Details of the Target

General Information of Target

Target ID LDTP08830
Target Name MICAL-like protein 1 (MICALL1)
Gene Name MICALL1
Gene ID 85377
Synonyms
KIAA1668; MIRAB13; MICAL-like protein 1; Molecule interacting with Rab13; MIRab13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLDFDSLSKDNVF
ENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFCSPGQAGVSPPRK
GLAPCSPPSVAPTPVEPEDVAQGEELSSGSLSEQGTGQTPSSTCAACQQHVHLVQRYLAD
GRLYHRHCFRCRRCSSTLLPGAYENGPEEGTFVCAEHCARLGPGTRSGTRPGPFSQPKQQ
HQQQLAEDAKDVPGGGPSSSAPAGAEADGPKASPEARPQIPTKPRVPGKLQELASPPAGR
PTPAPRKASESTTPAPPTPRPRSSLQQENLVEQAGSSSLVNGRLHELPVPKPRGTPKPSE
GTPAPRKDPPWITLVQAEPKKKPAPLPPSSSPGPPSQDSRQVENGGTEEVAQPSPTASLE
SKPYNPFEEEEEDKEEEAPAAPSLATSPALGHPESTPKSLHPWYGITPTSSPKTKKRPAP
RAPSASPLALHASRLSHSEPPSATPSPALSVESLSSESASQTAGAELLEPPAVPKSSSEP
AVHAPGTPGNPVSLSTNSSLASSGELVEPRVEQMPQASPGLAPRTRGSSGPQPAKPCSGA
TPTPLLLVGDRSPVPSPGSSSPQLQVKSSCKENPFNRKPSPAASPATKKATKGSKPVRPP
APGHGFPLIKRKVQADQYIPEEDIHGEMDTIERRLDALEHRGVLLEEKLRGGLNEGREDD
MLVDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEYELRCLLNKPEKDWTEEDRAR
EKVLMQELVTLIEQRNAIINCLDEDRQREEEEDKMLEAMIKKKEFQREAEPEGKKKGKFK
TMKMLKLLGNKRDAKSKSPRDKS
Target Bioclass
Other
Subcellular location
Recycling endosome membrane
Function
Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.
Uniprot ID
Q8N3F8
Ensemble ID
ENST00000215957.10
HGNC ID
HGNC:29804

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K708(2.50)  LDD0277  [2]
BTD
 Probe Info  		C597(0.95)  LDD2118  [3]
DA-P3
 Probe Info  		8.23  LDD0180  [4]
HHS-475
 Probe Info  		Y464(1.15)  LDD0264  [5]
HHS-465
 Probe Info  		Y464(8.08)  LDD2237  [6]
DBIA
 Probe Info  		C214(1.13); C218(1.13); C194(0.87)  LDD0078  [7]
CY4
 Probe Info  		H730(0.00); H733(0.00)  LDD0247  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C38(0.00); C12(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C764(0.00); C38(0.00); C16(0.00)  LDD0162  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NAIA_5
 Probe Info  		N.A.  LDD2225  [11]
IPM
 Probe Info  		C597(0.00); C764(0.00)  LDD0005  [12]
NPM
 Probe Info  		N.A.  LDD0016  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C630(0.00); C597(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C403
 Probe Info  		18.77  LDD2061  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C801(1.05); C597(0.93); C764(1.14); C214(0.87)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C194(1.36); C214(1.09); C218(1.09); C801(0.83)  LDD0813  [7]
 LDCM0216  AC100 HEK-293T C194(1.08); C214(1.08); C218(1.08)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C194(1.01); C214(1.01); C218(1.01)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C194(1.33); C214(1.33); C218(1.33)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C194(0.93); C214(0.93); C218(0.93)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C194(1.47); C214(1.47); C218(1.47)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C194(0.96); C214(0.96); C218(0.96)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C194(1.37); C214(1.37); C218(1.37)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C194(1.29); C214(1.29); C218(1.29)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C194(1.40); C214(1.40); C218(1.40)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C194(1.18); C214(1.18); C218(1.18)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C194(1.38); C214(1.14); C218(1.14); C801(0.97)  LDD0824  [7]
 LDCM0227  AC110 HEK-293T C194(1.29); C214(1.29); C218(1.29)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C194(1.20); C214(1.20); C218(1.20)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C194(1.24); C214(1.24); C218(1.24)  LDD0827  [7]
 LDCM0237  AC12 HEK-293T C194(1.26); C214(1.08); C218(1.08); C801(0.78)  LDD0835  [7]
 LDCM0246  AC128 HEK-293T C194(1.20); C214(1.20); C218(1.20)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C194(1.21); C214(1.21); C218(1.21)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C194(1.04); C214(1.04); C218(1.04)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C194(0.86); C214(0.86); C218(0.86)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C194(1.86); C214(1.86); C218(1.86)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C194(0.83); C214(0.83); C218(0.83)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C194(1.15); C214(1.15); C218(1.15)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C194(0.87); C214(0.87); C218(0.87)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C194(1.16); C214(1.16); C218(1.16)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C194(1.30); C214(1.30); C218(1.30)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C194(1.11); C214(1.11); C218(1.11)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C194(1.19); C214(1.19); C218(1.19)  LDD0856  [7]
 LDCM0259  AC14 HEK-293T C194(1.64); C214(1.32); C218(1.32); C801(1.00)  LDD0857  [7]
 LDCM0260  AC140 HEK-293T C194(0.98); C214(0.98); C218(0.98)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C194(1.32); C214(1.32); C218(1.32)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C194(1.12); C214(1.12); C218(1.12)  LDD0860  [7]
 LDCM0270  AC15 HEK-293T C194(1.37); C214(1.13); C218(1.13); C801(1.01)  LDD0868  [7]
 LDCM0276  AC17 HEK-293T C801(1.80)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C801(1.51)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C801(1.57)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C801(1.02); C597(0.95); C764(0.99); C214(1.00)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C801(1.64)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C801(1.32)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C801(1.93)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C801(1.99)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C801(1.78)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C801(1.09); C597(0.98); C764(1.07); C214(1.07)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C801(1.03); C597(1.01); C764(0.88); C214(0.90)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C801(0.92); C597(0.89); C764(0.93); C214(1.19)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C801(1.01); C597(1.04); C764(0.96); C214(0.92)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C801(1.01); C597(0.98); C764(0.88); C214(0.99)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C801(0.96); C597(0.99); C764(1.00); C214(0.82)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C801(1.01); C597(1.12); C764(1.05); C214(1.41)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C801(1.08); C597(0.99); C764(1.02); C214(0.87)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C801(1.00); C597(1.07); C764(1.00); C214(1.00)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C801(1.01); C597(1.02); C764(1.18); C214(0.94)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C801(1.06); C597(0.97); C764(0.85); C214(0.87)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C194(1.24); C214(1.24); C218(1.24)  LDD0894  [7]
 LDCM0297  AC36 HEK-293T C194(0.90); C214(0.90); C218(0.90)  LDD0895  [7]
 LDCM0298  AC37 HEK-293T C194(0.88); C214(0.88); C218(0.88)  LDD0896  [7]
 LDCM0299  AC38 HEK-293T C194(0.94); C214(0.94); C218(0.94)  LDD0897  [7]
 LDCM0300  AC39 HEK-293T C194(1.38); C214(1.38); C218(1.38)  LDD0898  [7]
 LDCM0301  AC4 HEK-293T C801(1.05); C597(1.09); C764(1.07); C214(0.90)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C194(0.75); C214(0.75); C218(0.75)  LDD0900  [7]
 LDCM0303  AC41 HEK-293T C194(0.98); C214(0.98); C218(0.98)  LDD0901  [7]
 LDCM0304  AC42 HEK-293T C194(1.06); C214(1.06); C218(1.06)  LDD0902  [7]
 LDCM0305  AC43 HEK-293T C194(1.02); C214(1.02); C218(1.02)  LDD0903  [7]
 LDCM0306  AC44 HEK-293T C194(1.14); C214(1.14); C218(1.14)  LDD0904  [7]
 LDCM0307  AC45 HEK-293T C194(1.27); C214(1.27); C218(1.27)  LDD0905  [7]
 LDCM0308  AC46 HEK-293T C801(1.10); C597(1.22); C764(1.10); C214(1.24)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C801(1.08); C597(1.13); C764(0.92); C214(0.80)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C801(1.12); C597(1.09); C764(0.94); C214(0.81)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C801(1.12); C597(0.99); C764(1.15); C214(1.23)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C801(1.01); C597(0.97); C764(0.94); C214(0.90)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C801(1.14); C597(0.92); C764(0.95); C214(0.84)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C801(1.11); C597(0.97); C764(0.98); C214(0.94)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C801(1.06); C597(1.13); C764(1.08); C214(0.98)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C801(1.06); C597(1.05); C764(0.89); C214(1.15)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C801(1.10); C597(1.24); C764(1.10); C214(1.33)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C801(1.14); C597(1.05); C764(1.01); C214(0.88)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C801(1.10); C597(1.02); C764(0.98); C214(0.94)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C194(1.13); C214(1.13); C801(0.85)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C194(1.14); C214(1.14); C801(0.77)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C194(1.14); C214(1.14); C801(0.81)  LDD0920  [7]
 LDCM0323  AC6 HEK-293T C194(1.06); C214(0.97); C218(0.97); C801(1.01)  LDD0921  [7]
 LDCM0324  AC60 HEK-293T C194(0.85); C214(0.85); C801(0.68)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C194(1.07); C214(1.07); C801(0.94)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C194(1.26); C214(1.26); C801(0.66)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C194(1.25); C214(1.25); C801(0.78)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C194(1.12); C214(1.12); C801(0.91)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C194(1.14); C214(1.14); C801(0.81)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C194(1.34); C214(1.34); C801(0.74)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C194(1.55); C214(1.55); C801(1.01)  LDD0929  [7]
 LDCM0332  AC68 HEK-293T C801(0.86)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C801(1.13)  LDD0931  [7]
 LDCM0334  AC7 HEK-293T C194(0.98); C214(0.96); C218(0.96); C801(1.25)  LDD0932  [7]
 LDCM0335  AC70 HEK-293T C801(1.21)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C801(1.03)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C801(1.03)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C801(1.08)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C801(1.46)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C801(1.37)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C801(1.06)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C801(1.00)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C801(1.26)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C801(1.22)  LDD0942  [7]
 LDCM0345  AC8 HEK-293T C194(1.19); C214(0.97); C218(0.97); C801(1.53)  LDD0943  [7]
 LDCM0346  AC80 HEK-293T C801(1.43)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C801(1.31)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C801(1.75)  LDD0946  [7]
 LDCM0349  AC83 HEK-293T C801(0.67)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C801(1.25)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C801(1.22)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C801(1.36)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C801(1.06)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C801(1.14)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C801(1.34)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C801(1.33)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C801(1.12)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C801(1.33)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C801(0.91)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C801(1.17)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C801(1.35)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C801(1.11)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C801(2.48)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C194(1.19); C214(1.19); C218(1.19)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C194(1.15); C214(1.15); C218(1.15)  LDD0964  [7]
 LDCM0248  AKOS034007472 HEK-293T C194(1.43); C214(1.17); C218(1.17); C801(0.90)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C194(1.20); C214(1.04); C218(1.04); C801(1.09)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C194(1.63); C214(1.34); C218(1.34); C801(1.24)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 11.49  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C214(1.13); C218(1.13); C194(0.87)  LDD0078  [7]
 LDCM0632  CL-Sc Hep-G2 C764(2.15); C630(0.72)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C801(2.37)  LDD0965  [7]
 LDCM0368  CL10 HEK-293T C801(2.50)  LDD0966  [7]
 LDCM0369  CL100 HEK-293T C801(0.94); C597(1.01); C764(1.05); C125(1.20)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C194(1.12); C214(1.08); C218(1.08); C801(1.40)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C194(2.45); C214(1.93); C218(1.93); C801(1.29)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C194(0.86); C214(0.81); C218(0.81); C801(1.33)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C194(1.15); C214(1.06); C218(1.06); C801(1.04)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C801(1.62)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C801(1.67)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C801(1.61)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C801(1.41)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C801(1.77)  LDD0976  [7]
 LDCM0379  CL11 HEK-293T C801(2.44)  LDD0977  [7]
 LDCM0380  CL110 HEK-293T C801(1.61)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C801(1.65)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C801(0.99); C597(1.02); C764(1.00); C125(0.90)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C801(0.94); C597(0.98); C764(0.84); C214(0.94)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C801(1.00); C597(1.09); C764(1.00); C214(1.21)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C801(1.03); C597(0.88); C764(1.06)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C801(1.03); C597(1.13); C764(1.05); C125(1.08)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C194(1.17); C214(1.17); C218(1.17)  LDD0985  [7]
 LDCM0388  CL118 HEK-293T C194(0.79); C214(0.79); C218(0.79)  LDD0986  [7]
 LDCM0389  CL119 HEK-293T C194(0.93); C214(0.93); C218(0.93)  LDD0987  [7]
 LDCM0390  CL12 HEK-293T C801(1.36)  LDD0988  [7]
 LDCM0391  CL120 HEK-293T C194(1.09); C214(1.09); C218(1.09)  LDD0989  [7]
 LDCM0392  CL121 HEK-293T C801(1.01); C597(0.97); C764(0.86); C214(1.32)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C801(1.07); C597(0.98); C764(1.04); C214(1.28)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C801(1.07); C597(1.07); C764(0.91)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C801(1.02); C597(1.25); C764(1.08); C125(0.78)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C194(1.04); C214(1.04); C801(0.81)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C194(0.89); C214(0.89); C801(0.69)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C194(0.97); C214(0.97); C801(0.62)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C194(1.19); C214(1.19); C801(0.82)  LDD0997  [7]
 LDCM0400  CL13 HEK-293T C801(1.39)  LDD0998  [7]
 LDCM0401  CL14 HEK-293T C801(1.51)  LDD0999  [7]
 LDCM0402  CL15 HEK-293T C801(3.36)  LDD1000  [7]
 LDCM0403  CL16 HEK-293T C801(1.22)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C801(1.39)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C801(1.62)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C801(1.17)  LDD1004  [7]
 LDCM0407  CL2 HEK-293T C801(1.43)  LDD1005  [7]
 LDCM0408  CL20 HEK-293T C801(1.32)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C801(1.49)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C801(1.11)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C801(0.91)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C801(1.21)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C801(1.15)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C801(1.08)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C801(1.20)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C801(0.90)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C801(1.09)  LDD1015  [7]
 LDCM0418  CL3 HEK-293T C801(1.68)  LDD1016  [7]
 LDCM0419  CL30 HEK-293T C801(1.40)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C801(2.09)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C801(1.54)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C801(3.33)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C801(1.39)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C801(1.64)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C801(1.31)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C801(1.31)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C801(2.42)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C801(1.21)  LDD1027  [7]
 LDCM0430  CL40 HEK-293T C801(1.62)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C801(1.91)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C801(1.90)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C801(1.64)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C801(1.57)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C801(2.39)  LDD1033  [7]
 LDCM0436  CL46 HEK-293T C801(1.87)  LDD1034  [7]
 LDCM0437  CL47 HEK-293T C801(1.24)  LDD1035  [7]
 LDCM0438  CL48 HEK-293T C801(1.41)  LDD1036  [7]
 LDCM0439  CL49 HEK-293T C801(1.10)  LDD1037  [7]
 LDCM0440  CL5 HEK-293T C801(1.49)  LDD1038  [7]
 LDCM0441  CL50 HEK-293T C801(1.34)  LDD1039  [7]
 LDCM0442  CL51 HEK-293T C801(1.15)  LDD1040  [7]
 LDCM0443  CL52 HEK-293T C801(0.84)  LDD1041  [7]
 LDCM0444  CL53 HEK-293T C801(1.05)  LDD1042  [7]
 LDCM0445  CL54 HEK-293T C801(1.00)  LDD1043  [7]
 LDCM0446  CL55 HEK-293T C801(1.15)  LDD1044  [7]
 LDCM0447  CL56 HEK-293T C801(1.05)  LDD1045  [7]
 LDCM0448  CL57 HEK-293T C801(1.10)  LDD1046  [7]
 LDCM0449  CL58 HEK-293T C801(0.90)  LDD1047  [7]
 LDCM0450  CL59 HEK-293T C801(1.25)  LDD1048  [7]
 LDCM0451  CL6 HEK-293T C801(1.61)  LDD1049  [7]
 LDCM0452  CL60 HEK-293T C801(1.37)  LDD1050  [7]
 LDCM0453  CL61 HEK-293T C801(0.88); C597(0.90); C764(0.90); C214(1.02)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C801(1.01); C597(0.92); C764(1.14); C214(1.18)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C801(1.06); C597(0.90); C764(1.13)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C801(1.10); C597(1.03); C764(0.94); C125(0.93)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C801(1.11); C597(0.96); C764(1.26); C214(0.91)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C801(1.02); C597(0.95); C764(0.84); C214(1.06)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C801(1.27); C597(0.87); C764(1.09); C214(0.89)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C801(1.25); C597(0.84); C764(1.09); C214(1.27)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C801(1.19); C597(0.67); C764(0.79); C214(0.99)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C801(1.54)  LDD1060  [7]
 LDCM0463  CL70 HEK-293T C801(1.22); C597(0.81); C764(1.13); C214(1.30)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C801(1.45); C597(0.89); C764(0.92); C214(1.00)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C801(1.18); C597(0.73); C764(0.88); C214(1.27)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C801(0.90); C597(0.93); C764(0.83); C214(0.95)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C801(1.01); C597(0.99); C764(1.14); C214(0.96)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C801(1.65)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C801(1.75)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C801(2.83)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C801(2.04)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C801(0.74)  LDD1071  [7]
 LDCM0474  CL80 HEK-293T C801(1.35)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C801(1.28)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C801(1.18)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C801(1.16)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C801(1.99)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C801(1.78)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C801(1.97)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C801(1.78)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C801(1.60)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C801(1.82)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C801(0.59)  LDD1082  [7]
 LDCM0485  CL90 HEK-293T C801(1.97)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C801(0.92); C597(0.90); C764(1.17); C214(1.04)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C801(0.98); C597(0.94); C764(1.03); C214(0.93)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C801(1.06); C597(0.81); C764(0.72); C214(0.96)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C801(1.05); C597(1.04); C764(1.12); C214(1.10)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C801(1.02); C597(0.92); C764(0.80); C214(0.87)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C801(0.93); C597(0.87); C764(0.80); C214(1.00)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C801(0.94); C597(1.08); C764(0.80); C214(0.92)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C801(0.92); C597(0.96); C764(1.09); C214(1.03)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C801(1.03); C597(1.02); C764(0.97)  LDD1697  [18]
 LDCM0028  Dobutamine HEK-293T 8.23  LDD0180  [4]
 LDCM0495  E2913 HEK-293T C801(1.03); C597(0.89); C764(1.24)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C597(1.36); C764(1.04)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C801(0.99); C597(0.97); C764(1.04)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C801(1.18)  LDD1025  [7]
 LDCM0116  HHS-0101 DM93 Y464(1.15)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y464(1.09)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y464(0.74)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y464(0.81)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y464(1.19)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C194(2.89); C218(2.89); C214(2.60)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C194(1.63); C218(1.63); C214(1.13)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C194(1.46); C218(1.46); C214(1.40)  LDD0082  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C597(0.95)  LDD2118  [3]
 LDCM0021  THZ1 HCT 116 C194(1.09); C214(1.09); C218(1.09)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-35 (RAB35) Rab family Q15286
EH domain-containing protein 3 (EHD3) Dynamin/Fzo/YdjA family Q9NZN3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EH domain-containing protein 1 (EHD1) Dynamin/Fzo/YdjA family Q9H4M9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402