Details of the Target

General Information of Target

Target ID LDTP09792
Target Name Inositol hexakisphosphate kinase 1 (IP6K1)
Gene Name IP6K1
Gene ID 9807
Synonyms
IHPK1; KIAA0263; Inositol hexakisphosphate kinase 1; InsP6 kinase 1; EC 2.7.4.21; Inositol hexaphosphate kinase 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
TGLSQKRKAPTEKNKIKRPRVH
Target Bioclass
Enzyme
Family
Inositol phosphokinase (IPK) family
Subcellular location
Cytoplasm
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Uniprot ID
Q92551
Ensemble ID
ENST00000321599.9
HGNC ID
HGNC:18360
ChEMBL ID
CHEMBL4523418

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Insertion: p.E211Ter DBIA    Probe Info 
HEC1 SNV: p.V222M DBIA    Probe Info 
HEC1B SNV: p.V222M .
HGC27 SNV: p.E343D DBIA    Probe Info 
MEWO SNV: p.S388F DBIA    Probe Info 
TE4 SNV: p.R243L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C248(0.50)  LDD2089  [2]
DA-P3
 Probe Info  		14.58  LDD0179  [3]
DBIA
 Probe Info  		C261(1.37); C275(1.37); C248(0.96)  LDD0078  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_4
 Probe Info  		C248(0.00); C372(0.00)  LDD2226  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C187(0.00); C221(0.00); C248(0.00); C48(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C248(1.06)  LDD2132  [2]
 LDCM0214  AC1 HCT 116 C221(0.89); C248(0.87)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C221(1.02); C248(1.98)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C261(0.80); C275(0.80); C248(1.14)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C261(1.09); C275(1.09); C248(1.26)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C261(1.08); C275(1.08); C248(1.06)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C261(0.86); C275(0.86); C248(1.08)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C261(1.12); C275(1.12); C248(0.93)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C261(1.09); C275(1.09); C248(1.02)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C261(0.85); C275(0.85); C248(1.12)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C261(0.88); C275(0.90); C248(1.19)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C261(1.05); C275(0.93); C248(1.17)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C261(1.03); C275(0.90); C248(0.98)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C221(1.16); C248(1.20)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C261(1.01); C275(1.07); C248(1.05)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C261(1.12); C275(1.07); C248(1.07)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C261(0.98); C275(1.06); C248(1.16)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C261(1.15); C275(1.15); C221(0.89)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C261(1.54); C275(1.54); C221(0.88)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C261(1.28); C275(1.28); C221(0.95)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C261(0.71); C275(0.71); C221(0.96)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C261(1.21); C275(1.21); C221(0.96)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C261(0.98); C275(0.98); C221(0.97)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C261(1.08); C275(1.08); C221(0.96)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C221(1.09); C248(1.28)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C261(1.35); C275(1.35); C221(0.88)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C261(0.76); C275(0.76); C221(1.00)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C261(0.88); C275(0.88); C221(1.00)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C261(1.23); C275(1.23); C221(0.87)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C261(0.70); C275(0.70); C221(1.05)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C261(0.96); C275(0.96); C221(1.04)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C261(0.78); C275(0.78); C221(0.94)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C261(0.78); C275(0.78); C221(0.98)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C261(1.50); C275(1.50); C248(0.89)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C261(1.01); C275(1.01); C248(1.05)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C261(0.92); C275(0.92); C248(1.29)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C261(1.48); C275(1.48); C248(1.05)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C261(1.08); C275(1.08); C248(1.42)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C261(1.25); C275(1.25); C248(1.39)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C261(1.61); C275(1.61); C248(1.28)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C261(1.06); C275(1.06); C248(1.18)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C261(1.40); C275(1.40); C248(1.39)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C261(1.14); C275(1.14); C248(1.06)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C261(1.81); C275(1.81); C248(1.04)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C261(1.36); C275(1.36); C248(1.68)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C221(1.07); C248(1.43)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C261(1.53); C275(1.53); C248(1.44)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C261(1.77); C275(1.77); C248(1.70)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C261(1.45); C275(1.45); C248(1.09)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C261(1.13); C275(1.13); C221(0.95); C248(1.18)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C221(0.78); C261(1.05); C275(1.05); C248(3.14)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C221(0.94); C261(1.25); C275(1.25); C248(1.42)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C221(0.90); C261(1.34); C275(1.34); C248(1.49)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C221(0.77); C261(1.47); C275(1.47); C248(2.43)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C221(0.73); C248(1.61); C261(1.85); C275(1.85)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C221(0.76); C261(1.11); C275(1.11); C248(1.50)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C221(0.98); C248(1.02)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C221(0.98); C261(1.06); C275(1.06); C248(2.47)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C221(0.93); C248(1.38); C261(1.52); C275(1.52)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C221(0.75); C248(1.56); C261(2.23); C275(2.23)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C221(0.90); C248(1.54); C261(1.76); C275(1.76)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C261(1.17); C275(1.17); C221(0.89); C248(1.92)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C261(1.29); C275(1.29); C221(0.88); C248(1.32)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C261(0.87); C275(0.87); C221(1.01); C248(1.25)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C261(1.17); C275(1.17); C221(0.99); C248(1.16)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C248(1.00); C221(1.10)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C248(0.84); C221(0.99)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C248(0.72); C221(1.06)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C248(0.99); C221(1.01)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C248(0.73); C221(1.06)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C248(0.55); C221(0.98)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C248(0.77); C221(1.01)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C248(0.79); C221(0.96)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C248(0.75); C221(1.01)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C221(0.57); C261(0.69); C275(0.69)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C221(0.54); C261(0.78); C275(0.78)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C221(0.51); C261(0.90); C275(0.90)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C221(0.55); C261(0.84); C275(0.84)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C221(0.64); C261(1.47); C275(1.47)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C248(0.94); C221(1.07)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C221(0.54); C261(1.44); C275(1.44)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C221(0.62); C261(1.09); C275(1.09)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C221(0.49); C261(1.25); C275(1.25)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C221(0.44); C261(0.89); C275(0.89)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C221(0.57); C261(1.48); C275(1.48)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C261(0.77); C275(0.77); C221(1.30)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C261(0.97); C275(0.97); C221(1.06)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C221(0.97); C261(1.07); C275(1.07)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C261(1.04); C275(1.04); C221(1.12)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C261(0.65); C275(0.65); C221(1.22)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C248(0.99); C221(1.20)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C261(0.92); C275(0.92); C221(1.10)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C221(0.96); C261(1.19); C275(1.19)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C221(1.04); C261(1.07); C275(1.07)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C221(1.05); C261(1.06); C275(1.06)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C261(0.96); C275(0.96); C221(1.00)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C221(0.96); C261(0.97); C275(0.97)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C221(1.00); C248(1.04); C261(1.81); C275(1.81)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C248(0.75); C221(1.01); C261(1.19); C275(1.19)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C221(0.98); C261(1.21); C275(1.21); C248(1.58)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C221(0.96); C248(1.08); C261(1.56); C275(1.56)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C248(0.97); C221(1.12)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C248(0.92); C221(0.96); C261(1.64); C275(1.64)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C221(0.95); C248(1.33); C261(2.13); C275(2.13)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C221(0.95); C248(1.29); C261(1.64); C275(1.64)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C221(0.86); C248(1.01); C261(1.54); C275(1.54)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C221(0.97); C248(1.17); C261(2.20); C275(2.20)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C221(0.91); C261(1.00); C275(1.00); C248(2.34)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C221(1.05); C261(1.35); C275(1.35); C248(1.83)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C248(1.88)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C248(1.52)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C248(1.58)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C221(0.99); C248(1.39)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C248(1.30)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C248(1.38)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C248(1.63)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C248(1.67)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C248(1.65)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C248(1.72)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C248(1.63)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C248(1.77)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C261(0.84); C275(0.84); C248(1.18)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C248(0.80); C261(1.37); C275(1.37)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C221(1.06); C248(1.36)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C261(0.91); C275(0.91); C248(1.39)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C248(0.92); C261(1.15); C275(1.15)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C248(0.95); C261(1.06); C275(1.06)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C261(1.35); C275(1.35); C248(1.64)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C248(0.94); C261(1.21); C275(1.21)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C261(1.61); C275(1.61); C248(1.71)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C261(1.13); C275(1.13); C248(1.25)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C261(0.89); C275(0.89); C248(1.23)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C261(0.93); C275(0.93); C248(1.50)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C261(1.11); C275(1.11); C248(1.12)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C221(1.03); C248(1.45)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C248(1.04); C261(1.09); C275(1.09)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C248(0.75); C261(1.05); C275(1.05)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C248(1.14); C261(1.44); C275(1.44)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C261(1.21); C275(1.21); C248(1.23)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C248(1.13); C261(1.31); C275(1.31)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C248(0.90); C261(1.35); C275(1.35)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C261(0.97); C275(0.97); C248(1.27)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C248(0.77); C261(1.06); C275(1.06)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C248(0.92); C261(1.07); C275(1.07)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C248(1.16); C261(1.58); C275(1.58)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C261(0.92); C275(0.92); C248(1.24)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C261(1.36); C275(1.36); C248(1.50)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C261(1.19); C275(1.19); C248(1.47)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C248(0.84); C261(1.21); C275(1.21)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C248(1.03); C261(1.13); C275(1.13)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C261(0.97); C275(0.97); C248(1.07)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C261(1.04); C275(1.04); C248(1.12)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C248(1.18); C261(1.28); C275(1.28)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C261(1.15); C275(1.15); C248(1.16)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C248(1.01); C261(1.06); C275(1.06)  LDD0683  [4]
 LDCM0545  Acetamide MDA-MB-231 C248(0.56)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C221(1.12); C248(1.06)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C248(1.08); C221(1.09)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C221(0.93); C248(1.19)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C261(1.37); C275(1.37); C248(0.96)  LDD0078  [4]
 LDCM0498  BS-3668 MDA-MB-231 C248(0.80)  LDD2091  [2]
 LDCM0632  CL-Sc Hep-G2 C248(1.12); C187(0.44)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C221(1.14)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C221(1.06)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C221(0.86); C248(1.23)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C221(0.98); C248(1.79)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C221(0.97); C248(1.13)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C221(1.05); C248(1.72)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C221(0.98); C248(1.09)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C248(0.67); C221(0.98)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C248(0.43); C221(0.90)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C248(0.74); C221(0.94)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C248(0.94); C221(0.96)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C248(0.88); C221(0.90)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C221(0.97)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C221(0.90); C248(1.00)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C221(0.92); C248(0.96)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C221(0.59); C261(1.15); C275(1.15)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C221(0.61); C261(1.37); C275(1.37)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C221(0.52); C261(1.60); C275(1.60)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C221(0.46); C261(1.63); C275(1.63)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C221(0.53); C261(1.31); C275(1.31)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C221(1.12); C261(1.32); C275(1.32)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C261(1.01); C275(1.01); C221(1.04)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C261(0.85); C275(0.85); C221(1.05)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C221(1.10)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C261(0.87); C275(0.87); C221(1.03)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C248(0.52); C221(0.77); C261(1.61); C275(1.61)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C221(0.88); C248(1.54); C261(2.32); C275(2.32)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C221(0.92); C261(1.48); C275(1.48); C248(1.82)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C221(0.89); C248(1.83); C261(1.86); C275(1.86)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C248(1.32)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C248(1.15)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C248(1.21)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C248(2.05)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C221(1.04)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C221(1.09)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C221(0.98)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C221(0.84); C248(1.03); C261(1.48); C275(1.48)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C221(0.91); C248(1.06); C261(2.58); C275(2.58)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C221(0.94); C248(1.07); C261(2.94); C275(2.94)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C221(0.98); C248(1.02); C261(1.38); C275(1.38)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C221(1.09)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C221(0.94); C248(1.24); C261(1.78); C275(1.78)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C221(0.89); C248(1.40); C261(2.14); C275(2.14)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C221(0.82); C248(1.61); C261(2.75); C275(2.75)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C248(1.00); C221(1.04); C261(1.40); C275(1.40)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C221(0.96); C248(1.25); C261(2.11); C275(2.11)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C261(1.57); C275(1.57); C221(0.91); C248(1.48)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C261(1.92); C275(1.92); C221(1.01); C248(1.06)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C261(2.02); C275(2.02); C221(0.96); C248(1.18)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C261(1.61); C275(1.61); C221(0.90); C248(1.19)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C261(2.19); C275(2.19); C221(0.97); C248(1.46)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C221(1.10)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C261(2.09); C275(2.09); C221(1.47); C248(0.96)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C261(1.04); C275(1.04); C221(0.98); C248(0.99)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C261(0.99); C275(0.99); C221(0.87); C248(1.10)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C261(0.85); C275(0.85); C221(0.80); C248(1.40)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C261(0.97); C275(0.97); C221(0.94); C248(1.14)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C261(1.32); C275(1.32); C221(0.88); C248(1.13)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C261(0.99); C275(0.99); C221(0.90); C248(1.01)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C261(1.06); C275(1.06); C221(0.92); C248(1.34)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C261(0.83); C275(0.83); C221(0.94); C248(1.37)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C221(0.99)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C261(0.92); C275(0.92); C221(0.81); C248(1.38)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C261(0.79); C275(0.79); C221(0.91); C248(1.03)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C261(0.77); C275(0.77); C221(1.02); C248(1.21)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C261(0.99); C275(0.99); C221(1.01); C248(1.31)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C261(1.22); C275(1.22); C221(0.95); C248(1.09)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C261(1.11); C275(1.11); C221(0.97); C248(1.19)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C261(2.31); C275(2.31); C221(0.96); C248(0.76)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C261(3.86); C275(3.86); C221(0.97); C248(0.90)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C261(3.43); C275(3.43); C221(0.98); C248(1.04)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C261(1.94); C275(1.94); C221(1.03); C248(0.71)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C221(1.07)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C261(3.92); C275(3.92); C221(1.01); C248(1.10)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C261(1.89); C275(1.89); C221(0.97); C248(1.10)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C261(2.41); C275(2.41); C221(0.98); C248(1.25)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C261(4.14); C275(4.14); C221(0.92); C248(0.87)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C261(3.81); C275(3.81); C221(0.92); C248(0.74)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C261(1.63); C275(1.63); C221(0.93); C248(1.11)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C261(2.66); C275(2.66); C221(0.97); C248(0.83)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C261(2.39); C275(2.39); C221(0.92); C248(1.04)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C261(2.35); C275(2.35); C221(1.07); C248(0.79)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C261(1.63); C275(1.63); C221(1.06); C248(1.06)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C221(1.22)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C261(3.06); C275(3.06); C221(1.03); C248(0.95)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C261(1.23); C275(1.23); C221(0.98)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C261(0.99); C275(0.99); C221(1.00)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C261(0.85); C275(0.85); C221(0.95)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C261(0.90); C275(0.90); C221(0.91)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C261(0.97); C275(0.97); C221(0.96)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C261(1.21); C275(1.21); C221(0.87)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C261(0.92); C275(0.92); C221(0.89)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C261(1.18); C275(1.18); C221(0.88)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C261(1.21); C275(1.21); C221(0.82)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C221(1.05)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C261(1.20); C275(1.20); C221(0.90)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C261(1.39); C275(1.39); C221(0.87)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C261(1.04); C275(1.04); C221(1.04)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C261(1.26); C275(1.26); C221(0.87)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C261(1.16); C275(1.16); C221(0.85)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C261(1.25); C275(1.25); C221(1.19); C248(0.74)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C261(1.09); C275(1.09); C221(1.10); C248(0.69)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C261(0.96); C275(0.96); C221(1.03); C248(0.79)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C261(1.32); C275(1.32); C221(1.28); C248(0.79)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C221(1.08)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C261(0.78); C275(0.78); C221(1.08); C248(0.89)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C261(0.81); C275(0.81); C221(1.39); C248(1.03)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C261(0.95); C275(0.95); C221(1.44); C248(0.98)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C261(0.91); C275(0.91); C221(1.59); C248(0.63)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C261(0.82); C275(0.82); C221(1.11); C248(0.73)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C261(1.06); C275(1.06); C221(1.11); C248(0.79)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C261(1.03); C275(1.03); C221(1.31); C248(0.97)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C261(1.05); C275(1.05); C221(1.78); C248(0.98)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C261(1.06); C275(1.06); C221(1.81); C248(0.90)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C261(0.89); C275(0.89); C221(1.25); C248(0.91)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C221(1.02)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C261(1.08); C275(1.08); C221(1.30); C248(0.83)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C221(0.87); C248(1.03)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C221(0.90); C248(1.38)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C221(1.13); C248(1.03)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C221(1.01); C248(1.74)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C221(0.97); C248(1.31)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C221(1.09); C248(0.77)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C221(1.06); C248(1.13)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C221(0.84); C248(1.13)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C221(0.91); C248(1.12)  LDD0811  [4]
 LDCM0028  Dobutamine HEK-293T 4.01  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 14.58  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C349(1.11); C48(1.02); C248(0.99); C221(0.97)  LDD1698  [13]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.63  LDD0183  [3]
 LDCM0625  F8 Ramos C248(1.31)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C248(2.24)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C248(4.25)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C248(1.03)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C248(1.37)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C248(0.62)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C248(0.72)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C248(1.20)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C248(1.23)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C248(1.22)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C248(1.06)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C248(1.36)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C248(0.97)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C248(1.89)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C261(1.03); C275(1.03); C221(0.83)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C248(1.32)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C248(0.95)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C261(1.03); C275(1.03); C221(0.93); C248(1.20)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C248(0.88)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C248(1.67)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C248(0.87)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C248(1.71)  LDD2188  [14]
 LDCM0022  KB02 HEK-293T C349(0.93); C248(0.91); C372(1.00); C221(0.98)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C221(8.76)  LDD0209  [15]
 LDCM0024  KB05 G361 C83(2.67)  LDD3311  [16]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C248(0.77)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C248(0.50)  LDD2089  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C248(0.69)  LDD2109  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C248(0.78)  LDD2150  [2]
 LDCM0032  Oleacein HEK-293T 5.82  LDD0184  [3]
 LDCM0029  Quercetin HEK-293T 5.04  LDD0181  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exosome complex component RRP42 (EXOSC7) RNase PH family Q15024
Ubiquitin conjugation factor E4 A (UBE4A) Ubiquitin conjugation factor E4 family Q14139
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vimentin (VIM) Intermediate filament family P08670
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840