Details of the Target

General Information of Target

Target ID LDTP01133
Target Name Copine-3 (CPNE3)
Gene Name CPNE3
Gene ID 8895
Synonyms
CPN3; KIAA0636; Copine-3; Copine III
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAQCVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYEVERTERIKNCLNPQFS
KTFIIDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSKKLTRPLVMKTG
RPAGKGSITISAEEIKDNRVVLFEMEARKLDNKDLFGKSDPYLEFHKQTSDGNWLMVHRT
EVVKNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLKEAS
RSSPVEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVDFTG
SNGDPRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQVSHE
FPMNFNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAATQQQTASQY
FVLLIITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGSLRSPLGE
VAIRDIVQFVPFRQFQNAPKEALAQCVLAEIPQQVVGYFNTYKLLPPKNPATKQQKQ
Target Bioclass
Transporter and channel
Family
Copine family
Subcellular location
Nucleus
Function Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.
Uniprot ID
O75131
Ensemble ID
ENST00000517490.6
HGNC ID
HGNC:2316

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.02  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y203(11.52)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K533(0.34)  LDD0274  [5]
STPyne
 Probe Info  		K149(10.00); K158(1.63); K184(7.69)  LDD0277  [5]
BTD
 Probe Info  		C385(2.28)  LDD1699  [6]
Probe 1
 Probe Info  		Y80(11.14)  LDD3495  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
THZ1-DTB
 Probe Info  		C506(0.98)  LDD0460  [8]
DA-P3
 Probe Info  		4.58  LDD0179  [9]
AHL-Pu-1
 Probe Info  		C54(2.04); C202(2.39)  LDD0169  [10]
EA-probe
 Probe Info  		C54(0.65)  LDD2210  [11]
HHS-482
 Probe Info  		Y203(1.10); Y392(0.98)  LDD0285  [12]
HHS-475
 Probe Info  		Y392(0.98); Y217(1.07); Y203(3.39)  LDD0264  [13]
HHS-465
 Probe Info  		Y203(10.00); Y392(6.37); Y43(8.92)  LDD2237  [14]
DBIA
 Probe Info  		C54(0.93)  LDD0078  [15]
ATP probe
 Probe Info  		K158(0.00); K184(0.00); K52(0.00); K125(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C506(0.00); C202(0.00); C54(0.00); C385(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C202(0.00); C249(0.00); C506(0.00); C214(0.00)  LDD0032  [18]
Lodoacetamide azide
 Probe Info  		C506(0.00); C54(0.00); C202(0.00); C31(0.00)  LDD0037  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [20]
WYneN
 Probe Info  		C54(0.00); C5(0.00)  LDD0021  [21]
WYneO
 Probe Info  		C249(0.00); C54(0.00); C5(0.00)  LDD0022  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
ENE
 Probe Info  		N.A.  LDD0006  [21]
IPM
 Probe Info  		N.A.  LDD0005  [21]
PF-06672131
 Probe Info  		N.A.  LDD0017  [23]
SF
 Probe Info  		N.A.  LDD0028  [24]
VSF
 Probe Info  		N.A.  LDD0007  [21]
Phosphinate-6
 Probe Info  		C5(0.00); C506(0.00); C54(0.00)  LDD0018  [25]
Ox-W18
 Probe Info  		N.A.  LDD2175  [26]
1c-yne
 Probe Info  		K167(0.00); K390(0.00); K523(0.00)  LDD0228  [27]
Acrolein
 Probe Info  		N.A.  LDD0217  [28]
Methacrolein
 Probe Info  		N.A.  LDD0218  [28]
W1
 Probe Info  		C249(0.00); C15(0.00); C202(0.00); Y392(0.00)  LDD0236  [29]
AOyne
 Probe Info  		8.40  LDD0443  [30]
MPP-AC
 Probe Info  		N.A.  LDD0428  [31]
NAIA_5
 Probe Info  		C506(0.00); C54(0.00); C202(0.00); C385(0.00)  LDD2223  [19]
TER-AC
 Probe Info  		N.A.  LDD0426  [31]
TPP-AC
 Probe Info  		N.A.  LDD0427  [31]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C388
 Probe Info  		36.76  LDD2047  [32]
FFF probe13
 Probe Info  		6.32  LDD0475  [33]
FFF probe3
 Probe Info  		5.98  LDD0465  [33]
JN0003
 Probe Info  		5.31  LDD0469  [33]
STS-1
 Probe Info  		N.A.  LDD0136  [34]
STS-2
 Probe Info  		N.A.  LDD0138  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C15(0.36); C249(0.26)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C15(0.35); C249(0.51)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C15(0.37); C54(0.36)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C54(0.79)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C15(0.91); C54(1.00); C385(0.13)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C54(1.23); C385(0.66)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C15(0.58); C54(0.44)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C54(0.62)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C54(2.88)  LDD0172  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C54(2.04); C202(2.39)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C15(1.47); C202(0.77); C385(1.44); C54(1.01)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C202(0.93); C385(0.95); C54(0.88)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C100(1.49); C98(1.49); C15(0.94); C202(1.01)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C100(0.52); C98(0.52); C15(0.47); C202(0.95)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C100(0.54); C98(0.54); C15(0.54); C202(1.10)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C100(0.23); C98(0.23); C15(0.28); C202(1.26)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C100(0.23); C98(0.23); C15(0.62); C202(1.44)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C100(0.26); C98(0.26); C15(0.37); C202(1.39)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C100(0.31); C98(0.31); C15(0.30); C202(1.46)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C100(0.24); C98(0.19); C15(0.27); C202(1.38)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C100(0.37); C98(0.47); C15(0.58); C202(1.17)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C100(0.35); C98(0.58); C15(0.78); C202(1.46)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C202(0.78); C385(0.47); C54(0.84)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C100(0.35); C98(0.44); C15(0.53); C202(1.85)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C100(0.39); C98(0.56); C15(0.51); C202(0.88)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C100(0.30); C98(0.23); C15(0.42); C202(0.89)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C100(1.04); C98(1.04); C202(1.06); C249(1.20)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C100(0.87); C98(0.87); C202(0.99); C249(1.13)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C100(0.44); C98(0.44); C202(1.14); C249(1.06)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C100(0.46); C98(0.46); C202(0.98); C249(1.20)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C100(0.63); C98(0.63); C202(0.96); C249(0.90)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C100(1.11); C98(1.11); C202(0.96); C249(1.11)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C100(0.87); C98(0.87); C202(1.08); C249(1.06)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C202(0.81); C385(0.95); C54(0.95)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C100(0.91); C98(0.91); C202(1.48); C249(1.13)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C100(1.27); C98(1.27); C202(0.94); C249(0.85)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C100(0.78); C98(0.78); C202(1.08); C249(1.05)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C100(1.17); C98(1.17); C202(0.89); C249(0.81)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C100(1.96); C98(1.96); C202(1.15); C249(1.02)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C100(0.79); C98(0.79); C202(1.29); C249(1.09)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C100(0.54); C98(0.54); C202(0.90); C249(1.09)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C100(0.56); C98(0.56); C202(1.09); C249(1.07)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C15(3.13); C202(2.61); C249(1.12); C385(2.42)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C15(1.46); C202(1.67); C249(1.13); C385(1.85)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C15(1.51); C202(1.61); C249(0.93); C385(1.43)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C15(1.62); C202(1.70); C249(1.14); C385(1.48)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C15(0.65); C202(1.20); C249(0.87); C385(1.11)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C15(1.29); C202(1.52); C249(0.78); C385(1.36)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C15(0.62); C202(1.16); C249(0.64); C385(1.09)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C15(0.76); C202(1.35); C249(0.71); C385(1.27)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C15(0.59); C202(1.11); C249(0.68); C385(1.08)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C15(0.70); C202(1.35); C249(0.85); C385(1.15)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C15(0.38); C202(0.92); C249(0.60); C385(0.87)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C15(0.43); C202(0.92); C249(0.66); C385(0.83)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C202(0.71); C385(0.85); C54(0.85)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C15(0.37); C202(0.88); C249(0.54); C385(0.86)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C15(0.41); C202(0.95); C249(0.63); C385(0.84)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C15(0.66); C202(1.17); C249(0.81); C385(1.20)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C249(0.77); C385(0.92); C54(1.04)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C249(0.32); C385(0.79); C54(0.92)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C385(0.76); C249(0.77); C54(0.86)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C249(0.36); C385(0.81); C54(0.84)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C249(0.33); C385(0.87); C54(0.89)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C249(0.10); C385(0.75); C54(0.83)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C249(0.24); C54(0.88); C385(0.92)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C202(0.71); C54(0.81); C385(1.22)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C249(0.78); C54(0.82); C385(0.96)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C54(0.79); C249(0.81); C385(0.85)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C249(0.23); C54(0.72); C385(0.81)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C249(0.10); C54(0.68); C385(0.84)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C249(0.38); C385(0.81); C54(0.72)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C249(0.56); C385(0.84); C54(0.69)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C249(0.76); C385(0.83); C54(0.80)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C249(0.68); C385(0.65); C54(0.66)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C249(0.93); C385(1.01); C15(1.19); C54(1.25)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C249(0.43); C15(0.50); C202(1.48); C54(1.62)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C15(1.11); C249(1.13); C54(1.54); C385(1.67)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C202(0.62); C15(0.79); C385(0.94); C54(0.95)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C385(1.04); C15(1.17); C249(1.31); C202(1.82)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C15(0.90); C249(1.18); C385(1.64); C54(1.78)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C15(0.96); C385(0.97); C249(1.62); C54(1.64)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C15(0.87); C249(1.29); C385(1.56); C54(1.67)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C385(0.98); C15(1.35); C54(1.40); C249(1.43)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C202(0.82); C54(1.07); C15(1.14); C249(1.23)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C202(0.51); C385(0.75); C15(0.78); C249(1.04)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C202(0.69); C385(0.83); C15(0.94); C249(1.13)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C202(0.59); C15(0.67); C385(0.78); C249(1.07)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C385(0.46); C15(0.49); C202(0.73); C249(1.02)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C202(0.72); C54(0.89); C385(1.19); C15(1.22)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C385(0.44); C15(0.47); C202(0.51); C249(0.66)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C202(0.59); C15(0.61); C385(0.66); C54(0.98)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C15(0.41); C202(0.44); C385(0.48); C249(0.59)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C202(0.63); C249(0.63); C15(0.91); C385(0.96)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C202(0.51); C249(0.52); C385(0.88); C15(0.95)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C54(1.04); C15(1.04); C202(1.08); C249(1.70)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C15(0.59); C202(0.98); C54(1.00); C385(1.34)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C15(0.78); C202(0.90); C54(0.93); C385(1.63)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C202(0.92); C385(0.98); C249(1.08); C54(1.10)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C15(0.64); C202(0.76); C54(0.89); C385(1.24)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C202(0.79); C54(1.42); C385(1.48); C15(1.86)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C15(0.50); C202(0.99); C385(1.14); C249(1.16)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C15(0.71); C385(0.94); C54(0.97); C249(1.11)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C15(0.48); C54(0.90); C202(0.97); C385(0.97)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C15(0.46); C385(0.78); C202(0.97); C54(0.98)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C15(0.43); C202(1.08); C385(1.26); C54(1.27)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C15(0.30); C202(0.86); C54(0.96); C385(1.42)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C100(0.39); C98(0.39); C385(0.43); C249(0.77)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C31(0.43); C385(0.66); C100(0.70); C98(0.70)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C100(0.28); C98(0.28); C31(0.33); C15(0.47)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C100(0.08); C98(0.08); C31(0.11); C15(0.21)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C202(0.85); C54(1.16); C385(1.49); C15(1.71)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C100(0.08); C98(0.08); C31(0.15); C15(0.25)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C385(0.52); C100(0.58); C98(0.58); C15(1.11)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C100(0.47); C98(0.47); C385(0.52); C15(0.74)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C100(0.28); C98(0.28); C31(0.36); C15(0.57)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C100(0.19); C98(0.19); C31(0.29); C15(0.43)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C100(0.11); C98(0.11); C31(0.15); C15(0.63)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C100(0.09); C98(0.09); C31(0.12); C15(0.30)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C202(0.66); C249(0.88); C54(1.06)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C202(0.71); C249(0.72); C54(1.34)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C202(0.61); C249(0.78); C54(1.10)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C385(0.93); C202(1.12); C54(1.85)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C202(0.72); C249(0.85); C54(1.55)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C202(0.63); C249(0.67); C54(0.98)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C202(0.66); C249(0.82); C54(1.10)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C202(0.72); C249(0.97); C54(1.41)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C202(0.67); C249(0.84); C54(1.25)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C249(0.56); C202(0.72); C54(1.24)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C249(0.65); C202(0.69); C54(1.10)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C202(0.59); C249(0.62); C54(1.45)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C202(0.69); C15(0.69); C385(0.74); C54(1.07)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C202(0.57); C385(0.78); C15(0.94); C54(1.04)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C385(0.92); C202(1.22); C54(1.38)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C202(0.34); C15(0.44); C385(0.59); C54(1.15)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C54(0.87); C202(0.93); C385(0.96); C15(1.24)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C15(0.52); C202(0.58); C385(0.71); C54(1.04)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C202(0.30); C385(0.49); C15(0.52); C54(1.55)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C202(0.31); C385(0.67); C15(1.35); C54(1.57)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C202(0.28); C15(0.46); C385(0.62); C54(1.95)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C202(0.39); C385(1.02); C15(1.19); C54(1.33)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C202(0.46); C15(0.57); C385(0.75); C54(1.35)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C385(0.70); C15(0.74); C202(0.82); C54(0.97)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C15(0.42); C202(0.66); C385(0.70); C54(0.99)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C385(0.82); C202(0.99); C54(1.48)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C202(0.44); C385(0.93); C54(1.09); C15(1.36)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C15(0.62); C202(0.67); C385(0.93); C54(1.10)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C202(0.38); C385(0.69); C15(1.07); C54(1.87)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C100(0.11); C98(0.11); C15(0.21); C385(0.49)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C100(0.17); C98(0.17); C15(0.25); C385(0.50)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C100(0.43); C98(0.43); C15(0.56); C385(0.58)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C202(0.49); C249(0.70); C100(0.84); C98(0.84)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C202(0.64); C249(0.83); C31(0.85); C385(0.96)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C202(0.51); C100(0.72); C98(0.72); C249(0.72)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C100(0.40); C98(0.40); C249(0.58); C15(0.60)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C202(0.48); C31(0.85); C54(1.32); C249(1.44)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C100(0.11); C98(0.11); C15(0.22); C249(0.77)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C100(0.22); C98(0.22); C15(0.37); C249(0.64)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C100(0.77); C98(0.77); C202(0.89); C15(0.93)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C31(0.88); C15(1.10); C385(1.12); C100(1.25)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C202(0.50); C385(0.73); C249(0.79); C100(0.89)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C100(0.51); C98(0.51); C15(0.68); C31(0.83)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C100(0.31); C98(0.31); C249(0.45); C202(0.46)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C100(0.04); C98(0.04); C15(0.16); C249(0.22)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C15(0.59); C249(0.61); C100(0.68); C98(0.68)  LDD0683  [15]
 LDCM0248  AKOS034007472 HCT 116 C202(0.90); C385(0.85); C54(0.70)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C385(0.60); C54(1.05); C202(1.07)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C202(0.55); C385(1.08); C54(1.20)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 11.61  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C54(0.93)  LDD0078  [15]
 LDCM0630  CCW28-3 231MFP C54(1.08)  LDD2214  [35]
 LDCM0108  Chloroacetamide HeLa C15(0.00); C249(0.00); C202(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C5(3.45); C54(0.62)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C385(0.87); C54(1.10); C249(1.13); C15(1.55)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C249(0.41); C15(0.86); C385(0.87); C54(1.37)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C202(0.76); C54(1.04); C385(1.20); C15(1.65)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C202(0.97); C54(1.27); C385(1.41)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C54(0.77); C202(0.87); C385(1.52)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C202(0.92); C385(1.30); C54(1.54)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C54(0.79); C202(0.87); C385(1.31)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C249(0.66); C15(0.66); C202(1.14); C54(1.29)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C15(0.38); C249(0.57); C202(1.85); C385(2.34)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C15(0.40); C249(0.48); C202(1.00); C54(1.41)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C15(0.30); C249(0.33); C202(0.84); C54(1.28)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C15(0.63); C249(0.83); C202(1.37); C385(1.40)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C249(0.39); C15(0.69); C385(0.95); C54(1.65)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C15(0.43); C249(0.51); C202(1.08); C385(1.24)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C15(0.73); C249(0.80); C385(1.23); C202(1.27)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C202(0.60); C385(0.88); C15(0.98); C54(1.02)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C385(0.51); C15(0.55); C202(0.73); C249(0.76)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C385(0.45); C15(0.45); C202(0.56); C249(0.84)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C385(0.59); C15(0.70); C202(0.73); C249(0.74)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C202(0.46); C249(0.61); C385(0.82); C54(0.89)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C15(0.15); C202(0.55); C249(1.06); C385(1.07)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C15(0.51); C385(0.96); C202(1.00); C54(1.10)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C15(0.48); C202(0.98); C54(1.07); C385(1.07)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C249(0.38); C385(1.01); C15(1.02); C54(1.73)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C385(0.93); C202(0.95); C54(0.96); C15(0.97)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C100(0.49); C98(0.49); C31(0.59); C249(0.64)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C100(0.25); C98(0.25); C31(0.30); C15(0.47)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C100(0.15); C98(0.15); C31(0.23); C15(0.39)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C100(0.11); C98(0.11); C31(0.19); C15(0.28)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C202(1.00); C249(1.01); C54(1.11)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C249(0.83); C202(0.89); C54(1.23)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C249(0.86); C202(0.94); C54(1.18)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C249(0.76); C202(0.85); C54(1.11)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C249(0.44); C15(0.77); C385(1.03); C54(1.98)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C249(0.84); C385(0.97); C15(1.26); C54(1.32)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C249(0.46); C15(0.86); C385(1.31); C54(1.46)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C202(0.43); C385(0.43); C100(0.61); C98(0.61)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C100(0.39); C98(0.39); C249(0.55); C31(0.57)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C100(0.18); C98(0.18); C31(0.34); C249(0.39)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C100(0.28); C98(0.28); C31(0.45); C249(0.60)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C385(0.84); C15(0.99); C249(1.04); C54(1.28)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C100(0.26); C98(0.26); C31(0.40); C249(0.52)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C100(0.12); C98(0.12); C31(0.23); C249(0.38)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C100(0.06); C98(0.06); C31(0.13); C249(0.29)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C100(0.31); C98(0.31); C31(0.54); C385(0.62)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C100(0.11); C98(0.11); C31(0.20); C249(0.38)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C100(0.18); C98(0.18); C202(0.67); C249(0.45)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C100(0.32); C98(0.32); C202(0.56); C249(0.56)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C100(0.39); C98(0.39); C202(0.79); C249(0.86)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C100(0.23); C98(0.23); C202(0.84); C249(0.52)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C100(0.21); C98(0.21); C202(1.33); C249(0.52)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C15(1.41); C249(1.00); C385(1.25); C54(1.22)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C100(0.40); C98(0.40); C202(1.14); C249(0.72)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C15(0.82); C202(0.96); C249(0.59); C31(0.79)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C15(0.41); C249(0.28); C31(0.44); C54(1.08)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C15(0.54); C249(0.33); C31(0.65); C54(1.11)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C15(0.26); C249(0.26); C31(0.29); C54(0.93)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C15(0.33); C249(0.25); C31(0.28); C54(1.11)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C15(0.39); C249(0.32); C31(0.42); C54(0.98)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C15(0.22); C249(0.23); C31(0.27); C54(1.12)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C15(0.27); C249(0.29); C31(0.30); C54(1.07)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C15(1.11); C249(0.84); C385(1.06); C54(1.10)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C15(0.51); C249(0.37); C31(0.50); C54(1.16)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C15(0.48); C249(0.41); C31(0.44); C54(1.20)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C15(0.13); C249(0.14); C31(0.10); C54(1.31)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C15(0.19); C249(0.17); C31(0.24); C54(2.13)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C15(0.32); C249(0.23); C31(0.34); C54(1.09)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C15(0.22); C249(0.21); C31(0.25); C54(0.86)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C202(1.45); C385(0.55); C54(1.34)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C202(1.11); C385(0.41); C54(1.10)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C202(1.39); C385(0.58); C54(1.19)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C202(1.28); C385(0.98); C54(0.97)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C15(1.02); C249(0.85); C385(1.34); C54(1.29)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C202(1.27); C385(0.83); C54(1.15)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C202(1.35); C385(0.70); C54(1.12)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C202(1.12); C385(0.47); C54(1.37)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C202(1.42); C385(0.45); C54(1.18)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C202(1.39); C385(0.60); C54(1.30)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C202(1.42); C385(0.80); C54(1.25)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C202(0.98); C385(0.66); C54(1.24)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C202(1.37); C385(0.60); C54(1.09)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C202(1.40); C385(0.78); C54(1.10)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C202(0.99); C385(0.81); C54(1.12)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C15(0.99); C249(0.64); C385(0.95); C54(1.61)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C202(0.98); C385(0.62); C54(1.10)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C100(0.61); C98(0.61); C15(0.83); C202(0.97)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C100(0.67); C98(0.67); C15(0.63); C202(0.95)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C100(0.46); C98(0.46); C15(0.46); C202(0.90)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C100(0.38); C98(0.38); C15(0.60); C202(1.00)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C100(0.56); C98(0.56); C15(1.14); C202(0.94)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C100(0.16); C98(0.16); C15(0.19); C202(1.02)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C100(0.37); C98(0.37); C15(0.38); C202(1.11)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C100(0.37); C98(0.37); C15(0.47); C202(1.10)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C100(0.56); C98(0.56); C15(0.89); C202(1.81)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C15(1.24); C249(0.56); C385(1.09); C54(1.43)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C100(0.46); C98(0.46); C15(0.45); C202(1.05)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C100(0.42); C98(0.42); C15(0.40); C202(1.11)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C100(0.82); C98(0.82); C15(0.90); C202(1.13)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C100(0.43); C98(0.43); C15(0.62); C202(1.35)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C100(0.42); C98(0.42); C15(0.54); C202(1.36)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C15(0.73); C202(0.96); C385(0.94); C54(0.99)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C15(0.75); C202(0.91); C385(0.73); C54(0.92)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C15(0.79); C202(0.93); C385(1.22); C54(1.08)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C15(0.44); C202(0.91); C385(0.76); C54(1.06)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C15(0.41); C249(0.33); C385(0.88); C54(1.64)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C15(0.76); C202(0.85); C385(1.11); C54(0.94)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C15(0.72); C202(0.99); C385(0.89); C54(0.93)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C15(0.16); C202(0.86); C385(1.10); C54(1.15)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C15(0.22); C202(0.71); C385(0.81); C54(1.18)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C15(0.15); C202(0.75); C385(0.81); C54(1.58)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C15(0.74); C202(0.96); C385(0.79); C54(1.14)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C15(1.19); C202(1.01); C385(0.88); C54(1.12)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C15(0.67); C202(1.00); C385(0.81); C54(1.17)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C15(0.30); C202(0.88); C385(0.93); C54(1.24)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C15(0.14); C202(0.76); C385(0.99); C54(1.45)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C15(0.87); C249(0.84); C385(0.83); C54(1.32)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C15(0.95); C202(0.76); C385(0.67); C54(0.82)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C15(0.49); C202(0.58); C385(1.08); C54(0.97)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C15(0.96); C202(1.07); C385(1.39); C54(1.10)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C15(2.37); C202(1.65); C385(1.74); C54(0.99)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C15(3.04); C202(2.08); C385(1.51); C54(1.21)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C15(0.78); C202(0.67); C385(1.14); C54(1.04)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C15(0.66); C202(0.72); C385(1.02); C54(0.82)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C15(0.54); C202(0.56); C385(0.83); C54(0.98)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C15(0.97); C202(0.59); C385(0.98); C54(1.04)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C15(1.27); C202(0.67); C385(1.19); C54(1.13)  LDD0811  [15]
 LDCM0634  CY-0357 Hep-G2 C54(2.96); C202(1.66); C249(1.65)  LDD2228  [19]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C54(4.62)  LDD0513  [36]
 LDCM0028  Dobutamine HEK-293T 4.14  LDD0180  [9]
 LDCM0027  Dopamine HEK-293T 4.58  LDD0179  [9]
 LDCM0495  E2913 HEK-293T C54(1.09); C385(1.11); C249(1.04); C15(0.92)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C54(0.76)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa C54(0.65)  LDD2210  [11]
 LDCM0625  F8 Ramos C54(1.65); C249(1.30); C15(1.05); C385(0.55)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C54(3.38); C249(0.40); C15(0.58); C202(0.56)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C54(0.69); C249(5.55); C15(8.25)  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C54(0.80); C249(0.45); C15(0.67); C202(0.57)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C54(0.89); C249(0.72); C15(0.94); C202(0.96)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C54(0.49); C249(0.59); C15(0.75); C202(0.84)  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C54(0.85); C249(0.29); C15(0.56); C202(0.50)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C54(0.91); C249(0.91); C15(0.94); C202(0.77)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C54(0.93); C249(0.14); C15(0.51); C202(0.31)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C54(0.92); C249(0.71); C15(0.93); C202(0.90)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C54(0.84); C249(0.55); C15(1.32); C202(0.56)  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C54(1.08); C249(0.67); C15(0.99); C202(0.97)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C54(0.81); C249(0.72); C15(1.15); C202(0.87)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C54(2.18); C249(0.45); C15(0.56); C202(0.60)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C100(0.47); C98(0.47); C15(0.53); C202(0.96)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C54(0.81); C249(0.69); C15(0.67); C202(0.56)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C54(0.79); C249(0.93); C15(1.06); C385(0.51)  LDD2184  [38]
 LDCM0427  Fragment51 HCT 116 C15(0.12); C249(0.15); C31(0.10); C54(1.08)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C54(1.05); C249(0.87); C15(0.80); C202(0.94)  LDD2204  [38]
 LDCM0614  Fragment56 Ramos C54(1.16); C249(1.00); C15(1.06); C202(0.69)  LDD2205  [38]
 LDCM0569  Fragment7 Ramos C54(1.21); C249(0.51); C15(1.00); C385(0.42)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C54(1.14); C249(0.32); C15(0.44); C202(0.45)  LDD2188  [38]
 LDCM0116  HHS-0101 DM93 Y392(0.98); Y217(1.07); Y203(3.39)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y217(0.88); Y203(0.92); Y392(1.12)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y392(1.05); Y217(1.17); Y203(2.45)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y217(0.96); Y392(0.98); Y203(6.25)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y392(0.97); Y217(1.15); Y203(3.15)  LDD0268  [13]
 LDCM0107  IAA HeLa C202(0.00); C249(0.00)  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y203(1.10); Y392(0.98)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y203(0.83); Y392(0.80)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y203(1.12); Y392(1.11)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y203(2.73); Y392(3.24)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y203(2.10); Y392(2.03)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y203(1.40); Y392(1.21)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y203(0.59); Y392(0.94)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y203(1.05); Y392(1.19)  LDD0292  [12]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 HCT 116 C98(3.83); C100(3.83); C249(1.30)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C98(13.20); C100(13.20); C249(1.07)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C98(3.31); C100(3.31); C249(1.35)  LDD0082  [15]
 LDCM0109  NEM HeLa H403(0.00); H166(0.00)  LDD0223  [28]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C249(1.23)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C54(1.01)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C15(0.92); C54(1.02); C385(0.95)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C385(0.98)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C385(0.52)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C54(0.45)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C15(0.98); C54(0.81); C385(0.46)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C15(0.22); C385(0.57)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C385(0.51); C249(0.80)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C385(0.33)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C54(1.58)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C15(0.31)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C15(0.74); C54(0.80)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C15(0.78); C54(1.15)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C15(0.62); C54(0.73)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C15(0.99); C54(0.86)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C54(0.73)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C54(0.46)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C54(0.93); C385(0.59)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C54(0.78); C385(0.80)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C54(2.11)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C54(0.97)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C54(0.86); C249(0.47)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C15(1.09); C54(0.78); C385(0.24)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C249(0.81)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C15(0.74); C54(0.92)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C15(0.89); C54(1.06); C249(0.93)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C54(0.66); C385(0.63)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C15(1.20); C54(0.97)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C54(0.70)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C54(0.44); C385(0.40)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C15(1.53); C54(1.02); C249(0.83)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C15(1.26); C54(1.07); C249(1.45); C202(1.30)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C15(0.91); C54(0.82)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C54(1.32); C385(1.17)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C15(0.85); C54(0.60); C385(0.54); C249(1.86)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C54(1.05)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C54(0.80); C385(1.49)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C15(2.78); C54(2.27); C385(0.60)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C15(0.13); C249(0.24)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C15(0.88); C54(0.94)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C385(1.30)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C54(0.53)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C54(0.92); C385(0.82)  LDD2149  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C54(0.16); C54(0.11)  LDD2206  [39]
 LDCM0628  OTUB2-COV-1 HEK-293T C54(1.22); C54(0.86)  LDD2207  [39]
 LDCM0131  RA190 MM1.R C249(1.23); C31(1.07); C54(1.05)  LDD0304  [40]
 LDCM0021  THZ1 HeLa S3 C506(0.98)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
23 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
26 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
27 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
31 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
32 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
33 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
34 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
35 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
36 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
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Mass spectrometry data entry: PXD044402
38 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
39 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
40 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.