Details of the Target

General Information of Target

Target ID LDTP01028
Target Name Protein arginine N-methyltransferase 3 (PRMT3)
Gene Name PRMT3
Gene ID 10196
Synonyms
HRMT1L3; Protein arginine N-methyltransferase 3; EC 2.1.1.319; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
Subcellular location
Cytoplasm
Function
Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (Probable). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity.
TTD ID
T76723
Uniprot ID
O60678
DrugMap ID
TTL4XSQ
Ensemble ID
ENST00000331079.11
HGNC ID
HGNC:30163
ChEMBL ID
CHEMBL5891

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.V199A .
HCT15 SNV: p.L92P .
HT SNV: p.D182V DBIA    Probe Info 
HT115 SNV: p.E231A .
Ishikawa (Heraklio) 02 ER SNV: p.A60T DBIA    Probe Info 
MCC13 Substitution: p.D128_L129delinsEF .
MFE280 SNV: p.S157F DBIA    Probe Info 
MFE319 SNV: p.C67Y DBIA    Probe Info 
REH SNV: p.R244Q DBIA    Probe Info 
TCCSUP SNV: p.G218S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K163(2.35)  LDD0277  [2]
DBIA
 Probe Info  		C67(1.33); C417(1.79)  LDD3310  [3]
BTD
 Probe Info  		C417(2.47)  LDD1700  [4]
DA-P3
 Probe Info  		4.43  LDD0179  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C363(0.00); C67(0.00); C264(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C67(0.00); C417(0.00); C264(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C67(0.00); C417(0.00); C363(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
ENE
 Probe Info  		N.A.  LDD0006  [8]
PPMS
 Probe Info  		N.A.  LDD0008  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
Acrolein
 Probe Info  		C417(0.00); H66(0.00)  LDD0217  [10]
AOyne
 Probe Info  		12.50  LDD0443  [11]
NAIA_5
 Probe Info  		C67(0.00); C264(0.00)  LDD2223  [12]
HHS-482
 Probe Info  		Y291(1.61)  LDD2239  [13]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C429
 Probe Info  		14.12  LDD2084  [14]
FFF probe3
 Probe Info  		9.43  LDD0465  [15]
STS-1
 Probe Info  		N.A.  LDD0136  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C417(1.09)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C417(1.40)  LDD2152  [4]
 LDCM0214  AC1 HEK-293T C264(0.73)  LDD0812  [17]
 LDCM0215  AC10 HEK-293T C264(2.01)  LDD0813  [17]
 LDCM0216  AC100 HEK-293T C417(1.09)  LDD0814  [17]
 LDCM0217  AC101 HEK-293T C417(1.22)  LDD0815  [17]
 LDCM0218  AC102 HEK-293T C417(1.10)  LDD0816  [17]
 LDCM0219  AC103 HEK-293T C417(1.17)  LDD0817  [17]
 LDCM0220  AC104 HEK-293T C417(1.11)  LDD0818  [17]
 LDCM0221  AC105 HEK-293T C417(1.10)  LDD0819  [17]
 LDCM0222  AC106 HEK-293T C417(1.04)  LDD0820  [17]
 LDCM0223  AC107 HEK-293T C417(1.11)  LDD0821  [17]
 LDCM0224  AC108 HEK-293T C417(1.04)  LDD0822  [17]
 LDCM0225  AC109 HEK-293T C417(1.18)  LDD0823  [17]
 LDCM0226  AC11 HEK-293T C264(1.11)  LDD0824  [17]
 LDCM0227  AC110 HEK-293T C417(1.07)  LDD0825  [17]
 LDCM0228  AC111 HEK-293T C417(1.08)  LDD0826  [17]
 LDCM0229  AC112 HEK-293T C417(1.05)  LDD0827  [17]
 LDCM0237  AC12 HEK-293T C264(1.76)  LDD0835  [17]
 LDCM0246  AC128 HEK-293T C417(0.90)  LDD0844  [17]
 LDCM0247  AC129 HEK-293T C417(0.95)  LDD0845  [17]
 LDCM0249  AC130 HEK-293T C417(0.84)  LDD0847  [17]
 LDCM0250  AC131 HEK-293T C417(0.97)  LDD0848  [17]
 LDCM0251  AC132 HEK-293T C417(0.99)  LDD0849  [17]
 LDCM0252  AC133 HEK-293T C417(0.96)  LDD0850  [17]
 LDCM0253  AC134 HEK-293T C417(0.94)  LDD0851  [17]
 LDCM0254  AC135 HEK-293T C417(0.98)  LDD0852  [17]
 LDCM0255  AC136 HEK-293T C417(1.05)  LDD0853  [17]
 LDCM0256  AC137 HEK-293T C417(1.03)  LDD0854  [17]
 LDCM0257  AC138 HEK-293T C417(0.88)  LDD0855  [17]
 LDCM0258  AC139 HEK-293T C417(0.99)  LDD0856  [17]
 LDCM0259  AC14 HEK-293T C264(1.36)  LDD0857  [17]
 LDCM0260  AC140 HEK-293T C417(0.94)  LDD0858  [17]
 LDCM0261  AC141 HEK-293T C417(0.95)  LDD0859  [17]
 LDCM0262  AC142 HEK-293T C417(0.96)  LDD0860  [17]
 LDCM0263  AC143 HEK-293T C417(1.07)  LDD0861  [17]
 LDCM0264  AC144 HEK-293T C417(1.03)  LDD0862  [17]
 LDCM0265  AC145 HEK-293T C417(0.97)  LDD0863  [17]
 LDCM0266  AC146 HEK-293T C417(1.07)  LDD0864  [17]
 LDCM0267  AC147 HEK-293T C417(1.12)  LDD0865  [17]
 LDCM0268  AC148 HEK-293T C417(1.06)  LDD0866  [17]
 LDCM0269  AC149 HEK-293T C417(1.00)  LDD0867  [17]
 LDCM0270  AC15 HEK-293T C264(0.97)  LDD0868  [17]
 LDCM0271  AC150 HEK-293T C417(1.04)  LDD0869  [17]
 LDCM0272  AC151 HEK-293T C417(0.94)  LDD0870  [17]
 LDCM0273  AC152 HEK-293T C417(0.94)  LDD0871  [17]
 LDCM0274  AC153 HEK-293T C417(0.97)  LDD0872  [17]
 LDCM0621  AC154 HEK-293T C417(0.97)  LDD2162  [17]
 LDCM0622  AC155 HEK-293T C417(1.05)  LDD2163  [17]
 LDCM0623  AC156 HEK-293T C417(1.07)  LDD2164  [17]
 LDCM0624  AC157 HEK-293T C417(1.01)  LDD2165  [17]
 LDCM0276  AC17 PaTu 8988t C67(0.81); C264(0.80)  LDD1155  [17]
 LDCM0277  AC18 PaTu 8988t C67(0.67); C264(0.57)  LDD1156  [17]
 LDCM0278  AC19 PaTu 8988t C67(0.70); C264(0.84)  LDD1157  [17]
 LDCM0279  AC2 HEK-293T C264(0.99)  LDD0877  [17]
 LDCM0280  AC20 PaTu 8988t C67(0.60); C264(0.63)  LDD1159  [17]
 LDCM0281  AC21 PaTu 8988t C67(0.60); C264(0.50)  LDD1160  [17]
 LDCM0282  AC22 PaTu 8988t C67(0.59); C264(0.47)  LDD1161  [17]
 LDCM0283  AC23 PaTu 8988t C67(0.47); C264(0.73)  LDD1162  [17]
 LDCM0284  AC24 PaTu 8988t C67(1.05); C264(0.85)  LDD1163  [17]
 LDCM0285  AC25 HEK-293T C67(1.29)  LDD0883  [17]
 LDCM0286  AC26 HEK-293T C67(1.35)  LDD0884  [17]
 LDCM0287  AC27 HEK-293T C67(1.51)  LDD0885  [17]
 LDCM0288  AC28 HEK-293T C67(1.51)  LDD0886  [17]
 LDCM0289  AC29 HEK-293T C67(1.23)  LDD0887  [17]
 LDCM0290  AC3 HEK-293T C264(0.74)  LDD0888  [17]
 LDCM0291  AC30 HEK-293T C67(1.40)  LDD0889  [17]
 LDCM0292  AC31 HEK-293T C67(1.78)  LDD0890  [17]
 LDCM0293  AC32 HEK-293T C67(1.45)  LDD0891  [17]
 LDCM0294  AC33 HEK-293T C67(1.34)  LDD0892  [17]
 LDCM0295  AC34 HEK-293T C67(1.66)  LDD0893  [17]
 LDCM0296  AC35 HEK-293T C417(1.00); C264(0.97)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C417(1.02); C264(1.07)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C417(0.99); C264(1.06)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C417(0.97); C264(1.05)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C417(1.03); C264(0.98)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C264(0.94)  LDD0899  [17]
 LDCM0302  AC40 HEK-293T C417(0.91); C264(1.12); C363(0.92)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C417(0.98); C264(1.10)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C417(0.89); C264(1.10)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C417(0.94); C264(0.99)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C417(0.95); C264(1.13)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C417(0.94); C264(1.09)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C264(1.21)  LDD0906  [17]
 LDCM0309  AC47 HEK-293T C264(1.04)  LDD0907  [17]
 LDCM0310  AC48 HEK-293T C264(1.28)  LDD0908  [17]
 LDCM0311  AC49 HEK-293T C264(1.23)  LDD0909  [17]
 LDCM0312  AC5 HEK-293T C264(0.99)  LDD0910  [17]
 LDCM0313  AC50 HEK-293T C264(1.21)  LDD0911  [17]
 LDCM0314  AC51 HEK-293T C264(1.31)  LDD0912  [17]
 LDCM0315  AC52 HEK-293T C264(1.25)  LDD0913  [17]
 LDCM0316  AC53 HEK-293T C264(1.57)  LDD0914  [17]
 LDCM0317  AC54 HEK-293T C264(1.33)  LDD0915  [17]
 LDCM0318  AC55 HEK-293T C264(1.37)  LDD0916  [17]
 LDCM0319  AC56 HEK-293T C264(1.67)  LDD0917  [17]
 LDCM0320  AC57 HEK-293T C264(1.35); C67(1.15)  LDD0918  [17]
 LDCM0321  AC58 HEK-293T C264(1.22); C67(1.27)  LDD0919  [17]
 LDCM0322  AC59 HEK-293T C264(1.54); C67(0.99)  LDD0920  [17]
 LDCM0323  AC6 HEK-293T C264(0.69)  LDD0921  [17]
 LDCM0324  AC60 HEK-293T C264(1.12); C67(0.84)  LDD0922  [17]
 LDCM0325  AC61 HEK-293T C264(1.20); C67(0.91)  LDD0923  [17]
 LDCM0326  AC62 HEK-293T C264(1.48); C67(0.98)  LDD0924  [17]
 LDCM0327  AC63 HEK-293T C264(1.08); C67(0.77)  LDD0925  [17]
 LDCM0328  AC64 HEK-293T C264(1.53); C67(1.18)  LDD0926  [17]
 LDCM0329  AC65 HEK-293T C264(1.35); C67(1.18)  LDD0927  [17]
 LDCM0330  AC66 HEK-293T C264(1.44); C67(0.87)  LDD0928  [17]
 LDCM0331  AC67 HEK-293T C264(1.58); C67(0.99)  LDD0929  [17]
 LDCM0332  AC68 HEK-293T C264(0.80); C67(0.86)  LDD0930  [17]
 LDCM0333  AC69 HEK-293T C264(0.87); C67(0.76)  LDD0931  [17]
 LDCM0334  AC7 HEK-293T C264(1.14)  LDD0932  [17]
 LDCM0335  AC70 HEK-293T C264(2.46); C67(0.77)  LDD0933  [17]
 LDCM0336  AC71 HEK-293T C264(1.08); C67(0.92)  LDD0934  [17]
 LDCM0337  AC72 HEK-293T C264(1.24); C67(0.87)  LDD0935  [17]
 LDCM0338  AC73 HEK-293T C264(1.31); C67(0.80)  LDD0936  [17]
 LDCM0339  AC74 HEK-293T C264(0.65); C67(1.13)  LDD0937  [17]
 LDCM0340  AC75 HEK-293T C264(0.60); C67(0.83)  LDD0938  [17]
 LDCM0341  AC76 HEK-293T C264(1.18); C67(0.83)  LDD0939  [17]
 LDCM0342  AC77 HEK-293T C264(0.85); C67(0.85)  LDD0940  [17]
 LDCM0343  AC78 HEK-293T C264(1.15); C67(0.67)  LDD0941  [17]
 LDCM0344  AC79 HEK-293T C264(0.78); C67(1.02)  LDD0942  [17]
 LDCM0345  AC8 HEK-293T C264(0.70)  LDD0943  [17]
 LDCM0346  AC80 HEK-293T C264(0.82); C67(0.80)  LDD0944  [17]
 LDCM0347  AC81 HEK-293T C264(1.02); C67(0.86)  LDD0945  [17]
 LDCM0348  AC82 HEK-293T C264(0.66); C67(0.85)  LDD0946  [17]
 LDCM0365  AC98 HEK-293T C417(1.02)  LDD0963  [17]
 LDCM0366  AC99 HEK-293T C417(1.12)  LDD0964  [17]
 LDCM0520  AKOS000195272 MDA-MB-231 C417(0.87)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C264(1.01)  LDD0846  [17]
 LDCM0356  AKOS034007680 HEK-293T C264(1.50)  LDD0954  [17]
 LDCM0275  AKOS034007705 HEK-293T C264(1.03)  LDD0873  [17]
 LDCM0156  Aniline NCI-H1299 13.49  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H66(0.00); C417(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C2(0.86)  LDD2227  [12]
 LDCM0367  CL1 PaTu 8988t C67(0.72)  LDD1246  [17]
 LDCM0368  CL10 PaTu 8988t C67(0.56)  LDD1247  [17]
 LDCM0369  CL100 HEK-293T C264(1.18)  LDD0967  [17]
 LDCM0370  CL101 HEK-293T C264(0.69)  LDD0968  [17]
 LDCM0371  CL102 HEK-293T C264(1.04)  LDD0969  [17]
 LDCM0372  CL103 HEK-293T C264(1.05)  LDD0970  [17]
 LDCM0373  CL104 HEK-293T C264(0.83)  LDD0971  [17]
 LDCM0374  CL105 PaTu 8988t C67(0.94); C264(0.72)  LDD1253  [17]
 LDCM0375  CL106 PaTu 8988t C67(0.86); C264(0.83)  LDD1254  [17]
 LDCM0376  CL107 PaTu 8988t C67(0.86); C264(0.69)  LDD1255  [17]
 LDCM0377  CL108 PaTu 8988t C67(1.00); C264(0.67)  LDD1256  [17]
 LDCM0378  CL109 PaTu 8988t C67(0.91); C264(0.69)  LDD1257  [17]
 LDCM0379  CL11 PaTu 8988t C67(0.67)  LDD1258  [17]
 LDCM0380  CL110 PaTu 8988t C67(0.74); C264(0.55)  LDD1259  [17]
 LDCM0381  CL111 PaTu 8988t C67(0.45); C264(0.47)  LDD1260  [17]
 LDCM0382  CL112 HEK-293T C67(1.56)  LDD0980  [17]
 LDCM0383  CL113 HEK-293T C67(1.53)  LDD0981  [17]
 LDCM0384  CL114 HEK-293T C67(1.40)  LDD0982  [17]
 LDCM0385  CL115 HEK-293T C67(1.54)  LDD0983  [17]
 LDCM0386  CL116 HEK-293T C67(1.40)  LDD0984  [17]
 LDCM0387  CL117 HEK-293T C417(0.98); C264(1.08)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C417(0.96); C264(1.04); C363(0.90); C50(0.84)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C417(0.99); C264(1.06)  LDD1593  [18]
 LDCM0390  CL12 PaTu 8988t C67(0.78)  LDD1269  [17]
 LDCM0391  CL120 HEK-293T C417(0.90); C264(1.03); C363(1.17)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C264(0.98)  LDD0990  [17]
 LDCM0393  CL122 HEK-293T C264(1.10)  LDD0991  [17]
 LDCM0394  CL123 HEK-293T C264(1.20)  LDD0992  [17]
 LDCM0395  CL124 HEK-293T C264(1.05)  LDD0993  [17]
 LDCM0396  CL125 HEK-293T C264(1.24); C67(1.36)  LDD0994  [17]
 LDCM0397  CL126 HEK-293T C264(1.35); C67(0.93)  LDD0995  [17]
 LDCM0398  CL127 HEK-293T C264(2.42); C67(0.81)  LDD0996  [17]
 LDCM0399  CL128 HEK-293T C264(1.14); C67(1.17)  LDD0997  [17]
 LDCM0400  CL13 PaTu 8988t C67(0.55)  LDD1279  [17]
 LDCM0401  CL14 PaTu 8988t C67(0.52)  LDD1280  [17]
 LDCM0402  CL15 PaTu 8988t C67(0.69)  LDD1281  [17]
 LDCM0403  CL16 HEK-293T C417(0.95)  LDD1001  [17]
 LDCM0404  CL17 HEK-293T C417(0.83)  LDD1002  [17]
 LDCM0405  CL18 HEK-293T C417(0.82)  LDD1003  [17]
 LDCM0406  CL19 HEK-293T C417(0.80)  LDD1004  [17]
 LDCM0407  CL2 PaTu 8988t C67(0.77)  LDD1286  [17]
 LDCM0408  CL20 HEK-293T C417(0.88)  LDD1006  [17]
 LDCM0409  CL21 HEK-293T C417(0.86)  LDD1007  [17]
 LDCM0410  CL22 HEK-293T C417(0.87)  LDD1008  [17]
 LDCM0411  CL23 HEK-293T C417(0.97)  LDD1009  [17]
 LDCM0412  CL24 HEK-293T C417(0.87)  LDD1010  [17]
 LDCM0413  CL25 HEK-293T C417(0.79)  LDD1011  [17]
 LDCM0414  CL26 HEK-293T C417(0.78)  LDD1012  [17]
 LDCM0415  CL27 HEK-293T C417(0.89)  LDD1013  [17]
 LDCM0416  CL28 HEK-293T C417(0.96)  LDD1014  [17]
 LDCM0417  CL29 HEK-293T C417(0.98)  LDD1015  [17]
 LDCM0418  CL3 PaTu 8988t C67(0.98)  LDD1297  [17]
 LDCM0419  CL30 HEK-293T C417(1.06)  LDD1017  [17]
 LDCM0420  CL31 HEK-293T C417(0.99); C264(0.87)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C417(1.06); C264(1.00)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C417(1.10); C264(1.13)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C417(1.07); C264(0.99)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C417(1.04); C264(0.90)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C417(1.10); C264(1.00); C363(1.29)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C417(0.97); C264(1.05)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C417(0.94); C264(1.07)  LDD1632  [18]
 LDCM0429  CL4 PaTu 8988t C67(0.70)  LDD1308  [17]
 LDCM0430  CL40 HEK-293T C417(0.95); C264(0.98); C363(0.98)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C417(1.00); C264(1.09)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C417(1.01); C264(1.05)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C417(0.98); C264(0.89)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C417(0.97); C264(1.13)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C417(1.04); C264(0.97)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C417(0.98); C67(1.21)  LDD1034  [17]
 LDCM0437  CL47 HEK-293T C417(0.89); C67(1.06)  LDD1035  [17]
 LDCM0438  CL48 HEK-293T C417(0.97); C67(1.13)  LDD1036  [17]
 LDCM0439  CL49 HEK-293T C417(0.94); C67(1.10)  LDD1037  [17]
 LDCM0440  CL5 PaTu 8988t C67(0.56)  LDD1319  [17]
 LDCM0441  CL50 HEK-293T C417(1.06); C67(1.09)  LDD1039  [17]
 LDCM0442  CL51 HEK-293T C417(0.91); C67(1.02)  LDD1040  [17]
 LDCM0443  CL52 HEK-293T C417(1.16); C67(0.98)  LDD1041  [17]
 LDCM0444  CL53 HEK-293T C417(1.33); C67(1.07)  LDD1042  [17]
 LDCM0445  CL54 HEK-293T C417(0.98); C67(0.85)  LDD1043  [17]
 LDCM0446  CL55 HEK-293T C417(0.80); C67(1.00)  LDD1044  [17]
 LDCM0447  CL56 HEK-293T C417(1.06); C67(0.80)  LDD1045  [17]
 LDCM0448  CL57 HEK-293T C417(0.96); C67(0.89)  LDD1046  [17]
 LDCM0449  CL58 HEK-293T C417(1.20); C67(0.93)  LDD1047  [17]
 LDCM0450  CL59 HEK-293T C417(0.87); C67(1.30)  LDD1048  [17]
 LDCM0451  CL6 PaTu 8988t C67(0.59)  LDD1330  [17]
 LDCM0452  CL60 HEK-293T C417(0.93); C67(1.31)  LDD1050  [17]
 LDCM0453  CL61 PaTu 8988t C67(0.92)  LDD1332  [17]
 LDCM0454  CL62 PaTu 8988t C67(0.87)  LDD1333  [17]
 LDCM0455  CL63 PaTu 8988t C67(0.96)  LDD1334  [17]
 LDCM0456  CL64 PaTu 8988t C67(0.78)  LDD1335  [17]
 LDCM0457  CL65 PaTu 8988t C67(0.96)  LDD1336  [17]
 LDCM0458  CL66 PaTu 8988t C67(0.75)  LDD1337  [17]
 LDCM0459  CL67 PaTu 8988t C67(1.07)  LDD1338  [17]
 LDCM0460  CL68 PaTu 8988t C67(0.70)  LDD1339  [17]
 LDCM0461  CL69 PaTu 8988t C67(0.63)  LDD1340  [17]
 LDCM0462  CL7 PaTu 8988t C67(0.56)  LDD1341  [17]
 LDCM0463  CL70 PaTu 8988t C67(0.80)  LDD1342  [17]
 LDCM0464  CL71 PaTu 8988t C67(0.92)  LDD1343  [17]
 LDCM0465  CL72 PaTu 8988t C67(1.25)  LDD1344  [17]
 LDCM0466  CL73 PaTu 8988t C67(0.93)  LDD1345  [17]
 LDCM0467  CL74 PaTu 8988t C67(0.81)  LDD1346  [17]
 LDCM0469  CL76 HEK-293T C417(0.87)  LDD1067  [17]
 LDCM0470  CL77 HEK-293T C417(1.06)  LDD1068  [17]
 LDCM0471  CL78 HEK-293T C417(1.43)  LDD1069  [17]
 LDCM0472  CL79 HEK-293T C417(1.10)  LDD1070  [17]
 LDCM0473  CL8 PaTu 8988t C67(0.64)  LDD1352  [17]
 LDCM0474  CL80 HEK-293T C417(1.14)  LDD1072  [17]
 LDCM0475  CL81 HEK-293T C417(1.07)  LDD1073  [17]
 LDCM0476  CL82 HEK-293T C417(1.04)  LDD1074  [17]
 LDCM0477  CL83 HEK-293T C417(0.86)  LDD1075  [17]
 LDCM0478  CL84 HEK-293T C417(1.23)  LDD1076  [17]
 LDCM0479  CL85 HEK-293T C417(1.24)  LDD1077  [17]
 LDCM0480  CL86 HEK-293T C417(1.44)  LDD1078  [17]
 LDCM0481  CL87 HEK-293T C417(0.89)  LDD1079  [17]
 LDCM0482  CL88 HEK-293T C417(0.91)  LDD1080  [17]
 LDCM0483  CL89 HEK-293T C417(1.05)  LDD1081  [17]
 LDCM0484  CL9 PaTu 8988t C67(0.59)  LDD1363  [17]
 LDCM0485  CL90 HEK-293T C417(0.86)  LDD1083  [17]
 LDCM0486  CL91 HEK-293T C264(1.09)  LDD1084  [17]
 LDCM0487  CL92 HEK-293T C264(0.93)  LDD1085  [17]
 LDCM0488  CL93 HEK-293T C264(1.05)  LDD1086  [17]
 LDCM0489  CL94 HEK-293T C264(0.95)  LDD1087  [17]
 LDCM0490  CL95 HEK-293T C264(0.94)  LDD1088  [17]
 LDCM0491  CL96 HEK-293T C264(1.37)  LDD1089  [17]
 LDCM0492  CL97 HEK-293T C264(1.04)  LDD1090  [17]
 LDCM0493  CL98 HEK-293T C264(0.87)  LDD1091  [17]
 LDCM0494  CL99 HEK-293T C264(1.09)  LDD1092  [17]
 LDCM0634  CY-0357 Hep-G2 C2(0.59)  LDD2228  [12]
 LDCM0028  Dobutamine HEK-293T 7.96  LDD0180  [5]
 LDCM0027  Dopamine HEK-293T 4.43  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C417(0.95); C264(1.09)  LDD1698  [18]
 LDCM0468  Fragment33 PaTu 8988t C67(0.68)  LDD1347  [17]
 LDCM0427  Fragment51 HEK-293T C417(0.98); C264(1.00); C363(0.83); C50(1.10)  LDD1631  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C417(0.97); C264(0.92); C67(1.02)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C417(0.99); C264(1.04); C67(1.10)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C67(1.33); C417(1.79)  LDD3310  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C417(0.99)  LDD2093  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C417(1.07)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C417(1.07)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C417(0.60)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C417(1.22)  LDD2111  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C417(0.98)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C417(0.96)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C67(1.98); C417(1.31)  LDD2129  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C417(1.12)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C67(1.80); C417(1.00)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C417(2.47)  LDD1700  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C417(1.16)  LDD2146  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C2(0.86)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C2(0.73)  LDD2207  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Small ribosomal subunit protein uS5 (RPS2) Universal ribosomal protein uS5 family P15880

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid22795084c1 Small molecular drug D0AF1J
S-adenosyl-l-homocysteine Small molecular drug DB01752
Sgc707 Small molecular drug D00JWB

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.