LDD0811  [3]
 LDCM0028  Dobutamine HEK-293T 4.00  LDD0180  [1]
 LDCM0427  Fragment51 HCT 116 C2621(0.53)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C2622(1.17)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C2622(1.31)  LDD1497  [6]
 LDCM0024  KB05 SKMEL24 C4006(0.56)  LDD3323  [7]
 LDCM0021  THZ1 HCT 116 C336(1.26); C343(1.26)  LDD2173  [3]

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840