Details of the Target

General Information of Target

Target ID LDTP09165
Target Name PDZ domain-containing protein 8 (PDZD8)
Gene Name PDZD8
Gene ID 118987
Synonyms
PDZK8; PDZ domain-containing protein 8; Sarcoma antigen NY-SAR-84/NY-SAR-104
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYL
YGGGRDEEPSGAAPEGGATPTAAPETPAPPTRETCYFLNATILFLFRELRDTALTRRWVT
KKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE
ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTH
WFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKKIIKRKHTLPNYKIRFKPFFPYQT
LQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ
RSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAIADLQRGDRLIAIG
GVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGAVLQDNFGQLEENFLSSSCQSGYEE
EAAGLTVDTESRELDSEFEDLASDVRAQNEFKDEAQSLSHSPKRVPTTLSIKPLGAISPV
LNRKLAVGSHPLPPKIQSKDGNKPPPLKTSEITDPAQVSKPTQGSAFKPPVPPRPQAKVP
LPSADAPNQAEPDVLVEKPEKVVPPPLVDKSAEKQAKNVDAIDDAAAPKQFLAKQEVAKD
VTSETSCPTKDSSDDRQTWESSEILYRNKLGKWTRTRASCLFDIEACHRYLNIALWCRDP
FKLGGLICLGHVSLKLEDVALGCLATSNTEYLSKLRLEAPSPKAIVTRTALRNLSMQKGF
NDKFCYGDITIHFKYLKEGESDHHVVTNVEKEKEPHLVEEVSVLPKEEQFVGQMGLTENK
HSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETSVCGATDRRIDR
TLKNLRLEGQETLLGLPPRVDAEASKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLSEPG
TDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNSTGIKLVRKEGGLDDSVFIAVKEIG
RDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDTRKKSLLSAALAKS
GERLQALTLLMIHYRAGIEDIETLESLSLDQHSKKISKYTDDTEEDLDNEISQLIDSQPF
SSISDDLFGPSESV
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum membrane
Function
Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons. Plays an indirect role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage.
Uniprot ID
Q8NEN9
Ensemble ID
ENST00000334464.7
HGNC ID
HGNC:26974

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K282(2.50)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
NAIA_5
 Probe Info  		C985(20.00)  LDD2227  [4]
DA-P3
 Probe Info  		4.96  LDD0180  [5]
DBIA
 Probe Info  		C884(1.52); C891(1.52); C667(2.01); C785(1.45)  LDD0080  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C700(1.21); C707(1.07); C717(0.77); C785(0.86)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C700(1.30); C707(1.20); C785(1.07)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C700(0.86); C707(0.97); C785(0.91)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C700(1.00); C707(1.05); C785(0.87)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C700(1.06); C707(0.99); C785(0.94)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C700(1.06); C707(1.16); C785(0.94)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C700(1.07); C707(1.01); C785(0.97)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C700(0.78); C707(0.83); C785(0.99)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C700(0.94); C707(0.97); C785(0.92)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C700(0.86); C707(0.90); C785(1.03)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C700(0.99); C707(1.04); C785(0.95)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C700(0.90); C707(0.89); C785(0.85)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C700(1.09); C707(1.05); C785(1.17)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C700(0.93); C707(1.02); C785(0.77)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C700(1.13); C707(1.13); C785(0.83)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C700(0.94); C707(1.00); C785(0.85)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C700(0.88); C707(0.88); C785(0.95); C884(1.09)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C700(0.71); C707(1.00); C785(0.97); C884(1.20)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C700(0.96); C707(0.92); C785(1.14); C884(1.27)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C700(0.92); C707(1.10); C785(1.17); C884(1.32)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C700(0.87); C707(0.93); C785(1.06); C884(1.21)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C700(0.98); C707(0.97); C785(0.98); C884(1.40)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C700(1.16); C707(0.94); C785(1.16); C884(2.18)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C700(1.02); C707(0.95); C785(1.01)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C700(0.80); C707(1.02); C785(1.08); C884(1.13)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C700(0.97); C707(0.96); C785(1.03); C884(1.32)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C700(0.75); C707(1.07); C785(1.05); C884(1.84)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C700(1.44); C707(0.97); C785(0.94); C884(1.61)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C700(1.04); C707(1.07); C785(0.96); C884(1.44)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C700(0.71); C707(1.16); C785(0.96); C884(1.28)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C700(1.00); C707(1.00); C785(1.13); C884(1.26)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C700(0.87); C707(0.97); C785(1.08); C884(1.46)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C707(1.30)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C707(1.44)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C707(1.50)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C707(1.40)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C707(1.79)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C707(1.69)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C707(1.68)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C707(1.68)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C707(1.70)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C707(1.45)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C707(2.05)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C707(1.82)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C700(1.20); C707(1.12); C785(1.18)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C707(2.49)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C707(2.10)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C707(1.69)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C700(0.91); C707(0.95); C785(0.97)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C700(0.84); C707(0.85); C785(1.09)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C707(0.87); C700(0.89); C785(1.09)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C707(0.79); C700(0.88); C785(1.18)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C707(0.84); C700(0.90); C785(0.96)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C707(0.89); C700(1.03); C785(1.13)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C707(0.86); C700(0.91); C785(1.21)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C707(1.09); C785(1.13); C700(1.16)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C707(0.80); C700(0.89); C785(1.14)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C707(0.89); C700(0.95); C785(1.18)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C707(0.88); C700(0.94); C785(1.26)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C707(0.84); C700(1.00); C785(1.50)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C700(0.88); C707(0.81); C785(1.15)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C700(0.92); C707(0.86); C785(1.39)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C700(0.94); C707(0.86); C785(1.33)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C700(0.88); C707(0.82); C785(1.28)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C884(0.85); C891(0.85); C785(0.90); C707(0.93)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C717(0.62); C884(0.92); C891(0.92); C707(1.03)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C785(0.86); C700(0.93); C667(0.93); C884(0.99)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C717(0.89); C785(0.95); C854(0.97); C707(1.01)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C785(0.88); C667(0.90); C700(0.90); C707(0.91)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C785(0.87); C884(0.88); C891(0.88); C667(0.88)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C667(0.80); C785(0.85); C884(0.87); C891(0.87)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C785(0.82); C667(0.82); C700(0.97); C707(1.03)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C785(0.81); C884(0.91); C891(0.91); C667(0.93)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C707(0.90); C717(1.02); C785(1.08); C700(1.20)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C707(0.86); C717(0.88); C785(1.06); C700(1.16)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C707(0.75); C700(0.98); C785(1.01); C717(1.02)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C707(0.78); C717(0.82); C700(1.03); C785(1.09)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C700(0.84); C707(0.89); C785(1.04); C717(1.07)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C785(0.90); C854(1.00); C707(1.07); C700(1.17)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C707(0.87); C700(0.93); C717(0.93); C785(1.04)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C707(0.86); C717(0.91); C785(1.04); C700(1.06)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C700(0.76); C717(0.90); C707(1.00); C785(1.15)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C717(0.94); C707(1.09); C785(1.10); C700(1.15)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C707(0.77); C700(0.83); C717(0.94); C785(1.28)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C717(0.83); C785(0.93)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C717(0.87); C785(0.95)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C785(0.87); C717(1.04)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C785(0.96); C717(1.00)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C717(0.89); C785(0.92)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C717(0.91); C785(0.94); C707(1.01); C854(1.16)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C717(0.91); C785(1.01)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C717(0.86); C785(0.94)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C717(0.86); C785(1.02)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C785(0.89); C717(0.95)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C717(0.82); C785(0.94)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C717(0.85); C785(1.07)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C700(0.71); C707(0.88); C785(0.94); C717(1.07)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C700(0.86); C717(0.90); C707(0.95); C785(0.99)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C700(0.73); C707(0.84); C785(0.94); C717(1.05)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C700(0.62); C707(0.87); C717(0.98); C785(1.22)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C717(0.78); C785(0.96); C854(1.09); C857(1.11)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C700(0.65); C707(0.84); C717(0.92); C785(1.13)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C700(0.73); C707(0.86); C785(0.92); C717(1.02)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C700(0.76); C707(0.94); C717(0.96); C785(1.04)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C700(0.96); C717(0.97); C785(1.06); C707(1.07)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C700(0.85); C707(0.88); C717(0.96); C785(1.14)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C700(0.82); C707(0.89); C717(0.93); C785(1.14)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C700(0.64); C707(0.75); C717(0.95); C785(1.41)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C707(0.79); C700(0.80); C884(1.07); C891(1.07)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C700(0.72); C707(0.76); C884(1.29); C891(1.29)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C700(0.76); C707(0.79); C884(1.10); C891(1.10)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C785(1.09); C707(1.10); C700(1.11)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C700(0.75); C707(0.78); C884(1.28); C891(1.28)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C700(0.80); C707(0.84); C667(1.13); C884(1.30)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C700(0.79); C707(0.82); C884(1.06); C891(1.06)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C700(0.72); C707(0.79); C884(1.25); C891(1.25)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C700(0.81); C707(0.81); C884(1.17); C891(1.17)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C700(0.77); C707(0.82); C884(1.19); C891(1.19)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C700(0.80); C707(0.83); C884(1.24); C891(1.24)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C884(0.74); C891(0.74); C700(0.78); C707(0.88)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C717(0.83); C854(0.98); C857(0.98); C785(0.99)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C884(0.81); C891(0.81); C854(0.82); C857(0.82)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C785(1.07); C707(1.14); C700(1.18)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C854(0.46); C857(0.46); C717(0.74); C884(0.76)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C854(0.89); C857(0.89); C717(0.92); C884(1.03)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C854(0.78); C857(0.78); C785(0.92); C884(0.97)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C854(0.61); C857(0.61); C884(0.82); C891(0.82)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C854(0.76); C857(0.76); C884(0.84); C891(0.84)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C854(0.64); C857(0.64); C884(0.85); C891(0.85)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C854(0.82); C857(0.82); C717(0.89); C785(0.90)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C717(0.84); C785(0.95); C854(1.00); C857(1.00)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C854(0.88); C857(0.88); C707(0.94); C785(0.96)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C854(0.75); C857(0.75); C717(0.87); C785(0.87)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C707(0.99); C700(1.05); C785(1.11)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C854(0.78); C857(0.78); C884(0.96); C891(0.96)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C717(0.87); C785(0.91); C854(0.92); C857(0.92)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C854(0.52); C857(0.52); C884(0.69); C891(0.69)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C700(1.02); C707(1.04); C884(1.16); C891(1.16)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C884(0.98); C891(0.98); C700(1.16); C707(1.20)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C700(1.03); C707(1.04); C884(1.06); C891(1.06)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C707(1.11); C700(1.11); C884(1.21); C891(1.21)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C700(1.13); C707(1.14); C884(1.37); C891(1.37)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C700(1.07); C707(1.07); C884(1.23); C891(1.23)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C707(1.07); C700(1.07); C884(1.19); C891(1.19)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C707(1.20); C700(1.20); C884(1.29); C891(1.29)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C707(1.07); C700(1.09); C884(1.29); C891(1.29)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C707(1.08); C700(1.09); C884(1.25); C891(1.25)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C884(1.01); C891(1.01); C700(1.07); C707(1.08)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C707(1.01); C884(1.07); C891(1.07); C700(1.08)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C700(0.97); C707(0.98); C884(1.30); C891(1.30)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C707(1.02); C700(1.06); C884(1.17); C891(1.17)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C700(1.06); C707(1.09); C884(1.22); C891(1.22)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C700(0.94); C785(1.00); C707(1.00)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C700(1.01); C785(1.02); C707(1.05)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C700(1.11); C707(1.03); C785(1.03)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C785(1.06); C707(1.06); C700(1.13)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C707(1.12); C700(1.15); C785(1.34)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C667(1.08); C884(1.24); C891(1.24)  LDD2171  [6]
 LDCM0632  CL-Sc Hep-G2 C985(20.00)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C707(0.89); C700(0.94); C717(1.06); C667(1.16)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C884(0.93); C891(0.93); C717(0.97); C667(0.98)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C717(0.73); C785(0.88); C707(1.01); C854(1.04)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C707(0.94); C700(1.00); C785(1.03)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C785(1.00); C707(1.26); C700(1.31)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C785(0.98); C707(1.07); C700(1.13)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C785(0.85); C707(1.07); C700(1.15)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C717(0.79); C707(0.89); C785(0.89); C667(0.96)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C717(0.81); C707(0.91); C884(1.01); C891(1.01)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C717(0.82); C884(0.94); C891(0.94); C667(0.98)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C884(0.76); C891(0.76); C717(0.89); C707(1.03)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C667(0.87); C785(0.90); C884(0.92); C891(0.92)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C667(0.94); C700(1.02); C717(1.02); C707(1.08)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C884(0.76); C891(0.76); C717(0.82); C785(0.96)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C884(0.91); C891(0.91); C667(0.99); C785(1.00)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C717(0.80); C707(0.92); C700(1.10); C785(1.10)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C700(0.73); C717(0.85); C707(0.93); C785(1.24)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C700(0.82); C717(0.92); C707(0.95); C785(1.02)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C707(0.53); C700(0.86); C717(0.94); C785(1.06)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C717(0.78); C707(0.81); C700(0.98); C785(1.12)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C717(0.83); C785(1.40)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C717(0.77); C785(0.98)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C785(0.95); C717(1.04)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C700(0.91); C717(0.99); C667(1.03); C707(1.05)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C717(0.78); C785(0.95)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C785(0.86); C700(0.98); C717(1.05); C707(1.09)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C700(0.74); C717(0.83); C707(0.88); C785(1.04)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C707(0.91); C717(0.92); C700(1.13); C785(1.20)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C700(0.84); C707(0.89); C717(0.93); C785(1.11)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C700(0.84); C667(0.89); C707(0.94); C884(1.39)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C700(0.76); C707(0.83); C667(0.91); C884(1.19)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C700(0.84); C707(0.88); C667(1.01); C884(1.20)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C707(0.88); C700(0.89); C884(1.10); C891(1.10)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C700(0.91); C707(0.94); C667(0.99); C884(1.12)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C707(0.91); C700(0.92); C667(0.92); C884(0.95)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C700(0.87); C667(0.90); C707(0.98); C717(1.00)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C785(0.93); C700(1.02); C707(1.03); C854(1.30)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C854(0.90); C857(0.90); C785(0.95); C707(0.99)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C785(0.76); C707(0.85); C700(0.95); C854(1.92)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C785(0.87); C707(1.00); C700(1.05); C854(1.29)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C884(0.80); C891(0.80); C707(0.92); C700(0.95)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C700(0.90); C707(0.91); C785(1.02); C854(1.43)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C785(0.98); C700(1.02); C707(1.03); C854(1.40)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C700(0.87); C707(0.96); C854(1.06); C857(1.06)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C707(0.88); C700(0.96); C785(0.97); C854(1.35)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C707(0.93); C700(1.00); C785(1.05); C854(1.39)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C700(1.29); C707(1.06); C785(1.07); C854(1.37)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C700(0.97); C707(0.94); C785(1.01); C854(1.10)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C700(1.02); C707(0.96); C785(1.05); C854(0.91)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C700(1.06); C707(0.99); C785(0.97); C854(1.55)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C700(0.95); C707(0.96); C785(0.96); C854(1.76)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C667(0.93); C700(1.02); C707(0.97); C717(1.24)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C700(1.11); C707(1.00); C785(0.95); C854(1.55)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C700(1.15); C707(1.11); C785(1.14); C854(0.89)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C700(1.09); C707(1.12); C785(0.98); C854(1.05)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C700(0.97); C707(1.01); C785(1.05); C854(0.80)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C700(1.01); C707(1.23); C785(1.22); C854(1.26)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C700(1.08); C707(1.02); C785(1.07); C854(1.54)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C700(0.97); C707(0.97); C785(1.22); C854(0.79)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C700(1.14); C707(1.06); C785(1.17); C854(0.94)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C700(1.19); C707(1.11); C785(1.06); C854(0.85)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C667(1.01); C700(0.84); C707(0.91); C717(1.19)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C700(1.03); C707(0.96); C785(1.13); C854(1.08)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C700(1.15); C707(1.08); C785(1.45); C854(0.93)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C700(1.03); C707(0.97); C785(1.47); C854(0.96)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C700(1.09); C707(1.04); C785(1.25); C854(1.03)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C700(1.23); C707(1.16); C785(1.30); C854(0.87)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C700(1.03); C707(1.08); C785(1.35); C854(1.12)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C667(1.03); C700(0.99); C707(1.07); C785(0.83)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C667(1.05); C700(0.86); C707(1.00); C785(0.86)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C667(1.00); C700(0.95); C707(1.02); C785(0.87)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C667(1.02); C700(0.90); C707(1.00); C785(0.95)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C667(1.05); C700(0.96); C707(0.96); C717(1.14)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C667(0.96); C700(0.94); C707(1.02); C785(0.86)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C667(0.97); C700(0.77); C707(0.94); C785(0.83)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C667(1.14); C700(0.88); C707(1.01); C785(0.91)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C667(0.92); C700(0.91); C707(0.96); C785(0.95)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C667(0.95); C700(0.96); C707(1.05); C785(0.80)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C667(0.97); C700(0.82); C707(0.90); C785(0.86)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C667(1.07); C700(0.84); C707(0.90); C785(0.95)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C667(1.08); C700(0.86); C707(0.92); C785(0.86)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C667(1.01); C700(0.81); C707(0.95); C785(0.81)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C667(1.09); C700(0.98); C707(0.99); C785(0.94)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C667(1.10); C700(1.07); C707(1.07); C717(1.02)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C667(0.96); C700(0.86); C707(0.91); C785(0.92)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C700(0.90); C707(0.90); C785(1.04)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C700(0.85); C707(0.82); C785(1.10)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C700(1.04); C707(0.91); C785(0.74)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C700(0.95); C707(0.94); C785(1.00)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C700(0.96); C707(0.92); C785(0.78)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C700(1.09); C707(1.03); C785(0.95)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C700(0.94); C707(0.93); C785(0.60)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C700(0.91); C707(0.87); C785(0.98)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C700(0.92); C707(0.87); C785(0.81)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C667(1.06); C700(0.96); C707(0.98); C717(1.63)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C700(0.98); C707(0.97); C785(1.02)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C700(0.83); C707(0.92); C785(0.79)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C700(0.85); C707(0.89); C785(0.79)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C700(0.86); C707(0.89); C785(0.66)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C700(0.85); C707(0.87); C785(0.67)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C700(1.08); C707(1.11)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C700(0.96); C707(1.01)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C700(0.90); C707(0.96)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C700(1.02); C707(1.05)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C667(1.05); C700(1.05); C707(1.07); C717(1.14)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C700(1.14); C707(1.14)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C700(1.03); C707(1.07)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C700(1.19); C707(1.19)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C700(1.08); C707(1.13)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C700(1.05); C707(1.09)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C700(1.01); C707(1.02)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C700(1.06); C707(1.06)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C700(1.12); C707(1.12)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C700(1.11); C707(1.11)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C700(1.08); C707(1.07)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C667(1.12); C700(0.78); C707(0.81); C717(1.16)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C700(1.14); C707(1.19)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C700(1.21); C707(1.16); C717(0.75); C785(1.14)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C700(0.96); C707(1.01); C717(0.62); C785(1.11)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C700(0.96); C707(0.97); C717(0.88); C785(0.88)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C700(1.03); C707(1.05); C717(0.73); C785(0.90)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C700(1.13); C707(1.12); C717(0.74); C785(1.12)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C700(1.16); C707(1.11); C717(0.71); C785(1.09)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C700(1.27); C707(1.28); C717(0.85); C785(1.11)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C700(1.33); C707(1.18); C717(0.89); C785(0.92)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C700(1.36); C707(1.16); C717(0.71); C785(0.95)  LDD0811  [6]
 LDCM0028  Dobutamine HEK-293T 4.96  LDD0180  [5]
 LDCM0495  E2913 HEK-293T C667(1.00); C707(1.00); C891(0.73)  LDD1698  [9]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.51  LDD0183  [5]
 LDCM0468  Fragment33 HCT 116 C700(0.93); C707(0.99); C785(0.82)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C700(0.95); C707(1.00); C785(1.31); C854(1.02)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C884(1.52); C891(1.52); C667(2.01); C785(1.45)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C884(2.14); C891(2.14); C667(1.16); C785(1.19)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C884(1.79); C891(1.79); C667(1.58); C785(1.25)  LDD0082  [6]
 LDCM0030  Luteolin HEK-293T 5.57  LDD0182  [5]
 LDCM0021  THZ1 HCT 116 C667(1.08); C884(1.24); C891(1.24)  LDD2173  [6]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402