Details of the Target

General Information of Target

Target ID LDTP06886
Target Name Centrosomal protein of 55 kDa (CEP55)
Gene Name CEP55
Gene ID 55165
Synonyms
C10orf3; URCC6; Centrosomal protein of 55 kDa; Cep55; Up-regulated in colon cancer 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL
EKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTTLLEQLEETTREGERREQVLKA
LSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK
NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDL
LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHK
TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACT
LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENRE
KVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney.
Uniprot ID
Q53EZ4
Ensemble ID
ENST00000371485.8
HGNC ID
HGNC:1161

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 Substitution: p.T99A DBIA    Probe Info 
IGROV1 SNV: p.V41A DBIA    Probe Info 
NALM6 Deletion: p.L381del DBIA    Probe Info 
OZ SNV: p.Y75C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K145(0.92); K207(5.00); K303(1.23); K31(3.89)  LDD0277  [1]
ONAyne
 Probe Info  		K233(9.03)  LDD0275  [1]
Probe 1
 Probe Info  		Y228(16.38)  LDD3495  [2]
BTD
 Probe Info  		C236(0.94)  LDD2120  [3]
DA-P3
 Probe Info  		8.23  LDD0180  [4]
AHL-Pu-1
 Probe Info  		C359(3.90)  LDD0168  [5]
Acrolein
 Probe Info  		N.A.  LDD0227  [6]
DBIA
 Probe Info  		C236(2.57); C159(2.40); C443(1.85)  LDD0080  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C443(0.00); C359(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C236(0.00); C443(0.00); C359(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C443(0.00); C236(0.00); C359(0.00); C159(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		C159(0.00); C236(0.00); C359(0.00); C440(0.00)  LDD2226  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
Compound 10
 Probe Info  		C159(0.00); C236(0.00); C443(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C159(0.00); C236(0.00); C359(0.00); C443(0.00)  LDD2213  [12]
IPM
 Probe Info  		N.A.  LDD0147  [13]
NPM
 Probe Info  		N.A.  LDD0016  [11]
TFBX
 Probe Info  		C443(0.00); C236(0.00)  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [11]
YN-1
 Probe Info  		N.A.  LDD0446  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C236(0.00); C462(0.00); C440(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		7.36  LDD1779  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C359(3.90)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C359(3.04); C236(2.50)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C159(1.34); C236(0.92); C359(1.32)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C159(1.17); C236(1.09); C359(1.33); C443(1.17)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C236(1.09); C443(1.11)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C236(1.14); C443(1.39)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C236(1.14); C443(1.05)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C236(1.49); C443(1.51)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C236(1.21); C443(1.18)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C236(1.36); C443(1.32)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C236(1.37); C443(1.32)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C236(1.44); C443(1.41)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C236(1.10); C443(1.33)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C236(1.00); C443(1.22)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C159(1.32); C236(1.39); C359(1.28); C443(1.01)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C236(1.11); C443(1.37)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C236(1.13); C443(1.33)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C236(1.34); C443(1.41)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C236(1.01); C443(1.13)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C236(1.23); C443(1.19)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C236(1.38); C443(1.00)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C236(1.47); C443(0.92)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C236(1.16); C443(0.98)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C236(1.02); C443(1.10)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C236(1.22); C443(1.10)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C159(1.30); C236(1.09); C359(1.00); C443(1.03)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C236(1.27); C443(1.40)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C236(0.98); C443(0.98)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C236(1.05); C443(0.96)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C236(1.03); C443(1.28)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C236(0.97); C443(1.08)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C236(1.03); C443(1.04)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C236(1.25); C443(1.17)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C236(1.28); C443(0.98)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C236(1.10); C359(1.30); C443(0.63)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C236(0.86); C359(1.04); C443(0.64)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C236(1.10); C359(1.27); C443(0.95)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C236(0.91); C359(1.05); C443(0.91)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C236(0.89); C359(0.93); C443(0.89)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C236(0.94); C359(1.01); C443(1.07)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C236(1.08); C359(1.19); C443(1.30)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C236(1.06); C359(1.33); C443(0.99)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C236(1.01); C359(1.02); C443(0.88)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C236(1.01); C359(0.98); C443(1.11)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C236(1.17); C359(1.14); C443(1.06)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C236(1.09); C359(1.07); C443(0.96)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C159(0.82); C236(0.97); C359(1.34); C443(1.17)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C236(1.17); C359(1.11); C443(1.06)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C236(1.14); C359(0.98); C443(1.16)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C236(0.87); C359(0.86); C443(0.98)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C159(1.14); C236(1.18)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C159(1.32); C236(1.48)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C159(0.98); C236(1.23)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C159(1.10); C236(1.46)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C159(1.11); C236(1.61)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C159(1.71); C236(1.94)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C159(1.31); C236(1.62)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C236(0.89); C159(1.10); C443(1.11); C359(1.29)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C159(0.97); C236(1.25)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C159(0.95); C236(1.12)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C159(1.25); C236(1.53)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C159(1.98); C236(2.10)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C159(1.38); C236(1.33)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C159(1.29); C236(1.39)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C159(0.78); C236(1.10)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C159(0.81); C236(1.02)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C359(0.93); C443(0.97); C236(1.08); C159(1.44)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C159(0.78); C443(0.81); C359(0.83); C236(1.40)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C159(0.77); C359(0.98); C443(1.03); C236(1.09)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C236(0.99); C159(1.00); C359(1.24)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C359(0.79); C159(0.98); C443(1.12); C236(1.13)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C359(0.94); C443(0.99); C159(1.01); C236(1.15)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C359(0.73); C159(0.94); C236(1.04); C443(1.08)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C359(0.88); C159(0.90); C443(1.02); C236(1.18)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C359(0.84); C236(0.98); C159(1.05); C443(1.16)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C159(0.98); C236(1.10); C443(1.15)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C159(1.01); C443(1.10); C236(1.19)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C159(0.95); C236(1.20); C443(1.29)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C159(0.96); C443(1.02); C236(1.26)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C236(1.30); C159(1.31); C443(1.35)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C236(0.84); C159(1.24); C359(1.34)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C236(1.28); C443(1.44); C159(1.50)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C159(1.00); C236(1.13); C443(1.23)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C159(1.12); C443(1.43); C236(1.49)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C159(1.01); C443(1.21); C236(1.28)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C443(1.25); C159(1.36); C236(1.53)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C236(0.84); C443(0.93)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C236(0.93); C443(1.05)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C443(0.81); C236(0.86)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C236(0.98); C443(1.28)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C443(1.04); C236(1.06)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C236(0.81); C159(1.23); C359(1.48)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C443(0.95); C236(1.08)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C236(0.97); C443(1.07)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C236(1.08); C443(1.14)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C236(1.02); C443(1.09)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C443(0.78); C236(0.92)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C443(0.82); C236(1.11)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C159(0.92); C236(1.12)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C159(1.03); C236(1.11)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C159(0.89); C236(1.01)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C236(1.07); C159(1.29)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C236(0.90); C159(1.16); C359(1.62)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C236(0.90); C159(1.11)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C159(0.78); C236(0.93)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C159(0.95); C236(0.97)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C236(1.18); C159(1.19)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C236(0.90); C159(1.16)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C236(1.15); C159(1.30)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C236(1.20); C159(1.77)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C359(1.16); C236(1.50)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C359(1.41); C236(1.57)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C236(1.50); C359(1.52)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C236(1.11); C159(1.12); C443(1.23); C359(1.26)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C359(1.06); C236(1.44)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C236(1.35); C359(1.38)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C236(1.60); C359(1.69)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C359(1.18); C236(1.42)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C359(1.45); C236(1.57)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C236(1.52); C359(2.03)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C236(1.43); C359(1.67)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C359(1.70); C236(1.75)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C359(0.77); C159(0.88); C236(1.24)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C159(0.71); C359(0.90); C236(1.26)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C443(0.95); C236(1.06); C359(1.12); C159(1.13)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C159(0.70); C359(0.92); C236(1.30)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C159(0.71); C359(0.80); C236(1.08)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C159(0.70); C359(0.93); C236(1.33)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C159(0.88); C359(1.03); C236(1.78)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C159(0.72); C359(0.82); C236(1.60)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C159(0.74); C359(0.92); C236(1.78)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C359(0.90); C159(0.93); C236(1.27)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C359(0.89); C159(1.01); C236(1.45)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C159(0.93); C359(0.94); C236(1.17)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C159(0.97); C359(1.01); C236(1.19)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C159(1.09); C236(1.10); C359(1.14); C443(1.15)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C359(0.76); C159(0.93); C236(1.24)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C159(0.87); C359(0.98); C236(1.06)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C359(0.78); C159(0.81); C236(1.80)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C443(1.25); C236(1.60)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C443(1.35); C236(1.53)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C443(1.37); C236(1.40)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C443(1.30); C236(1.31)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C236(1.12); C443(1.30)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C236(1.25); C443(1.37)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C236(1.36); C443(1.56)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C236(1.04); C443(1.57)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C443(1.11); C236(1.58)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C443(1.19); C236(1.47)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C236(1.22); C443(1.25)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C443(0.84); C236(1.27)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C236(1.18); C443(1.42)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C443(0.99); C236(1.25)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C443(1.44); C236(1.58)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C443(1.62); C236(1.65)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C236(1.18); C443(1.51)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C159(1.19); C236(1.06); C359(1.05); C443(1.06)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C359(1.19); C443(1.29); C236(1.42); C159(1.45)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C236(1.08); C159(1.13); C443(1.47); C359(1.68)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C236(0.92); C443(0.79)  LDD2171  [7]
 LDCM0630  CCW28-3 231MFP C159(1.49)  LDD2214  [18]
 LDCM0632  CL-Sc Hep-G2 C236(1.07)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C236(1.06); C159(1.11); C443(1.24)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C443(1.13); C236(1.15); C159(1.16)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C236(0.91); C159(1.15); C359(1.44)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C236(0.86); C159(0.93); C443(1.35); C359(1.43)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C443(1.06); C236(1.17); C359(1.25); C159(1.29)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C236(0.97); C443(1.07); C159(1.10); C359(1.12)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C236(0.94); C359(1.09); C443(1.13); C159(1.16)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C159(0.67); C443(0.93); C359(1.10); C236(1.11)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C159(0.62); C443(0.65); C359(1.20); C236(1.39)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C159(0.75); C443(1.07); C359(1.17); C236(1.40)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C159(0.82); C443(0.99); C236(1.32); C359(1.40)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C159(0.92); C443(0.98); C359(1.12); C236(1.22)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C443(0.94); C159(1.06); C236(1.30)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C443(1.11); C159(1.18); C236(1.25); C359(1.53)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C159(0.72); C443(0.79); C359(1.04); C236(1.19)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C443(0.95); C236(1.01); C159(1.05)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C443(1.25); C159(1.34); C236(1.41)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C236(1.16); C443(1.39); C159(1.61)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C236(1.21); C443(1.27); C159(1.38)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C236(1.21); C159(1.24); C443(1.42)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C443(1.12); C236(1.47)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C443(0.90); C236(0.97)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C236(1.04); C443(1.09)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C159(1.12); C236(1.19); C443(1.26)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C236(0.93); C443(1.08)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C159(0.96); C236(1.09)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C236(0.93); C159(1.06)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C236(1.06); C159(1.44)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C236(1.18); C159(1.27)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C236(0.97); C359(0.97)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C236(1.10); C359(1.33)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C359(1.05); C236(1.11)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C359(1.34); C236(1.46)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C159(1.06); C236(1.12); C443(1.30)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C236(0.99); C443(1.06); C159(1.17)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C443(0.83); C159(1.07); C236(1.17)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C359(0.87); C236(1.07); C443(1.19)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C443(0.85); C359(0.99); C159(1.06); C236(1.24)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C159(0.98); C236(1.11); C359(1.19); C443(1.20)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C236(1.03); C159(1.06); C359(1.17); C443(1.19)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C159(0.92); C236(0.99); C443(1.10)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C359(1.25); C443(1.30); C159(1.31); C236(1.37)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C443(0.96); C159(1.16); C236(1.48); C359(1.51)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C159(0.98); C443(1.14); C236(1.60); C359(1.60)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C159(0.92); C359(1.07); C236(1.37); C443(1.41)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C443(1.07); C159(1.11); C359(1.36); C236(1.53)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C159(0.94); C236(1.21); C359(1.24); C443(1.10)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C159(0.94); C236(1.14); C359(1.05); C443(1.36)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C159(0.90); C236(1.01); C359(1.44); C443(1.20)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C159(0.98); C236(1.26); C359(1.46); C443(1.26)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C159(1.18); C236(1.06); C359(1.28); C443(1.42)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C159(0.83); C236(0.96); C443(0.84)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C159(0.91); C236(1.28); C359(1.01); C443(1.28)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C159(0.87); C236(1.18); C359(1.10)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C236(1.21); C359(1.16)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C236(1.24); C359(1.17)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C236(1.51); C359(0.98)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C236(1.61); C359(1.01)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C236(1.21); C359(2.02)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C236(1.49); C359(1.53)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C236(1.55); C359(0.91)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C159(1.06); C236(1.03); C443(1.02)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C236(1.55); C359(0.81)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C236(1.29); C359(1.57)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C236(1.94); C359(1.56)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C236(1.48); C359(1.39)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C236(1.53); C359(0.94)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C236(1.70); C359(1.23)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C236(0.92); C359(0.80); C443(0.95)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C236(0.96); C359(0.79); C443(0.89)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C236(1.10); C359(0.80); C443(0.98)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C236(0.93); C359(0.85); C443(1.07)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C159(0.82); C236(1.02); C443(1.40)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C236(0.95); C359(0.89); C443(1.05)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C236(1.10); C359(0.86); C443(0.86)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C236(1.01); C359(0.93); C443(1.06)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C236(1.05); C359(0.89); C443(1.18)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C236(0.90); C359(0.77); C443(1.03)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C236(0.93); C359(0.77); C443(1.10)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C236(1.02); C359(0.96); C443(0.93)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C236(0.93); C359(0.89); C443(1.05)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C236(0.98); C359(0.84); C443(0.98)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C236(1.04); C359(0.92); C443(1.01)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C159(0.95); C236(1.06); C443(0.98)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C236(1.19); C359(0.70); C443(1.06)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C159(0.98); C236(1.05); C359(1.27); C443(1.00)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C159(0.89); C236(1.12); C359(1.04); C443(1.08)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C159(1.16); C236(1.25); C359(1.06); C443(1.09)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C159(1.09); C236(1.22); C359(1.18); C443(1.07)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C159(1.37); C236(1.03); C359(1.05); C443(0.97)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C159(1.20); C236(1.35); C359(1.42); C443(1.03)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C159(1.26); C236(1.30); C359(1.23); C443(1.21)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C159(1.25); C236(1.19); C359(1.36); C443(1.02)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C159(0.78); C236(1.09); C359(1.01); C443(1.39)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C159(0.95); C236(1.10); C443(1.05)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C159(0.99); C236(1.21); C359(1.09); C443(1.05)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C159(1.08); C236(1.24); C359(1.19); C443(1.06)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C159(0.91); C236(1.07); C359(1.00); C443(1.30)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C159(1.03); C236(1.05); C359(1.05); C443(1.04)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C159(1.29); C236(1.20); C359(1.13); C443(0.97)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C236(1.05); C443(0.89)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C236(1.00); C443(1.00)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C236(1.09); C443(1.03)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C236(0.98); C443(1.07)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C159(0.96); C236(1.65); C443(1.25)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C236(0.97); C443(1.03)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C236(0.95); C443(0.98)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C236(0.82); C443(0.99)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C236(0.94); C443(0.95)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C236(1.03); C443(0.86)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C236(1.09); C443(1.17)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C236(1.07); C443(1.13)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C236(0.95); C443(1.17)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C236(0.96); C443(1.20)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C236(0.96); C443(0.90)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C159(1.03); C236(1.21); C443(1.04)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C236(1.08); C443(0.99)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C159(1.04); C236(1.07); C359(1.24)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C159(1.15); C236(1.03); C359(1.27)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C159(0.98); C236(0.89); C359(1.12)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C159(1.46); C236(0.83); C359(1.38)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C159(1.24); C236(0.98); C359(1.39)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C159(0.94); C236(0.95); C359(1.27)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C159(1.16); C236(0.98); C359(1.44)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C159(1.26); C236(1.03); C359(1.43)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C159(1.25); C236(1.01); C359(1.41)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C236(1.35)  LDD2228  [10]
 LDCM0028  Dobutamine HEK-293T 8.23  LDD0180  [4]
 LDCM0495  E2913 HEK-293T C236(1.00); C443(1.08); C462(0.99); C440(1.06)  LDD1698  [19]
 LDCM0468  Fragment33 HCT 116 C159(1.21); C236(1.10); C359(1.22); C443(0.93)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C236(2.26); C359(1.54)  LDD0744  [7]
 LDCM0022  KB02 HCT 116 C236(2.57); C159(2.40); C443(1.85)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C236(1.94); C159(1.43); C443(1.61)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C236(3.26); C159(2.83); C443(1.77)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0227  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C236(0.94)  LDD2120  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C236(1.09)  LDD2128  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C236(4.44)  LDD2147  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C359(0.27)  LDD2206  [20]
 LDCM0032  Oleacein HEK-293T 4.29  LDD0184  [4]
 LDCM0029  Quercetin HEK-293T 6.72  LDD0181  [4]
 LDCM0021  THZ1 HCT 116 C236(0.92); C443(0.79)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dystrobrevin beta (DTNB) Dystrophin family O60941
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Tyrosine-protein phosphatase non-receptor type 23 (PTPN23) Protein-tyrosine phosphatase family Q9H3S7
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Tripeptidyl-peptidase 1 (TPP1) . O14773
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A11 (ANXA11) Annexin family P50995
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Huntingtin (HTT) Huntingtin family P42858
Inactive serine/threonine-protein kinase TEX14 (TEX14) Protein kinase superfamily Q8IWB6
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
REST corepressor 3 (RCOR3) CoREST family Q9P2K3
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Calcium-responsive transcription factor (CARF) . Q8N187
Transcriptional enhancer factor TEF-3 (TEAD4) . Q15561
Other
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1) CCBE1 family Q6UXH8
Cell division control protein 45 homolog (CDC45) CDC45 family O75419
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Putative golgin subfamily A member 8D (GOLGA8DP) GOLGA8 family Q0D2H9
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) MISS family Q8NDC0
Pre-mRNA-splicing factor RBM22 (RBM22) SLT11 family Q9NW64
SNW domain-containing protein 1 (SNW1) SNW family Q13573
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Collagen alpha-1(VIII) chain (COL8A1) . P27658
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Galectin-4 (LGALS4) . P56470
Heat shock factor 2-binding protein (HSF2BP) . O75031
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leucine-rich repeat-containing protein 23 (LRRC23) . Q53EV4
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Peflin (PEF1) . Q9UBV8
Pleckstrin homology domain-containing family G member 6 (PLEKHG6) . Q3KR16
Programmed cell death 6-interacting protein (PDCD6IP) . Q8WUM4
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Protein TFG (TFG) . Q92734
Rho guanine nucleotide exchange factor 15 (ARHGEF15) . O94989
Splicing factor 45 (RBM17) . Q96I25

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.