Details of the Target

General Information of Target

Target ID LDTP10361
Target Name BLOC-1-related complex subunit 6 (BORCS6)
Gene Name BORCS6
Gene ID 54785
Synonyms
C17orf59; BLOC-1-related complex subunit 6; Lysosome-dispersing protein; Lyspersin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAPWALLSPGVLVRTGHTVLTWGITLVLFLHDTELRQWEEQGELLLPLTFLLLVLGSLLL
YLAVSLMDPGYVNVQPQPQEELKEEQTAMVPPAIPLRRCRYCLVLQPLRARHCRECRRCV
RRYDHHCPWMENCVGERNHPLFVVYLALQLVVLLWGLYLAWSGLRFFQPWGQWLRSSGLL
FATFLLLSLFSLVASLLLVSHLYLVASNTTTWEFISSHRIAYLRQRPSNPFDRGLTRNLA
HFFCGWPSGSWETLWAEEEEEGSSPAV
Target Bioclass
Other
Family
BORCS6 family
Subcellular location
Lysosome membrane
Function
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
Uniprot ID
Q96GS4
Ensemble ID
ENST00000389017.6
HGNC ID
HGNC:25939

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K357(0.50)  LDD0277  [2]
DA-P3
 Probe Info  		6.08  LDD0180  [3]
DBIA
 Probe Info  		C176(1.09)  LDD0078  [4]
5E-2FA
 Probe Info  		H102(0.00); H20(0.00); H57(0.00)  LDD2235  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C356(0.00); C67(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C356(0.00); C67(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		C325(0.00); C356(0.00)  LDD0027  [7]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C67(0.00); C176(0.00); C126(0.00)  LDD0018  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C176(0.00); C356(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C176(0.98)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C176(0.85)  LDD0813  [4]
 LDCM0216  AC100 HCT 116 C176(1.46)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C176(0.88)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C176(1.05)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C176(2.13)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C176(1.43)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C176(0.92)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C176(1.53)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C176(1.80)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C176(0.93)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C176(1.18)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C176(1.42)  LDD0824  [4]
 LDCM0227  AC110 HCT 116 C176(1.64)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C176(1.01)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C176(1.30)  LDD0546  [4]
 LDCM0230  AC113 HEK-293T C176(0.89)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C176(0.92)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C176(1.08)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C176(1.37)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C176(0.95)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C176(0.98)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C176(0.75)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C176(1.35)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C176(0.64)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C176(0.76)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C176(1.05)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C176(0.77)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C176(0.99)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C176(0.76)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C176(0.95)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C176(1.02)  LDD0843  [4]
 LDCM0259  AC14 HEK-293T C176(0.92)  LDD0857  [4]
 LDCM0263  AC143 HCT 116 C176(1.09)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C176(1.44)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C176(0.88)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C176(1.14)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C176(1.23)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C176(1.64)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C176(1.48)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C176(0.74)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C176(1.11)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C176(0.93)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C176(1.52)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C176(2.39)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C176(1.63)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C176(1.22)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C176(1.21)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C176(1.10)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C176(0.67)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C176(1.41)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C176(1.64)  LDD0876  [4]
 LDCM0279  AC2 HCT 116 C176(1.02)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C176(1.01)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C176(0.96)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C176(1.22)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C176(1.17)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C176(1.43)  LDD0882  [4]
 LDCM0285  AC25 PaTu 8988t C176(0.86)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C176(0.79)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C176(0.64)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C176(1.12)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C176(0.69)  LDD1168  [4]
 LDCM0290  AC3 HCT 116 C176(1.22)  LDD0607  [4]
 LDCM0291  AC30 PaTu 8988t C176(1.12)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C176(1.72)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C176(0.86)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C176(1.52)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C176(1.71)  LDD1174  [4]
 LDCM0296  AC35 PaTu 8988t C296(0.95)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C296(1.17)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C296(0.93)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C296(1.03)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C296(1.11)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C176(1.25)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C296(1.09)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C296(0.95)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C296(1.10)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C296(0.87)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C296(0.89)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C296(1.08)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C296(1.07); C176(2.05)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C296(0.91); C176(1.56)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C296(0.83); C176(1.07)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C296(1.25); C176(2.04)  LDD1190  [4]
 LDCM0312  AC5 HCT 116 C176(1.02)  LDD0629  [4]
 LDCM0313  AC50 PaTu 8988t C296(1.38); C176(2.06)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C296(0.87); C176(0.40)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C296(0.98); C176(1.75)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C296(1.07); C176(1.38)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C296(0.98); C176(2.02)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C296(1.03); C176(1.82)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C296(1.27); C176(1.17)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C176(1.22)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C176(0.98)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C176(1.16)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C176(1.36)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C176(1.10)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C176(0.89)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C176(0.81)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C176(0.85)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C176(1.09)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C176(0.89)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C176(0.77)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C176(0.85)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C176(0.74)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C176(0.81)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C176(1.30)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C176(0.94)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C176(0.68)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C176(0.67)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C176(0.66)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C176(0.55)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C176(1.02)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C176(0.93)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C176(0.75)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C176(0.84)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C176(0.99)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C176(1.19)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C176(0.83)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C176(0.86)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C176(0.76)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C176(1.30)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C176(0.97)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C176(1.06)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C176(1.03)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C176(0.90)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C176(0.95)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C176(1.24)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C176(0.68)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C176(1.85)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C176(1.45)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C176(0.96)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C176(1.60)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C176(1.75)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C176(1.89)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C176(1.34)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C176(2.22)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C176(2.32)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C176(0.99)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C176(0.84)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C176(1.27)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 12.28  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C176(1.09)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C176(1.82); C356(1.08); C67(0.51)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C176(0.77)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C176(1.14)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C176(1.07)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C176(1.09)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C176(1.09)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C176(1.05)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C176(1.15)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C176(0.99)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C176(0.88)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C176(1.46)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C176(0.83)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C176(1.57)  LDD0976  [4]
 LDCM0379  CL11 HCT 116 C176(1.23)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C176(1.16)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C176(2.16)  LDD0979  [4]
 LDCM0382  CL112 PaTu 8988t C176(1.51)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C176(0.91)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C176(1.27)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C176(1.55)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C176(1.07)  LDD1265  [4]
 LDCM0387  CL117 PaTu 8988t C296(0.93)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C296(1.16)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C296(1.07)  LDD1268  [4]
 LDCM0390  CL12 HCT 116 C176(1.05)  LDD0707  [4]
 LDCM0391  CL120 PaTu 8988t C296(1.04)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C296(1.37); C176(1.45)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C296(1.35); C176(2.28)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C296(0.86); C176(1.35)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C296(1.09); C176(1.71)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C176(0.94)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C176(1.04)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C176(1.05)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C176(1.17)  LDD0997  [4]
 LDCM0400  CL13 HCT 116 C176(0.83)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C176(0.92)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C176(0.80)  LDD0719  [4]
 LDCM0403  CL16 PaTu 8988t C176(1.29)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C176(1.35)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C176(1.16)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C176(1.28)  LDD1285  [4]
 LDCM0407  CL2 HCT 116 C176(1.07)  LDD0724  [4]
 LDCM0408  CL20 PaTu 8988t C176(2.11)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C176(1.89)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C176(1.38)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C176(1.26)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C176(1.25)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C176(0.96)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C176(1.48)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C176(1.08)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C176(1.68)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C176(1.70)  LDD1296  [4]
 LDCM0418  CL3 HCT 116 C176(1.08)  LDD0735  [4]
 LDCM0419  CL30 PaTu 8988t C176(1.07)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C176(1.37)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C176(2.26)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C176(1.85)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C176(1.75)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C176(1.53)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C176(1.55)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C176(2.01)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C176(1.86)  LDD1307  [4]
 LDCM0429  CL4 HCT 116 C176(0.76)  LDD0746  [4]
 LDCM0430  CL40 PaTu 8988t C176(1.96)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C176(2.14)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C176(2.88)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C176(3.27)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C176(2.37)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C176(2.14)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C67(0.92); C242(1.44); C356(0.96); C176(0.97)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C67(1.01); C242(1.09); C356(0.96); C176(0.97)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C67(1.05); C242(1.33); C356(1.10); C176(1.03)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C67(0.97); C242(1.15); C356(0.97); C176(1.21)  LDD1643  [13]
 LDCM0440  CL5 HCT 116 C176(0.83)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C67(0.99); C242(1.08); C356(1.00); C296(0.87)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C67(1.04); C242(1.11); C356(1.06); C176(0.68)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C67(1.08); C242(1.05); C356(0.91); C176(0.86)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C67(0.94); C242(1.20); C356(1.08); C296(0.82)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C67(1.10); C242(1.02); C356(1.17); C176(1.10)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C67(1.07); C242(1.08); C356(0.93); C296(0.97)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C67(1.10); C242(1.04); C356(0.88); C176(1.47)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C67(0.91); C242(1.61); C356(0.90); C176(0.83)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C67(0.94); C242(1.44); C356(1.01); C176(1.03)  LDD1653  [13]
 LDCM0451  CL6 HCT 116 C176(1.06)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C67(1.08); C242(1.32); C356(1.05); C176(1.00)  LDD1655  [13]
 LDCM0453  CL61 PaTu 8988t C296(1.08); C176(1.02)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C296(1.65); C176(1.69)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C296(1.53); C176(1.65)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C296(1.05); C176(1.75)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C296(1.13); C176(1.54)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C296(1.46); C176(1.43)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C296(1.33); C176(1.63)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C296(1.25); C176(1.76)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C296(1.18); C176(1.82)  LDD1340  [4]
 LDCM0462  CL7 HCT 116 C176(0.89)  LDD0779  [4]
 LDCM0463  CL70 PaTu 8988t C296(1.43); C176(1.60)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C296(1.25); C176(1.44)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C296(0.97); C176(1.61)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C296(1.45); C176(1.91)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C296(1.15); C176(1.16)  LDD1346  [4]
 LDCM0469  CL76 HEK-293T C67(0.91); C242(1.14); C356(1.02); C176(0.69)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C67(0.95); C242(1.21); C356(0.85); C176(1.27)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C67(1.01); C242(1.13); C356(0.97); C296(0.89)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C67(0.99); C242(0.96); C356(1.13); C176(1.04)  LDD1675  [13]
 LDCM0473  CL8 HCT 116 C176(1.47)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C67(0.92); C242(0.90); C356(1.02); C296(1.02)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C67(0.95); C242(1.14); C356(0.95); C176(1.24)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C67(0.91); C242(1.39); C356(0.99); C176(0.97)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C67(0.92); C242(1.27); C356(0.95); C176(1.17)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C67(0.87); C242(1.66); C356(0.91); C176(0.98)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C67(0.93); C242(1.09); C356(1.00); C176(0.98)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C67(0.87); C242(1.14); C356(1.00); C296(0.91)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C67(0.86); C242(1.02); C356(0.95); C176(0.82)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C67(0.83); C242(1.19); C356(1.02); C176(1.01)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C67(0.93); C242(1.12); C356(0.98); C176(1.12)  LDD1686  [13]
 LDCM0484  CL9 HCT 116 C176(1.22)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C67(0.77); C242(1.06); C356(0.95); C296(0.86)  LDD1688  [13]
 LDCM0486  CL91 HCT 116 C176(1.48)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C176(1.01)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C176(0.99)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C176(1.10)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C176(1.13)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C176(0.84)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C176(1.23)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C176(1.47)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C176(1.06)  LDD0811  [4]
 LDCM0028  Dobutamine HEK-293T 6.08  LDD0180  [3]
 LDCM0495  E2913 HEK-293T C67(1.10); C242(0.90); C356(1.06); C176(1.00)  LDD1698  [13]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.46  LDD0183  [3]
 LDCM0625  F8 Ramos C67(6.68)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C67(2.56)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C67(13.57)  LDD2190  [14]
 LDCM0575  Fragment13 Ramos C67(0.71)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C67(0.43)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C67(0.92)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C67(0.72)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C67(1.19)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C67(0.99)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C67(0.75)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C67(1.88)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C67(2.17)  LDD2200  [14]
 LDCM0468  Fragment33 PaTu 8988t C296(1.38); C176(1.67)  LDD1347  [4]
 LDCM0596  Fragment38 Ramos C67(3.18)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C67(0.95)  LDD2184  [14]
 LDCM0427  Fragment51 PaTu 8988t C176(2.05)  LDD1306  [4]
 LDCM0610  Fragment52 Ramos C67(1.27)  LDD2204  [14]
 LDCM0569  Fragment7 Ramos C67(1.24)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C67(0.78)  LDD2188  [14]
 LDCM0022  KB02 HCT 116 C176(1.44)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C176(1.22)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C176(1.32)  LDD0082  [4]
 LDCM0032  Oleacein HEK-293T 4.01  LDD0184  [3]
 LDCM0029  Quercetin HEK-293T 8.51  LDD0181  [3]
 LDCM0131  RA190 MM1.R C296(1.35)  LDD0304  [15]
 LDCM0021  THZ1 HCT 116 C176(1.03)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Mediator of RNA polymerase II transcription subunit 21 (MED21) Mediator complex subunit 21 family Q13503
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
E3 ubiquitin-protein ligase SHPRH (SHPRH) SNF2/RAD54 helicase family Q149N8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
F-box only protein 44 (FBXO44) . Q9H4M3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Homeobox protein PKNOX1 (PKNOX1) TALE/MEIS homeobox family P55347
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX2 (BEX2) BEX family Q9BXY8
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Dynactin subunit 2 (DCTN2) Dynactin subunit 2 family Q13561
Epidermal growth factor receptor kinase substrate 8 (EPS8) EPS8 family Q12929
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM9C (FAM9C) FAM9 family Q8IZT9
Ragulator complex protein LAMTOR2 (LAMTOR2) GAMAD family Q9Y2Q5
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Inhibitory synaptic factor 1 (INSYN1) INSYN1 family Q2T9L4
KxDL motif-containing protein 1 (KXD1) KXD1 family Q9BQD3
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
RIB43A-like with coiled-coils protein 1 (RIBC1) RIB43A family Q8N443
UPF0449 protein C19orf25 (C19orf25) UPF0449 family Q9UFG5
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.