Details of the Target

General Information of Target

Target ID LDTP18130
Target Name Phosphotriesterase-related protein (PTER)
Gene Name PTER
Gene ID 9317
Synonyms
Phosphotriesterase-related protein; EC 3.1.-.-; Parathion hydrolase-related protein; hPHRP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVSGVLRLLALIFAIVTTWMFIRSYMSFSMKTIRLPRWLAASPTKEIQVKKYKCGLIKP
CPANYFAFKICSGAANVVGPTMCFEDRMIMSPVKNNVGRGLNIALVNGTTGAVLGQKAFD
MYSGDVMHLVKFLKEIPGGALVLVASYDDPGTKMNDESRKLFSDLGSSYAKQLGFRDSWV
FIGAKDLRGKSPFEQFLKNSPDTNKYEGWPELLEMEGCMPPKPF
Target Bioclass
Enzyme
Family
Metallo-dependent hydrolases superfamily, Phosphotriesterase family
Uniprot ID
Q96BW5
Ensemble ID
ENST00000298942.4
HGNC ID
HGNC:9590

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.I269T .
HEC1B SNV: p.T137I .
NCIH2286 SNV: p.G102A .
RT112 SNV: p.T109M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P3
 Probe Info  		4.05  LDD0179  [2]
HHS-465
 Probe Info  		Y65(10.00)  LDD2237  [3]
DBIA
 Probe Info  		C36(1.00); C38(1.00); C43(1.00)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C289(0.00); C249(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C249(0.00); C289(0.00); C196(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		13.20  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C289(1.03); C43(1.14)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C35(1.05); C43(1.05)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C35(0.85); C43(0.85)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C35(0.80); C43(0.80)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C35(0.92); C43(0.92)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C35(1.00); C43(1.00)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C35(0.93); C43(0.93)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C35(0.93); C43(0.93)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C35(0.80); C43(0.80)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C35(0.87); C43(0.87)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C35(0.83); C43(0.83)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C35(1.05); C43(1.05)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C35(1.11); C43(1.11)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C35(0.85); C43(0.85)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C35(0.88); C43(0.88)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C35(0.86); C43(0.86)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C35(0.86); C43(0.86)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C35(1.14); C43(1.18)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C35(1.02); C43(1.24)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C35(1.13); C43(1.21)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C35(1.04); C43(1.11)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C35(1.12); C43(1.12)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C35(1.00); C43(1.21)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C35(0.90); C43(0.90)  LDD0835  [4]
 LDCM0238  AC120 HCT 116 C35(1.13); C43(1.20)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C35(0.96); C43(1.00)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C35(1.10); C43(1.29)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C35(1.04); C43(1.11)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C35(1.05); C43(1.10)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C35(1.24); C43(1.11)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C35(1.30); C43(1.15)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C35(1.13); C43(1.07)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C35(1.04); C43(1.04)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C35(1.12); C43(1.12)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C35(1.02); C43(1.02)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C35(1.18); C43(1.18)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C35(1.16); C43(1.16)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C35(1.17); C43(1.17)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C35(1.68); C43(1.68)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C35(1.40); C43(1.40)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C35(1.08); C43(1.08)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C35(1.12); C43(1.12)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C35(1.40); C43(1.40)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C35(1.31); C43(1.31)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C35(0.96); C43(0.96)  LDD0857  [4]
 LDCM0260  AC140 HCT 116 C35(1.53); C43(1.53)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C35(1.70); C43(1.70)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C35(1.20); C43(1.20)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C35(0.67); C43(0.67)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C35(0.74); C43(0.74)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C35(0.78); C43(0.78)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C35(1.13); C43(1.13)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C35(0.70); C43(0.70)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C35(0.93); C43(0.93)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C35(0.89); C43(0.89)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C35(0.85); C43(0.85)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C35(1.06); C43(1.06)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C35(0.70); C43(0.70)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C35(1.58); C43(1.58)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C35(0.66); C43(0.66)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C35(0.77); C43(0.77)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C35(0.84); C43(0.84)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C35(0.85); C43(0.85)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C35(1.19); C43(1.19)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C35(1.47); C43(1.47)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C35(1.51); C43(1.51)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C35(1.25); C43(1.25)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C43(1.00)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C35(1.12); C43(1.12)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C35(0.96); C43(0.96)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C35(1.05); C43(1.05)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C35(1.14); C43(1.14)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C35(1.17); C43(1.17)  LDD0882  [4]
 LDCM0285  AC25 HCT 116 C43(0.87)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C43(1.34)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C43(1.12)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C43(1.04)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C43(1.99)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C43(1.13)  LDD1529  [10]
 LDCM0291  AC30 HCT 116 C43(2.20)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C43(1.44)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C43(1.59)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C43(1.50)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C43(1.58)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C43(1.24)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C43(0.80)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C43(1.25)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C43(1.45)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C43(1.07)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C43(0.94)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C43(1.43)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C43(2.36)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C43(1.53)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C43(1.54)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C43(1.39)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C43(1.46)  LDD0905  [4]
 LDCM0308  AC46 HCT 116 C43(1.33)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C43(1.08)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C43(1.13)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C43(1.40)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C43(1.00)  LDD1551  [10]
 LDCM0313  AC50 HCT 116 C43(1.58)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C43(1.07)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C43(1.28)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C43(1.39)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C43(1.25)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C43(0.68)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C43(0.75)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C35(0.49); C43(0.49)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C35(0.81); C43(0.81)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C35(0.95); C43(0.95)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C35(1.06); C43(1.06)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C35(1.09); C43(1.09)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C35(0.65); C43(0.65)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C35(0.67); C43(0.67)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C35(0.75); C43(0.75)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C35(0.72); C43(0.72)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C35(0.76); C43(0.76)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C35(0.87); C43(0.87)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C35(0.78); C43(0.78)  LDD0648  [4]
 LDCM0332  AC68 HEK-293T C43(0.84)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C43(1.12)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C35(1.22); C43(1.22)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C43(0.95)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C43(0.96)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C43(1.18)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C43(1.13)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C43(0.78)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C43(1.01)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C43(0.89)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C43(0.89)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C43(1.07)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C43(0.91)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C35(1.29); C43(1.29)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C43(0.98)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C43(0.91)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C43(0.85)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C35(0.52); C43(0.52)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C35(0.54); C43(0.54)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C35(0.53); C43(0.53)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C35(0.60); C43(0.60)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C35(0.59); C43(0.59)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C35(0.54); C43(0.54)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C35(0.58); C43(0.58)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C35(0.54); C43(0.54)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C35(0.45); C43(0.45)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C35(0.50); C43(0.50)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C35(0.56); C43(0.56)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C35(0.50); C43(0.50)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C35(0.83); C43(0.83)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C35(0.85); C43(0.85)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C35(0.66); C43(0.66)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C35(0.80); C43(0.80)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C35(0.90); C43(0.90)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C35(1.36); C43(1.36)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C35(0.93); C43(0.93)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C35(1.07); C43(1.07)  LDD0873  [4]
 LDCM0020  ARS-1620 HCC44 C36(1.00); C38(1.00); C43(1.00)  LDD0078  [4]
 LDCM0367  CL1 HEK-293T C43(1.12)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C43(1.40)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C43(1.01)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C35(1.83); C43(1.83)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C35(2.12); C43(2.12)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C35(1.16); C43(1.16)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C35(1.11); C43(1.11)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C35(1.07); C43(1.07)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C35(1.60); C43(1.60)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C35(0.91); C43(0.91)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C35(1.39); C43(1.39)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C35(1.26); C43(1.26)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C43(1.39)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C35(2.23); C43(2.23)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C35(1.93); C43(1.93)  LDD0979  [4]
 LDCM0382  CL112 HCT 116 C43(1.31)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C43(1.47)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C43(2.17)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C43(1.44)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C43(1.28)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C43(1.45)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C43(1.00)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C43(1.03)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C43(1.15)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C43(1.04)  LDD0989  [4]
 LDCM0392  CL121 HCT 116 C43(1.15)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C43(2.14)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C43(1.56)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C43(1.13)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C35(0.93); C43(0.93)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C35(2.01); C43(2.01)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C35(1.19); C43(1.19)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C35(0.82); C43(0.82)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C43(1.32)  LDD1604  [10]
 LDCM0403  CL16 HEK-293T C43(1.10)  LDD1607  [10]
 LDCM0404  CL17 HCT 116 C35(1.32); C43(1.32)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C35(1.21); C43(1.21)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C35(1.38); C43(1.38)  LDD0723  [4]
 LDCM0408  CL20 HCT 116 C35(1.61); C43(1.61)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C35(2.41); C43(2.41)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C35(2.51); C43(2.51)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C35(0.85); C43(0.85)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C35(1.75); C43(1.75)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C35(1.41); C43(1.41)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C35(1.36); C43(1.36)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C35(1.23); C43(1.23)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C35(3.37); C43(3.37)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C35(1.50); C43(1.50)  LDD0734  [4]
 LDCM0419  CL30 HCT 116 C35(1.40); C43(1.40)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C35(1.36); C43(1.36)  LDD0737  [4]
 LDCM0421  CL32 HEK-293T C43(1.09)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C43(1.26)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C43(1.01)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C43(0.91)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C43(1.10)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C43(1.01)  LDD1630  [10]
 LDCM0429  CL4 HEK-293T C43(1.17)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C43(1.03)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C289(1.12); C43(1.11)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C43(1.13)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C43(1.10)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C43(1.08)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C43(1.21)  LDD1639  [10]
 LDCM0436  CL46 HCT 116 C35(1.70); C43(1.36)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C35(1.35); C43(1.21)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C35(1.87); C43(1.36)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C35(1.75); C43(1.29)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C289(1.08); C43(1.25)  LDD1644  [10]
 LDCM0441  CL50 HCT 116 C35(1.70); C43(1.28)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C35(1.28); C43(1.22)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C35(1.83); C43(1.43)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C35(1.67); C43(1.39)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C35(1.61); C43(1.23)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C35(1.06); C43(0.95)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C35(1.62); C43(1.30)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C35(2.10); C43(1.53)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C35(2.15); C43(1.49)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C35(1.07); C43(0.98)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C43(1.21)  LDD1654  [10]
 LDCM0452  CL60 HCT 116 C35(1.15); C43(1.11)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C35(0.73); C43(0.88)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C35(0.72); C43(0.83)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C35(1.51); C43(1.51)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C35(0.66); C43(0.76)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C35(0.64); C43(0.75)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C35(0.86); C43(0.86)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C35(0.75); C43(0.83)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C35(1.38); C43(1.38)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C35(0.72); C43(0.78)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C43(1.22)  LDD1665  [10]
 LDCM0463  CL70 HCT 116 C35(0.57); C43(0.61)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C35(0.83); C43(1.02)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C35(0.81); C43(1.05)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C35(0.85); C43(1.06)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C35(0.83); C43(0.93)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C43(1.03)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C289(1.52); C43(1.55)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C43(1.15)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C43(0.96)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C43(1.10)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C43(0.95)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C43(1.06)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C43(1.02)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C43(0.99)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C43(1.09)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C43(0.88)  LDD1682  [10]
 LDCM0482  CL88 HEK-293T C43(1.03)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C289(1.08); C43(1.27)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C43(1.11)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C43(1.12)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C43(0.86)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C43(1.04)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C43(1.07)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C43(1.23)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C43(1.40)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C43(1.09)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C43(1.03)  LDD1695  [10]
 LDCM0028  Dobutamine HEK-293T 11.25  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 4.05  LDD0179  [2]
 LDCM0468  Fragment33 HCT 116 C35(0.87); C43(1.09)  LDD0785  [4]
 LDCM0022  KB02 HCT 116 C35(7.86); C43(7.86)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C35(1.97); C43(1.97)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C35(2.27); C43(2.27)  LDD0082  [4]
 LDCM0029  Quercetin HEK-293T 26.03  LDD0181  [2]
 LDCM0021  THZ1 HCT 116 C38(1.08); C43(1.08); C164(1.16); C172(1.16)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402