Details of the Target

General Information of Target

Target ID LDTP10834
Target Name RUN and FYVE domain-containing protein 1 (RUFY1)
Gene Name RUFY1
Gene ID 80230
Synonyms
RABIP4; ZFYVE12; RUN and FYVE domain-containing protein 1; FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Zinc finger FYVE domain-containing protein 12
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGR
RKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLL
LSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTL
DVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANG
YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPID
LCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRK
EYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGEL
DMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTL
LELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVT
SGDPPLLKFKAPIEEMEEKVHGCCRIS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.
Uniprot ID
Q96T51
Ensemble ID
ENST00000319449.9
HGNC ID
HGNC:19760

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II SNV: p.D222H DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.A209T DBIA    Probe Info 
MOLT4 SNV: p.M120I IA-alkyne    Probe Info 
NCIN87 SNV: p.E60K DBIA    Probe Info 
VCAP SNV: p.G135D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K164(10.00); K201(10.00); K390(1.45); K469(4.27)  LDD0277  [3]
BTD
 Probe Info  		C320(0.38)  LDD2089  [4]
Sulforaphane-probe2
 Probe Info  		1.95  LDD0160  [5]
DA-P3
 Probe Info  		5.03  LDD0179  [6]
AHL-Pu-1
 Probe Info  		C320(2.36); C184(2.25)  LDD0168  [7]
DBIA
 Probe Info  		C81(1.09); C8(0.95)  LDD0078  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C107(0.00); C648(0.00); C8(0.00); C603(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C320(0.00); C603(0.00); C351(0.00); C544(0.00)  LDD0036  [11]
IPIAA_L
 Probe Info  		C544(0.00); C155(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C81(0.00); C107(0.00); C320(0.00); C603(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
NAIA_4
 Probe Info  		C81(0.00); C155(0.00); C184(0.00); C320(0.00)  LDD2226  [14]
TFBX
 Probe Info  		C81(0.00); C184(0.00)  LDD0027  [13]
WYneC
 Probe Info  		N.A.  LDD0014  [15]
WYneN
 Probe Info  		C184(0.00); C320(0.00); C81(0.00)  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
IPM
 Probe Info  		N.A.  LDD0005  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		C8(0.00); C81(0.00)  LDD0018  [17]
Acrolein
 Probe Info  		C544(0.00); C320(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		C320(0.00); C351(0.00)  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		15.00  LDD0443  [20]
NAIA_5
 Probe Info  		C603(0.00); C184(0.00); C155(0.00)  LDD2223  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C320(0.82)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C320(1.01); C8(0.93); C695(0.98); C184(0.67)  LDD2117  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C320(0.75)  LDD2131  [4]
 LDCM0025  4SU-RNA HEK-293T C320(2.36); C184(2.25)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C184(3.23)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C351(1.05); C107(0.91); C184(0.63); C648(0.98)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C351(1.14); C107(1.11); C184(1.17); C648(1.17)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C351(0.82); C107(1.12); C184(1.10); C648(0.77)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C351(0.75); C107(1.05); C184(1.02); C648(0.77)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C351(0.91); C107(1.26); C184(0.93); C648(0.79)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C351(0.94); C107(1.12); C184(1.15); C648(1.17)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C351(0.89); C107(1.00); C184(1.00); C648(0.83)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C351(1.17); C107(1.29); C184(1.24); C648(1.20)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C351(0.80); C107(1.09); C184(0.79); C648(1.32)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C351(0.76); C107(1.18); C184(1.04); C648(1.15)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C351(0.88); C107(1.13); C184(0.82); C648(0.90)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C351(0.95); C107(1.16); C184(1.06); C648(0.64)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C351(0.91); C107(0.91); C184(1.01); C648(1.11)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C351(0.96); C107(1.13); C184(1.11); C648(0.67)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C351(0.98); C107(0.97); C184(1.02); C648(0.72)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C351(1.25); C107(0.96); C184(0.88); C648(0.71)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C351(1.01); C107(1.23); C184(1.14); C648(1.04)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C351(1.03); C107(1.23); C184(1.09); C648(1.26)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C351(1.37); C107(1.65); C184(0.90); C648(1.56)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C351(1.13); C107(1.18); C184(1.00); C648(1.53)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C351(1.09); C107(1.25); C184(1.09); C648(1.17)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C351(1.09); C107(1.35); C184(1.08); C648(1.20)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C351(1.32); C107(1.25); C184(0.99); C648(1.18)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C351(1.12); C107(1.11); C184(1.06); C648(0.95)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C351(1.09); C107(1.00); C184(1.05); C648(0.81)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C351(0.94); C107(1.29); C184(1.07); C648(1.17)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C351(1.13); C107(1.23); C184(1.14); C648(1.28)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C351(0.99); C107(1.07); C184(0.96); C648(1.22)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C351(0.95); C107(1.23); C184(1.09); C648(1.08)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C351(1.00); C107(1.28); C184(0.98); C648(1.26)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C351(0.97); C107(1.41); C184(1.06); C648(1.35)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C351(0.98); C107(2.06); C184(1.12); C648(1.29)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C351(0.88); C107(0.64); C184(1.21); C648(1.38)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C351(1.00); C107(0.87); C184(1.08); C648(1.06)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C351(0.88); C107(0.94); C184(1.11); C648(1.26)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C351(1.01); C107(1.07); C184(1.10); C648(1.08)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C351(1.12); C107(0.96); C184(1.21); C648(1.13)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C351(1.10); C107(1.28); C184(1.10); C648(1.34)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C351(1.12); C107(1.17); C184(1.23); C648(1.41)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C351(1.00); C107(1.10); C184(1.16); C648(1.34)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C351(1.13); C107(1.00); C184(1.25); C648(1.04)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C351(1.19); C107(0.89); C184(1.05); C648(1.04)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C351(1.41); C107(1.01); C184(1.20); C648(1.28)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C351(1.51); C107(1.76); C184(1.29); C648(1.20)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C351(1.26); C107(0.87); C184(0.94); C648(1.24)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C351(1.37); C107(1.56); C184(1.06); C648(1.45)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C351(1.34); C107(1.44); C184(1.18); C648(1.23)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C351(1.21); C107(1.39); C184(1.03); C648(0.99)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C351(0.90); C8(0.78); C184(0.83); C648(0.98)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C107(1.06); C184(1.08); C648(1.25); C351(1.34)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C184(0.95); C648(1.09); C351(1.15); C8(1.17)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C351(0.91); C8(1.04); C648(1.07); C107(1.08)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C351(0.92); C107(1.04); C184(1.12); C8(1.15)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C351(0.95); C648(1.36); C8(1.37); C107(1.47)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C351(0.80); C648(1.20); C8(1.43); C107(1.50)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C81(0.84); C184(0.93); C107(1.01); C8(1.05)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C8(0.90); C648(0.96); C107(0.99); C351(1.13)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C351(0.82); C107(0.89); C648(1.09); C184(1.35)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C351(0.93); C107(1.03); C648(1.09); C184(1.28)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C351(0.80); C107(1.38); C648(1.57); C184(1.63)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C351(0.82); C107(1.26); C184(1.18); C648(1.19)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C351(0.80); C107(1.15); C184(1.67); C648(1.01)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C351(0.96); C107(0.96); C184(1.36); C648(0.92)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C351(0.79); C107(1.12); C184(1.35); C648(0.98)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C184(0.77); C107(0.99); C351(1.39)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C107(0.77); C184(0.83); C351(1.28)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C184(0.92); C107(0.94); C351(1.07)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C184(0.89); C351(0.92); C107(0.94); C648(1.10)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C107(0.80); C184(0.81); C351(1.18)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C184(0.77); C107(0.85); C351(0.95)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C107(0.81); C351(0.92); C184(1.04)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C184(0.88); C107(0.93); C351(0.97)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C351(0.81); C184(0.85); C107(0.92)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C184(0.56); C351(0.86); C648(1.12); C107(1.22)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C184(0.69); C351(0.99); C107(1.23); C648(1.27)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C184(0.85); C351(1.06); C107(1.07); C648(1.25)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C184(0.75); C351(1.06); C648(1.17); C107(1.30)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C184(0.82); C107(0.93); C351(1.27); C648(1.29)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C351(0.92); C184(1.08); C107(1.12); C648(1.16)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C184(1.15); C648(1.23); C107(1.27); C351(1.39)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C184(0.79); C351(1.02); C648(1.32); C81(1.48)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C184(0.76); C351(1.14); C648(1.54); C107(1.86)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C184(0.87); C351(1.07); C107(1.39); C648(1.42)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C184(0.86); C107(0.92); C351(1.10); C648(1.30)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C648(0.73); C107(0.82); C351(0.94)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C648(0.93); C351(1.02); C107(1.07)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C107(0.77); C351(0.82); C648(0.91)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C648(0.95); C107(1.11); C351(1.13)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C107(0.93); C648(0.98); C351(1.06)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C184(0.80); C351(1.05); C107(1.06); C8(1.08)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C107(0.82); C351(0.97); C648(1.03)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C648(0.82); C351(0.95); C107(0.97)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C648(0.82); C107(1.01); C351(1.05)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C648(0.92); C107(0.97); C351(1.18)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C351(0.83); C107(0.93); C648(0.95)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C107(0.70); C351(0.75); C648(1.05)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C351(1.43)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C351(1.15)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C351(1.50)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C351(1.38)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C184(0.85); C107(0.97); C351(1.06); C8(1.10)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C351(1.38)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C351(1.15)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C351(1.11)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C351(0.91)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C351(1.18)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C351(0.86)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C351(1.03)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C351(1.06); C184(1.18); C648(1.28); C107(1.63)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C351(1.04); C184(1.18); C107(1.19); C648(1.21)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C184(1.03); C351(1.15); C648(1.42); C107(1.49)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C107(0.96); C81(1.03); C8(1.04); C184(1.06)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C351(1.03); C184(1.10); C107(1.14); C648(1.42)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C184(0.97); C351(1.15); C107(1.23); C648(1.23)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C184(0.96); C351(1.04); C107(1.30); C648(1.55)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C351(1.03); C107(1.04); C184(1.26); C648(1.34)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C107(0.98); C351(1.05); C184(1.19); C648(1.40)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C351(1.01); C184(1.08); C648(1.19); C107(1.45)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C648(0.99); C351(1.07); C184(1.09); C107(1.22)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C107(1.11); C184(1.12); C648(1.13); C351(1.19)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C184(0.94); C81(1.02); C107(1.05); C648(1.11)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C184(0.84); C648(0.90); C107(1.08); C351(1.11)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C351(0.81); C81(1.00); C648(1.00); C107(1.00)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C648(0.82); C184(0.99); C107(1.01); C351(1.13)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C648(0.79); C351(0.89); C184(0.91); C107(0.95)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C648(0.92); C184(0.95); C107(1.05); C351(1.14)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C184(0.99); C107(1.01); C648(1.34); C351(1.36)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C107(0.69); C184(0.82); C351(0.84); C648(1.39)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C107(0.83); C184(0.98); C351(1.24); C648(1.83)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C184(0.82); C351(0.83); C107(0.91); C648(1.04)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C107(0.88); C184(0.92); C351(1.10); C648(1.36)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C648(0.91); C107(0.94); C184(0.99); C351(1.13)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C648(0.79); C184(0.90); C107(1.08); C351(1.16)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C81(0.90); C351(0.92); C648(0.98); C184(1.01)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C351(0.86); C107(0.94); C184(0.96); C648(0.96)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C648(0.60); C184(0.93); C107(1.11); C81(1.41)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C107(0.79); C184(0.88); C351(0.91); C648(1.24)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C648(1.07); C351(1.13); C107(1.69); C81(1.90)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C648(0.88); C351(1.08); C107(1.27); C81(1.38)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C648(0.85); C8(1.17); C351(1.26); C107(1.35)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C648(1.03); C351(1.18); C8(1.21); C107(1.42)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C648(0.81); C351(1.08); C8(1.08); C107(1.49)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C648(0.98); C351(1.17); C107(1.30); C8(1.49)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C648(1.06); C351(1.22); C107(1.46); C8(1.47)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C8(0.90); C648(0.97); C351(1.19); C107(1.62)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C351(1.03); C648(1.19); C107(1.34); C81(1.69)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C351(1.13); C648(1.23); C107(1.58); C8(1.75)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C648(0.86); C351(1.10); C81(1.42); C107(1.44)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C648(0.91); C107(0.96); C351(1.12); C81(1.54)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C648(0.93); C351(1.16); C107(1.17); C8(1.61)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C81(0.94); C648(1.02); C351(1.07); C107(1.14)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C648(0.97); C351(1.16); C107(1.53); C8(2.28)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C107(0.97); C351(1.10); C184(1.12); C81(1.28)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C648(0.78); C184(1.05); C107(1.16); C81(1.31)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C320(0.72)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C351(1.18); C107(0.97); C184(0.98); C648(1.12)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C8(0.72); C351(0.89); C107(0.93); C184(1.10)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C81(0.88); C107(0.90); C184(1.06); C351(1.13)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.98  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C81(1.09); C8(0.95)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C320(0.30); C107(0.69)  LDD2091  [4]
 LDCM0630  CCW28-3 231MFP C81(0.59)  LDD2214  [21]
 LDCM0108  Chloroacetamide HeLa C544(0.00); C81(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C184(1.72); C603(1.49); C703(0.80); C320(0.67)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C8(0.77); C184(0.81); C351(0.89); C648(1.05)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C8(0.78); C351(1.01); C648(1.14); C184(1.42)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C107(0.97); C351(1.00); C184(1.01); C8(1.10)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C8(0.62); C81(0.90); C107(0.91); C184(1.08)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C8(0.61); C351(0.98); C184(1.01); C81(1.03)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C107(0.88); C81(0.90); C351(0.93); C648(0.94)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C81(0.88); C107(0.89); C648(0.94); C184(1.04)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C107(0.87); C184(0.94); C351(1.31)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C107(0.94); C184(1.05); C351(1.67)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C107(0.75); C184(0.94); C351(1.24)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C107(0.92); C184(1.07); C351(1.18)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C107(0.80); C184(0.88); C351(1.42)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C8(0.78); C648(0.84); C184(1.11); C351(1.71)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C184(0.78); C107(0.95); C351(1.26)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C184(0.80); C107(1.02); C351(1.03)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C184(0.72); C648(0.84); C351(0.87); C107(1.14)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C184(0.66); C351(1.08); C648(1.16); C107(1.42)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C184(0.65); C648(0.89); C351(1.10); C81(1.19)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C184(0.76); C648(1.07); C351(1.13); C81(1.15)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C184(0.74); C648(1.16); C351(1.19); C107(1.20)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C107(0.95); C351(1.06); C648(1.35)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C648(0.89); C351(1.09); C107(1.35)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C648(0.93); C107(1.01); C351(1.01)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C351(0.95); C8(0.96); C648(1.20); C184(1.35)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C107(0.86); C648(0.89); C351(1.09)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C351(1.06)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C351(1.08)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C351(0.91)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C351(1.21)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C648(0.99); C184(1.06); C351(1.12); C107(1.96)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C648(0.93); C351(0.98); C184(1.00); C107(1.10)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C351(0.92); C648(1.03); C184(1.25); C107(1.56)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C184(0.90); C351(0.98); C107(1.33); C648(1.44)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C8(0.97); C648(1.03); C351(1.13); C184(1.27)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C184(0.76); C8(0.83); C351(0.95); C648(0.97)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C8(0.81); C648(0.83); C351(0.87); C184(1.04)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C81(0.75); C8(0.93); C107(0.97); C648(1.16)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C81(0.55); C184(0.80); C648(0.87); C351(1.03)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C81(0.81); C184(0.89); C351(0.94); C107(1.01)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C8(0.80); C184(0.90); C107(1.01); C351(1.05)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C184(0.78); C8(1.04); C351(1.20); C648(1.31)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C184(0.81); C8(1.04); C351(1.20); C81(1.27)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C8(0.71); C184(0.93); C351(1.00); C81(1.32)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C184(0.84); C8(1.02); C107(1.37); C81(2.33)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C184(0.85); C81(1.04); C8(1.06); C107(1.07)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C351(1.28); C107(1.35); C184(1.13); C648(1.80)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C351(1.35); C107(1.23); C184(0.87); C648(1.65)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C351(1.32); C107(1.06); C184(0.90); C648(1.28)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C351(1.23); C107(1.48); C184(1.00); C648(1.81)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C351(1.29); C107(1.26); C184(0.85); C648(1.62)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C351(1.23); C107(1.46); C184(0.80); C648(1.92)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C351(0.98); C184(0.91); C648(0.98); C8(1.02)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C351(1.57); C107(1.20); C184(0.99); C648(1.37)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C351(1.03); C107(1.10); C184(1.03)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C351(1.00); C107(1.01); C184(1.54); C8(1.01)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C351(1.15); C107(1.11); C184(1.04); C8(0.79)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C351(1.19); C107(1.27); C184(1.34); C8(0.83)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C351(1.26); C107(1.20); C184(1.42); C8(0.88)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C351(1.08); C107(1.23); C184(1.05); C8(0.67)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C351(1.15); C107(1.35); C184(1.03); C8(0.63)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C351(0.97); C107(1.16); C184(1.31); C8(0.80)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C351(1.18); C184(1.00); C648(1.00); C8(0.74)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C351(1.09); C107(1.14); C184(1.06); C8(0.52)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C351(1.11); C107(1.19); C184(1.12); C8(0.47)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C351(1.10); C107(1.61); C184(1.24); C8(0.70)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C351(0.85); C107(1.24); C184(1.39); C8(0.65)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C351(0.95); C107(1.19); C184(0.97); C8(0.68)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C351(0.88); C107(1.35); C184(1.11); C8(0.56)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C107(1.23); C184(0.68); C8(0.73)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C107(0.98); C184(0.80); C8(1.19)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C107(0.92); C184(0.78); C8(1.23)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C107(0.97); C184(0.78); C8(1.27)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C351(0.96); C184(0.88); C648(1.18); C8(0.89)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C107(1.08); C184(0.76); C8(0.80)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C107(1.10); C184(0.91); C8(0.80)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C107(1.17); C184(0.81); C8(0.87)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C107(0.86); C184(1.10); C8(0.76)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C107(1.03); C184(0.80); C8(0.76)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C107(0.87); C184(0.88); C8(0.68)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C107(0.96); C184(0.82); C8(1.01)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C107(1.06); C184(0.74); C8(0.76)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C107(1.06); C184(0.82); C8(0.83)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C107(1.01); C184(0.83); C8(0.69)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C351(1.02); C184(0.78); C648(1.02); C8(0.75)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C107(0.94); C184(0.93); C8(0.73)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C351(0.99); C107(1.50); C184(1.04)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C351(0.94); C107(1.54); C184(0.96)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C351(1.04); C107(1.24); C184(0.89)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C351(0.99); C107(1.35); C184(1.04)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C351(1.12); C107(1.95); C184(1.08)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C351(0.97); C107(1.66); C184(0.92)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C351(1.08); C107(1.45); C184(1.00)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C351(1.10); C107(1.39); C184(0.96)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C351(0.99); C107(1.61); C184(1.10)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C351(1.14); C184(0.98); C648(1.15); C8(0.98)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C351(1.04); C107(1.45); C184(1.09)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C351(1.18); C107(1.62); C184(1.04)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C351(1.24); C107(1.83); C184(1.10)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C351(0.96); C107(1.46); C184(1.01)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C351(1.19); C107(1.42); C184(1.01)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C351(0.95); C107(1.28); C648(1.15); C81(1.08)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C351(0.97); C107(1.15); C648(0.81); C81(0.96)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C351(0.95); C107(1.04); C648(1.32); C81(1.04)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C351(0.99); C107(1.19); C648(1.60); C81(0.93)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C351(1.08); C184(1.10); C648(0.99); C8(0.79)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C351(1.02); C107(1.07); C648(1.05); C81(1.01)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C351(0.85); C107(1.28); C648(1.39); C81(0.88)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C351(0.89); C107(0.82); C648(1.92); C81(0.81)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C351(0.94); C107(1.13); C648(1.42); C81(0.81)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C351(1.01); C107(0.98); C648(2.03); C81(1.11)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C351(1.05); C107(0.95); C648(1.10); C81(1.00)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C351(1.07); C107(1.00); C648(0.80); C81(0.92)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C351(0.99); C107(0.95); C648(1.02); C81(0.85)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C351(0.98); C107(0.85); C648(1.37); C81(0.88)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C351(0.95); C107(0.95); C648(2.25); C81(0.88)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C351(1.21); C184(0.98); C648(1.08); C8(0.85)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C351(0.78); C107(0.93); C648(0.60); C81(1.00)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C351(1.13); C107(1.01); C184(0.96); C648(1.16)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C351(0.91); C107(0.94); C184(1.06); C648(0.93)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C351(0.92); C107(0.95); C184(0.77); C648(1.16)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C351(0.86); C107(0.92); C184(1.00); C648(1.41)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C351(0.97); C107(0.94); C184(0.95); C648(1.11)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C351(1.11); C107(0.93); C184(0.98); C648(1.25)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C351(1.15); C107(0.96); C184(0.95); C648(1.19)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C351(1.02); C107(1.08); C184(1.07); C648(1.12)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C351(1.02); C107(1.05); C184(1.30); C648(1.12)  LDD0811  [8]
 LDCM0634  CY-0357 Hep-G2 C320(1.15); C107(0.74)  LDD2228  [14]
 LDCM0028  Dobutamine HEK-293T 7.70  LDD0180  [6]
 LDCM0027  Dopamine HEK-293T 5.03  LDD0179  [6]
 LDCM0495  E2913 HEK-293T C8(0.92); C107(1.07); C320(0.93); C351(0.98)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C320(1.21); C351(0.92)  LDD1702  [4]
 LDCM0625  F8 Ramos C184(1.18); C81(1.37)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C184(0.97); C81(1.15)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C184(0.37)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C81(1.17)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C184(0.84); C81(0.82)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C184(1.74); C81(0.58)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C184(1.50); C81(1.21)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C184(1.02); C81(0.72)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C184(2.09); C81(0.78)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C184(0.91); C81(0.85)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C184(0.70); C81(0.72)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C184(1.12); C81(1.11)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C184(0.96); C81(0.95)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C184(1.93); C81(1.30)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C351(1.08); C107(1.57); C184(1.04)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C184(0.69); C81(0.63)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C184(1.33); C81(0.99)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C351(0.78); C107(1.36); C184(1.20); C8(0.62)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C184(1.87); C81(0.89)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C184(1.01); C81(1.25)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C184(1.08)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C184(1.96)  LDD2188  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C81(2.19); C107(2.85); C667(0.97); C675(0.97)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C81(1.90); C107(2.00); C667(1.16); C675(1.16)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C81(3.98); C107(2.41); C667(1.34); C675(1.34)  LDD0082  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C320(1.04)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C320(0.57)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C320(0.38)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C320(1.08); C8(1.10)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C320(0.91)  LDD2092  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C320(1.04)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C320(0.38)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C320(0.78)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C320(0.89); C351(1.02)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C320(1.14)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C320(0.91)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C320(1.28); C8(0.93)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C320(0.85); C8(1.46); C184(1.30)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C320(0.96)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C320(1.08)  LDD2109  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C320(0.94)  LDD2114  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C320(0.27); C351(0.47)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C544(1.30)  LDD2119  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C351(0.75)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C320(0.65); C695(1.13)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C351(0.54)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C8(0.99); C184(0.99); C81(0.69); C351(0.70)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C351(0.48)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C81(0.64)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C320(0.89)  LDD2128  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C8(1.30)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C81(1.21); C351(0.60)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C81(1.02)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C320(0.83); C184(1.32); C81(0.46); C351(0.89)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C8(0.72)  LDD2141  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C695(0.43)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C351(0.44)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C320(0.33)  LDD2150  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C320(1.30); C8(1.08)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C184(1.50)  LDD2206  [24]
 LDCM0029  Quercetin HEK-293T 11.74  LDD0181  [6]
 LDCM0003  Sulforaphane MDA-MB-231 1.95  LDD0160  [5]
 LDCM0021  THZ1 HCT 116 C8(1.20); C107(1.10); C648(1.09)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 SUMO-protein ligase PIAS2 (PIAS2) PIAS family O75928
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Ras-related protein Rab-39B (RAB39B) Rab family Q96DA2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thioredoxin domain-containing protein 17 (TXNDC17) Thioredoxin family Q9BRA2
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Rab-3A-interacting protein (RAB3IP) SEC2 family Q96QF0
U3 small nucleolar RNA-associated protein 25 homolog (UTP25) UTP25 family Q68CQ4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.