Details of the Target

General Information of Target

Target ID LDTP08684
Target Name Phosphatase and actin regulator 4 (PHACTR4)
Gene Name PHACTR4
Gene ID 65979
Synonyms
Phosphatase and actin regulator 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDPFEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKE
TSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPV
QVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHE
ASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLAKTVNLSVTPSPAPRTLPAAPAS
TNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGI
PSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPP
FPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIR
IQQALTSPLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEE
EEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDESYQSALAN
KVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQ
RNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRA
DKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP
Target Bioclass
Enzyme
Family
Phosphatase and actin regulator family
Subcellular location
Cytoplasm
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.
Uniprot ID
Q8IZ21
Ensemble ID
ENST00000373836.4
HGNC ID
HGNC:25793

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 Deletion: p.P346HfsTer33 .
HCC1187 SNV: p.E513D .
HCC1806 SNV: p.K569R .
HUH28 SNV: p.S685C .
LS180 Insertion: p.S248KfsTer17 .
MEWO Substitution: p.L637F .
MFE296 Deletion: p.N608MfsTer35 .
MOLT4 SNV: p.T31A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K626(10.00)  LDD0277  [2]
DBIA
 Probe Info  		C578(2.73)  LDD3331  [3]
DA-P3
 Probe Info  		5.08  LDD0180  [4]
AHL-Pu-1
 Probe Info  		C568(2.73)  LDD0171  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
NAIA_5
 Probe Info  		C328(0.00); C568(0.00)  LDD2225  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C568(2.73)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C568(0.99); C328(1.16)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C568(1.14); C328(0.94)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C568(1.07)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C568(1.08); C328(1.08)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C568(0.98); C328(0.89)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C568(0.95); C328(0.88)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C568(1.00); C328(0.91)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C568(1.01); C328(1.11)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C568(0.98)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C568(1.14); C328(0.87)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C568(0.99); C328(0.97)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C568(0.93); C328(0.94)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C568(1.00); C328(1.02)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C568(1.10); C328(0.78)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C568(1.02); C328(1.04)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C568(0.93); C328(0.82)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C568(1.12); C328(1.06)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C568(0.99)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C568(1.02); C328(0.95)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C568(0.94); C328(0.99)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C568(1.09)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C568(1.01); C328(0.83)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C568(1.08); C328(0.86)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C568(0.95); C328(1.31)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C568(0.97); C328(0.83)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C568(1.15); C328(0.91)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C568(1.20)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C568(1.08); C328(1.11)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C568(1.06); C328(0.88)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C568(1.02); C328(0.88)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C568(0.87); C328(0.87)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C568(1.02); C328(1.06)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C568(0.94); C328(0.88)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C568(1.08); C328(0.97)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C568(1.16); C328(0.98)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C568(1.12)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C568(1.00); C328(0.96)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C568(1.04); C328(1.11)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C568(0.99); C328(0.98)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C568(0.87); C328(1.18)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C568(1.01); C328(1.01)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C568(0.99); C328(1.34)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C568(0.98); C328(0.95)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C568(1.08); C328(1.20)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C568(1.21)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C568(1.07); C328(1.08)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C568(1.06); C328(1.01)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C568(0.99); C328(0.76)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C568(0.94); C328(1.17)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C568(1.03); C328(0.83)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C568(0.92); C328(1.18)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C568(1.09); C328(0.89)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C568(1.02)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C568(1.00); C328(1.26)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C568(0.99); C328(1.28)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C568(1.01); C328(1.06)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C568(1.01); C328(0.85)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C568(1.13); C328(1.08)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C568(1.03); C328(0.97)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C568(1.00); C328(1.05)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C568(1.05); C328(0.90)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C568(0.97); C328(1.15)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C568(0.97); C328(1.18)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C568(0.87); C328(0.87)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 11.63  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C568(0.95)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C568(1.04); C328(0.86)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C568(1.10)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C568(0.99)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C568(1.08)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C568(0.94); C485(0.88); C328(1.11)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C568(1.05)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C568(0.97)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C568(1.01)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C568(0.91); C485(0.88); C328(0.75)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C568(1.06)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C568(0.94)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C568(0.79); C328(0.89)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C568(0.94)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C568(0.88); C485(0.81); C328(0.97)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C568(1.11)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C568(1.01)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C568(1.00)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C568(0.90); C485(0.59); C328(1.21)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C568(1.15)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C568(1.03)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C568(1.06)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C568(0.89); C485(0.87); C328(0.99)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C568(1.00); C328(0.86)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C568(1.02)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C568(0.99)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C568(1.00)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C568(0.89); C485(0.90); C328(0.76)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C568(1.01)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C568(1.01)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C568(1.04)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C568(0.98); C485(0.91); C328(1.03)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C568(1.04)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C568(0.94)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C568(1.07)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C568(0.88); C485(0.75); C328(0.68)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C568(1.10)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C568(0.85); C328(1.18)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C568(1.04); C328(0.89)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C568(1.08)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C568(1.14)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C568(0.90); C328(0.98)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C568(1.04); C328(0.87)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C568(0.96); C328(0.83)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C568(0.95); C328(0.82)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C568(0.91); C328(1.04)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C568(1.03)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C568(1.07)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C568(1.01); C485(0.71); C328(1.03)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C568(1.11)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C568(0.95); C328(0.88)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C568(0.97); C485(0.90); C328(1.52)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C568(1.01); C328(0.95)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C568(1.06)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C568(0.95); C328(0.98)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C568(0.86); C328(0.68)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C568(0.99); C328(0.61)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C568(0.99); C328(0.73)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C568(0.93); C328(1.29)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C568(0.94)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C568(1.06); C485(0.75); C328(0.82)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C568(1.07)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C568(1.02)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C568(0.89); C328(0.74)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C568(0.91); C328(0.85)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C568(0.99)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C568(0.96); C328(0.99)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C568(1.22); C328(0.88)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C568(0.96); C328(0.90)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C568(1.10); C328(0.99)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C568(0.95); C328(0.95)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C568(0.95)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C568(0.88); C328(1.20)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C568(1.05)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C568(1.05)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C568(0.85); C328(0.77)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C568(0.94); C328(0.75)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C568(1.02)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C568(0.98); C328(1.04)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C568(0.97); C328(0.81)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C568(0.95); C328(0.85)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C568(0.80); C328(0.77)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C568(1.02); C328(0.69)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C568(0.97); C328(0.76)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C568(1.11)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C568(1.10)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C568(0.96); C485(0.95); C328(0.95)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C568(0.96)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C568(0.93); C328(1.16)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C568(1.02); C328(1.07)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C568(1.01)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C568(1.02); C328(0.94)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C568(1.01); C328(0.88)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C568(1.09)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C568(0.95); C328(0.77)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C568(0.87); C328(0.72)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C568(0.87); C328(0.98)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C568(1.00)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C568(1.10)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C568(1.07)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C568(0.85); C328(0.93)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C568(1.06); C328(0.81)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C568(0.98)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C568(1.04); C328(0.89)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C568(0.91); C328(1.01)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C568(0.95); C328(0.94)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C568(0.97); C328(0.81)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C568(1.02); C328(0.78)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C568(0.91); C328(0.82)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C568(1.03)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C568(1.14)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C568(1.02); C485(0.83); C328(1.17)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C568(1.07)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C568(1.00); C328(1.01)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C568(1.05); C328(0.94)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C568(0.96); C328(0.71)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C568(1.13)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C568(0.90); C328(1.08)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C568(1.00); C328(0.83)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C568(0.98); C328(0.79)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C568(1.08); C328(0.81)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C568(1.09); C328(0.94)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C568(0.98)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C568(1.03)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C568(1.06); C485(0.79); C328(1.10)  LDD1697  [10]
 LDCM0028  Dobutamine HEK-293T 5.08  LDD0180  [4]
 LDCM0495  E2913 HEK-293T C568(0.99); C485(0.80); C328(1.21)  LDD1698  [10]
 LDCM0031  Epigallocatechin gallate HEK-293T 14.03  LDD0183  [4]
 LDCM0468  Fragment33 HEK-293T C568(0.94); C485(0.88); C328(0.79)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C568(1.07)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C568(1.04); C328(0.98); C485(0.91)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C568(1.05); C328(0.98); C485(1.11)  LDD1497  [10]
 LDCM0024  KB05 MKN-1 C578(2.73)  LDD3331  [3]
 LDCM0030  Luteolin HEK-293T 14.65  LDD0182  [4]
 LDCM0029  Quercetin HEK-293T 6.33  LDD0181  [4]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402