Details of the Target

General Information of Target

Target ID LDTP11539
Target Name Regulator of nonsense transcripts 3B (UPF3B)
Gene Name UPF3B
Gene ID 65109
Synonyms
RENT3B; UPF3X; Regulator of nonsense transcripts 3B; Nonsense mRNA reducing factor 3B; Up-frameshift suppressor 3 homolog B; hUpf3B; Up-frameshift suppressor 3 homolog on chromosome X; hUpf3p-X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVVVIDSITAQTLQVLEKH
KADVVKVKWARENYHHNIGSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQ
WLWNQDASRDLLLAIHPPNYIVLWNADTGTKLWKKSYADNILSFSFDPFDPSHLTLLTSE
GIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLATATGAKKALNKVKILITQEKPSAE
FITLNDCLQLAYLPSKRNHMLLLYPREILILDLEVNQTVGVIAIERTGVPFLQVIPCFQR
DGLFCLHENGCITLRVRRSYNNIFTTSNEEPDPDPVQELTYDLRSQCDAIRVTKTVRPFS
MVCCPVNENAAALVVSDGRVMIWELKSAVCNRNSRNSSSGVSPLYSPVSFCGIPVGVLQN
KLPDLSLDNMIGQSAIAGEEHPRGSILREVHLKFLLTGLLSGLPAPQFAIRMCPPLTTKN
IKMYQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSFATSTPNNM
GLVRNELQLVDLPTGRSIAFRGERGNDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTC
TLLREMSKNFPTITALEWSPSHNLKSLRKKQLATREAMARQTVVSDTELSIVESSVISLL
QEAESKSELSQNISAREHFVFTDIDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKG
DTLVLGDMDGNLNFWDLKGRVSRGIPTHRSWVRKIRFAPGKGNQKLIAMYNDGAEVWDTK
EVQMVSSLRSGRNVTFRILDVDWCTSDKVILASDDGCIRVLEMSMKSACFRMDEQELTEP
VWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKK
LLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLS
NPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLET
SADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADAC
RYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSV
AETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYADYARSLKNLGFKQGAVLFA
SKAGAAGKDLLNELESPKEEPIEE
Target Bioclass
Other
Family
RENT3 family
Subcellular location
Nucleus
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.
Uniprot ID
Q9BZI7
Ensemble ID
ENST00000276201.7
HGNC ID
HGNC:20439

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 Insertion: p.N189KfsTer2 DBIA    Probe Info 
HEC1 SNV: p.R436H DBIA    Probe Info 
HT115 SNV: p.A446V DBIA    Probe Info 
KARPAS422 SNV: p.K214Q DBIA    Probe Info 
MM1S SNV: p.I431M .
NCIH196 SNV: p.G116D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C319(1.08)  LDD2096  [2]
DA-P3
 Probe Info  		4.17  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C453(3.69)  LDD0169  [4]
HHS-465
 Probe Info  		Y98(4.80)  LDD2237  [5]
DBIA
 Probe Info  		C319(1.10); C453(1.06)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C453(0.00); C319(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C453(0.00); C319(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C319(0.00); C453(0.00)  LDD0037  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		C319(0.00); C453(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		13.70  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe13
 Probe Info  		13.09  LDD0475  [14]
FFF probe2
 Probe Info  		8.25  LDD0463  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C453(3.69)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C319(1.10)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C319(1.23)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C319(0.99)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C319(0.78)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C319(0.97)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C319(1.15)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C319(1.23)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C319(0.88)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C319(1.25)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C319(0.57)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C319(1.30)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C319(1.62)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C319(1.55)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C319(1.70)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C319(1.39)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C319(0.76)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C319(1.31)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C319(1.53)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C319(1.65)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C319(1.86)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C319(1.30)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C319(0.81)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C319(1.30)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C319(1.27)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C319(1.20)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C319(1.24)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C319(1.23)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C319(1.12)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C319(1.31)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C319(1.07)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C319(1.59)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C319(1.77)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C319(1.62)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C319(0.83)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C319(1.01)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C319(0.78)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C319(0.98)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C319(0.99)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C319(1.09)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C319(1.43)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C319(1.00)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C319(0.82)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C319(1.00)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C319(1.07)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C319(1.21)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C319(0.94)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C319(0.94)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C319(0.79)  LDD0579  [6]
 LDCM0263  AC143 HEK-293T C319(1.03)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C319(0.93)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C319(1.17)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C319(1.20)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C319(1.15)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C319(1.16)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C319(0.89)  LDD0867  [6]
 LDCM0270  AC15 HCT 116 C319(1.13)  LDD0587  [6]
 LDCM0271  AC150 HEK-293T C319(1.15)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C319(1.06)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C319(0.99)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C319(0.99)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C319(0.92)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C319(1.00)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C319(1.16)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C319(1.42)  LDD2165  [6]
 LDCM0276  AC17 HCT 116 C319(1.43)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C319(1.30)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C319(1.56)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C319(1.04)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C319(1.41)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C319(1.99)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C319(1.49)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C319(1.55)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C319(1.32)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C319(1.24)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C319(1.40)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C319(1.41)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C319(1.42)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C319(1.40)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C319(0.99)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C319(1.11)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C319(1.27)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C319(1.38)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C319(1.68)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C319(1.98)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C319(0.99)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C319(0.82)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C319(1.22)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C319(1.28)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C319(1.19)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C319(0.99)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C319(1.01)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C319(0.76)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C319(1.14)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C319(1.35)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C319(1.13)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C319(2.07)  LDD0905  [6]
 LDCM0308  AC46 HCT 116 C319(1.07)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C319(1.20)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C319(0.89)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C319(1.82)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C319(0.97)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C319(2.89)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C319(0.87)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C319(1.02)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C319(1.50)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C319(1.92)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C319(2.37)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C319(4.53)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C319(1.24)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C319(1.40)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C319(1.43)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C319(1.28)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C319(0.87)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C319(0.90)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C319(1.06)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C319(0.90)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C319(1.24)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C319(0.51)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C319(0.52)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C319(0.71)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C319(1.12)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C319(1.43)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C319(1.23)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C319(1.28)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C319(0.92)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C319(1.29)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C319(1.74)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C319(2.02)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C319(2.29)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C319(1.31)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C319(1.41)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C319(1.11)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C319(1.14)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C319(1.82)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C319(1.48)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C319(1.37)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C319(2.67)  LDD0665  [6]
 LDCM0349  AC83 HEK-293T C319(0.99)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C319(1.10)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C319(1.15)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C319(1.16)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C319(1.33)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C319(1.27)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C319(1.19)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C319(1.16)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C319(1.33)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C319(1.10)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C319(1.21)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C319(1.40)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C319(1.26)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C319(1.34)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C319(2.03)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C319(1.81)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C319(0.75)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C319(1.82)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C319(1.64)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C319(1.17)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.56  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C319(1.10); C453(1.06)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 PaTu 8988t C319(1.30)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C319(1.35)  LDD1247  [6]
 LDCM0369  CL100 HCT 116 C319(1.21)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C319(1.09)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C319(1.19)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C319(1.36)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C319(1.16)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C319(1.21)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C319(1.74)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C319(1.32)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C319(1.47)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C319(1.47)  LDD0695  [6]
 LDCM0379  CL11 PaTu 8988t C319(0.83)  LDD1258  [6]
 LDCM0380  CL110 HCT 116 C319(1.68)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C319(1.65)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C319(0.94)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C319(1.76)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C319(1.21)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C319(1.66)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C319(1.10)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C319(1.22)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C319(0.86)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C319(0.87)  LDD0987  [6]
 LDCM0390  CL12 PaTu 8988t C319(0.68)  LDD1269  [6]
 LDCM0391  CL120 HEK-293T C319(0.99)  LDD0989  [6]
 LDCM0392  CL121 HCT 116 C319(1.10)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C319(1.08)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C319(1.32)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C319(1.68)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C319(0.86)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C319(0.76)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C319(0.63)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C319(1.66)  LDD0716  [6]
 LDCM0400  CL13 PaTu 8988t C319(1.17)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C319(1.34)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C319(1.67)  LDD1281  [6]
 LDCM0403  CL16 HCT 116 C319(1.13)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C319(1.00)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C319(1.42)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C319(1.41)  LDD0723  [6]
 LDCM0407  CL2 PaTu 8988t C319(1.58)  LDD1286  [6]
 LDCM0408  CL20 HCT 116 C319(1.15)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C319(2.33)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C319(3.52)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C319(1.84)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C319(2.18)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C319(2.08)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C319(1.65)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C319(1.47)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C319(1.65)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C319(1.89)  LDD0734  [6]
 LDCM0418  CL3 PaTu 8988t C319(2.00)  LDD1297  [6]
 LDCM0419  CL30 HCT 116 C319(1.54)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C319(1.10)  LDD1018  [6]
 LDCM0421  CL32 HCT 116 C319(1.44)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C319(0.86)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C319(0.86)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C319(1.05)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C319(0.92)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C319(1.37)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C319(1.28)  LDD0745  [6]
 LDCM0429  CL4 PaTu 8988t C319(1.51)  LDD1308  [6]
 LDCM0430  CL40 HCT 116 C319(0.82)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C319(0.99)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C319(0.81)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C319(1.06)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C319(1.43)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C319(0.80)  LDD0752  [6]
 LDCM0436  CL46 HEK-293T C319(1.15)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C319(0.97)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C319(1.34)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C319(1.41)  LDD1037  [6]
 LDCM0440  CL5 PaTu 8988t C319(1.42)  LDD1319  [6]
 LDCM0441  CL50 HEK-293T C319(1.60)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C319(1.41)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C319(0.86)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C319(1.29)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C319(1.41)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C319(0.98)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C319(1.36)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C319(1.60)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C319(0.94)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C319(1.11)  LDD1048  [6]
 LDCM0451  CL6 PaTu 8988t C319(1.35)  LDD1330  [6]
 LDCM0452  CL60 HEK-293T C319(1.39)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C319(1.00)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C319(1.18)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C319(1.30)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C319(1.66)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C319(0.99)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C319(1.17)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C319(1.17)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C319(1.33)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C319(1.21)  LDD1059  [6]
 LDCM0462  CL7 PaTu 8988t C319(1.72)  LDD1341  [6]
 LDCM0463  CL70 HEK-293T C319(1.17)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C319(1.23)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C319(0.90)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C319(1.74)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C319(1.58)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C319(0.98)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C319(1.18)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C319(0.78)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C319(0.92)  LDD1070  [6]
 LDCM0473  CL8 PaTu 8988t C319(1.36)  LDD1352  [6]
 LDCM0474  CL80 HEK-293T C319(0.95)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C319(0.90)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C319(0.97)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C319(1.06)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C319(0.99)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C319(0.91)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C319(0.92)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C319(1.10)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C319(1.11)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C319(0.93)  LDD1081  [6]
 LDCM0484  CL9 PaTu 8988t C319(1.18)  LDD1363  [6]
 LDCM0485  CL90 HEK-293T C319(1.52)  LDD1083  [6]
 LDCM0486  CL91 HCT 116 C319(1.08)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C319(1.10)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C319(1.20)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C319(1.47)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C319(1.09)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C319(1.25)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C319(1.08)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C319(1.43)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C319(1.13)  LDD0811  [6]
 LDCM0028  Dobutamine HEK-293T 4.05  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 4.17  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C453(0.96)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C319(1.06)  LDD1702  [2]
 LDCM0625  F8 Ramos C453(1.35); C319(1.45)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C453(1.48); C319(2.05)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C453(0.23)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C453(1.18); C319(0.89)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C453(1.35)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C453(0.89); C319(1.24)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C453(1.01); C319(0.92)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C453(1.23); C319(1.13)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C453(1.73); C319(1.22)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C453(1.24)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C453(0.86); C319(0.85)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C453(1.44); C319(1.21)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C453(1.34); C319(1.19)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C453(1.63); C319(2.46)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C319(1.95)  LDD1066  [6]
 LDCM0596  Fragment38 Ramos C453(1.19); C319(1.12)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C453(0.89); C319(0.87)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C319(1.07)  LDD0744  [6]
 LDCM0614  Fragment56 Ramos C453(2.15); C319(1.47)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C453(1.00); C319(0.98)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C453(1.39); C319(1.23)  LDD2188  [16]
 LDCM0022  KB02 HCT 116 C453(1.31); C319(1.75)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C453(1.40); C319(1.13)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C453(1.54); C319(1.44)  LDD0082  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C319(1.08)  LDD2096  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C319(1.10)  LDD2118  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C319(1.36)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C319(1.13)  LDD2122  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C319(1.16)  LDD2124  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C319(0.83)  LDD2126  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C319(1.68)  LDD2143  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
Regulator of nonsense transcripts 1 (UPF1) DNA2/NAM7 helicase family Q92900
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein mago nashi homolog (MAGOH) Mago nashi family P61326
RNA-binding protein 8A (RBM8A) RBM8A family Q9Y5S9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Regulator of nonsense transcripts 3A (UPF3A) RENT3 family Q9H1J1
Regulator of nonsense transcripts 2 (UPF2) . Q9HAU5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578